scholarly journals Study on canine hip dysplasia and its diagnosis by imaging and molecular genetics techniques

2021 ◽  
Vol 78 (1) ◽  
pp. 1
Author(s):  
Felix Daniel LUCACI ◽  
Radu LĂCĂTUȘ ◽  
Robert Cristian PURDOIU ◽  
Dana Liana PUSTA
Keyword(s):  
Molecular Genetics ◽  
Standard Method ◽  
Hip Dysplasia ◽  
Molecular Genetic ◽  
Radiological Examination ◽  
Gold Standard Method ◽  
Digital Radiology ◽  
Extended Position ◽  
The Individual ◽  
Canine Hip Dysplasia

The present paper is a bibliographical research on canine hip dysplasia using imaging and molecular genetics techniques. Ever since the first description in 1935 made by Schnelle, canine hip dysplasia has remained one of the most diagnosed orthopedic conditions present in the dog breeds. The gold standard method of diagnosis of hip dysplasia is the radiological examination in hip-extended position. While the radiological examination focuses mainly on the individual for the diagnosis of this condition, methods of diagnosis of an entire population are sought, and these methods are represented by molecular genetics techniques. Naming the etiology of canine hip dysplasia and finding out the latest methods of genetically and radiologically diagnosis of canine hip dysplasia and the best alternatives of treatment for this disease. Canine hip dysplasia continues to be a major problem for owners, breeders and veterinarians. Currently, there are five standardized systems worldwide that deal with the grading of canine hip dysplasia. In addition to digital radiology, CT and ultrasonographic examination are feasible diagnosis methods. Even if the standard method of diagnosis remains the radiological examination in the present, the near future provides to be of the molecular genetic techniques.

Hip dysplasia: understanding the options (surgical management)

2019 ◽  
Vol 24 (5) ◽  
pp. 249-256
Author(s):  
Philip Georg Witte
Keyword(s):  
Surgical Management ◽  
Hip Dysplasia ◽  
Surgical Techniques ◽  
Individual Case ◽  
Developmental Dysplasia ◽  
Human Infants ◽  
Surgical Interventions ◽  
Surgical Options ◽  
The Individual ◽  
Canine Hip Dysplasia

The majority of vets in practice will be familiar with options for conservative management of canine hip dysplasia. However, there may be less familiarity with the various surgical options. Knowledge of the reported surgical techniques; selection criteria for these options; and their outcomes and potential complications provide the basis for an evidence-based approach to management of the individual case. In this article a brief comparison with developmental dysplasia of the hips in human infants is given by way of an introduction to surgical options, since there is some overlap with options for hip dysplasia in dogs. A description of the surgical interventions that have been reported for canine hip dysplasia is presented, and, where possible, the evidence regarding outcomes is summarised. It is hoped this article will help the general practitioner giving advice regarding surgical management of canine hip dysplasia.

scholarly journals Comparison of Three Methods to Quantify Laxity in the Canine Hip Joint

2018 ◽  
Vol 31 (01) ◽  
pp. 023-029 ◽  
Author(s):  
Aldo Vezzoni ◽  
Evelien Bogaerts ◽  
Mileva Bertal ◽  
Tim Bosmans ◽  
Emmelie Stock ◽  
...  
Keyword(s):  
Hip Joint ◽  
Hip Dysplasia ◽  
Interobserver Agreement ◽  
Classification Criteria ◽  
Joint Laxity ◽  
Measurement Variability ◽  
Novel Method ◽  
The Individual ◽  
Canine Hip Dysplasia ◽  
Norberg Angle

Objectives Comparison of PennHIP and a novel method to diagnose hip laxity, called the Vezzoni modified Badertscher distension device technique. Methods In a total of 10 dogs, it was first assessed whether the distraction index (DI) from the PennHIP evaluation center could be reproduced by two individual observers. In the next two steps, the DI measurements made by the individual observers and the PennHIP evaluation center were compared with the laxity index (LI) measured on the Vezzoni modified Badertscher distension device view. Finally, the interobserver agreement of the DI, LI and Norberg angle was assessed and compared with classification criteria. Results The results were similar for the first three comparisons: there was no evidence for bias, the relation between DI and LI was linear and the variability was small. A comparison of the interobserver agreement showed that the measurement variability for the NA was substantial, while the reproducibility for the DI and LI was equal. Clinical Significance While the standard ventrodorsal hip extended radiograph is most commonly used for diagnosis and screening of canine hip dysplasia, it lacks sensitivity to diagnose laxity. To improve the identification of hip joint laxity, distraction-based radiographic techniques are helpful. The Vezzoni modified Badertscher distension device technique allows for a reliable in-house evaluation of canine hip joint laxity.

Evaluation of Sacroiliac Wedge Rotation to Increase Acetabular Ventroversion

1999 ◽  
Vol 12 (04) ◽  
pp. 173-177 ◽  
Author(s):  
R. L. Aper ◽  
M. D. Brown ◽  
M. G. Conzemius
Keyword(s):  
Hip Joint ◽  
Hip Dysplasia ◽  
Clinical Effect ◽  
Pelvic Osteotomy ◽  
Alternative Method ◽  
Angular Measurements ◽  
Si Joint ◽  
In Vivo Effects ◽  
Canine Hip Dysplasia

SummaryTreatment of canine hip dysplasia (CHD) via triple pelvic osteotomy (TPO) is widely accepted as the treatment that best preserves the existing hip joint. TPO, however, has several important disadvantages. In an effort to avoid some of the difficulties associated with TPO an alternative method of creating acetabular ventroversion (AW) was sought. The purpose of this study was to explore the effects of placement of a wedge in the sacroiliac (SI) joint on A W and to compare this to the effect of TPO on A W . On one hemipelvis a 30° pelvic osteotomy plate was used for TPO. The contralateral hemipelvis had a 28° SI wedge inserted into the SI joint. Pre- and postsurgical radiographs of each pelvis were taken and the angular measurements were recorded. On average, the 28° SI wedge resulted in 20.9° of A W, the 30° canine pelvic osteotomy plate resulted in 24.9° A W . Significant differences were not found (p >0.05) between the two techniques. Sacroiliac wedge rotation effectively creates A W and has several theoretical advantages when compared to TPO. The in vivo effects of sacroiliac wedge rotation should be studied in order to evaluate the clinical effect of the technique.Sacroiliac wedge rotation was tested as an alternative method to increase the angle of acetabular ventroversion. This technique effectively rotated the acetabulum and has several theoretical advantages when compared to triple pelvic osteotomy.

Canine Hip Dysplasia in Sweden

1972 ◽  
Vol 12 ◽  
pp. 175-180 ◽  
Author(s):  
Bengt Henricson ◽  
Gunnela Ljunggren ◽  
Sten-Erik Olsson
Keyword(s):  
Hip Dysplasia ◽  
Canine Hip Dysplasia

scholarly journals Molecular genetics of bipolar disorder

2001 ◽  
Vol 178 (S41) ◽  
pp. s128-s133 ◽  
Author(s):  
Nick Craddock ◽  
Ian Jones
Keyword(s):  
Bipolar Disorder ◽  
Candidate Gene ◽  
Molecular Genetics ◽  
Ethical Issues ◽  
Association Studies ◽  
Single Gene ◽  
Molecular Genetic ◽  
Genetic Dissection ◽  
Adoption Studies ◽  
Candidate Gene Association

BackgroundA robust body of evidence from family, twin and adoption studies demonstrates the importance of genes in the pathogenesis of bipolar disorder. Recent advances in molecular genetics have made it possible to identify these susceptibility genes.AimsTo present an overview for clinical psychiatrists.MethodReview of current molecular genetics approaches and emerging findings.ResultsOccasional families may exist in which a single gene plays a major role in determining susceptibility, but the majority of bipolar disorder involves more complex genetic mechanisms such as the interaction of multiple genes and environmental factors. Molecular genetic positional and candidate gene approaches are being used for the genetic dissection of bipolar disorder. No gene has yet been identified but promising findings are emerging. Regions of interest include chromosomes 4p16, 12q23–q24, 16p13, 21q22, and Xq24–q26. Candidate gene association studies are in progress but no robust positive findings have yet emerged.ConclusionIt is almost certain that over the next few years the identification of bipolar susceptiblity genes will have a major impact on our understanding of disease pathophysiology. This is likely to lead to major improvements and treatment in patient care, but will also raise important ethical issues.

The PennHIP method of predicting canine hip dysplasia

In Practice ◽  
2014 ◽  
Vol 36 (2) ◽  
pp. 66-74 ◽  
Author(s):  
Mike Guilliard
Keyword(s):  
Hip Dysplasia ◽  
Canine Hip Dysplasia

Unlocking the genetic make-up of canine hip dysplasia: We can work it out

2009 ◽  
Vol 181 (2) ◽  
pp. 77-78 ◽  
Author(s):  
Hannes Lohi ◽  
Frank W. Nicholas
Keyword(s):  
Hip Dysplasia ◽  
Canine Hip Dysplasia

scholarly journals Volume of the ligamentum capitis femoris in osteoarthritic hip joints of adult dogs

2003 ◽  
Vol 74 (1) ◽  
Author(s):  
J.D. Mande ◽  
P.M.F. Mbithi ◽  
S.W. Mbugua ◽  
I.B.J. Buoro ◽  
P.K. Gathumbi
Keyword(s):  
General Anaesthesia ◽  
Crucial Role ◽  
Hip Dysplasia ◽  
Inverse Correlation ◽  
Water Displacement ◽  
Hip Joints ◽  
Ligamentum Capitis Femoris ◽  
The Mean ◽  
Canine Hip Dysplasia

Ventrodorsal pelvic radiographs were made of 32 adult dogs under general anaesthesia. The hip joints were evaluated according to the severity of osteoarthritic changes graded as 0, 1, 2 or 3. The dogs were euthanased, the hip joints opened and the ligamentum capitis femoris dissected out in toto. The volume of each ligament was determined using a water displacement technique and the mean volume compared to the four radiographic grades of osteoarthritis. There was an inverse correlation (r = -0.75) between the mean volume of the ligamentum capitis femoris and the increasing severity of osteoarthritis as assessed by radiography. The results confirmed the crucial role of radiography in the clinical evaluation of hip dysplasia and osteoarthritis in the adult dog. Assessment of the volume of the ligamentum capitis femoris revealed that it is an important tool for research in canine hip dysplasia and osteoarthritis.

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