scholarly journals Neurotrophins, cytokines, oxidative parameters and funcionality in Progressive Muscular Dystrophies

2015 ◽  
Vol 87 (3) ◽  
pp. 1809-1818 ◽  
Author(s):  
CLARISSA M. COMIM ◽  
GISIANE B. MATHIA ◽  
ANDREZA HOEPERS ◽  
LISIANE TUON ◽  
FLÁVIO KAPCZINSKI ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Muscular Dystrophy ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Superoxide Dismutase Activity ◽  
Age And Gender ◽  
Tnf Α ◽  
Cytokine Levels ◽  
And Gender ◽  
Anti Inflammatory Cytokine

We investigated the levels of brain derived-neurotrophic factor (BDNF), cytokines and oxidative parameters in serum and tried to correlate them with the age and functionality of patients with Progressive Muscle Dystrophies (PMD). The patients were separated into six groups (case and controls pared by age and gender), as follows: Duchenne Muscular Dystrophy (DMD); Steinert Myotonic Dystrophy (SMD); and Limb-girdle Muscular Dystrophy type-2A (LGMD2A). DMD patients (±17.9 years old) had a decrease of functionality, an increase in the IL-1β and TNF-α levels and a decrease of IL-10 levels and superoxide dismutase activity in serum. SMD patients (±25.8 years old) had a decrease of BDNF and IL-10 levels and superoxide dismutase activity and an increase of IL-1β levels in serum. LGMD2A patients (±27.7 years old) had an decrease only in serum levels of IL-10. This research showed the first evidence of BDNF involvement in the SMD patients and a possible unbalance between pro-inflammatory and anti-inflammatory cytokine levels, along with decreased superoxide dismutase activity in serum of DMD and SMD patients.

scholarly journals Fungal Exposure and Low Levels of IL-10 in Patients with Sarcoidosis

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Marjeta Terčelj ◽  
Sanja Stopinšek ◽  
Alojz Ihan ◽  
Barbara Salobir ◽  
Saša Simčič ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Healthy Controls ◽  
Serum Cytokine ◽  
Fungal Cell ◽  
Fungal Exposure ◽  
Cytokine Levels ◽  
Exposure Levels ◽  
Low Levels ◽  
Anti Inflammatory Cytokine

Background and Objectives. Sarcoidosis is an inflammatory disease with increased levels of inflammatory cytokines. Previous studies have shown a relation between the degree of granuloma infiltration and serum cytokine levels, except for interleukin- (IL-) 10. The aim of the study was to further investigate the serum levels of IL-10 in patients with sarcoidosis and relate them to fungal exposure in terms of the amount of fungi in the air of their homes andβ-glucan in bronchoalveolar lavage (BAL) fluid.Methods. Patients with sarcoidosis (n=71) and healthy controls (n=27) were enrolled. IL-10 was determined in serum. BAL was performed and the amount ofβ-glucan was measured. Domestic exposure to fungi was determined by measuring airborneβ-N-acetylhexosaminidase (NAHA) in the bedrooms.Results. At high levels of fungal exposure (domestic fungal exposure andβ-glucan in BAL), serum IL-10 values were lower than at low and intermediate exposure levels.Conclusion. The low serum IL-10 values at high fungal exposure suggest that fungal cell wall agents play a role in granuloma formation in sarcoidosis by inhibiting the secretion of the anti-inflammatory cytokine IL-10.

scholarly journals Increased Serum Cu/Zn SOD in Individuals with Clinical Depression Normalizes after Zinc and Anti-oxidant Therapy

2010 ◽  
Vol 3 ◽  
pp. NMI.S5044 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Superoxide Dismutase ◽  
Serum Concentration ◽  
Serum Levels ◽  
Clinical Depression ◽  
Healthy Controls ◽  
Age And Gender ◽  
Anti Oxidant ◽  
And Gender

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with clinical depression. Subjects and Methods Serum from 36 individuals diagnosed with clinical depression and 18 healthy controls were tested for Cu/Zn SOD serum concentration using ELISAs. Results Serum Cu/Zn SOD levels of depressed individuals (both with and without secondary anxiety) were significantly higher than age and gender similar controls. We also found that, post anti-oxidant therapy, Cu/Zn SOD levels normalized to the level of normal healthy controls. Discussion These results suggest an association between Cu/Zn SOD serum levels and clinical depression.

scholarly journals Cytokine profiles in highly active antiretroviral treatment non-adherent, adherent and naive HIV-1 infected patients in Western Kenya

2021 ◽  
Vol 21 (4) ◽  
pp. 1584-92
Author(s):  
Fauzia Musa ◽  
Nathan Shaviya ◽  
Fidelis Mambo ◽  
Collins Abonyo ◽  
Erick Barasa ◽  
...  
Keyword(s):  
Inflammatory Cytokine ◽  
Antiretroviral Treatment ◽  
Healthy Controls ◽  
Highly Active ◽  
Cytokine Balance ◽  
Tnf Α ◽  
Cytokine Levels ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine ◽  
Hiv 1

Background: Cytokines play an important role in signaling the immune system to build an adequate immune responseagainst HIV. HIV distorts the balance between pro and anti-inflammatory cytokines causing viral replication. Highly active antiretroviral treatment (HAART) acts by trying to restore pro and anti-inflammatory cytokine balance. It is not clear how HAART non-adherence influences circulating cytokine levels. This study therefore determined cytokine levels in HAART non-adherent individuals. Methods: This cross-sectional study recruited 163 participants (51 controls, 23 HIV-1+ HAART naive, 28 HAART-adherent6 months, 19 HAART-adherent 12 months and 42 HAART non-adherent). Cytokines were analyzed by ELISA while CD4 T cells determined in 3.0 μl of whole blood using BD FACSCaliburTM and viral load in 0.2ml plasma sample using Abbott Molecular m2000sp sample preparation and m2000rt real-time amplification and detection systems (Abbott MolecularInc., Illinois, USA) according to the manufacturer’s methods. Results: IL-4, IL-6, IL-10, TNF-α and TGF-β were significantly elevated in HIV-1 HAART non-adherent compared withHIV-1 HAART adherent and healthy controls P<0.01. IFN- γ was significantly decreased in HIV-1 HAART non-adherentcompared with HIV-1 HAART adherent and healthy controls P<0.01. TNF-α and TGF-β were significantly reduced in HIV-1 HAART adherent patients at 12 months compared to those at 6 months P<0.01. IL-4 and IL-10 correlated positively withviral load. IL-4, IL-6, IL-10, TNF-α and TGF- β associated inversely with CD4 T cell counts and body mass index (BMI). Conclusion: This study established that HAART adherence is immunologically beneficial to the pro and anti-inflammatory cytokine balance milieu while non-adherence appears to cause alterations in pro and anti-inflammatory cytokines warping the balance in this dichotomy. Keywords: Cytokines; non-adherence; HAART.

2340 – The role of age and gender in predicting serum levels of IL-6 and TNF-α in patients with schizophrenia and major depression

2013 ◽  
Vol 28 ◽  
pp. 1
Author(s):  
M. Pantovic ◽  
B. Dunjic-Kostic ◽  
N. Radonjic ◽  
V. Vukovic ◽  
A. Damjanovic ◽  
...  
Keyword(s):  
Major Depression ◽  
Serum Levels ◽  
Age And Gender ◽  
Tnf Α ◽  
And Gender

scholarly journals Increased Serum Cu/Zn Superoxide Dismutase in Individuals with Anxiety

2010 ◽  
Vol 3 ◽  
pp. PRI.S5180 ◽  
Author(s):  
A.J. Russo
Keyword(s):  
Superoxide Dismutase ◽  
Anxiety Disorder ◽  
Serum Concentration ◽  
Serum Levels ◽  
Age And Gender ◽  
Immunosorbent Assays ◽  
And Gender

The aim of this study was to assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with anxiety disorder. Serum from 16 individuals diagnosed with anxiety (no secondary depression) and 18 age and gender matched controls were tested for Cu/Zn SOD serum concentration using Enzyme Linked Immunosorbent Assays (ELISAs). Serum Cu/Zn SOD levels of anxiety individuals were significantly higher than age and gender matched controls. These results suggest an association between Cu/Zn SOD serum levels and Anxiety Disorder.

Increased Serum Cu/Zn SOD in Individuals with Bipolar Disorder

2010 ◽  
Vol 3 ◽  
pp. PRI.S5527
Author(s):  
A.J. Russo
Keyword(s):  
Bipolar Disorder ◽  
Superoxide Dismutase ◽  
Serum Concentration ◽  
Serum Levels ◽  
Age And Gender ◽  
And Gender

Aim To assess serum Cu/Zn SOD (Superoxide Dismutase) concentration in individuals with bipolar disorder. Subjects and methods Serum from 20 individuals diagnosed with bipolar disorder and 20 age and gender similar controls were tested for Cu/Zn SOD serum concentration using ELISAs. Results Serum Cu/Zn SOD levels of individuals with bipolar disorder were significantly higher than age and gender matched controls. Discussion These results suggest an association between Cu/Zn SOD serum levels and bipolar disorder.

scholarly journals Synthesis of some Heterocyclic compounds bearing Coumarin nucleus and their Anti-inflammatory activity

2016 ◽  
Vol 12 (5) ◽  
pp. 4442-4452 ◽  
Author(s):  
Nadia T. A. Dawoud1 ◽  
Nahed. F.Abdel-Ghaffar ◽  
Mona M Abdl-gali ◽  
Fekria M. A. Soliman ◽  
Heba M Zaki
Keyword(s):  
Heterocyclic Compounds ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Inflammatory Activity ◽  
Paw Edema ◽  
Edema Volume ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine ◽  
Pro Inflammatory Cytokines

Starting from 6-amino-4-methyl-2H-chromen-2-one 1, a series of some new heterocyclic compounds (2-14) incorporating coumarin moiety was synthesized and assessed for their anti-inflammatory activity using the carrageenan-induced hind paw edema method. The tested coumarin derivatives reduce the edema volume and serum levels of the pro inflammatory cytokines, IL-6 and TNF-α, and have effects on promoting production of anti-inflammatory cytokine, IL-10.

scholarly journals Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarction

2008 ◽  
Vol 116 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Christian Stumpf ◽  
Sebastian Petzi ◽  
Katrin Seybold ◽  
Gerald Wasmeier ◽  
Martin Arnold ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Cardiac Function ◽  
Inflammatory Cytokines ◽  
Inflammatory Cytokine ◽  
Serum Levels ◽  
Left Ventricular ◽  
Lv Function ◽  
Tnf Α ◽  
Anti Inflammatory ◽  
Anti Inflammatory Cytokine

LV (left ventricular) remodelling is the basic mechanism of HF (heart failure) following MI (myocardial infarction). Although there is evidence that pro-inflammatory cytokines [including TNF-α (tumour necrosis factor-α) and IL-6 (interleukin-6)] are involved in the remodelling process, only little is known about the role of anti-inflammatory cytokines, such as IL-10. As accumulating evidence has revealed that statins possess anti-inflammatory properties, the aim of the present study was to elucidate the effect of atorvastatin on the modulation of the anti-inflammatory cytokine IL-10 and its effect on LV function in rats with HF subsequent to MI. Rats with MI, induced by permanent LAD (left anterior descending) branch coronary artery ligation, were treated for 4 weeks with atorvastatin (10 mg·kg−1 of body weight·day−1 via oral gavage) starting on the first day after induction of MI. Cardiac function was assessed by echocardiography and cardiac catheterization 4 weeks after MI induction. Membrane-bound and soluble fractions of TNF-α, IL-6 and IL-10 protein, the TNF-α/IL-10 ratio, serum levels of MCP-1 (monocyte chemoattractant protein-1) as well as myocardial macrophage infiltration were analysed. Treatment with atorvastatin significantly improved post-MI LV function (fractional shortening, +120%; dP/dtmax, +147%; and LV end-diastolic pressure, −27%). Furthermore atorvastatin treatment markedly decreased the levels of TNF-α, IL-6 and MCP-1, reduced myocardial infiltration of macrophages and significantly increased myocardial and serum levels of the anti-inflammatory cytokine IL-10. Thus the balance between pro-inflammatory and anti-inflammatory cytokines was shifted in the anti-inflammatory direction, as shown by a significantly decreased TNF-α/IL-10 ratio. Atorvastatin ameliorated early LV remodelling and improved LV function in rats with HF subsequent to MI. Our study suggests that the modulation of the balance between pro- and anti-inflammatory cytokines towards the anti-inflammatory cytokine IL-10 is one salutary mechanism underlying how atorvastatin influences post-MI remodelling and thus improves LV function.

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