scholarly journals Research of the choice of the basis of a semi-solid medicine with a semi-solid extract of Feverfew (Tanacetum parthenium)

2021 ◽  
pp. 51-59
Author(s):  
Mariia Velia ◽  
Olena Ruban ◽  
Maryna Khalavka ◽  
Larisa Hohlova
Keyword(s):  
Colloidal Stability ◽  
Optical Diffraction ◽  
Biologically Active ◽  
Rheological Parameters ◽  
Tanacetum Parthenium ◽  
Newtonian Type ◽  
Semi Solid ◽  
Rotary Viscometer ◽  
Active Substances

The aim. To conduct the research on the choice of the basis for a mild drug with a semi-solid extract of feverfew for use in dermatology. Materials and methods. In the study of the solubility of a semi-solid extract of feverfew (SSFE) used the method of optical microscopy using a laboratory microscope “Konus Academy”. Determination of pH and homogeneity of the studied samples was performed according to the methods described in SPhU, Vol.1. The bioavailability of the model samples was investigated by diffusion in 3 % agar gel. Colloidal stability and thermal stability were determined according to the methods of GOST 29188.3-91. Measurements of rheological parameters were performed on a rotary viscometer “MYR 3000 V 2R” (Viskotech, Spain). Determination of particle distribution was performed using a laser diffraction analyzer of particle size Mastersizer 3000. Results. The best results in determining the organoleptic properties, stability and degree of release of biologically active substances (BAS) showed samples prepared on emulgel and gel bases. Structural and mechanical parameters of the samples on these bases proved the presence of a non-Newtonian type of flow with plastic and thixotropic properties. When determining the distribution of SSFE particles by optical diffraction, their smaller size was determined in the sample on an emulgel basis in comparison with the gel. Conclusions. Emulgel loaded with specific drugs has been found effective in some topical disorders, and it is emerging as potential drug delivery system in the area of dermatology. Since emu-lgel shows enhanced spreadability, adhesion, viscosity and extrusion. Based on the obtained results, an emulsion gel base was chosen as a carrier for a semi-solid drug with SSFE

Hemodynamic control using models of electroacoustic signals of an oxygenated neuron

2021 ◽  
Vol 21 (3) ◽  
pp. 50-54
Author(s):  
B.G. Tsugkiev ◽  
◽  
L.Ch. Gagieva ◽  
T.V. Tsugkieva ◽  
M.M. Chegaev ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Nutritional Value ◽  
Growing Season ◽  
Comparative Assessment ◽  
Biologically Active ◽  
Onobrychis Viciifolia ◽  
Iron Copper ◽  
Calcium Phosphorus ◽  
Active Substances

The paper presents a comparative assessment of the nutritional value depending on the phenological phase of Onobrychis viciifolia Scop., as well as the determination of the regularity of the accumulation of biologically active substances and heavy metals in the herb of the species. The yield of green mass of plants was determined. From each hectare of sowing, 9,7 centners of protein can be obtained; the yield of fiber is 13 centners, BEV is 22,9 centners, fat is 1,6 centners, ash is 4 centners and carotene is 13.0 kg. Depending on the growing season, the chemical composition in the grass of Onobrychis viciifolia changes. The content of calcium, phosphorus increases, and the presence of iron, copper, cobalt, zinc, manganese and molybdenum and amino acids decreases.

scholarly journals RESEARCH OF RHEOLOGICAL PROPERTIES OF MEDICINAL SYRUP FOR ORAL USE

2020 ◽  
Vol 73 (4) ◽  
pp. 696-699
Author(s):  
Lena L. Davtian ◽  
Galyna P. Kukhtenko ◽  
Alona S. Voronkina ◽  
Viktoria V. Kudria
Keyword(s):  
Rheological Properties ◽  
Mechanical Stability ◽  
Rheological Parameters ◽  
Dynamic Flow ◽  
Shear Rates ◽  
Coaxial Cylinders ◽  
Low Degree ◽  
Newtonian Type ◽  
Rotary Viscometer

The aim of the present research was to investigate the rheological properties of the medicinal syrup for oral administration with glucosamine hydrochloride and levocarnitine. Matherials and methods: Coefficient of the dynamic flow (at shear rates of 3,49 and 10,3 s -1, as well as at shear rates of 27.2 and 149.0 s-1), mechanical stability, the index of destruction and restoration were studied. The rheological (structural-mechanical) properties of the samples were determined using a Rheolab QC rotary viscometer (AntonPaar, Austria) with coaxial cylinders CC27 / S-SN29766. The rheological parameters were studied at the temperature 20±0,5 °С. Results: It is established that the syrup has weakly expressed plastic viscous and thixotropic properties (the hysteresis area for the syrupis 1710.19 Pas/s). Such results characterize the system as a reopex. Conclusions: The results of the study enables classification of the research object as system with a low degree of fluidity. Such dependence is typical for systems of the Newtonian type of flow and characterizes the syrup under investigation as a weakly structured disperse system.

scholarly journals SPECTROPHOTOMETRIC DETERMINATION OF ANTIOXIDANT SODIUM METABISULPHITE CONTENT IN PREPARED MEDICINAL FORMS OF VETERINARY MEDICINAL PRODUCTS

2020 ◽  
Vol 21 (2) ◽  
pp. 189-198
Author(s):  
H. Yu. Teslyar ◽  
M. Ya. Smolinska ◽  
I. Ya. Kotsyumbas ◽  
N. M. Chyhyn ◽  
N. G. Rohulia ◽  
...  
Keyword(s):  
Spectrophotometric Determination ◽  
Storage Time ◽  
Analytical Signal ◽  
Veterinary Drugs ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Optimal Conditions ◽  
Sodium Metabisulphite ◽  
Active Substances

An analytical method for the quantitative determination of antioxidant sodium metabisulphite in veterinary drugs has been proposed by spectrophotometric method. Based on the literature data, the optimal conditions of the analytical reaction were selected experimentally. The dependence of the value of the analytical signal on the temperature of the reaction medium, concentration of p-rosaniline and duration of the reaction was investigated to establish the optimal conditions of the analytical reaction and obtain a stable analytical signal. The stability of the colored analytical form in time was also checked and the linear dependence of the value of the analytical signal on the concentration of sodium metabisulphite was investigated. The analytical reaction at room temperature is optimal. The maximum analaytical signal is achieved by carrying out the analytical reaction for 10 minutes and then practically does not change for an hour. To achieve the maximum analytical signal, it is necessary to use a 20-fold excess of dye relative to sodium metabisulphite. The analytical signal remains stable only for the first hour, then gradually begins to decrease. Metrological characteristics of the method of determination of metabisulphite in veterinary drugs are calculated, the limits of spectrophotometric determination are 0.33 – 2.50 μg/ml. The correctness of the developed method was checked on model solutions by the method of "introduced-found" method of comparison in the presence of various biologically active substances that are part of drugs together with sodium metabisulphite. The content of sodium metabisulphite in veterinary drugs of domestic and foreign production at different intervals of their storage time was established. It is shown that the content of sodium metabisulphite in drugs decreases during their storage time, until complete disappearance, which directly affects the content of the active substance, because in the absence of antioxidant oxidative processes with biologically active substances begin to take place.

scholarly journals Flavonoid’s Content Determination in Irradiated Samples via Spectrophotometric Analysis

2019 ◽  
Vol 5 (10) ◽  
pp. 32-39 ◽  
Author(s):  
A. Sarukhanov ◽  
A. Morozova ◽  
N. Vasilyeva ◽  
D. Krylenkin
Keyword(s):  
Quantitative Determination ◽  
Raw Materials ◽  
General Information ◽  
Spectrophotometric Analysis ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Qualitative And Quantitative ◽  
Content Determination ◽  
Active Substances

General information about biologically active substances flavonoids is concisely presented. The need for the quantitative determination of its content in products and the influence of product processing on flavonoid’s content is justified. Methods of qualitative and quantitative determination of flavonoids content in various products, medications and raw materials were studied. Based on this study the method of quantitative determination of flavonoid’s in samples of irradiated coriander is compiled and tested. Further ways to improve and adjust the compiled method for flavonoid’s content determination in irradiated samples via spectrophotometric analysis is considered.

DETERMINATION OF BIOLOGICALLY ACTIVE SUBSTANCES – FLAVONOIDS IN FRUIT TREES WITH HEALING PROPERTIES

2020 ◽  
pp. 94-96
Author(s):  
P. Mirkhamidova ◽  
D. B. Babakhanova ◽  
G. I. Mukhamedov ◽  
R. A. Alimova
Keyword(s):  
Fruit Trees ◽  
Biologically Active Substances ◽  
Biologically Active ◽  
Active Substances

A kinetic determination of ultramicroquantities of some biologically active substances

1980 ◽  
Vol 25 (3) ◽  
pp. 380-387 ◽  
Author(s):  
G.A. Milovanović ◽  
T.J. Janjić ◽  
S. Petrović ◽  
G. Kuzmanović
Keyword(s):  
Biologically Active Substances ◽  
Biologically Active ◽  
Kinetic Determination ◽  
Active Substances
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