scholarly journals Extranodal lymphoma in a bush dog (Speothos venaticus) - case report

2020 ◽  
Vol 72 (3) ◽  
pp. 754-760
Author(s):  
T.F. Carvalho ◽  
Â.T. Pessanha ◽  
F. Pierezan ◽  
H.P. Tinoco ◽  
A.R. Hoffmann ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Adrenal Glands ◽  
Cell Tumor ◽  
Cell Surface Markers ◽  
Round Cell ◽  
Distinct Cell ◽  
Bush Dog ◽  
Speothos Venaticus ◽  
Round Cell Tumors ◽  
Pleomorphic Cells

ABSTRACT A captive 7-year-old male bush dog (Speothos venaticus) was diagnosed with lymphoma affecting the kidneys, adrenal glands, liver, and spleen. The animal developed renal failure and was euthanized due to poor prognosis. Grossly, both kidneys were enlarged with multiple nodules. Histologically, the neoplasm was an infiltrative and poorly demarcated round cell tumor. Two morphologically distinct cell populations were observed, smaller cells with a lymphocytic morphology, and another population of larger and pleomorphic cells. Most of the smaller cell population, approximately 40% of the population within the neoplasm, were CD3 positive. Neoplastic cells were CD45, CD11d, and granzime B positive, and negative for CD20, CD79a, PAX5, CD163, and myeloperoxidase. This is the first reported case of lymphoma in a bush dog. This report demonstrated the suitability of several cell surface markers for differential diagnosis of round cell tumors in this species.

scholarly journals Cytology of Canine Cutaneous Round Cell Tumors

1979 ◽  
Vol 16 (6) ◽  
pp. 673-679 ◽  
Author(s):  
J. R. Duncan ◽  
K. W. Prasse
Keyword(s):  
Mast Cell ◽  
Final Diagnosis ◽  
Cell Tumor ◽  
Histologic Examination ◽  
Round Cell ◽  
Mast Cell Tumors ◽  
Mast Cell Tumor ◽  
Round Cell Tumors

Sixty-four canine cutaneous round cell tumors were divided into 25 mast cell tumors, 15 histiocytomas, nine cutaneous lymphosarcomas and 15 transmissible venereal tumors. The final diagnosis was made from cytologic, clinical and histologic findings. Cytologic features were significantly distinctive in mast cell tumor, transmissible venereal tumor, and most cases of histiocytoma and lymphosarcoma to allow a diagnostic opinion. This opinion was supported by subsequent histologic examination. In some instances cytology was considered essential in rendering a diagnostic opinion even though histology was available.

High-Dose Chemotherapy in Poor-Prognosis Adult Small Round-Cell Tumors: Clinical and Molecular Results From a Prospective Study

2002 ◽  
Vol 20 (8) ◽  
pp. 2181-2188 ◽  
Author(s):  
Alexia Bertuzzi ◽  
Luca Castagna ◽  
Andrea Nozza ◽  
Vittorio Quagliuolo ◽  
Licia Siracusano ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Local Treatment ◽  
Prognostic Significance ◽  
High Dose Chemotherapy ◽  
High Dose ◽  
Round Cell ◽  
Fusion Transcripts ◽  
Small Round Cell ◽  
Round Cell Tumors

PURPOSE: The prognosis of metastatic/high-risk localized small round-cell tumors (SRCTs) treated conventionally is dismal. In this phase II study, we explored a high-dose chemotherapy (HD-CT) approach and analyzed the clinical significance of fusion transcripts detection. PATIENTS AND METHODS: From June 1997 to November 1999, 28 SRCT patients (median age, 26 years; 14 peripheral primitive neuroectodermal tumors [pPNETs], seven rhabdomyosarcomas [RMSs], and seven desmoplastic small round-cell tumors [DSRCTs]) received induction chemotherapy with ifosfamide, epirubicin, and vincristine followed by HD-CT. Local treatment (radiotherapy and/or surgery) was performed when possible. Molecular analysis was performed on peripheral-blood and leukapheresis products by reverse-transcriptase polymerase chain reaction. RESULTS: Overall response (OR) was 65% (18 of 28), with 40% complete response and 25% partial response. According to histology, the OR rate was 86% in pPNET and 43% in both RMS DSRCT. With a median follow-up of 35 months, median overall survival was 16 months and median progression-free survival (PFS) was 10 months. PFS was statistically better in pPNET than other histologic types (P = .0045). No correlation was found between the fusion transcript and clinical outcome during follow-up. Furthermore, transcript detection in leukapheretic products was not of prognostic significance. CONCLUSION: Intensive HD-CT seems to enhance the response rate and survival when compared with conventional treatment in poor-prognosis pPNET. The poor results of this treatment in RMS and DSRCT do not support the inclusion of such an approach in these patient subsets. No definitive conclusions can currently be drawn concerning the clinical implications of the detection of fusion transcripts during treatment or follow-up.

scholarly journals Epidemiological profile of canine neoplasms in São Luís/MA: a retrospective study (2008-2015)

2020 ◽  
Vol 9 (12) ◽  
pp. e8291210496
Author(s):  
Tatiane Avelar Ribeiro ◽  
Valéria Raiana Fonseca Ferreira ◽  
Renata Mondêgo-Oliveira ◽  
Fábio Henrique Evangelista Andrade ◽  
Ana Lúcia Abreu-Silva ◽  
...  
Keyword(s):  
Mast Cell ◽  
Mammary Gland ◽  
Medical Records ◽  
Cell Tumor ◽  
State University ◽  
Round Cell ◽  
Mast Cell Tumor ◽  
Epidemiological Profile ◽  
Veterinary Hospital ◽  
Round Cell Tumors

The diversity of neoplasms observed in dogs can vary geographically depending on individual susceptibility, the habitat of the animals, and environmental characteristics. The aim of this study was to evaluate the epidemiological aspects of neoplasms in dogs treated at the Veterinary Hospital of the State University of Maranhão from 2008 to 2015. We studied the medical records of 1089 dogs affected by neoplasms and treated at a hospital during the period of study, relating to the casuistry with their breed, age, sex and origin. The present study included 764 cases that were confirmed through cytopathology. The most prevalent tumors were transmissible venereal tumors (TVT) (20.17%), adenocarcinoma of the mammary gland (19.53%), mixed malignant tumor of the mammary gland (18.63%), mast cell tumor (11.31%), and mammary carcinoma (6.42%). Females with a mean age of 9.2 years were the most affected, as were SRDs, Poodles, American Pitbulls, and Dobermann Pinschers. According to the cytomorphogenetic classification, the round cell tumors were the most prevalent, with values close to those of epithelial, followed by mixed and mesenchymal cells.

Small Round Cell Tumors

1977 ◽  
Vol 35 ◽  
pp. 528-529
Author(s):  
B. Mackay ◽  
D. Garza
Keyword(s):  
Cell Tumor ◽  
Round Cell ◽  
Cell Type ◽  
Clinical Behavior ◽  
Specific Diagnosis ◽  
Small Round Cell ◽  
Heterogenous Group ◽  
Architectural Organization ◽  
Round Cell Tumors ◽  
Selection Of

The term "small round cell tumor" is used to designate a heterogenous group of neoplasms that have in common the fact that they are composed of small round, polygonal, or occasionally ovoid cells, compactly grouped with little or no evidence of architectural organization. Identification of tumors within this group by light microscopy can be difficult and is often not possible. Selection of a specific diagnosis by the pathologist is frequently influenced by the clinical behavior and location of the tumor, and by the age of the patient. For example, tumors with this morphology occurring in young children are usually assumed to be rhabdomyosarcoma, neuroblastoma, Ewing's sarcoma, or lymphoma.By studying these neoplasms with the electron microscope and correlating the findings with the light microscopic and clinical data, it is possible to reach a specific diagnosis in most cases. Each tumor possesses distinctive ultrastructural features that serve to identify the cell type.

Desmoplastic Small Round Cell Tumors: Cytologic, Histologic, and Immunohistochemical Features

2006 ◽  
Vol 130 (5) ◽  
pp. 728-732 ◽  
Author(s):  
Fuju Chang
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Cavity ◽  
Cell Tumor ◽  
Round Cell ◽  
Cytologic Diagnosis ◽  
Small Round Cell ◽  
Karyotypic Abnormality ◽  
The Family ◽  
Cytogenetic Profile ◽  
Round Cell Tumors

Abstract Desmoplastic small round cell tumor (DSRCT) is a recently recognized clinicopathologic entity that has a predilection for adolescent males and usually affects the abdominal cavity. Due to its uncommon nature, many pathologists lack experience with this tumor. The literature regarding DSRCT is reviewed with special attention to its histologic and cytologic diagnosis. Morphologic features of DSRCT and its immunohistochemical and cytogenetic profile are summarized and differential diagnosis with other small round cell tumors is discussed. As observed by both histologic and cytologic examinations, small round blue cells and fibrosclerotic stroma are the striking morphologic features of DSRCT. The typical immunohistochemical profile is characterized by coexpression of epithelial, mesenchymal, myogenic, and neural markers. Cytogenetically, this tumor harbors a specific karyotypic abnormality, namely t(11;22)(p13;q12). These features distinguish DSRCT from other members of the family of small round cell tumors.

DESMOPLASTIC SMALL ROUND CELL TUMOR: A CASE REPORT

2021 ◽  
pp. 7-8
Author(s):  
Bhuwan Kumar ◽  
Rajde Singh ◽  
Anurag Mishra
Keyword(s):  
Young Adults ◽  
Case Report ◽  
Poor Prognosis ◽  
Malignant Neoplasm ◽  
Cell Tumor ◽  
Round Cell ◽  
Round Cell Tumor ◽  
Small Round Cell Tumor ◽  
Small Round Cell ◽  
Mesenchymal Tissue

Desmoplastic small round cell tumor is a rare, highly malignant neoplasm originating from mesenchymal tissue which was initially described in 1 1991 by Gerald and Rosai. It is composed of small round tumor cells of uncertain histogenesis associated with prominent stromal desmoplasia and 2 polyphenotypic differentiation. It typically occurs in adolescents and young adults. Usually presents with widespread abdominal, serosal, and mesenteric involvement with poor prognosis.

scholarly journals Prognostic Role of Ultrasound Imaging in Desmoplastic Small Round Cell Tumor: A Retrospective Study and Literature Review

2021 ◽  
Author(s):  
Jing Zhang ◽  
Xueqing Cheng ◽  
Juxian Liu ◽  
Jiakai Liu ◽  
Qiang Lu ◽  
...  
Keyword(s):  
Ultrasound Imaging ◽  
Poor Prognosis ◽  
Univariate Analysis ◽  
Staging System ◽  
Cell Tumor ◽  
Bone Involvement ◽  
Round Cell ◽  
Round Cell Tumor ◽  
Small Round Cell Tumor ◽  
Small Round Cell

Abstract Background: Desmoplastic small round cell tumor (DSRCT) mostly arose in the abdominopelvic cavity is an aggressive sarcoma with poor prognosis. The purpose of this study is to analyze ultrasonographic performance in prediction of prognosis of DSRCT.Method: Between March 1999 and October 2019, a total of 27 patients with pathologically confirmed DSRCT in our hospital were conducted. Clinical and ultrasonographic characterizations, including age, sex, symptoms, tumor size, number, location, shape, margin, echogenicity, homogeneity, vascularity, and metastases were recorded and analyzed with overall survival (OS) by using univariate analysis.Result: Ultrasonographic performance of DSRCT were irregular (74%), posterior echo enhancement (63%), calcification (51.9%), and liquefaction (55.6%) in tumors companied with ascites (63%), hydronephrosis (59%) and metastases (63%). The median OS was 22 months (range 7–36 months) and 5-year OS rate was 19.6%. Using univariate analysis, a higher hazard ratio (HR) of mortality was associated with liquefaction (HR: 3.09, 95% CI:1.23-7.76, p=0.016) and bone metastasis (HR: 2.95, 95%CI: 1.16-7.49, p=0.023). According to a risk staging system developed by selected predictors (low = neither liquefaction nor bone involvement; moderate = either liquefaction or bone involvement; high = both liquefaction and bone involvement), 40%, 10%, and 0 of 3-year survival were found in the low, moderate, and high risk patients, respectively.Conclusion: Ultrasound imaging is effective to evaluate prognosis of DSRCT. Findings of liquefaction and bone involvement in the ultrasonography may predict a poor prognosis of DSRCT patients.

Desmoplastic Small Round Cell Tumors With Atypical Presentations: A Report of 34 Cases

2018 ◽  
Vol 27 (3) ◽  
pp. 236-243 ◽  
Author(s):  
Alyaa Al-Ibraheemi ◽  
Cory Broehm ◽  
Munir R. Tanas ◽  
Andrew E. Horvai ◽  
Brian P. Rubin ◽  
...  
Keyword(s):  
Abdominal Cavity ◽  
Small Cell ◽  
Cell Tumor ◽  
Round Cell ◽  
Cell Sarcoma ◽  
Young Males ◽  
Small Round Cell ◽  
Atypical Presentations ◽  
Round Cell Tumors ◽  
Head Neck

Objectives. Desmoplastic small round cell tumor (DSRCT) is an aggressive round cell sarcoma that arises in the abdominal cavity/pelvis of young males. We sought to expand its clinicopathologic spectrum. Methods. Cases of DSRCT presenting in patients >30 years of age or tumors arising outside of the abdominal cavity/pelvis were retrieved. Results. Thirty-four cases were identified. Sixteen tumors arose at atypical sites (head/neck, intracranial, thigh, axilla/shoulder, inguinal/paratesticular, intraosseous, and uterine corpus). The remaining 18 patients were older than 30 years, and their tumors involved the abdomen or pelvis. The majority of cases showed areas with classic histology, while 6 cases exhibited solid growth and 5 showed macronodular architecture. Cytologic appearance included round cell, rhabdoid, epithelioid, and small cell. Conclusion. DSRCT may arise at nonabdominal locations in both pediatric and adult populations, as well as intra-abdominally in older adults, and these tumors exhibit high rates of metastasis and morbidity.

Small Blue Round Cell Tumor

2011 ◽  
Vol 101 (4) ◽  
pp. 363-369 ◽  
Author(s):  
J. Marshall Devall ◽  
Katherine M. Frush ◽  
Lori Steiner
Keyword(s):  
Genetic Testing ◽  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Definitive Diagnosis ◽  
Cell Tumor ◽  
Round Cell ◽  
Tissue Mass ◽  
Case Presentation ◽  
Poorly Differentiated ◽  
Round Cell Tumors

Small blue round cell tumors of childhood rarely present in the foot or ankle. The following is a case presentation of an 18-year-old male with a large soft-tissue mass of the foot with associated lung metastasis. A definitive diagnosis could not be fully made, even with immunohistochemical and genetic testing. Diagnosis favored poorly differentiated synovial sarcoma. (J Am Podiatr Med Assoc 101(4): 363–369, 2011)

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