Negative effects of alcohol intake and estrogen deficiency combination on osseointegration in a rat model

2010 ◽  
pp. 110220121911010
Author(s):  
Leonardo Marchini ◽  
Camila de Deco ◽  
Adriana Marchini ◽  
Mary Anne Barbara ◽  
Luana Vasconcellos ◽  
...  
Keyword(s):  
Rat Model ◽  
Alcohol Intake ◽  
Estrogen Deficiency ◽  
Negative Effects

Negative Effects of Alcohol Intake and Estrogen Deficiency Combination on Osseointegration in a Rat Model

2011 ◽  
Vol 37 (6) ◽  
pp. 633-639 ◽  
Author(s):  
Camila Porto de Deco ◽  
Adriana Mathias Pereira da Silva Marchini ◽  
Mary Anne Moreira Bárbara ◽  
Luana Marotta Reis de Vasconcellos ◽  
Rosilene Fernandes da Rocha ◽  
...  
Keyword(s):  
Alcohol Intake ◽  
Sucrose Solution ◽  
Estrogen Deficiency ◽  
Ethanol Solution ◽  
Female Rats ◽  
Negative Effects ◽  
Isocaloric Diet ◽  
Control Food ◽  
Implant Therapy ◽  
Ad Libitum

Alcohol intake and estrogen deficiency can both affect bone physiology and have shown to have an adverse effect on dental implant therapy. However, the combination of both factors on osseointegration is unknown. The aim of this study was to evaluate osseointegration in rats fed with alcohol and presenting induced estrogen deficiency. Ninety-six female rats were divided according to diet and hormonal condition into 6 groups as follows: group Sh-W: sham (simulated ovariectomy) control, food and water ad libitum; group Sh-Et: sham, food and 20% ethanol solution ad libitum; group Sh-Su: sham, food and sucrose solution controlled to ensure an isocaloric diet in relation to Sh-Et; group Ov-W: ovariectomy, food and water ad libitum; group Ov-Et: ovariectomy, food and 20% ethanol solution ad libitum; and group Ov-Su: ovariectomy, food and sucrose solution controlled to ensure an isocaloric diet as Ov-Et. The groups were subdivided according to time of euthanasia: 30 and 45 days after placement of implants. Implant surgery was performed 1 month after ovariectomy or sham. After euthanasia, the femurs were removed and evaluated by histomorphometry. Groups Ov-Et and Ov-Su showed the lowest percentage of bone-to-implant contact. The combination of alcohol intake and estrogen deficiency, and the combination of estrogen deficiency and reduced ingestion of food can negatively affect osseointegration in rats.

β-Sitosterol attenuates liver injury in a rat model of chronic alcohol intake

2020 ◽  
Vol 43 (11) ◽  
pp. 1197-1206
Author(s):  
Zhenjuan Chen ◽  
Ancheng Wu ◽  
Hongmei Jin ◽  
Fuhui Liu
Keyword(s):  
Liver Injury ◽  
Rat Model ◽  
Alcohol Intake ◽  
Chronic Alcohol

The Effects of Hyperthermic Intraperitoneal Chemoperfusion on Colonic Anastomosis: An Experimental Study in a Rat Model

2017 ◽  
Vol 103 (3) ◽  
pp. 307-313 ◽  
Author(s):  
Afag Aghayeva ◽  
Cigdem Benlice ◽  
Ismail Ahmet Bilgin ◽  
Pinar Atukeren ◽  
Gulen Dogusoy ◽  
...  
Keyword(s):  
Mitomycin C ◽  
Rat Model ◽  
Colonic Anastomosis ◽  
Colorectal Anastomosis ◽  
Sigmoid Resection ◽  
Albino Rats ◽  
Bursting Pressure ◽  
Negative Effects ◽  
Significant Difference ◽  
Group 2

Introduction Cytoreductive surgery (CRS) with subsequent hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising modality to treat and prevent peritoneal metastases. However, this treatment is associated with signficant morbidity and mortality. Whether or not CRS with HIPEC interferes with anastomotic healing has also been debated. This study was designed to investigate the effects of mitomycin C, cisplatin, oxaliplatin, and doxorubicin used in HIPEC treatment on colonic anastomosis healing in a rat model. Methods Sixty Wistar albino rats were employed in the study. Sigmoid resection and end-to-end colorectal anastomosis was performed in all rats. Group 1 rats underwent the surgical procedure alone, while group 2 rats were given hyperthermic intraperitoneal lavage with heated saline following surgery. Groups 3, 4, 5, and 6 had surgery with concomitant HIPEC treatment with mitomycin C, cisplatin, oxaliplatin, and doxorubicin, respectively. Anastomotic bursting pressures and hydroxyproline levels were evaluated. Results Regarding the hydroxyproline levels, groups 1 and 2 showed significantly higher values than other groups (p<0.001). However, there was no significant difference between the HIPEC treatment groups (groups 3, 4, 5, and 6) (p>0.05). When groups were compared regarding bursting pressure values, no significant differences were observed (p = 0.81). Conclusions This study demonstrated that the HIPEC procedure with mitomycin C, cisplatin, oxaliplatin and doxorubicin had negative effects on hydroxyproline levels, but had no detrimental effect on anastomotic bursting pressure in a rat model.

Effects of nicotine on alcohol intake in a rat model of depression

2002 ◽  
Vol 72 (1-2) ◽  
pp. 355-364 ◽  
Author(s):  
Dolores Martı́nez-González ◽  
Oscar Prospéro-Garcı́a ◽  
Stefan Mihailescu ◽  
René Drucker-Colı́n
Keyword(s):  
Rat Model ◽  
Alcohol Intake

scholarly journals The monoamine stabilizer OSU6162 has anxiolytic-like properties and reduces voluntary alcohol intake in a genetic rat model of depression

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Philippe A. Melas ◽  
Malin Wirf ◽  
Helder André ◽  
Nitya Jayaram-Lindström ◽  
Aleksander A. Mathé ◽  
...  
Keyword(s):  
Rat Model ◽  
Alcohol Intake ◽  
Depressive Disorders ◽  
Anxiety And Depression ◽  
Clinical Settings ◽  
Alcohol Abstinence ◽  
Significant Difference ◽  
Sensitive Line ◽  
Excessive Alcohol

AbstractAlcohol use disorders (AUD) often co-occur with anxiety and depressive disorders, and anxiety often drives relapse during alcohol abstinence. Optimal AUD pharmacotherapies may thus need to target both excessive alcohol intake and elevated anxiety. (−)-OSU6162 (OSU) is a monoamine stabilizer that attenuates alcohol-mediated behaviors in both preclinical and clinical settings. However, OSU’s effect on anxiety-like behavior following long-term drinking remains unknown. To this end, we utilized a genetic rat model that exhibits increased anxiety- and depression-like behaviors (Flinders Sensitive Line; FSL) and their controls (Flinders Resistant Line; FRL). Using the novelty suppressed feeding (NSF) test, we evaluated anxiety-like behaviors (1) at baseline, (2) following long-term voluntary drinking and after 24 h of alcohol deprivation, and (3) following OSU administration in the same animals. At baseline, FSL animals displayed significantly elevated anxiety-like characteristics compared to FRL. Compared to alcohol-naïve animals, long-term drinking significantly reduced anxiety-like behaviors in FSL, without any significant effects in FRL animals. Compared to vehicle, OSU administration significantly reduced anxiety-like behaviors in alcohol-naïve FSL and long-term drinking FRL animals. While there was no significant difference in alcohol intake between FSL and FRL, OSU attenuated alcohol intake in both strains. Conclusively, in addition to the compound’s previously identified ability to suppress alcohol-mediated behaviors, OSU may also possess anxiolytic properties, warranting further clinical evaluation in both AUD and anxiety disorder settings.

scholarly journals Clinically Used Hormone Formulations Differentially Impact Memory, Anxiety-Like, and Depressive-Like Behaviors in a Rat Model of Transitional Menopause

2021 ◽  
Vol 15 ◽  
Author(s):  
Stephanie V. Koebele ◽  
Ryoko Hiroi ◽  
Zachary M. T. Plumley ◽  
Ryan Melikian ◽  
Alesia V. Prakapenka ◽  
...  
Keyword(s):  
Hormone Therapy ◽  
Rat Model ◽  
Ovarian Follicle ◽  
Clinical Findings ◽  
Negative Effects ◽  
Primary Indication ◽  
Endocrine Status ◽  
Conjugated Equine Estrogens ◽  
Physiological Profiles ◽  
Hormonal Milieu

A variety of U.S. Food and Drug Administration-approved hormone therapy options are currently used to successfully alleviate unwanted symptoms associated with the changing endogenous hormonal milieu that occurs in midlife with menopause. Depending on the primary indication for treatment, different hormone therapy formulations are utilized, including estrogen-only, progestogen-only, or combined estrogen plus progestogen options. There is little known about how these formulations, or their unique pharmacodynamics, impact neurobiological processes. Seemingly disparate pre-clinical and clinical findings regarding the cognitive effects of hormone therapies, such as the negative effects associated with conjugated equine estrogens and medroxyprogesterone acetate vs. naturally circulating 17β-estradiol (E2) and progesterone, signal a critical need to further investigate the neuro-cognitive impact of hormone therapy formulations. Here, utilizing a rat model of transitional menopause, we administered either E2, progesterone, levonorgestrel, or combinations of E2 with progesterone or with levonorgestrel daily to follicle-depleted, middle-aged rats. A battery of assessments, including spatial memory, anxiety-like behaviors, and depressive-like behaviors, as well as endocrine status and ovarian follicle complement, were evaluated. Results indicate divergent outcomes for memory, anxiety, and depression, as well as unique physiological profiles, that were dependent upon the hormone regimen administered. Overall, the combination hormone treatments had the most consistently favorable profile for the domains evaluated in rats that had undergone experimentally induced transitional menopause and remained ovary-intact. The collective results underscore the importance of investigating variations in hormone therapy formulation as well as the menopause background upon which these formulations are delivered.

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