Juglomycins G-J: Isolation from Streptomycetes and Structure Elucidation

2005 ◽  
Vol 60 (2) ◽  
pp. 183-188 ◽  
Author(s):  
R. P. Maskey ◽  
H. Lessmann ◽  
S. Fotso ◽  
I. Grün-Wollny ◽  
H. Lackner ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Absolute Configuration ◽  
Structure Elucidation ◽  
Mass Spectra ◽  
2D Nmr ◽  
Cd Spectra ◽  
Streptomyces Spp ◽  
Nmr Data ◽  
Related Compounds ◽  
Weak Antibacterial Activity

From the Streptomyces spp. 815 and GW4184, four new 4-juglon-2-ylbutyric acid derivatives, the juglomycins G - J (3a, 4a, 4c, 5c), have been isolated and characterised. The structures were derived from the 1D and 2D NMR data and mass spectra and confirmed by comparison with structurally related compounds. The absolute configuration was deduced from the CD spectra. The new natural products exhibited weak antibacterial activity similar to juglomycin A (5a).

scholarly journals Methylkarranjic acid and Pongamol from Derris indica Seeds and their Antibacterial Activity

1970 ◽  
Vol 6 (1) ◽  
pp. 9-13 ◽  
Author(s):  
M Abdullahil Baki ◽  
Golam Sadik ◽  
KAM Shahadat Hossain Mondal ◽  
M Ashilk Mosaddik ◽  
M Mukhlesur Rahman
Keyword(s):  
Antibacterial Activity ◽  
Phenolic Compounds ◽  
Soluble Fraction ◽  
Ethanolic Extract ◽  
2D Nmr ◽  
Shigella Dysenteriae ◽  
E Coli ◽  
Nmr Data ◽  
Test Organisms ◽  
Derris Indica

Two phenolic compounds, methylkarranjic (1) acid and pongamol (2), were isolated from the petroleum ether soluble fraction of an ethanolic extract of Derris indica seeds. The structures of these compounds were confirmed by LC-MS and a series of 1D and 2D NMR data. The solvent solvent partionates of the ethanolic extract and compounds (1 and 2) exhibited moderate antibacterial activity against several test organisms. The minimum inhibitory concentrations (MICs) of 1 and 2 were found to be in the range of 32-128 μg/ml against Bacillus megatorium, Streptococcus β-haemolyticus, Shigella dysenteriae and E. coli. Key words: Derris indica; Leguminosae; Methylkarranjic acid; Pongamol; Antibacterial activity Dhaka Univ. J. Pharm. Sci. 6(1): 9-13, 2007 (June) The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website

Computer-assisted structure elucidation of natural products with limited 2D NMR data: application of the StrucEluc system

2003 ◽  
Vol 41 (5) ◽  
pp. 359-372 ◽  
Author(s):  
Kirill A. Blinov ◽  
Dean Carlson ◽  
Mikhail E. Elyashberg ◽  
Gary E. Martin ◽  
Eduard R. Martirosian ◽  
...  
Keyword(s):  
Natural Products ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Computer Assisted ◽  
Nmr Data ◽  
Data Application ◽  
Computer Assisted Structure Elucidation

scholarly journals Isolation and Structure Elucidation of Secondary Metabolites from a Microcystis sp. Bloom Material Collected in Southern Israel

2018 ◽  
Vol 13 (10) ◽  
pp. 1934578X1801301
Author(s):  
Ohad Hasin ◽  
Shmuel Carmeli
Keyword(s):  
Serine Proteases ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Coupling Constants ◽  
Chiral Hplc ◽  
Mass Spectrometric Data ◽  
Spectrometric Data ◽  
Nmr Data ◽  
Hydrophilic Extract ◽  
New Metabolites

The hydrophilic extract of Microcystis sp. bloom material collected from Bror Hayil Reservoir in southern Israel afforded four new metabolites, (2 S,3 S)-3-hydeoxy-1,4-diphenylbutan-2-yl-acetate, aeruginosins BH604, BH462A and BH462B, and two known metabolites cyanopeptolins S and SS. The planar structure of 1–4 was established by analyses of their 1D and 2D NMR data and mass spectrometric data. The absolute configurations of the chiral centers of 1 were established by Mosher method and analysis of the coupling constants between H-2 and H-3, and those of 2–4 by Merfay's method and advanced Merfay's method and chiral HPLC. The compounds do not inhibit the serine proteases trypsin and thrombin.

scholarly journals Terpenes from Zingiber montanum and Their Screening against Multi-Drug Resistant and Methicillin Resistant Staphylococcus aureus

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 385 ◽  
Author(s):  
Holly Siddique ◽  
Barbara Pendry ◽  
M. Mukhlesur Rahman
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Secondary Metabolites ◽  
Mass Spectra ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Drug Resistant ◽  
Two Dimensional ◽  
Methicillin Resistant ◽  
One Dimensional ◽  
Nmr Data

Bioassay directed isolation of secondary metabolites from the rhizomes of Zingiber montanum (Fam. ‎Zingiberaceae) led to the isolation of mono-, sesqui-, and di-terpenes. The compounds were characterized as (E)-8(17),12-labdadiene-15,16-dial (1), zerumbol (2), zerumbone (3), buddledone A (4), furanodienone (5), germacrone (6), borneol (7), and camphor (8) by analysing one-dimensional (1D) (1H and 13C) and two-dimensional (2D) (COSY, HSQC, HMBC, and NOESY) NMR data and mass spectra. Among these terpenes, compounds 1 and 2 revealed potential antibacterial activity (minimum inhibitory concentrations (MIC) values 32–128 µg/mL; 0.145–0.291 mM)) against a series of clinical isolates of multi-drug resistant (MDR) and Methicillin resistant Staphylococcus aureus (MRSA).

scholarly journals New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015

Marine Drugs ◽  
2019 ◽  
Vol 17 (7) ◽  
pp. 398 ◽  
Author(s):  
Xiaoyan Pang ◽  
Guodi Cai ◽  
Xiuping Lin ◽  
Limbadri Salendra ◽  
Xuefeng Zhou ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
2D Nmr ◽  
Specific Rotation ◽  
Human Gastric Cancer ◽  
X Ray Diffraction ◽  
Gastric Cancer Cells ◽  
Penicillium Sp ◽  
Ic50 Value ◽  
Rice Medium ◽  
Weak Antibacterial Activity

The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium yielded twenty-one compounds (1–21), including two new alkaloids (1 and 2) and one new pyrone derivative (3). Their structures were elucidated by analysis of 1D/2D NMR data and HR–ESI–MS. Their absolute configurations were established by single-crystal X-ray diffraction analysis and comparison of the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic activity against the human gastric cancer cells MGC803, with IC50 value of 5.19 μM. Compounds 9 and 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii, respectively, both with MIC values of 57 μg/mL. Furthermore, compound 16 displayed potent antibacterial activity against S. aureus with an MIC value of 3.75 μg/mL.

scholarly journals Antialactone: A New γ-Lactone from Antiaris Africana, and its Absolute Configuration Determined from TDDFT CD Calculations

2008 ◽  
Vol 3 (2) ◽  
pp. 1934578X0800300 ◽  
Author(s):  
Vouffo Bertin ◽  
Hidayat Hussain ◽  
Simeon F. Kouam ◽  
Etienne Dongo ◽  
Gennaro Pescitelli ◽  
...  
Keyword(s):  
Natural Product ◽  
Absolute Configuration ◽  
Betulinic Acid ◽  
Spectroscopic Data ◽  
Nmr Spectra ◽  
2D Nmr ◽  
Stem Bark ◽  
Cd Spectra ◽  
2D Nmr Spectra ◽  
First Time

Four compounds were isolated from the stem bark of Antiaris africana. One of them, a γ-lactone named antialactone (1a), is reported for the first time as a natural product. The structures were determined by comprehensive analyses of their 1D and 2D NMR spectra and EI MS data. The absolute configuration of antialactone acetate (1b) was established by TDDFT CD calculations and comparison with measured CD spectra. The remaining three known compounds were identified, by comparing their spectroscopic data with those reported in the literature, as lichenxanthone, β-sitosterol, and betulinic acid.

Application of a New Expert System for the Structure Elucidation of Natural Products from Their 1D and 2D NMR Data

2002 ◽  
Vol 65 (5) ◽  
pp. 693-703 ◽  
Author(s):  
Mikhail E. Elyashberg ◽  
Kirill A. Blinov ◽  
Antony J. Williams ◽  
Eduard R. Martirosian ◽  
Sergey G. Molodtsov
Keyword(s):  
Natural Products ◽  
Expert System ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Nmr Data

Benzoylcyclopropane Derivatives from Hypoxis hemerocallidea Corms

Planta Medica ◽  
2021 ◽  
Author(s):  
Fazila Zulfiqar ◽  
Pankaj Pandey ◽  
Siddharth K. Tripathi ◽  
Zulfiqar Ali ◽  
Amar G. Chittiboyina ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Antimicrobial Activity ◽  
Antibacterial Activity ◽  
Structure Elucidation ◽  
2D Nmr ◽  
Alcoholic Extract ◽  
Data Analyses ◽  
Source Structure ◽  
Hypoxis Hemerocallidea

AbstractTwo monobenzoylcyclopropane (hypoxhemerol A (1) and hypoxhemeroloside G (2)) and three dibenzoylcyclopropane (hypoxhemerol B (3), hypoxhemeroloside H (4), and hypoxhemeroloside I (5)) derivatives were isolated from the hydro-alcoholic extract of Hypoxis hemerocallidea corms. This is the first instance where benzoylcyclopropane analogs were isolated from any natural source. Structure elucidation was mainly based on 1D- and 2D-NMR and HRESIMS data. The absolute configuration (2R, 4R) of 1 was determined via NOESY NMR and experimental and calculated ECD data analyses. Compounds 1–5 and 11 recently reported metabolites (hypoxoside, obtuside A, interjectin, acuminoside, curcapicycloside, and hypoxhemerolosides A – F) were screened for in vitro antimicrobial activity against various bacterial and fungal strains. Curcapicycloside and acuminoside exhibited antibacterial activity against Escherichia coli with 78 and 79% inhibition at 20 µg/mL, respectively. Hypoxhemeroloside A showed mild antifungal activity against Cryptococcus neoformans with 63% inhibition at 20 µg/mL.

9α-Hydroxyparthenolide from Zoegea baldschuanica C. WINKL. and its absolute configuration

1984 ◽  
Vol 49 (3) ◽  
pp. 637-641 ◽  
Author(s):  
Miloš Buděšínský ◽  
David Šaman ◽  
Gerard Nowak ◽  
Bohdan Drożdż ◽  
Miroslav Holub
Keyword(s):  
Absolute Configuration ◽  
Cd Spectra ◽  
H Nmr ◽  
Aerial Parts ◽  
Nmr Data

From the aerial parts of Zoegea baldschuanica C. WINKL. was isolated 9α-hydroxyparthenolide (I), whose absolute configuration was established on the basis of CD spectra. 1 H NMR data for I, parthenolide (VI) and the derivatives III and IV are discussed.

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