Evaluation of nicotine patch in pain control of patients undergoing laparoscopic cholecystectomy

ABSTRACT Objective: to analyze the effects of nicotine patch on pain control, occurrence of nausea and its hemodynamic repercussions in laparoscopic cholecystectomy procedures. Methods: we conducted an analytical, prospective, randomized, triple-blinded, clinical study between January and July 2017. The sample consisted of 17 patients who underwent laparoscopic cholecystectomy for the treatment of cholelithiasis. Nine patients used nicotine patch, and eight, placebo patch. The studied variables were pain, nausea, patient satisfaction, blood pressure, heart rate, oximetry and morphine rescue. Results: taking into account the pain and nausea parameters, there was no statistically significant difference between the groups (p>0.05). Also, the evaluation of rescue medication, both opioids and prokinetics, did not show any significant statistical difference between the groups. Among the hemodynamic parameters, there was only one statistically significant difference in the analysis of oxygen saturation and systolic blood pressure (SBP) six hours after surgery: the mean oxygen saturation was higher in the Test group (97.89 x 95.88) and the mean SBP was higher in the Control group (123.89 x 110.0). Conclusion: although pain levels were lower for nicotine within 24 hours, the action of nicotine and the need for rescue opioids in pain control were not statistically significant between the groups and at the time intervals studied. There was no clinical repercussion in the hemodynamic parameters.

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Assessment of the Tissue Response to Modification of the Surface of Dental Implants with Carboxyethylphosphonic Acid and Basic Fibroblastic Growth Factor Immobilization (Fgf-2): An Experimental Study on Minipigs

Biology ◽

10.3390/biology10050358 ◽

2021 ◽

Vol 10 (5) ◽

pp. 358

Author(s):

Javier Aragoneses ◽

Ana Suárez ◽

Nansi López-Valverde ◽

Francisco Martínez-Martínez ◽

Juan Manuel Aragoneses

Keyword(s):

Surface Treatment ◽

Test Group ◽

Mean Value ◽

Control Group ◽

P Value ◽

Implant Surface ◽

Bone Contact ◽

Bone Implant ◽

Significant Difference ◽

The Mean

The aim of this study was to evaluate the effect of implant surface treatment with carboxyethylphosphonic acid and fibroblast growth factor 2 on the bone–implant interface during the osseointegration period in vivo using an animal model. The present research was carried out in six minipigs, in whose left tibia implants were inserted as follows: eight implants with a standard surface treatment, for the control group, and eight implants with a surface treatment of carboxyethylphosphonic acid and immobilization of FGF-2, for the test group. At 4 weeks after the insertion of the implants, the animals were sacrificed for the histomorphometric analysis of the samples. The means of the results for the implant–bone contact variable (BIC) were 46.39 ± 17.49% for the test group and 34.00 ± 9.92% for the control group; the difference was not statistically significant. For the corrected implant–bone contact variable (BICc), the mean value of the test group was 60.48 ± 18.11%, and that for the control group, 43.08 ± 10.77%; the difference was statistically significant (p-value = 0.035). The new bone formation (BV/TV) showed average results of 27.28 ± 3.88% for the test group and 26.63 ± 7.90% for the control group, meaning that the differences were not statistically significant (p-value = 0.839). Regarding the bone density at the interthread level (BAI/TA), the mean value of the test group was 32.27 ± 6.70%, and that of the control group was 32.91 ± 7.76%, with a p-value of 0.863, while for the peri-implant density (BAP/TA), the mean value of the test group was 44.96 ± 7.55%, and that for the control group was 44.80 ± 8.68%, without a significant difference between the groups. The current research only found a significant difference for the bone–implant contact at the cortical level; therefore, it could be considered that FGF-2 acts on the mineralization of bone tissue. The application of carboxyethylphosphonic acid on the surface of implants can be considered a promising alternative as a biomimetic coating for the immobilization of FGF-2. Despite no differences in the new bone formation around the implants or in the interthread or peri-implant bone density being detected, the biofunctionalization of the implant surface with FGF-2 accelerates the mineralization of the bone–implant interface at the cortical level, thereby reducing the osseointegration period.

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Pentachlorophenol Residues in Porcine Tissue Following Preslaughter Exposure to Treated Wood Shavings

Journal of Food Protection ◽

10.4315/0362-028x-54.6.448 ◽

1991 ◽

Vol 54 (6) ◽

pp. 448-450 ◽

Cited By ~ 5

Author(s):

KELLY M. BUTLER ◽

RICHARD FRANK

Keyword(s):

Degrees Of Freedom ◽

Treated Wood ◽

Test Group ◽

Liver Fat ◽

Control Group ◽

Porcine Tissue ◽

Wood Shavings ◽

Significant Difference ◽

The Mean ◽

Level Of Significance

Sixty market hogs originating from one producer and finished in a concrete and steel facility were divided into two groups of 30 and housed for approximately 60 h on either straw (control group) or pentachlorophenol (PCP) treated wood shavings (test group). Feed, straw, and shavings were analyzed for PCP residues. Both feed and straw yielded nondetectable levels of PCP residues, while shavings ranged from 0.03 to 12.0 ppm. The hogs were shipped to slaughter without bedding, and liver, fat and muscle (muscle from the test group only) samples were collected postmortem. The mean level of PCP residue in control (straw) hog livers was 0.037 ppm, while that of livers of hogs bedded with contaminated shavings was 0.342 ppm, a highly significant difference. The t-value using Welch's approximation equalled 9.77 using 28.5 degrees of freedom, indicating the mean PCP residue level was higher for the treated than the control group at a 0.01% level of significance.

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Investigation of the effect of the virtual reality application on experimental pain severity in healthy

Revista da Associação Médica Brasileira ◽

10.1590/1806-9282.65.3.446 ◽

2019 ◽

Vol 65 (3) ◽

pp. 446-451

Author(s):

Dilek Karaman ◽

Funda Erol ◽

Dilek Yılmaz ◽

Yurdanur Dikmen

Keyword(s):

Blood Pressure ◽

Virtual Reality ◽

Control Group ◽

Control Groups ◽

Adult Type ◽

Significant Difference ◽

The Mean ◽

And Control ◽

Experimental Group ◽

Virtual Reality Application

SUMMARY OBJECTIVE: This study aimed to investigate the effect of virtual reality application on experimental ischemic pain created with a blood pressure instrument in healthy volunteers. METHODS: The research sample consisted of 172 volunteer adult students who conformed to the inclusion criteria. These individuals were assigned into an experimental (n=86) and a control group (n=86) by a simple randomization method. All individuals in the experimental and control groups wereexperimentally subjected to pain for two minutes by applying 260 mmHg of pressure 3-4 cm above the antecubital region of the left arm with an aneroid adult-type blood pressure instrument. During the procedure, the volunteers in the experimental group watched virtual reality images, while those in the control group received no intervention. Immediately after the procedure, the pain levels of the individuals in both groups were assessed with a Visual Analog Scale (VAS). RESULTS: We found that the mean pain score of the individuals in the experimental group was 2.62±1.82, and that of individuals in the control group was 5.75±1.65. Results of the statistical analysis showed a statistically significant difference between the mean pain scores of the individuals in the experimental and control groups (p<0.001). CONCLUSION: This study found that the use of virtual reality was effective in reducing the level of pain in healthy individuals. This method used a smartphone with widespread availability and ease of transportation, which can be used by health professionals as a non-pharmacological method in the management of pain.

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INVESTIGATING THE EFFECT OF REFLEXOLOGY IN INTENSITY OF PAIN AND ANXIETY AMONG PATIENTS SUFFERING FROM METASTATIC CANCER IN ADULTS’ HEMATOLOGY WARD

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i6.25212 ◽

2018 ◽

Vol 11 (6) ◽

pp. 401 ◽

Cited By ~ 5

Author(s):

Simin Jahani ◽

Fatemeh Salari ◽

Nasrin Elahi ◽

Bahman Cheraghian

Keyword(s):

Cancer Patients ◽

Metastatic Cancer ◽

Test Group ◽

Control Group ◽

Anxiety Management ◽

Patients With Cancer ◽

Significant Difference ◽

Before And After ◽

The Mean ◽

And Control

Objective: Findings suggest dissatisfaction of half of the cancer patients regarding pain and anxiety management. This study aimed to determine the effect of reflexology on the intensity of pain and anxiety among patients with metastatic cancer hospitalized inadulthematology ward. Methods: In this study, the samples were selected from adult hematology ward in Baghaei 2 hospital in Ahwaz, Iran, according to the inclusion criteria. They were then assigned into treatment and control groups. In the treatment group, reflexology protocol was performed following manual reflexology method by Fr Josef Eugster based on Ingham method on the patient’s bed. In the control group, sole touching was used as the placebo. Reflexology was performed for three days, 30 min per day. Spielberger questionnaire were provided to the samples and completed in the first and third days, and Spielberger questionnaire was provided to the samples and completed. The data obtained from this study were then analyzed by SPSS 20.Results: The two groups did not show a significant difference in terms of demographic characteristics (p>0.05). Based on the obtained results, it was found that in the test group, there was a significant difference between the mean intensity of pain before and after the treatment across all 3 days as well as the mean anxiety of the 1st and 3rd days (p<0.05). However, in the control group, there was no significant difference in terms of mean pain intensity before and after the treatment across 3 days (p>0.05). No significant difference was observed between the mean anxiety of the 1st and 3rd days either (p>0.05).Conclusion: Considering the findings of this research, it can be concluded that reflexology has a positive effect on mitigating the intensity of pain and anxiety in metastatic cancer patients. Therefore, it is recommended that nurses employed in cancer centers benefit from the findings of this research to further help patients with cancer. It is also suggested that further research be conducted on the effect of reflexology on the pain and anxiety of other patients.

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Comparing the effects of cold compress and Xyla-p cream on hemodynamic changes in hemodialysis patients during venipuncture

Journal of Complementary and Integrative Medicine ◽

10.1515/jcim-2019-0154 ◽

2019 ◽

Vol 17 (2) ◽

Author(s):

Ziba Ghoreyshi ◽

Monireh Amerian ◽

Farzaneh Amanpour ◽

Reza Mohammadpourhodki ◽

Hossein Ebrahimi

Keyword(s):

Blood Pressure ◽

Physiological State ◽

Vital Signs ◽

Hemodialysis Patients ◽

Control Group ◽

Intermittent Hemodialysis ◽

Significant Difference ◽

Before And After ◽

The Mean ◽

The Difference

AbstractBackgroundThe vital signs reflect the physiological state of patients in various clinical conditions. The purpose of this study was to compare the effects of cold compress and Xyla-P cream on hemodynamical changes during venipuncture in hemodialysis patients.Methods and MaterialIn this clinical trial study, 50 patients under hemodialysis were selected by simple random sampling. The patients were then randomly assigned to either Xyla-P cream, cold compress or placebo groups. The vital signs (blood pressure and pulse) were measured upon two intermittent hemodialysis sessions before and after venipuncture. Data were analyzed using repeated measures analysis of variance.ResultsThe mean alternation in systolic blood pressure was significantly different comparing the placebo and cold compress groups before and after intervention (p<0.001). However, the difference was not significant between the Xyla-P cream group and either placebo (p=0.402) or ice compress (p=0.698) groups. The difference of the mean diastolic blood pressure was significant comparing the placebo group with either the Xyla-P cream group (p=0.003) or cold compress group (p<0.001) before and after intervention. In addition, there was a significant difference in the mean number of heartbeats comparing the control group with either the Xyla-P cream group (p<0.001) or cold compress group (p<0.001) before and after the intervention.ConclusionsConsidering the beneficial effects of ice compress and the Xyla-P cream on reduction of cardiovascular parameters, it is recommended to use these methods in hemodialysis patients during venipuncture.

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Analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain: A randomized clinical trial

10.21203/rs.2.18913/v1 ◽

2019 ◽

Author(s):

Seyyed Hamid Pakzad Moghadam ◽

Masoud Pourparizi ◽

Reza Goujani ◽

Tayyebeh Mirzaei Khalilabadi ◽

Ali Ravari ◽

...

Keyword(s):

Blood Pressure ◽

Clinical Trial ◽

Intravenous Administration ◽

Normal Saline ◽

Analgesic Effect ◽

Pain Control ◽

Opioid Analgesic ◽

Saline Control ◽

Control Group ◽

Significant Difference

Abstract Background Pain control after every surgery, especially cesarean is highly important, and physicians are striving to discover pain control methods using the least amount of opioid and Paracetamol is a non-opioid analgesic with few complications. The present study was aimed to investigate the analgesic effect of preoperative intravenous administration of paracetamol on post-cesarean pain.Methods This randomized double-blind clinical trial was conducted on 240 pregnant women under spinal anesthesia who were candidate for elective cesarean. The patients’ weight, height, age and body mass index (BMI) were recorded, and patients were randomly divided into two equal groups (n=120). In the first group, 10 mg/kg paracetamol in 100cc normal saline (paracetamol group) and in the second group 100cc normal saline (control group) administered 15 minutes before surgery intravenously. Blood pressure, pulse rate, chills and nausea were recorded during and 1 hour after surgery, and pain visual analogue scale (VAS) and need for additional analgesic were recorded 1, 2, 4, 6, 12 and 24 hours after surgery.Results No significant difference was found between the two groups in frequency of chills and nausea (p>0.05). Mean pethidine consumed was lower in paracetamol group than control group but not significantly. Systolic blood pressure of both groups during surgery and one hour after surgery did not show a significant difference, but diastolic blood pressure was significantly lower in paracetamol group 15 minutes (p=0.046) and 60 minutes after surgery (p=0.042) than control group. The mean scores of pain were significantly lower in paracetamol group than control group 6 hours (0.008) and 24 hours (p=0.038) after surgery.Conclusions Within the limitations of the current study, preoperative intravenous administration of paracetamol significantly reduced post-cesarean pain within 24 hours.

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A Clinical Trial on the Effects of Different Regimens of Phenylephrine on Maternal Hemodynamic After Spinal Anesthesia for Cesarean Section

Anesthesiology and Pain Medicine ◽

10.5812/aapm.58048 ◽

2020 ◽

Vol 10 (4) ◽

Author(s):

Mahshid Nikooseresht ◽

Mohammad Ali Seifrabiei ◽

Pouran Hajian ◽

Shadab Khamooshi

Keyword(s):

Blood Pressure ◽

Clinical Trial ◽

Cesarean Section ◽

Spinal Anesthesia ◽

Cesarean Delivery ◽

Saline Control ◽

Control Group ◽

Significant Difference ◽

The Mean ◽

Phenylephrine Infusion

Background: Phenylephrine is used to prevent and treat hypotension during spinal anesthesia for cesarean delivery. Objectives: The present study aims to investigate the effects of different regimens of phenylephrine on blood pressure of candidates for the cesarean section. Methods: In this double-blind, randomized clinical trial, a total of 120 candidates of elective cesarean delivery under spinal anesthesia was randomly categorized into three groups. Groups 1, 2, and 3 received bolus and prophylactic saline (control group), prophylactic bolus phenylephrine (100 µg), and prophylactic phenylephrine infusion (50 µg/min), respectively. The incidence of hypotension, maternal hemodynamics, hypertension, rescue phenylephrine dose, nausea, and vomit were compared between the groups. Results: In all the three groups, the incidence of nausea and vomit, bradycardia, hypertension, and neonatal Apgar score were not statistically different (P > 0.05). However, the adjuvant phenylephrine dose requirement was remarkably different. Moreover, the mean systolic blood pressure differed significantly in the second and 7th minutes after the spinal block (P < 0.05). 35% in the first group, 15% in the second group, and 2.5% in the third group had hypotension (P = 0.001). Apart from the first measurement after spinal anesthesia, the mean heart rate showed no significant difference between the groups. Conclusions: The use of prophylactic phenylephrine infusion is recommended to control the optimal blood pressure in parturients undergoing cesarean section after spinal anesthesia.

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Hypertension Exercise Videos Reduce Blood Pressure of Hypertension Patients

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2021.6496 ◽

2021 ◽

Vol 9 (T4) ◽

pp. 296-299

Author(s):

Harmilah Harmilah ◽

Bondan Palestin ◽

Ana Ratnawati ◽

Agus Sarwo Prayogi ◽

Catur Budi Susilo

Keyword(s):

Blood Pressure ◽

Systolic Blood Pressure ◽

Sampling Technique ◽

The Elderly ◽

Reduce Blood Pressure ◽

Control Group ◽

P Value ◽

Significant Difference ◽

Quasi Experimental ◽

The Mean

BACKGROUND: Hypertension is a symptom of a cardiovascular degenerative disease that is mostly experienced by the elderly and cause is not certain. However, the reduction of blood pressure with drugs and non drugs can reduce damage to target organs and prevent cardiovascular diseases. AIM: Identified the effect of hypertension exercise videos of lowering blood pressure. METHODS: The type of research that has been used is quasi experimental with Pretest and Posttest design with control group. The sampling technique used was random sampling, the number of samples was 30 samples which were the treatment group and 30 samples were control the control group. The data analysis used was the T test and Wilcoxon and Mann Whitney test. RESULTS: The mean reduction in systolic blood pressure in respondents who did exercise was 13.67 mm Hg with a standard deviation of 10.57, while the mean in systolic blood pressure in respondents who did not exercise was 0.50 mmHg a pressure were 40.95 in the group of respondents who did hypertension exercise with p value =0.000.This mean that there is significant difference, in the mean reduction in systolic and diastolic blood pressure between respondents those who do exercise. CONCLUSION. Hypertension exercise video reduce blood pressure of hypertension patients.

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The Effect of the Behavioral Systems Model on the Concern of Mothers of Children Admitted to the Surgical Ward

Medical - Surgical Nursing Journal ◽

10.5812/msnj.116676 ◽

2021 ◽

Vol 10 (1) ◽

Author(s):

Mahya Ahmadii ◽

Fatemeh Jafari ◽

Fatemeh Ahmadinezhad ◽

Fatemeh Khabazzadeh ◽

Malihe Kabusi ◽

...

Keyword(s):

Test Group ◽

T Test ◽

Control Group ◽

Systems Model ◽

Surgical Ward ◽

Significant Difference ◽

Before And After ◽

The Mean ◽

Maternal Concern ◽

And Control

Background: The crisis caused by the child's illness and hospitalization affects all family members. Fear, worry, and anxiety are common issues of hospitalized children’s mothers. Betty Newman's system model plays a vital role in adapting to stress detection and control. Objectives: This study aimed to examine the effect of the behavioral systems model on the concerns of mothers of children admitted to the surgical ward. Methods: This quasi-experimental study was conducted on 60 mothers of children admitted to the surgical ward of the Mousavi Hospital, Gorgan, Iran, in 2020. The participants were selected using convenience sampling and then divided into test and control groups using non-probability sampling. According to Neuman's systems model, participants in the test group received nursing care in 3 - 4 sessions (each lasting 30 - 45 minutes). Participants in the control group received only routine ward care. Data were collected using the Parental Concern Scale and analyzed with IBM SPSS Statistics 21 software using statistical tests (analysis of covariance, unpaired samples t-test, and paired sample test). Results: The mean score of maternal concerns before the intervention was 42.6 ± 3.06 in the control group and 43.21 ± 2.27 in the test group. The results of the independent samples t-test did not show any significant difference between the groups in terms of maternal concerns (P = 0.11). The mean post-intervention maternal concern score was 37.6 ± 2.71 and 41.716 ± 2.55 in the test and control groups, showing a significant difference between the groups as indicated by the t-test results (P < 0.01). However, the paired t-test outcomes showed no difference in the mean maternal concern score in the control group before and after the intervention (P = 0.92). In contrast, there was a significant difference in the mean maternal concern score in the test group before and after the intervention (P < 0.01). Conclusions: Given the effectiveness of Betty Neuman’s systems model, it can be used as a low-cost, effective care method to reduce maternal stress as the model was developed for understanding clients’ and caregivers’ needs and reducing their stress.

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Evaluation of Levels of Some Inflammatory Cytokines in Preeclamptic Women in Owerri

Journal of Pharmaceutical Research International ◽

10.9734/jpri/2021/v33i42a32384 ◽

2021 ◽

pp. 53-65

Author(s):

Obioma Raluchukwu Emeka-Obi ◽

Nancy C. Ibeh ◽

Emmanuel Ifeanyi Obeagu ◽

Hope M. Okorie

Keyword(s):

Blood Pressure ◽

Pregnant Women ◽

Inflammatory Cytokines ◽

Demographic Data ◽

Test Group ◽

Control Group ◽

Mortality And Morbidity ◽

The Mean ◽

Anti Inflammatory ◽

Pro Inflammatory Cytokines

Preeclampsia is a serious and life-threatening pregnancy complication. In this study, the levels of inflammatory cytokines were measured in preeclamptic women in Owerri, Imo State. A total of 120 pregnant women aged 18-45 years at 20-40 weeks of pregnancy were recruited; 60 were preeclamptic women (test group) while 60 were normotensive pregnant women (control group). Preeclampsia was determined by the presence of ≥2+ protein in the urine using combi 2 dipstick for urinalysis and sphygmomanometer blood pressure reading of ≥ 140/90 mmHg. From the demographic data obtained in the studied subject through questionnaire, it showed that nulliparity and family history of high blood pressure were the most dominant risk factor of preeclampsia. The mean of the pro-inflammatory cytokines (IL-6 and TNF-α) in the test group were 4.33±1.42 pg/ml and 8.23±2.73 pg/ml while that of the control group were 3.38±1.22 pg/ml and 6.89±1.88 pg/ml. There was a significant increase in the pro-inflammatory cytokines of the preeclamptic women when compared to the control group. The mean of the anti-inflammatory cytokines (IL-10 & IL-4) of the group were 78.88±14.28 pg/ml and 27.92±7.22pg/ml while the control group was 91.39± 18.46 pg/ml and 31.25±6.90 pg/ml. There was a significant decrease in the result obtained from the test group when compared to the control group. The levels of the pro-inflammatory cytokines were higher than the levels of the anti-inflammatory cytokines of the test group when compared with the control group. Hence there is need to manage the disorder with an anti inflammatory drugs in order to enhance obstetric care, thereby reducing maternal mortality and morbidity that may occur from haemostatic abnormalities.

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