Long-Term Outcome of Childhood-Onset Epilepsy

Purpose To examine prevalence, course, and long-term outcome of childhood migraine and other headaches. Method Using questionnaires, 1185 children were followed for recurrent headaches at ages seven, 14 and 32 years, respectively. Results At age seven years, 4.0% of the 1185 children (girls 3.7%, boys 4.3%) had migraine and 24% (25%/23%) had nonmigrainous headache. In adulthood, 16% (22%/8%) had migraine and 60% (64%/54%) nonmigrainous headache. Childhood migraine persisted into adulthood in 65% of females and 21% of males, and nonmigrainous headache in 62% and 59%, respectively. After childhood, 17% of females and 7% of males started to have episodes of migraine. No recurrent headache during the follow-up was reported by 11% (6%/16%). In a multivariate analysis, compared with no childhood headache, childhood migraine increased the risk of adulthood migraine by 3.36-fold (95% CI 1.94–5.82) and that of nonmigrainous headache by 1.72-fold (1.14–2.60). Discussion and conclusions Headaches are generally as common in preschool girls as boys. From early school years, headaches steadily increase up to young adulthood, but among boys the prevalence levels off after adolescence. About two thirds of children experienced changes in their headache status during a 25-year follow-up. Any kind of recurrent headache at school entry predicts an increased risk of headache in young adulthood. Special attention should be paid to girls and particularly those girls who have recurrent headache when they start school.

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Long-term outcome of 424 childhood-onset myasthenia gravis patients

Journal of Neurology ◽

10.1007/s00415-015-7638-2 ◽

2015 ◽

Vol 262 (4) ◽

pp. 823-830 ◽

Cited By ~ 15

Author(s):

Mengcui Gui ◽

Xuan Luo ◽

Jing Lin ◽

Yue Li ◽

Min Zhang ◽

...

Keyword(s):

Myasthenia Gravis ◽

Childhood Onset ◽

Term Outcome ◽

Long Term Outcome

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Clozapine Treatment of Childhood-Onset Schizophrenia: Evaluation of Effectiveness, Adverse Effects, and Long-Term Outcome

Journal of the American Academy of Child & Adolescent Psychiatry ◽

10.1097/chi.0b013e31812eed10 ◽

2007 ◽

Vol 46 (10) ◽

pp. 1349-1356 ◽

Cited By ~ 57

Author(s):

ALEXANDRA L. SPORN ◽

ANOOP VERMANI ◽

DEANNA K. GREENSTEIN ◽

AARON J. BOBB ◽

EDGAR P. SPENCER ◽

...

Keyword(s):

Adverse Effects ◽

Childhood Onset ◽

Term Outcome ◽

Long Term Outcome ◽

Clozapine Treatment ◽

Childhood Onset Schizophrenia

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Long-term effects of growth hormone replacement therapy in childhood-onset craniopharyngioma: results of the German Craniopharyngioma Registry (HIT-Endo)

Acta Endocrinologica ◽

10.1530/eje-18-0505 ◽

2018 ◽

Vol 179 (5) ◽

pp. 331-341 ◽

Cited By ~ 8

Author(s):

Svenja Boekhoff ◽

Agnieszka Bogusz ◽

Anthe S Sterkenburg ◽

Maria Eveslage ◽

Hermann L Müller

Keyword(s):

Growth Hormone ◽

Hormone Replacement ◽

Cross Sectional Study ◽

Long Term Effects ◽

Childhood Onset ◽

Survival Prognosis ◽

Term Outcome ◽

Cross Sectional ◽

Long Term Outcome

Objective Quality of survival, prognosis and long-term outcome are often severely impaired in childhood-onset craniopharyngioma (CP) patients. Identification of risk factors for sequelae such as growth hormone (GH) deficiency is important for appropriate treatment and rehabilitation. Design In a cross-sectional study, 79 CP patients recruited in HIT-Endo before 2000 were analyzed according to GH substitution: (a) CP never GH treated (noGH); (b) CP GH treated only during childhood (pedGH); (c) CP under GH, initiated at adulthood (adultGH); (d) CP under GH during childhood and continued during adulthood (contGH). Methods Progression-free (PFS) and overall survival (OS), height, BMI, psychosocial and neuropsychological status (EORTC QLQ-C30, MFI-20). Results OS and PFS rates were similar in all subgroups. ContGH and pedGH CP presented with increases in height (P = 0.002; P = 0.0001) during long-term follow-up when compared with baseline. In all subgroups except for pedGH, increases in BMI were observed when compared with BMI at diagnosis. For emotional functionality and physical fatigue, adultGH CP showed worse (P = 0.037; P = 0.034) response (mean: 61.4%; 12.5%) when compared with pedGH CP (mean: 83.5%; 7.7%). Observed differences were not related to irradiation and hypothalamic involvement. In terms of psychosocial status, no differences were observed between subgroups. Conclusions We conclude that GH substitution was safe with regard to risk of tumor progression/relapse in CP. Growth was improved by GH, whereas the development of obesity was not influenced by GH substitution. However, early initiation of GH substitution after CP diagnosis might have beneficial effects on weight development and neuropsychological outcome.

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Fusiform dilatation of the internal carotid artery in childhood-onset craniopharyngioma: multicenter study on incidence and long-term outcome

Pituitary ◽

10.1007/s11102-016-0722-5 ◽

2016 ◽

Vol 19 (4) ◽

pp. 422-428 ◽

Cited By ~ 18

Author(s):

Anika Hoffmann ◽

Monika Warmuth-Metz ◽

Kristin Lohle ◽

Julia Reichel ◽

Anna M. M. Daubenbüchel ◽

...

Keyword(s):

Carotid Artery ◽

Internal Carotid Artery ◽

Multicenter Study ◽

Internal Carotid ◽

Childhood Onset ◽

Term Outcome ◽

Long Term Outcome

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Long-Term Outcomes and Predictors of Childhood-Onset Schizophrenia: A Naturalistic Study of 6-year Follow-Up in China

Frontiers in Psychiatry ◽

10.3389/fpsyt.2021.679807 ◽

2021 ◽

Vol 12 ◽

Author(s):

Zheng Liangrong ◽

Zhang Guican ◽

Zhu Qi ◽

Yang Weirui ◽

Zhang Yaqi ◽

...

Keyword(s):

Depressive Symptoms ◽

Long Term Outcomes ◽

Childhood Onset ◽

Occupational Education ◽

Term Outcome ◽

Long Term Outcome ◽

Childhood Onset Schizophrenia ◽

Education Status

Objectives: The long-term outcome of childhood-onset schizophrenia (COS) and its influencing factors remain unclear. The current study aimed to assess the long-term outcomes of COS and identify possible outcome predictors.Methods: We retrospectively investigated 276 patients with COS. Diagnosis made according to the ICD-10 criteria for schizophrenia, and the age of the first onset was ≤ 14 years. Follow-up was completed for 170 patients, with a median follow-up period of 5.6 years. Outcome variables included occupational/education status and readmission. Spearman correlation was performed to assess the relationship between predictors and outcome variables. Binary logistic regression was conducted to detect possible predictor variables for outcome variables.Results: At the end of the follow-up, 89 patients (52.3%) were at school, 70 patients (41.2%) were employed, and only 11 patients (6.5%) were dropped out of school or unemployed. The duration to the first admission and depressive symptoms were identified as predictors of occupational/educational status. The length of follow-up and obsessive-compulsive symptoms (OCS) were distinguished as predictors of readmission. Duration to the first admission and length of follow-up were risk factors, and depressive symptoms and OCS were protective factors for the outcomes of COS.Conclusion: We found a favorable long-term outcome on occupational/education status in COS, and depressive symptoms and OCS may be associated with more positive long-term outcomes in COS. Our findings suggest that COS patients may benefit from early intervention and require appropriate treatment.

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