scholarly journals Neurological diseases in Peru: a systematic analysis of the global burden disease study

2020 ◽  
Vol 78 (5) ◽  
pp. 282-289
Author(s):  
Carlos ALVA-DÍAZ ◽  
Andrely HUERTA-ROSARIO ◽  
Kevin PACHECO-BARRIOS ◽  
Roberto A. MOLINA ◽  
Alba NAVARRO-FLORES ◽  
...  
Keyword(s):  
Disease Burden ◽  
Neurological Diseases ◽  
Age Groups ◽  
Epidemiological Data ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Systematic Analysis ◽  
Life Years ◽  
Disease Study ◽  
The Impact

ABSTRACT Background: Disease burden indicators assess the impact of disease on a population. They integrate mortality and disability in a single indicator. This allows setting priorities for health services and focusing resources. Objective: To analyze the burden of neurological diseases in Peru from 1990-2015. Methods: A descriptive study that used the epidemiological data published by the Institute for Health Metrics and Evaluation of Global Burden of Diseases from 1990 to 2015. Disease burden was measured using disability-adjusted life years (DALY) and their corresponding 95% uncertainty intervals (UIs), which results from the addition of the years of life lost (YLL) and years lived with disability (YLD). Results: The burden of neurological diseases in Peru were 9.06 and 10.65%, in 1990 and 2015, respectively. In 2015, the main causes were migraine, cerebrovascular disease (CVD), neonatal encephalopathy (NE), and Alzheimer’s disease and other dementias (ADD). This last group and nervous system cancer (NSC) increased 157 and 183% of DALY compared to 1990, respectively. Young population (25 to 44 years old) and older (>85 years old) were the age groups with the highest DALY. The neurological diseases produced 11.06 and 10.02% of the national YLL (CVD as the leading cause) and YLD (migraine as the main cause), respectively. Conclusion: The burden of disease (BD) increased by 1.6% from 1990 to 2015. The main causes were migraine, CVD, and NE. ADD and NSC doubled the DALY in this period. These diseases represent a significant cause of disability attributable to the increase in the life expectancy of our population among other factors. Priority actions should be taken to prevent and treat these causes.

scholarly journals Burden of Eating Disorders in China, 1990-2019: An Updated Systematic Analysis of the Global Burden of Disease Study 2019

2021 ◽  
Vol 12 ◽  
Author(s):  
Zhitao Li ◽  
Lili Wang ◽  
Haixia Guan ◽  
Cheng Han ◽  
Peng Cui ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Burden Of Disease ◽  
National Level ◽  
Epidemiological Data ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Systematic Analysis ◽  
Disability Adjusted Life ◽  
Life Years ◽  
Disease Study

Background: Eating disorders, including anorexia nervosa (AN) and bulimia nervosa (BN), are complex mental disorders. A better understanding of the burden of eating disorders is essential for improving their management. Information about the burden of eating disorders at the national level in China remains unclear.Methods: This is a systematic analysis of the Global Burden of Disease Study (GBD) 2019. The sex- and age-specific prevalence, incidence, and disability-adjusted life years (DALYs) of eating disorders in China were estimated by systematically reviewing all available epidemiological data and inputting these data into a Bayesian meta-regression tool (DisMod-MR 2.0). Trends in the age-standardized prevalence, incidence, and DALYs due to AN and BN were assessed from 1990 to 2019.Results: The age-standardized incidence rate (ASIR), prevalence rate (ASPR), and DALY rate per 100,000 population were estimated to be 13.22 (95% UI, 9.35–18.23), 38.08 (95% UI: 26.37–55.73), and 8.38 (95% UI, 4.87–13.35) for AN and 130.05 (95% UI, 84.02–187.13), 75.21 (95% UI, 48.52–105.97), and 16.16 (95% UI, 9.23–25.40) for BN, respectively, in 2019. The prevalence, incidence, and DALY rate of AN peaked at 15–19 years old. The prevalence and DALY rate of BN peaked at 30–34 years old. Females had a higher burden of AN and a lower burden of BN than males. The ASIR, ASPR, and DALY significantly increased by 1.3% (95% CI: 1.3–1.4%), 1.6% (95% CI, 1.5–1.6%), and 1.6% (95% CI, 1.5–1.7%) for AN and 1.4% (95% CI: 1.4–1.4%), 2.0% (95% CI, 2.0–2.1%), and 2.0% (95% CI, 2.0–2.1%) for BN, respectively, from 1990 to 2019 in China. In addition, the increments in all the age-standardized measures of BN were higher in males than in females.Conclusions: The burden of eating disorders in China showed unexpected patterns that varied by sex and age, with increasing trends of AN and BN from 1990 to 2019. More attention should be given to improving the burden of BN in males in China.

scholarly journals A heavy burden on young minds: the global burden of mental and substance use disorders in children and youth

2014 ◽  
Vol 45 (7) ◽  
pp. 1551-1563 ◽  
Author(s):  
H. E. Erskine ◽  
T. E. Moffitt ◽  
W. E. Copeland ◽  
E. J. Costello ◽  
A. J. Ferrari ◽  
...  
Keyword(s):  
Substance Use ◽  
Infectious Diseases ◽  
Substance Use Disorders ◽  
Disease Burden ◽  
Children And Youth ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Middle Income ◽  
Life Years ◽  
Disease Study

BackgroundMental and substance use disorders are common and often persistent, with many emerging in early life. Compared to adult mental and substance use disorders, the global burden attributable to these disorders in children and youth has received relatively little attention.MethodData from the Global Burden of Disease Study 2010 was used to investigate the burden of mental and substance disorders in children and youth aged 0–24 years. Burden was estimated in terms of disability-adjusted life years (DALYs), derived from the sum of years lived with disability (YLDs) and years of life lost (YLLs).ResultsGlobally, mental and substance use disorders are the leading cause of disability in children and youth, accounting for a quarter of all YLDs (54.2 million). In terms of DALYs, they ranked 6th with 55.5 million DALYs (5.7%) and rose to 5th when mortality burden of suicide was reattributed. While mental and substance use disorders were the leading cause of DALYs in high-income countries (HICs), they ranked 7th in low- and middle-income countries (LMICs) due to mortality attributable to infectious diseases.ConclusionsMental and substance use disorders are significant contributors to disease burden in children and youth across the globe. As reproductive health and the management of infectious diseases improves in LMICs, the proportion of disease burden in children and youth attributable to mental and substance use disorders will increase, necessitating a realignment of health services in these countries.

scholarly journals National burden of cancer in Italy, 1990–2017: a systematic analysis for the global burden of disease study 2017

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Cristina Bosetti ◽  
Eugenio Traini ◽  
Tahiya Alam ◽  
Christine A. Allen ◽  
Giulia Carreras ◽  
...  
Keyword(s):  
Burden Of Disease ◽  
Absolute Number ◽  
Global Burden Of Disease ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Mortality Trends ◽  
Systematic Analysis ◽  
Life Years ◽  
Using Data ◽  
Disease Study

AbstractWe monitored the burden of cancer in Italy and its trends over the last three decades, providing estimates of cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years (DALYs), for cancer overall and 30 cancer sites using data from the Global Burden of Disease study 2017. An overview of mortality trends between 1990 and 2017 was also provided. In 2017, there were 254,336 new cancer cases in men and 214,994 in women, corresponding to an age-standardized incidence rate (ASIR) of 438 and 330/100,000, respectively. Between 1990 and 2017, incident cancer cases, and, to a lesser extent, ASIRs significantly increased overall and for almost all cancer sites, but ASIRs significantly declined for lung and other tobacco-related neoplasms. In 2017, there were 101,659 cancer deaths in men (age-standardized death rate, ASDR, 158.5/100,000) and 78,918 in women (ASDR 93.9/100,000). Cancer deaths significantly increased between 1990 and 2017 (+ 18%), but ASDR significantly decreased (− 28%). Deaths significantly increased for many cancer sites, but decreased for stomach, esophageal, laryngeal, Hodgkin lymphoma, and testicular cancer. ASDRs significantly decreased for most neoplasms, with the main exceptions of cancer of the pancreas and uterus, and multiple myeloma. In 2017, cancer caused 3,204,000 DALYs. Between 1990 and 2017, DALYs and age-standardized DALY rates significantly declined (-3.4% and -33%, respectively). Age-standardized mortality rates in Italy showed favorable patterns over the last few decades. However, the absolute number of cancer cases and, to a lower extent, of cancer deaths increased likely due to the progressive ageing of the population, this calling for a continuous effort in cancer prevention, early diagnosis, and treatment.

scholarly journals 1262Burden of disease and injury in Australia

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
Michelle Gourley ◽  
Keyword(s):  
Burden Of Disease ◽  
Disease Burden ◽  
Age Groups ◽  
Health Impact ◽  
Chronic Obstructive ◽  
Healthy Life ◽  
Life Years ◽  
Total Burden ◽  
Disease Study ◽  
The Impact

Abstract Background Burden of disease describes the impact of living with and dying prematurely from different diseases or injuries. The Australian Burden of Disease Study (ABDS) 2018 estimated the health impact of 219 diseases and injuries on the Australian population. Methods Burden of disease measures years of healthy life lost from living with (non-fatal) and dying prematurely from (fatal) disease and injury. Fatal and non-fatal burden combined provides the total burden, measured in disability-adjusted life years (DALY). One DALY equals 1 year of healthy life lost. Disease burden was estimated for the years 2018, 2015, 2011 and 2003 for Australia. Results In 2018, 5.0 million years of healthy life were lost from disease and injury. Living with illness or injury caused more total disease burden than dying prematurely (52% vs 48%). Between 2003 and 2018, total burden decreased by 13%, driven by less premature deaths. Disease groups with the biggest absolute reductions in burden (DALY rate) were cardiovascular diseases and cancers. The five leading causes of burden were coronary heart disease, back pain, dementia, chronic obstructive pulmonary disease and lung cancer. Males experienced more burden than females for most age groups. Conclusions Overall burden of disease declined between 2003 and 2018, due to a large reduction in burden from dying prematurely. Living with the impact of chronic diseases contributed substantial burden in Australia in 2018. Key messages Living with illness or injury accounts for most of the disease burden in Australia. There have been improvements in fatal burden since 2003.

scholarly journals Global, regional, and national burden of suicide mortality 1990 to 2016: systematic analysis for the Global Burden of Disease Study 2016

BMJ ◽  
2019 ◽  
pp. l94 ◽  
Author(s):  
Mohsen Naghavi
Keyword(s):  
Burden Of Disease ◽  
Age Groups ◽  
Mortality Rates ◽  
Global Burden Of Disease ◽  
Suicide Mortality ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Uncertainty Interval ◽  
Systematic Analysis ◽  
Disease Study

Abstract Objectives To use the estimates from the Global Burden of Disease Study 2016 to describe patterns of suicide mortality globally, regionally, and for 195 countries and territories by age, sex, and Socio-demographic index, and to describe temporal trends between 1990 and 2016. Design Systematic analysis. Main outcome measures Crude and age standardised rates from suicide mortality and years of life lost were compared across regions and countries, and by age, sex, and Socio-demographic index (a composite measure of fertility, income, and education). Results The total number of deaths from suicide increased by 6.7% (95% uncertainty interval 0.4% to 15.6%) globally over the 27 year study period to 817 000 (762 000 to 884 000) deaths in 2016. However, the age standardised mortality rate for suicide decreased by 32.7% (27.2% to 36.6%) worldwide between 1990 and 2016, similar to the decline in the global age standardised mortality rate of 30.6%. Suicide was the leading cause of age standardised years of life lost in the Global Burden of Disease region of high income Asia Pacific and was among the top 10 leading causes in eastern Europe, central Europe, western Europe, central Asia, Australasia, southern Latin America, and high income North America. Rates for men were higher than for women across regions, countries, and age groups, except for the 15 to 19 age group. There was variation in the female to male ratio, with higher ratios at lower levels of Socio-demographic index. Women experienced greater decreases in mortality rates (49.0%, 95% uncertainty interval 42.6% to 54.6%) than men (23.8%, 15.6% to 32.7%). Conclusions Age standardised mortality rates for suicide have greatly reduced since 1990, but suicide remains an important contributor to mortality worldwide. Suicide mortality was variable across locations, between sexes, and between age groups. Suicide prevention strategies can be targeted towards vulnerable populations if they are informed by variations in mortality rates.

The global burden of 29 cancer groups from 2010 to 2019: A systematic analysis for the Global Burden of Disease study 2019.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 10577-10577
Author(s):  
Jonathan M Kocarnik ◽  
Kelly Compton ◽  
Franny Dean ◽  
Weijia Fu ◽  
Brian Gaw ◽  
...  
Keyword(s):  
Cancer Control ◽  
Rate Of Change ◽  
Estimation Methods ◽  
Global Burden ◽  
Years Of Life Lost ◽  
Systematic Analysis ◽  
Cancer Burden ◽  
Life Years ◽  
Global Burden Of Diseases ◽  
Disease Study

10577 Background: Cancer is a major cause of morbidity and mortality worldwide, and global efforts to reduce health loss from cancer require systematic estimates that can measure progress from national to global levels. As part of the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019), we examined global cancer burden in order to highlight areas where cancer burden is inequitably distributed and to inform cancer control efforts around the world. Methods: Using estimation methods from GBD 2019, we analyzed the incidence, mortality, years lived with disability, years of life lost (YLLs), and disability-adjusted life years (DALYs) for 29 cancer groups and 204 countries and territories from 2010 to 2019. Cancer burden was compared to health burden from other categories of diseases and injuries in the GBD. Results were assessed globally and by socio-demographic index (SDI), a summary measure of income per capita, average educational attainment, and total fertility rate. Point estimates and 95% Uncertainty Intervals (UIs) are reported. Results: There were 23.6 million (95% UI 22.2-24.9 million) incident cancer cases globally in 2019 (17.2 [15.9-18.5] million excluding non-melanoma skin cancer), and 10.0 (9.36-10.6) million cancer deaths. There were 250 (235-264) million DALYs globally due to cancer, 97% of which came from years of life lost. The leading five cancers by DALYs in 2019 were: tracheal, bronchus, and lung cancer (45.9 [42.3-49.3] million); colon and rectum cancer (24.3 [22.6-25.7] million); stomach cancer (22.2 [20.3-24.1] million); breast cancer (20.6 [19.0-22.2] million; and liver cancer (12.5 [11.4-13.7] million). Compared to other diseases and injuries in the GBD, cancer was responsible for the second-highest number of deaths, YLLs, and DALYs globally in 2019. These rankings of cancer burden differed by SDI quintile: cancer was the leading cause of absolute DALYs in high SDI countries but was ranked 10th in low SDI countries. From 2010-2019, the number of global cancer cases increased by 26.3% (20.3-32.3%), deaths by 20.9% (14.2-27.6%), and DALYs by 16.0% (9.29-22.8%). The largest annualized rate of change in absolute cases and deaths over this period occurred in the low and low-middle SDI quintiles. Conclusions: Cancer cases and deaths are growing globally, with the largest relative growth over the last decade occurring in low to middle SDI countries. Improvements in cancer prevention efforts and ensuring access to timely diagnosis and care will be necessary to make equitable progress in reducing the global burden of cancer.

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