scholarly journals STRUCTURE ELUCIDATION OF FOUR STEROIDS FROM THE SOFT CORAL SINULARIA NANOLOBATA

2017 ◽  
Vol 55 (3) ◽  
pp. 258
Author(s):  
Ninh Thi Ngoc ◽  
Nguyen Van Thanh ◽  
Nguyen Xuan Cuong ◽  
Nguyen Hoai Nam ◽  
Do Cong Thung ◽  
...  
Keyword(s):  
Detailed Analysis ◽  
Structure Elucidation ◽  
Soft Coral ◽  
2D Nmr ◽  
Chromatographic Methods ◽  
Nmr Data

Four steroids namely 3β-hydroxyergosta-5,24(28)-diene-7-one (1), dissesterol (2), 16α-hydroxysarcosterol (3), and sarcophytosterol (4) were isolated form the soft coral Sinularia nanolobata using various chromatographic methods. Their structures were elucidated by detailed analysis of the 1D and 2D NMR data and comparison with the reported values.

scholarly journals STRUCTURE ELUCIDATION AND CYTOTOXIC ACTIVITY OF ATTENUATOSIDE B-1, PLANCISIDE A, AND CULCITOSIDE C2 FROM THE STARFISH ACANTHASTER PLANCI

2018 ◽  
Vol 56 (1) ◽  
pp. 1
Author(s):  
Le Thi Vien ◽  
Tran Thi Hong Hanh ◽  
Phan Thi Thanh Huong ◽  
Do Thi Thao ◽  
Nguyen Van Thanh ◽  
...  
Keyword(s):  
Cytotoxic Activity ◽  
Detailed Analysis ◽  
Cell Lines ◽  
Structure Elucidation ◽  
Human Cancer ◽  
2D Nmr ◽  
Human Cancer Cell ◽  
Acanthaster Planci ◽  
Human Cancer Cell Lines ◽  
Nmr Data

Detailed analysis of the 1D and 2D NMR data and comparison with the reported values, the structures of attenuatoside B-1 (1), planciside A (2), and culcitoside C2 (3) from starfish Acanthaster planci were clearly elucidated. Culcitoside C2 (3) showed weak cytotoxic activity against five human cancer cell lines including HepG2, KB, LNCaP, MCF7, and SK-Mel2.

scholarly journals A NEW CYTOTOXIC DOLABELLANE FROM THE INDONESIAN SOFT CORAL Anthelia sp.

2013 ◽  
Vol 13 (3) ◽  
pp. 216-220 ◽  
Author(s):  
Anggia Murni ◽  
Novriyandi Hanif ◽  
Junichi Tanaka
Keyword(s):  
Mass Spectrometry ◽  
Drug Development ◽  
Ethyl Acetate ◽  
Spectroscopic Data ◽  
Soft Coral ◽  
Ethyl Acetate Extract ◽  
2D Nmr ◽  
Cancer Drug ◽  
Nmr Data ◽  
Anti Cancer

One new dolabellane (1) and two known diterpenoids stolonidiol (2) and clavinflol B (3) have been isolated from the ethyl acetate extract of the Indonesian soft coral Anthelia sp. A new compound 1 exhibited a moderate cytotoxicity against NBT-T2 cells at 10 µg/mL, while known compounds 2 and 3 showed cytotoxicity at 1 and 0.5 µg/mL, respectively. Structure of the new compound 1 was elucidated by interpretation of NMR spectroscopic data (1D and 2D NMR data) and mass spectrometry (ESIMS data) as well as comparison with those of related ones. This finding should be useful for anti cancer drug development of the promising dolabellane-types compound.

Juglomycins G-J: Isolation from Streptomycetes and Structure Elucidation

2005 ◽  
Vol 60 (2) ◽  
pp. 183-188 ◽  
Author(s):  
R. P. Maskey ◽  
H. Lessmann ◽  
S. Fotso ◽  
I. Grün-Wollny ◽  
H. Lackner ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Absolute Configuration ◽  
Structure Elucidation ◽  
Mass Spectra ◽  
2D Nmr ◽  
Cd Spectra ◽  
Streptomyces Spp ◽  
Nmr Data ◽  
Related Compounds ◽  
Weak Antibacterial Activity

From the Streptomyces spp. 815 and GW4184, four new 4-juglon-2-ylbutyric acid derivatives, the juglomycins G - J (3a, 4a, 4c, 5c), have been isolated and characterised. The structures were derived from the 1D and 2D NMR data and mass spectra and confirmed by comparison with structurally related compounds. The absolute configuration was deduced from the CD spectra. The new natural products exhibited weak antibacterial activity similar to juglomycin A (5a).

Computer-assisted structure elucidation of natural products with limited 2D NMR data: application of the StrucEluc system

2003 ◽  
Vol 41 (5) ◽  
pp. 359-372 ◽  
Author(s):  
Kirill A. Blinov ◽  
Dean Carlson ◽  
Mikhail E. Elyashberg ◽  
Gary E. Martin ◽  
Eduard R. Martirosian ◽  
...  
Keyword(s):  
Natural Products ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Computer Assisted ◽  
Nmr Data ◽  
Data Application ◽  
Computer Assisted Structure Elucidation

scholarly journals Structure Revision and Protein Tyrosine Phosphatase Inhibitory Activity of Drazepinone

Marine Drugs ◽  
2021 ◽  
Vol 19 (12) ◽  
pp. 714
Author(s):  
Fei Cao ◽  
Li Pan ◽  
Wen-Bin Gao ◽  
Yun-Feng Liu ◽  
Cai-Juan Zheng ◽  
...  
Keyword(s):  
Detailed Analysis ◽  
Protein Tyrosine Phosphatase ◽  
Inhibitory Activity ◽  
Chemical Shifts ◽  
Tyrosine Phosphatase ◽  
2D Nmr ◽  
Nmr Data ◽  
Structure Revision ◽  
Ic50 Values

From the marine-derived fungus Penicillium sumatrense (Trichocomaceae), a pair of enantiomers [(+)-1 and (−)-1] were isolated with identical 1D NMR data to drazepinone, which was originally reported to have a trisubstituted naphthofuroazepinone skeleton. In this study, we confirmed the structures of the two enantiomers as drazepinone and revised their structures by detailed analysis of extensive 2D NMR data and a comparison of the calculated 13C chemical shifts, ECD, VCD, and ORD spectra with those of the experiment ones. (+)-1 and (−)-1 were evaluated for their PTP inhibitory activity in vitro. (−)-1 showed selective PTP inhibitory activity against PTP1B and TCPTP with IC50 values of 1.56 and 12.5 μg/mL, respectively.

scholarly journals Isolation and Structure Elucidation of Secondary Metabolites from a Microcystis sp. Bloom Material Collected in Southern Israel

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301
Author(s):  
Ohad Hasin ◽  
Shmuel Carmeli
Keyword(s):  
Serine Proteases ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Coupling Constants ◽  
Chiral Hplc ◽  
Mass Spectrometric Data ◽  
Spectrometric Data ◽  
Nmr Data ◽  
Hydrophilic Extract ◽  
New Metabolites

The hydrophilic extract of Microcystis sp. bloom material collected from Bror Hayil Reservoir in southern Israel afforded four new metabolites, (2 S,3 S)-3-hydeoxy-1,4-diphenylbutan-2-yl-acetate, aeruginosins BH604, BH462A and BH462B, and two known metabolites cyanopeptolins S and SS. The planar structure of 1–4 was established by analyses of their 1D and 2D NMR data and mass spectrometric data. The absolute configurations of the chiral centers of 1 were established by Mosher method and analysis of the coupling constants between H-2 and H-3, and those of 2–4 by Merfay's method and advanced Merfay's method and chiral HPLC. The compounds do not inhibit the serine proteases trypsin and thrombin.

scholarly journals A New Trinor-guaiane Sesquiterpene from an Indonesian Soft Coral Anthelia sp

2015 ◽  
Vol 10 (11) ◽  
pp. 1934578X1501001 ◽  
Author(s):  
Novriyandi Hanif ◽  
Anggia Murni ◽  
Marie Yamauchi ◽  
Masahiro Higashi ◽  
Junichi Tanaka
Keyword(s):  
Soft Coral ◽  
Optical Rotation ◽  
2D Nmr ◽  
Planar Structure ◽  
Nmr Data ◽  
Relative Stereochemistry ◽  
Absolute Stereochemistry

A new trinor-guaiane sesquiterpene has been isolated from an Indonesian soft coral Anthelia sp. The planar structure, possessing an octahydroazulene skeleton, and relative stereochemistry were established by analyzing 1D and 2D NMR data, including NOE experiments. Its absolute stereochemistry was elucidated to be 1 S, 4 S, 7 R, and 10 R by comparing observed and calculated optical rotation values. The new compound showed weak cytotoxicity against NBT-T2 cells.

Application of a New Expert System for the Structure Elucidation of Natural Products from Their 1D and 2D NMR Data

2002 ◽  
Vol 65 (5) ◽  
pp. 693-703 ◽  
Author(s):  
Mikhail E. Elyashberg ◽  
Kirill A. Blinov ◽  
Antony J. Williams ◽  
Eduard R. Martirosian ◽  
Sergey G. Molodtsov
Keyword(s):  
Natural Products ◽  
Expert System ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Nmr Data

Structure Elucidator: A Versatile Expert System for Molecular Structure Elucidation from 1D and 2D NMR Data and Molecular Fragments

ChemInform ◽  
2004 ◽  
Vol 35 (30) ◽  
Author(s):  
Mikhail E. Elyashberg ◽  
Kirill A. Blinov ◽  
Antony J. Williams ◽  
Sergey G. Molodtsov ◽  
Gary E. Martin ◽  
...  
Keyword(s):  
Molecular Structure ◽  
Expert System ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Molecular Fragments ◽  
Nmr Data
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