scholarly journals Rosuvastatin in patients with arterial hypertension and dyslipidemia: effects on microcirculation and pulse wave parameters

2012 ◽  
Vol 11 (6) ◽  
pp. 9-15
Author(s):  
O. M. Drapkina ◽  
O. N. Korneeva ◽  
L. O. Palatkina ◽  
E. V. Zyatenkova ◽  
N. P. Balakhonova ◽  
...  
Keyword(s):  
High Risk ◽  
Arterial Stiffness ◽  
Arterial Hypertension ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Erythrocyte Aggregation ◽  
Stiffness Index ◽  
Atorvastatin Group ◽  
Group I ◽  
Rosuvastatin Group

Aim. To investigate the parameters of pulse wave contour analysis (PWCA) and microcirculation (MC) in patients with arterial hypertension (AH), dyslipidemia (DLP), and high cardiovascular risk levels (SCORE >5%); to compare the dynamics of these parameters during the treatment with rosuvastatin or atorvastatin. Material and methods. The study included 82 patients (mean age 53±10 years) with the high-risk AH (SCORE levels >5%), DLP, and no strict contraindications to statins. All patients were randomised into two comparable groups: Group I (n=40; mean age 51±10 years), receiving atorvastatin and standard AH treatment; and Group II (n=42; mean age 52±10 years), receiving rosuvastatin and standard AH treatment. At baseline and after 5 weeks, all patients underwent the MC assessment (conjunctival biomicroscopy) and PWCA (AngioScan-01). The following parameters were assessed: stiffness index (SI), reflection index (RI), augmentation index (AIx), and increased pulse wave amplitude (PWA). Results. In the atorvastatin group, mean SI values were 5,87±2,05 m/s, RI values 35,64±19,98%, mean AIx values for heart rate of 75 beats per minute (AIx75) 41,21±14,56%, and mean central blood pressure (BP, Spa) levels 144,35±22,31 mm Hg. In the rosuvastatin group, the respective values were 5,01±2,56 m/s (SI), 37,01±14,56% (RI), 41,23±14,35% (AIx75), and 148,98±7,89 mm Hg (BP, Spa). All participants demonstrated PW Types A and B, as a marker of increased arterial stiffness, and positive AIx and AIx75 values. The treatment with atorvastatin and rosuvastatin was associated with a significant reduction in ∆SI (-0,87 and -0,89 m/s, respectively). Both groups demonstrated a non-significant reduction in ∆RI (-7,89 and -7,21%, respectively) and ∆AIx (-1,88 and -1,92%, respectively). PWA increased by 1,82±0,62 times in the atorvastatin group and by 1,95±0,81 times in the rosuvastatin group. At baseline, both groups demonstrated disturbed conjunctival MC (arterio-venular coefficient 1:3, stasis, and Stage III erythrocyte aggregation). Atorvastatin and rosuvastatin treatment was linked to a regression in the last two parameters, which could be explained by the improved vascular wall elasticity. Conclusion. In high-risk patients with AH, the PWCA data suggested an increase in arterial stiffness, which was combined with conjunctival MC disturbances. Statin therapy improved not only blood lipid levels, but also MC, vascular stiffness, and endothelial function parameters, which was more pronounced in the rosuvastatin group.

scholarly journals Anemia in Patients with Axial Spondyloarthritis is Not Associated with an Increase of Arterial Stiffness and Intima-Media Thickness (Results of a Single-Center Cross-Sectional Study)

2021 ◽  
Vol 11 (4) ◽  
pp. 284-291
Author(s):  
K. N. Safarova ◽  
V. I. Makhina ◽  
K. D. Dorogoykina ◽  
A. P. Rebrov
Keyword(s):  
Arterial Stiffness ◽  
Pulse Wave ◽  
Axial Spondyloarthritis ◽  
Augmentation Index ◽  
Subclinical Atherosclerosis ◽  
Intima Media Thickness ◽  
Vascular Wall ◽  
Stiffness Index ◽  
Media Thickness ◽  
Wall Stiffness

Aim: to study parameters of arterial stiffness and subclinical atherosclerosis in patients with axial spondyloarthritis (axSpA) without clinically manifest cardiovascular pathology depending on the presence of anemia.Material and methods. 102 patients with axSpA (mean age – 37.7±9.8 years, axSpA duration – 13.5±8.7 years, 66 (64.7%) men) were included. The BASDAI index and C-reactive protein (CRP)-based ASDAS score were measured, the hemogram, the erythrocyte sedimentation rate (ESR), and the level of CRP were studied. Parameters of arterial stiffness were studied by oscillography and photoplethysmography, intima-media thickness (IMT) was evaluated by B-mode ultrasound according to standard protocols.Results. During analysis of pulse wave properties, no statistically significant differences in parameters of vascular wall stiffness were found in axSpA patients with and without anemia. Aortic pulse wave velocity (PWVao) in patients with anemia was 7.4±1.5 m/sec, aortic augmentation index (Aix-ao) was 19.1±13.7%, stiffness index (SI) was 8.2±1.7 m/sec; in patients without anemia – 7.4±1.4 m/sec, 17.3±10.6% and 8.8±2.0 m/sec, respectively (p >0.05 for all). IMT in patients with anemia was 0.70±0.13 cm, in patients without anemia – 0.73±0.16 cm (p >0.05). Correlation analysis was performed and significant correlations were noted between Aix-ao, PWVao, SI, IMT and age (r=0.488, r=0.516, r=0.289, r=0.461, respectively, p <0.05); Aix-ao, PWVao and the BASDAI index (r=0.243, r=0.253, respectively, p <0.05). Significant correlations between PWVao and Aix-ao (r=0.442, p <0.001), SI (r=0.273, p=0.011) and IMT (r=0.236, p=0.034) were found.Conclusion. The present study did not confirm the negative effect of anemia on vascular wall stiffness parameters and IMT in patients with axSpA. We consider that potential protective effect of anemia, due to well-known pathophysiological patterns — a decrease in blood viscosity and the induction of nitric oxide synthesis, plays an important role. Further studies are required to assess relationship between hemoglobin levels and markers of endothelial dysfunction in patients with axSpA.

scholarly journals The association between augmentation index and arterial stiffness index

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Yan Liu ◽  
Litong Qi ◽  
Ying Yang ◽  
Lei Meng ◽  
Baowei Zhang ◽  
...  
Keyword(s):  
Arterial Stiffness ◽  
Local Community ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Ankle Brachial Index ◽  
Systolic Pressure ◽  
Arterial System ◽  
Stiffness Index ◽  
Bilateral Carotid ◽  
Significant Difference

Objective To explore the association between arterial system augmentation index(AI) and brachial-ankle pulse wave velocity (baPWV). Methods All subjects were selected from a local community. The study included 1752 people living in Shijingshan district, Beijing during April to June,2010. Subjects whose age ranged from 23 to 90 years old [(59.82±11.88) years old] were included and 56.7% of the subjects were women. Pulse wave at the left radial artery was measured and the AI was calculated by Colin pulse wave detection device HEM9000AI. baPWV and ankle-brachial index (ABI) were measured using Colin noninvasive arteriosclerosis tester VP-1000. Color doppler flow imaging was used to measure intima-media thickness (IMT) of the bilateral carotid artery. Results The baPWV was significantly higher in ABI0.9 group and IMT0.9 mm group, while there was no significant difference of AI75 between groups. AI had a low correlation with baPWV (r = -0.068, P = 0.005). Partial correlation analysis showed that there was no significant association between AI and baPWV (r = -0.033, P = 0.17). In multiple stepwise regression analysis, the factors of AI included gender, age, BMI, waist-to-hip ratio, heart rate, ABI and systolic pressure. Conclusion No significant correlation can be found between AI and baPWV. Various factors may influence the measurement of AI. This study suggests that AI may not be a sensitive and reliable index for the evaluation of arterial stiffness.

scholarly journals EFFECT OF GOLIMUMAB ON IMMUNOLOGICAL MARKERS FOR BONE METABOLISM AND ON ARTERIAL STIFFNESS IN PATIENTS WITH RHEUMATOID ARTHRITIS

2018 ◽  
Vol 56 (3) ◽  
pp. 286-292 ◽  
Author(s):  
L. A. Knyazeva ◽  
N. Damjanov ◽  
L. I. Knyazeva ◽  
N. S. Meshcherina ◽  
I. I. Goryainov
Keyword(s):  
Rheumatoid Arthritis ◽  
Arterial Stiffness ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Molecular System ◽  
Stiffness Index ◽  
Contour Analysis ◽  
Concentration Changes ◽  
Group 2 ◽  
Group 1

Objective: to evaluate the effect of golimumab (GLM) on the receptor activator of NF-κB ligand (RANKL)/osteoprotegerin (OPG) transmembrane molecular system and arterial stiffness in patients with rheumatoid arthritis (RA).Subjects and methods. Thirty-six patients with RA were examined and randomized into 2 groups based on disease duration (less than or more than 2 years). The serum levels of OPG, and RANKL, were investigated. Dual-energy X-ray absorptiometry and pulse wave contour analysis were performed before and 52 weeks after GLM treatment.Results and discussion. Group 1 patients demonstrated increased serum OPG levels that were on average 3.6 times higher than in the controls (р=0.005) and 2.1 times higher than in Group 2 (р=0.01). In Group 2 patients, the RANKL concentration was 9-fold higher than that in the controls (p=0.001) and 30.6% higher than in Group 1 (p=0.01). The examinees were found to be diagnosed with subclinical damage to the great arteries (increases in augmentation index (AIp), stiffness index (SI), and reflection (RI) index), which progressed with a longer RA duration. After GLM treatment, serum OPG and RANKL levels decreased in Group 1 patients by 2.1- (p<0.001) and 1.7-fold (p<0.01), respectively. In Group 2, the level of RANKL dropped by 32.2% (p<0.01), without significant OPG concentration changes. After GLM treatment, the pulse wave contour analysis parameters in Group 1 did not differ from those in the controls; Group 2 showed significant decreases in AIp by an average of 1.8 times (p<0.01), in SI by 1.2 times (p<0.01), and in RI by 1.6 times (p<0.01).Conclusion. GLM treatment in RA patients is accompanied by a lower imbalance in the RANKL/OPG transmembrane molecular system and exerts a vasoprotective effect on the large elastic vessels (reductions in AIp and SI) and small muscular arteries (a decrease in RI). 

Arterial stiffness is a potential mechanism and promising indicator of orthostatic hypotension in the general population

VASA ◽  
2014 ◽  
Vol 43 (6) ◽  
pp. 423-432 ◽  
Author(s):  
Qingtao Meng ◽  
Si Wang ◽  
Yong Wang ◽  
Shixi Wan ◽  
Kai Liu ◽  
...  
Keyword(s):  
General Population ◽  
Arterial Stiffness ◽  
Orthostatic Hypotension ◽  
Operating Characteristic ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Multiple Logistic Regression Analysis ◽  
The Elderly ◽  
Baroreceptor Sensitivity ◽  
Roc Curve Analysis

Background: Orthostatic hypotension (OH) is a disease prevalent among middle-aged men and the elderly. The association between arterial stiffness and OH is unclear. This study evaluates whether arterial stiffness is correlated with OH and tests the usefulness of brachial-ankle pulse wave velocity (baPWV), an arterial stiffness marker, with regard to identifying OH. Patients and methods: A sample of 1,010 participants was recruited from the general population (64.8 ± 7.7 years; 426 men) who attended health check-ups. BaPWV and the radial augmentation index (rAI) were both assessed as the arterial stiffness markers, and OH was determined using blood pressure (BP) measured in the supine position, as well as 30 seconds and 2 minutes after standing. Results: The prevalence of OH in this population was 4.9 %. Compared with the non-OH group, both baPWV (20.5 ± 4.5 vs 17.3 ± 3.7, p < 0.001) and rAI (88.1 ± 10.8 vs 84.2 ± 10.7, p < 0.05) were significantly higher in the OH group. In the multiple logistic regression analysis, baPWV (OR, 1.3; 95 % CI, 1.106–1.528; p < 0.05) remained associated with OH. Moreover, the degree of orthostatic BP reduction was related to arterial stiffness. In addition, increases in arterial stiffness predicted decreases in the degree of heart rate (HR) elevation. Finally, a receiver operating characteristic (ROC) curve analysis showed that baPWV was useful in discriminating OH (AUC, 0.721; p < 0.001), with the cut-off value of 18.58 m/s (sensitivity, 0.714; specificity, 0.686). Conclusions: Arterial stiffness determined via baPWV, rather than rAI, was significantly correlated with the attenuation of the orthostatic hemodynamic response and the resultant OH. The impaired baroreceptor sensitivity might be the mechanism. In addition, baPWV appears to be a relatively sensitive and reliable indicator of OH in routine clinical practice.

Markers of arterial stiffness in peripheral arterial disease

VASA ◽  
2015 ◽  
Vol 44 (5) ◽  
pp. 341-348 ◽  
Author(s):  
Marc Husmann ◽  
Vincenzo Jacomella ◽  
Christoph Thalhammer ◽  
Beatrice R. Amann-Vesti
Keyword(s):  
Arterial Stiffness ◽  
Peripheral Arterial Disease ◽  
Pulse Wave ◽  
Augmentation Index ◽  
Arterial Disease ◽  
Care Physician ◽  
Additional Information ◽  
Non Invasive ◽  
Assessment Techniques ◽  
Peripheral Arterial

Abstract. Increased arterial stiffness results from reduced elasticity of the arterial wall and is an independent predictor for cardiovascular risk. The gold standard for assessment of arterial stiffness is the carotid-femoral pulse wave velocity. Other parameters such as central aortic pulse pressure and aortic augmentation index are indirect, surrogate markers of arterial stiffness, but provide additional information on the characteristics of wave reflection. Peripheral arterial disease (PAD) is characterised by its association with systolic hypertension, increased arterial stiffness, disturbed wave reflexion and prognosis depending on ankle-brachial pressure index. This review summarises the physiology of pulse wave propagation and reflection and its changes due to aging and atherosclerosis. We discuss different non-invasive assessment techniques and highlight the importance of the understanding of arterial pulse wave analysis for each vascular specialist and primary care physician alike in the context of PAD.

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