Modern determinants of endometrium hyperplastic processes pathogenesis

The objective: to еxplore the relationship between the activity of endometrial proliferation and the state of the local immune response in the uterus in the conditions berprestasi process. Patients and methods. Examined 228 women of reproductive and perimenopausal age with endometrial pathology using ultrasound and then performing hysteroresectoscopy. Determination of the concentrations of the cytokines IL-1, IL-2, IL-6 and TNF was performed by solid phase ELISA. Results. Found a trend that confirms the loss of sensitivity to hormones at the stage of malignancy of the endometrium and can be used as diagnostic determinants in determining the nature of intrauterine pathology and criterion of the effectiveness of conservative therapy. Conclusion. Improving etiopatogenetice approach to the therapy of hyperplastic proce.sses of endometrium with determination of receptor phenotype of the endometrium is a research direction in modern gynecology, which will help to improve the results of treatment and prevention of intrauterine pathology. Key words: endometrial hyperplasia,the receptors for progesterone and estrogen, immunohistochemical method.

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PROGNOSTIC SIGNIFICANCE OF REARRANGEMENTS OF EML4-ALK IN PATIENTS WITH STAGE TI-II ADENOCARCINOMA IN THE RELATIONSHIP WITH SOME CLINICAL AND MORPHOLOGICAL PARAMETERS

Russian Journal of Oncology ◽

10.18821/1028-9984-2017-22-4-194-197 ◽

2017 ◽

Vol 22 (4) ◽

pp. 194-197

Author(s):

Ashot M. Avdalyan ◽

A. U Panasyan ◽

A. A Ivanov ◽

O. V Samuilenkova ◽

S. Y Bakharev ◽

...

Keyword(s):

Survival Rate ◽

Lymph Nodes ◽

Prognostic Significance ◽

Stage I ◽

Immunohistochemical Method ◽

Her2 Gene ◽

Gene Status ◽

The Relationship

The purpose of the study: determination of ALK gene status (mutation) in patients with stage TI-II adenocarcinoma in the relationship with survival, stage, size, metastases in bronchopulmonary lymph nodes and the amplification of Her2/Neu. Materials. 98 stage I-II adenocarcinoma patients. Cases with a mutation in ALK account for 20 (4.8% without randomization). There was used the immunohistochemical method and in situ hybridization. Results. The survival rate of adenocarcinoma patients with metastases in the lymph nodes was lower than in cases without metastases: 8.3 ± 7.8% and 40.9 ± 13% respectively. None of patients with a mutation ALK lived up to 9 years in contrast to the cases without mutations (37.4 ± 12.6%). In the presence of amplification of the Her2 gene survival rate in adenocarcinoma patients was lower if compared to cases without amplification (p = 0.02). Correlation between ALK mutation and amplification of Her2 with increased N is not revealed. Thus, an independent criterion of the prognosis for cases with of stage I-II lung adenocarcinoma is the N index (χ2 = 9.6, p = 0.001). The rate of mutation of ALK was lower, but had the second largest impact on the prognosis (χ2 = 7.7, p = 0.005).

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Thromboplastin Related Differences in the Determination of International Normalised Ratio: A Cause for Concern?

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648883 ◽

1994 ◽

Vol 72 (03) ◽

pp. 426-429 ◽

Cited By ~ 31

Author(s):

S Kitchen ◽

I D Walker ◽

T A L Woods ◽

F E Preston

Keyword(s):

Patient Management ◽

External Quality Assessment ◽

Oral Anticoagulant Therapy ◽

Warfarin Dosage ◽

External Quality ◽

External Quality Assessment Scheme ◽

International Normalised Ratio ◽

The Uk ◽

The Relationship

SummaryWhen the International Normalised Ratio (INR) is used for control of oral anticoagulant therapy the same result should be obtained irrespective of the laboratory reagent used. However, in the UK National External Quality Assessment Scheme (NEQAS) for Blood Coagulation INRs determined using different reagents have been significantly different.For 18 NEQAS samples Manchester Reagent (MR) was associated with significantly lower INRs than those obtained using Diagen Activated (DA, p = 0.0004) or Instrumentation Laboratory PT-Fib HS (IL, p = 0.0001). Mean INRs for this group were 3.15, 3.61, and 3.65 for MR, DA, and IL respectively. For 61 fresh samples from warfarin-ised patients with INRs of greater than 3.0 the relationship between thromboplastins in respect of INR was similar to that observed for NEQAS data. Thus INRs obtained with MR were significantly lower than with DA or IL (p <0.0001). Mean INRs for this group were 4.01, 4.40, and 4.59 for MR, DA, and IL respectively.We conclude that the differences between INRs measured with the thromboplastins studied here are sufficiently great to influence patient management through warfarin dosage schedules, particularly in the upper therapeutic range of INR. There is clearly a need to address the issues responsible for the observed discrepancies.

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218. Determination of Formaldehyde Using Solid Phase Microextraction for Both Instantaneous and Timeweighted Average Sampling

10.3320/1.2762606 ◽

1999 ◽

Author(s):

P.A. Martos ◽

J. Pawliszyn

Keyword(s):

Solid Phase Microextraction ◽

Solid Phase ◽

Average Sampling

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Calculating the aerodynamics of vertical axis wind turbines

Vietnam Journal of Mechanics ◽

10.15625/0866-7136/34/3/2358 ◽

2012 ◽

Vol 34 (3) ◽

pp. 169-184 ◽

Cited By ~ 1

Author(s):

Hoang Thi Bich Ngoc

Keyword(s):

Wind Turbine ◽

Incidence Angle ◽

Vertical Axis ◽

Rotor Blades ◽

Vertical Axis Wind Turbine ◽

Horizontal Axis Wind Turbine ◽

Velocity Triangle ◽

Relationship Of ◽

The Relationship

Vertical axis wind turbine technology has been applied last years, very long after horizontal axis wind turbine technology. Aerodynamic problems of vertical axis wind machines are discussible. An important problem is the determination of the incidence law in the interaction between wind and rotor blades. The focus of the work is to establish equations of the incidence depending on the blade azimuth, and to solve them. From these results, aerodynamic torques and power can be calculated. The incidence angle is a parameter of velocity triangle, and both the factors depend not only on the blade azimuth but also on the ratio of rotational speed and horizontal speed. The built computational program allows theoretically selecting the relationship of geometric parameters of wind turbine in accordance with requirements on power, wind speed and installation conditions.

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Tire Treadwear — A Comprehensive Evaluation of the Factors: Generic Type, Aspect Ratio, Tread Pattern, and Tread Composition Part I: Introduction and Details on the Organization of the Program

Tire Science and Technology ◽

10.2346/1.2148774 ◽

1986 ◽

Vol 14 (4) ◽

pp. 201-218 ◽

Cited By ~ 3

Author(s):

A. G. Veith

Keyword(s):

Aspect Ratio ◽

Comprehensive Evaluation ◽

Test Method ◽

Interactive Effects ◽

Data Analyses ◽

Main Effect ◽

Systematic Determination ◽

Relationship Of ◽

The Relationship

Abstract This four-part series of papers addresses the problem of systematic determination of the influence of several tire factors on tire treadwear. Both the main effect of each factor and some of their interactive effects are included. The program was also structured to evaluate the influence of some external-to-tire conditions on the relationship of tire factors to treadwear. Part I describes the experimental design used to evaluate the effects on treadwear of generic tire type, aspect ratio, tread pattern (groove or void level), type of pattern (straight rib or block), and tread compound. Construction procedures and precautions used to obtain a valid and functional test method are included. Two guiding principles to be used in the data analyses of Parts II and III are discussed. These are the fractional groove and void concept, to characterize tread pattern geometry, and a demonstration of the equivalence of wear rate for identical compounds on whole tread or multi-section tread tires.

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The Awareness Level of the Safety and Health of the Operational Level

ADVANCES IN BUSINESS RESEARCH INTERNATIONAL JOURNAL ◽

10.24191/abrij.v3i1.10036 ◽

2017 ◽

Vol 3 (1) ◽

pp. 42

Author(s):

Roshanira Che Mohd Noor ◽

Nur Atiqah Rochin Demong

Keyword(s):

Health And Safety ◽

Health Conditions ◽

Effective Strategies ◽

Operational Level ◽

Safety And Health ◽

Health Factors ◽

The Cost ◽

The Relationship ◽

Awareness Level

Providing a safe and healthy workplace is one of the most effective strategies in for holding down the cost of doing construction business. It was a part of the overall management system to facilitate themanagement of the occupational health and safety risk that are associated with the business of the organization. Factors affected the awareness level inclusive of safety and health conditions, dangerous working area, long wait care and services and lack of emergency communication werethe contributed factors to the awareness level for the operational level. Total of 122 incidents happened at Telekom Malaysia Berhad as compared to year 2015 only 86 cases. Thus, the main objective of this study was to determine the relationship between safety and health factors and the awareness level among operational workers.The determination of this research was to increase the awareness level among the operational level workerswho committing to safety and health environment.

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