Oral cavity squamous cell carcinoma presenting as a nasal mass in the setting of a dental implant

2021 ◽  
Author(s):  
Alyssa Civantos ◽  
Karthik Rajasekaran
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Dental Implant ◽  
Squamous Cell ◽  
Unusual Case ◽  
Oral Cavity Cancer ◽  
Nasal Mass ◽  
History Of ◽  
Oral Malignancy

Primary oral cavity squamous cell carcinomas can rarely occur in anatomic vicinity of a dental implant in patients with no history of prior oral malignancy or premalignancy. This typically presents as a symptomatic oral gingival lesion. We report the unusual case of a 65-year-old former-smoker female with an implant-supported upper denture who developed an isolated nasal mass on exam, found to be a squamous cell carcinoma originating from the hard palate. Although very rare, an oral cavity cancer should be taken into consideration in the differential diagnosis of a nasal cavity mass in the setting of dental implants.

scholarly journals The result of using free flap reconstruction for oral cavity cancer

2020 ◽  
Vol 10 (5) ◽  
Author(s):  
Mai Anh Bùi ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Survival Rate ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Free Flap ◽  
Oral Cavity Cancer ◽  
Team Work ◽  
Wide Resection ◽  
After Cancer

Abstract Introduction: In recent years, cancer in the oral cavity is a fairly common disease in Vietnam. The treatment of this pathology requires the coordination of many different specialties such as wide resection removal of the tumor, reconstructive surgery, radiotherapy ... Reconstruction of post-excision tumor in the oral cavity is always a challenge with the surgeon. The report aims for providing results and sharing the team’s experience in using free flap to cover gaps in the oral cavity after cancer removal. Materials and Methods: Cross-sectional study on 21 patients who had surgery to wide resection cancers tumor in the oral cavity and been covered with free flap. Research randomly selected for age and gender. The results are evaluate the falp survival rate, the degree of coverage, function and aesthetics after surgery, the 5-year overallsurvivalrates. Results: 21 patients had the ratio of male / female: 15/6; ages 39-62 years old. Pathologys results of 16/21 patients were squamous cell carcinoma; 3/21 is adenoma mucoepidermoid carcinoma, 2/21 mandibular osteosarcoma. The proportion of patients having chemotherapy before surgery is 4/21, radiation before surgery is 6/21. 100% flap survival rate is 19/21; Partial necrosis of the flap 2/21. 19/21 patients had radiation therapy after surgery. The 5 – years overall survival rate to the end of the study were 11/21. Conclusions: Using free flap to cover the defect after cancer tumor remoaval in oral cavity is an optimal choice with many advantages: the ability to cover a wide defect so it can be cut broadly, preserving the maximum function of the oral, minimize morbidity at donor site. However, the surgery needs a team work of highly trained, multi-specialists coordination and modern equipment. Keywords: Microsurgical flap, oral cavity cancer, squamous cell carcinoma. Tóm tắt Đặt vấn đề: Trong những năm gần đây, ung thư trong khoang miệng là bệnh lý thường gặp tại Việt Nam. Việc điều trị bệnh lý này yêu cầu phối hợp của nhiều chuyên khoa khác nhau như phẫu thuật cắt bỏ khối ung thư rộng rãi, tạo hình che phủ, hóa xạ trị… Tạo hình che phủ sau cắt bỏ ung thư trong khoang miệng luôn là một thách thức với các phẫu thuật viên. Báo cáo nhằm đưa ra kết quả và chia sẻ những kinh nghiệm của nhóm nghiên cứu trong sử dụng vạt vi phẫu che phủ khuyết hổng trong khoang miệng sau cắt bỏ ung thư. Phương pháp nghiên cứu: Nghiên cứu lâm sàng trên 21 người bệnh được phẫu thuật cắt khối ung thư trong khoang miệng và che phủ khuyết hổng bằng vạt vi phẫu lấy ngẫu nhiên về độ tuổi và giới tính. Đánh giá kết quả theo tỷ lệ sống của vạt, mức độ che phủ, chức năng và thẩm mỹ sau phẫu thuật, tỷ lệ sống trên 05 năm của người bệnh. Kết quả: 21 người bệnh có tỷ lệ nam/nữ : 15/6; độ tuổi từ 39 - 62 tuổi. Kết quả giải phẫu bệnh 16/21 người bệnh là ung thư biểu mô tế bào vảy; 3/21 là ung thư tuyến nước bọt phụ, 2/21 ung thư xương hàm dưới. Tỷ lệ người bệnh có điều trị hóa chất trước phẫu thuật là 4/21, xạ trị trước phẫu thuật là 6/21. Tỷ lệ sống vạt 100 % là 19/21; hoại tử một phần đầu xa của vạt 2/21. 19/21 người bệnh có xạ trị sau phẫu thuật. Tỷ lệ sống trên 5 năm đến thời điểm kết thúc nghiên cứu là 11/21. Kết luận: Sử dụng vạt vi phẫu trong che phủ khuyết hổng sau cắt bỏ ung thư là một lựa chọn tối ưu do có nhiều ưu điểm: khả năng che phủ rộng nên có thể cắt u rộng rãi, giữ được chức năng tối đa nơi bị cắt bỏ khối u, di chứng nơi cho vạt là ít nhất. Tuy nhiên, kỹ thuật cần yêu cầu đội ngũ phẫu thuật viên đào tạo chuyên sâu, sự phối hợp đa chuyên khoa và trang thiết bị hiện đại. Từ khóa: Vạt vi phẫu, ung thư khoang miệng, ung thư biểu mô tế bào vảy.

scholarly journals The Copenhagen Oral Cavity Squamous Cell Carcinoma database: protocol and report on establishing a comprehensive oral cavity cancer database

2019 ◽  
Vol Volume 11 ◽  
pp. 733-741 ◽  
Author(s):  
Jakob Schmidt Jensen ◽  
Kathrine Kronberg Jakobsen ◽  
Christian Mirian ◽  
Julie Thor Christensen ◽  
Katrine Schneider ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Oral Cavity Cancer

Spindle Cell Carcinoma of the Tongue: Fallacies in Its Diagnosis

2018 ◽  
Vol 3 (02) ◽  
Author(s):  
Amrit Kaur Kaler, Shweta C, Smitha Chandra B.C, Rajeev Naik
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Cell Population ◽  
Squamous Cell ◽  
Spindle Cell ◽  
Spindle Cell Carcinoma ◽  
Biphasic Tumor ◽  
Carcinoma Of The Tongue ◽  
Ihc Markers

Spindle cell carcinoma is a rare aggressive biphasic tumor, composed of neoplastic proliferation of both epithelial (squamous) and spindle cell population. It constitutes about 1% of all oral cavity tumors 2a and is almost rare on the tongue; only few cases have been reported so far. This variant of squamous cell carcinoma, comprises major diagnostic problems due to its varied histomorphology and resemblance to sarcomatous lesion; hence diligent screening and IHC markers are mandatory for its diagnosis.

PD-L1 and survival in oral cavity squamous cell carcinoma

2020 ◽  
Vol 25 (4) ◽  
pp. 287-294
Author(s):  
S. I. Kutukova ◽  
N. P. Beliak ◽  
G. A. Raskin ◽  
M. S. Mukhina ◽  
Yu. V. Ivaskova ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Immune Cells ◽  
Negative Impact ◽  
Progression Free Survival ◽  
Negative Effect ◽  
Effect Of Pd

Relevance. Prognostic value of PD-L1 expression in oral cavity squamous cell carcinoma (OCSCC) and its effect on survival is still controversial. It should be to determine the prognostic role of PD-L1 expression on tumor and immune cells of OCSCC and assess their effect on overall survival (OS) and progression-free survival (PFS).Materials and methods. A prospective study included 145 patients, first diagnosed with OCSCC. PD-L1 expression on tumor and immune cells, infiltrating tumor and its microenvironment, was assessed in all tumor samples by IHC, CPS was calculated. Cut-off values were determined by ROC analysis for identification of PD-L1 expression effect on OS and PFS.Results. Most patients with oral mucosa squamous cell carcinoma showed positive expression of PD-L1 on tumor (77.2%) and immune cells (92.4%). The median PD-L1 expression on tumor cells was 13.5% [1.0-40.0], the median PD-L1 expression on immune cells was 5.0% [1.0-11.0], and the median CPS – 18.0 [3.0-7.8]. Univariate and multivariate analyses revealed a significant negative effect of PD-L1 expression on immune cells ≤ 7% on OS (HR 0.66; 95% CI 0.45-0.93; p = 0.0498); PD-L1 expression in tumor cells ≤ 15% (HR 0.65; 95% CI 0.43-0.98; p = 0.0416) and CPS ≤ 21 (HR 0.62; 95% CI 0.44-0.92; p = 0.0183) for PFS. PD-L1 expression in tumor cells ≤ 6% (HR 0.71; 95% CI 0.47-1.08; p = 0.1096) and CPS ≤ 7 (RR 0.67; 95% CI 0.44-1.01; p = 0.0575) had a confident tendency to negative impact on OS.Conclusion. Positive PD-L1 expression in tumor and immune cells as well as CPS are effective additional factors in the prognosis of the disease course, OS and PFS in patients with OCSCC.

The Length of Peri-Neural Spreading in Clinically Mandibular Invaded Oral Cavity Squamous Cell Carcinoma

2020 ◽  
pp. 459-464
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphovascular Invasion ◽  
Perineural Invasion ◽  
Inferior Alveolar Nerve ◽  
Surgical Margin ◽  
Neural Invasion ◽  
Resected Margin

Background: The objective of surgical management of oral squamous cell carcinoma (OSCC) is adequate resection with a clear margin. However, there is still a debate as to the optimal length for a mandibular resected margin. Objective: To examine the length of peri-neural spreading in T4 mandibular invaded oral cavity squamous cell carcinoma. Materials and Methods: Twenty-eight T4 pathological OSCC specimens that involved mandible and serial slices were studied and the length of tumor spreading along the inferior alveolar nerve (IAN) was determined. Tumor characteristics, risk factors, and survival were analyzed. Results: The incidence of peri-neural invasion was 11.11%, and IAN invasion was found in 14.29% of the tumor-invaded mandibular marrow. The length of tumor spreading along IAN was 3 to 12 mm. Poor prognostic factors of T4 OSCC were it being located on the tongue (HR 14.16), was pathological N2-3 (HR 31.05), and had high-risk features such as peri-neural invasion, lymphovascular invasion, and extra-nodal extension. Conclusion: A mandibular resected margin of at least 18 mm is recommended as a clear surgical margin in cases of T4 mandibular invasion OSCC. Keywords: Oral cancer, Perineural invasion, Inferior alveolar nerve, Squamous cell carcinoma, Mandibulectomy

Comparative E-Cadherin Digital Expression Analysis in HPV and non-HPV Related Squamous Cell Carcinoma of the Oral Cavity

2021 ◽  
Vol 41 (1) ◽  
pp. 163-167
Author(s):  
ARISTEIDIS CHRYSOVERGIS ◽  
VASILEIOS PAPANIKOLAOU ◽  
NICHOLAS MASTRONIKOLIS ◽  
DESPOINA SPYROPOULOU ◽  
MARIA ADAMOPOULOU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Expression Analysis ◽  
Squamous Cell ◽  
Digital Expression ◽  
Digital Expression Analysis ◽  
E Cadherin

Primary squamous cell carcinoma of the ampulla of Vater: management and review of the literature

2021 ◽  
Vol 14 (1) ◽  
pp. e236477
Author(s):  
Subhash Soni ◽  
Poonam Elhence ◽  
Vaibhav Kumar Varshney ◽  
Sunita Suman
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Survival Rates ◽  
Ampulla Of Vater ◽  
Metallic Stent ◽  
Biological Behaviour ◽  
Curative Intent ◽  
Term Survival ◽  
History Of

Squamous cell carcinoma (SCC) of the ampulla of Vater is a rare pathology and only few cases are reported in the literature. With limited experience of primary SCC in the ampulla of Vater, its biological behaviour, prognosis and long-term survival rates are not well known. A 38-year-old woman presented with a history of painless progressive jaundice for which self-expending metallic stent was placed 3 years back. She was evaluated and initially diagnosed as probably periampullary adenocarcinoma. She underwent pancreaticoduodenectomy and histopathology with immunohistochemistry was suggestive of SCC of ampulla of Vater. She received adjuvant chemotherapy and doing well with no recurrence after 1 year of follow-up. In conclusion, SCC of the ampulla is an unusual pathology that should be kept as a differential diagnosis for periampullary tumours. Surgical treatment with curative intent should be performed whenever feasible even in the setting of bulky tumour to improve the outcome.

Immunophenotypic Analysis of Normal Mucosa and Squamous Cell Carcinoma of the Oral Cavity

1999 ◽  
Vol 23 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Jozsef Piffko ◽  
Agnes Bankfalvi ◽  
Ulrich Joos ◽  
Dietmar Ofner ◽  
Melanie Krassort ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Normal Mucosa ◽  
Immunophenotypic Analysis
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