scholarly journals Astragalus polysaccharide attenuates overexercise-induce myocardial injury via activating AMPK signaling pathway to suppress inflammation and oxidative stress

2022 ◽  
Vol 94 (1) ◽  
Author(s):  
XINLING TUO ◽  
ZHIJIAN DENG ◽  
GUOCHAO HUANG ◽  
HUIPING GONG ◽  
HEZHI XIE
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Myocardial Injury ◽  
Ampk Signaling ◽  
Astragalus Polysaccharide ◽  
And Oxidative Stress

Adiponectin alleviates exacerbation of airway inflammation and oxidative stress in obesity-related asthma mice partly through AMPK signaling pathway

2019 ◽  
Vol 67 ◽  
pp. 396-407 ◽  
Author(s):  
Lili Zhu ◽  
Xiuzhen Chen ◽  
Lei Chong ◽  
Ludan Kong ◽  
Shunhang Wen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Airway Inflammation ◽  
Signaling Pathway ◽  
Ampk Signaling ◽  
And Oxidative Stress

scholarly journals Mechanism of miR-218-5p in autophagy, apoptosis and oxidative stress in rheumatoid arthritis synovial fibroblasts is mediated by KLF9 and JAK/STAT3 pathways

2021 ◽  
pp. jim-2020-001437
Author(s):  
Ming Chen ◽  
Minghui Li ◽  
Na Zhang ◽  
Wenwen Sun ◽  
Hui Wang ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Oxidative Stress ◽  
Signaling Pathway ◽  
Synovial Tissue ◽  
Synovial Fibroblasts ◽  
Reverse Transcription Pcr ◽  
Stat3 Signaling ◽  
Stat3 Signaling Pathway ◽  
Interfering Rna ◽  
And Oxidative Stress

This study was aimed to investigate the effects of miR-218-5p on the proliferation, apoptosis, autophagy, and oxidative stress of rheumatoid arthritis synovial fibroblasts (RASFs), and the related mechanisms. Quantitative reverse transcription–PCR showed that the expression of miR-218-5p in rheumatoid arthritis synovial tissue was significantly higher than that in healthy synovial tissue. Compared with healthy synovial fibroblasts, miR-218-5p expression was obviously upregulated in RASFs, while KLF9 protein expression was markedly downregulated. Mechanistically, miR-218-5p could directly bind to the 3′ untranslated region of KLF9 to inhibit the expression of KLF9. Additionally, transfection of miR-218-5p small interfering RNA (siRNA) inhibited the proliferation but promoted apoptosis and autophagy of RASFs. Simultaneously, miR-218-5p silencing reduced reactive oxygen species and malondialdehyde levels and increased superoxide dismutase and glutathione peroxidase activity to improve oxidative stress in RASFs. More importantly, the introduction of KLF9 siRNA reversed the effects of miR-218-5p siRNA transfection on RASF proliferation, apoptosis, autophagy, and oxidative stress. What is more, silencing miR-218-5p inhibited the activation of JAK2/STAT3 signaling pathway by targeting KLF9. Collectively, knockdown of miR-218-5p could regulate the proliferation, apoptosis, autophagy and oxidative stress of RASFs by increasing the expression of KLF9 and inhibiting the activation of the JAK2/STAT3 signaling pathway, which may provide a potential target for the mechanism research of RA.

The impact of polystyrene microplastics on cardiomyocytes pyroptosis through NLRP3 /Caspase‐1 signaling pathway and oxidative stress in Wistar rats

2021 ◽  
Author(s):  
Jialiu Wei ◽  
Xifeng Wang ◽  
Qian Liu ◽  
Na Zhou ◽  
Shuxiang Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Wistar Rats ◽  
Caspase 1 ◽  
The Impact ◽  
And Oxidative Stress

scholarly journals Sargassum serratifolium attenuates RANKL-induced osteoclast differentiation and oxidative stress through inhibition of NF-κB and activation of the Nrf2/HO-1 signaling pathway

2018 ◽  
Vol 12 (3) ◽  
pp. 257-265 ◽  
Author(s):  
Hong Jae Kim ◽  
Cheol Park ◽  
Gi-Young Kim ◽  
Eui Kyun Park ◽  
You-Jin Jeon ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Osteoclast Differentiation ◽  
Sargassum Serratifolium ◽  
And Oxidative Stress

scholarly journals Oleuropein alleviates gestational diabetes mellitus by activating AMPK signaling

2020 ◽  
Author(s):  
Zhiwei Zhang ◽  
Hui Zhao ◽  
Aixia Wang
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Body Weight ◽  
Blood Glucose ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Signaling Pathway ◽  
Hepatic Glycogen ◽  
Ampk Signaling ◽  
Tnf Α

Background: Gestational diabetes mellitus (GDM) has a high incidence rate among pregnant women. The objective of the study was to assess the effect of plant-derived oleuropein in attenuating inflammatory and oxidative stress of GDM. Methods: Oleuropein was administered to GDM mice at the doses of 5 or 10 mg/kg/day. Body weight, blood glucose, insulin and hepatic glycogen levels were recorded. To evaluate the effect of oleuropein in reducing oxidative stress, enzyme-linked immunosorbent assay (ELISA) was used to measure the hepatic oxidative stress markers. The inflammation levels of GDM mice were evaluated by measuring serum levels of IL-6 and TNF-α by ELISA, and mRNA levels of IL-1β, TNF-α and IL-6 by real-time PCR (RT-PCR). The AMP-activated protein kinase (AMPK) signaling pathway was assessed by Western blot. Gestational outcome was analyzed through comparing litter size and birth weight. Results: Oleuropein attenuated the elevated body weight of GDM mice, and efficiently reduced blood glucose, insulin and hepatic glycogen levels. Oxidative stress and inflammation were alleviated by oleuropein treatment. The AMPK signaling was activated by oleuropein in GDM mice. Gestational outcome was markedly improved by oleuropein treatment. Conclusions: Our study suggests that oleuropein is effective in alleviating symptoms of GDM and improving gestational outcome in the mouse model. This effect is achieved by attenuating oxidative stress and inflammation, which is mediated by the activation of the AMPK signaling pathway.

Protective Effects of Puerarin on Premature Ovarian Failure via Regulation of Wnt/β-catenin Signaling Pathway and Oxidative Stress

2020 ◽  
Author(s):  
Cheng Chen ◽  
Song Li ◽  
Cong Hu ◽  
Weiwei Cao ◽  
Qingfeng Fu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Premature Ovarian Failure ◽  
Ovarian Failure ◽  
Protective Effects ◽  
And Oxidative Stress

scholarly journals MsrA Suppresses Inflammatory Activation of Microglia and Oxidative Stress to Prevent Demyelination via Inhibition of the NOX2-MAPKs/NF-κB Signaling Pathway

2020 ◽  
Vol Volume 14 ◽  
pp. 1377-1389
Author(s):  
Hua Fan ◽  
Damiao Li ◽  
Xinlei Guan ◽  
Yanhui Yang ◽  
Junqiang Yan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
Inflammatory Activation ◽  
And Oxidative Stress

scholarly journals P-Hydroxyacetophenone Ameliorates Alcohol-Induced Steatosis and Oxidative Stress via the NF-κB Signaling Pathway in Zebrafish and Hepatocytes

2020 ◽  
Vol 10 ◽  
Author(s):  
Sha Huang ◽  
Chuying Zhou ◽  
Ting Zeng ◽  
Yujia Li ◽  
Yuqi Lai ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathway ◽  
And Oxidative Stress

Oleanolic acid derivative isolated from Gardenia jasminoides var. radicans alleviates LPS-induced acute kidney injury in mice by reducing oxidative stress and inflammatory responses via the TLR4/NF-κB/NLRP3 signaling pathway

2020 ◽  
Vol 44 (5) ◽  
pp. 2091-2101
Author(s):  
Mengnan Zeng ◽  
Yangang Cao ◽  
Ruiqi Xu ◽  
Yuanyuan Wu ◽  
Yangyang Wang ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Kidney Injury ◽  
Signaling Pathway ◽  
Acid Derivative ◽  
Oleanolic Acid ◽  
Inflammatory Responses ◽  
Kidney Injury ◽  
Gardenia Jasminoides ◽  
And Oxidative Stress ◽  
Oleanolic Acid Derivative

Acute kidney injury (AKI) is a frequent complication of sepsis with hallmarks including inflammation and oxidative stress.

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