scholarly journals Primary Mucoepidermoid Carcinoma Arising from Ectopic Salivary Tissue within an Intraparotid Lymph Node

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Fatemah Faras ◽  
Fawaz Abo-Alhassan ◽  
Jassem Bastaki ◽  
Mutlaq K. Al-Sihan
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Needle Aspiration ◽  
Low Grade ◽  
Warthin Tumor ◽  
Diagnostic Pitfall ◽  
Deep Margin ◽  
Intermediate Cells ◽  
The Right

Ectopic salivary tissue is commonly found in intraparotid and periparotid lymph nodes. Warthin tumor is the most common tumor arising in ectopic salivary gland tissue and in intraparotid lymph nodes. Although rare, neoplastic transformation of the ectopic salivary tissues is conceivable and other types of salivary gland neoplasms arising in intraparotid lymph nodes have been reported. Herein we report a rare case of a 32-year-old Kuwaiti male who presented with a mass in the right parotid gland. A preoperative fine needle aspiration suggested Warthin tumor. The patient underwent a superficial parotidectomy. The specimen showed a mass within the parotid parenchyma abutting the deep margin. Hematoxylin and Eosin stained sections of the lesion showed solid islands and cysts composed of epidermoid cells, mucus cells, and intermixed smaller “intermediate” cells within an intraparotid lymph node. The tumor was seen infiltrating the parotid parenchyma at the deep margin. Metastasis from distant sites was ruled out clinically, and the diagnosis rendered was MEC, low-grade, arising from ectopic salivary tissue in an intraparotid lymph node. Such cases are extremely rare and the presence of malignancies within lymph nodes may pose a diagnostic pitfall, which can affect patient management.

scholarly journals Parotid gland adenocarcinoma in a cow: case report

2018 ◽  
Vol 70 (3) ◽  
pp. 758-766
Author(s):  
P.J.B. Queiroz ◽  
T.D. Queiroz ◽  
P.L. Magalhães ◽  
N.C. Borges ◽  
D.B. Martins ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Nodes ◽  
Polyclonal Antibodies ◽  
Malignant Neoplasm ◽  
Needle Aspiration ◽  
Undifferentiated Carcinoma ◽  
Submandibular Region ◽  
Parotid Region ◽  
Needle Aspiration Cytology ◽  
The Right

ABSTRACT A 9-year-old Girolando dairy cow, weighing 400kg, with a history of increased volume in the right parotid region, which extended to the submandibular region, was assisted. Fine needle aspiration cytology was performed, and the cytological findings were consistent with malignant neoplasm of epithelial origin (carcinoma). Because of the unfavorable prognosis, the animal was euthanized and submitted to an anatomopathological examination. Samples of the increased parotid and affected lymph nodes were collected for histopathological evaluation. The microscopic changes were accentuated features of anaplasia, moderate cell proliferation, atypical mitotic figures, and necrosis. Stroma ranged from delicate to scirrhous, and the tumor boundaries were not distinct. These findings substantiated the preliminary histomorphological diagnosis of undifferentiated carcinoma with metastasis in lymph nodes. Immunohistochemical tests were performed with anti-CK Pan (clone AE1AE3), anti-CK HMW (clone 34βE12), anti-CK19 (clone RCK108), anti-vimentin (clone V9), anti-S100 (polyclonal), and anti-androgen (polyclonal) antibodies. The immunophenotype favored the diagnosis of salivary gland adenocarcinoma. Despite the rareness in cattle, salivary gland adenocarcinoma should be considered in the differential diagnosis of diseases that occur with increased volume in the head, lymphadenopathy, drooling, dysphagia, and progressive weight loss.

scholarly journals Low-Grade Ovarian Serous Adenocarcinoma with Lymph Node Metastasis in Neck

Diagnostics ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 1804
Author(s):  
Shih-Lung Chen ◽  
Tsan-Yu Hsieh ◽  
Shih-Wei Yang
Keyword(s):  
Ovarian Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Neck Mass ◽  
Serous Carcinoma ◽  
Low Grade ◽  
Serous Adenocarcinoma ◽  
Ovarian Serous Adenocarcinoma ◽  
The Right ◽  
Radioactivity Uptake

Low-grade ovarian serous adenocarcinoma is rarely encountered in the neck region. The diagnosis of this rare malignancy entity in the neck is challenging for both clinicians and pathologists. A 53-year-old female with a chief complaint of a right lower neck mass that had been growing for approximately 2 weeks. The ultrasound-guided fine needle aspiration cytology favored malignancy. The positron emission tomography/computed tomography scan revealed the clustered enlarged lymph nodes with increased radioactivity uptake in the right neck level V, and strong radioactivity uptake was also displayed in the right ovarian regions. Pelvis magnetic resonance imaging displayed right adnexal complex mass supporting the ovarian cancer. An en bloc resection of the right neck lymph node was conducted. Ovarian serous adenocarcinoma with metastasis of lymph nodes in the neck was confirmed through histopathological findings. This study reviews the clinical features of low-grade ovarian serous carcinoma metastasizing to lymph nodes in neck. Although very rare, ovarian cancer with neck metastasis should be considered in the differential diagnosis of a neck mass lesion. The clinical staging would be relatively high due to the quiet entity of the cancer.

Pitfalls in Salivary Gland Fine-Needle Aspiration Cytology: Lessons From the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology

2005 ◽  
Vol 129 (1) ◽  
pp. 26-31 ◽  
Author(s):  
Jonathan H. Hughes ◽  
Emily E. Volk ◽  
David C. Wilbur
Keyword(s):  
Salivary Gland ◽  
Fine Needle Aspiration ◽  
False Positive ◽  
Interlaboratory Comparison ◽  
False Negative ◽  
Diagnostic Errors ◽  
Poor Performance ◽  
Needle Aspiration ◽  
Low Grade ◽  
Fine Needle

Abstract Context.—We use data from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology to identify common diagnostic errors in salivary gland fine-needle aspiration (FNA). Objective.—To identify salivary gland FNA cases with poor performance characteristics in the Nongynecologic Cytology Program surveys, so that the most common diagnostic pitfalls can be avoided. Design.—A retrospective review of the College of American Pathologists Nongynecologic Cytology Program's cumulative data from 1999 to 2003 revealed the most common false-positive and false-negative interpretations on FNA for common salivary gland lesions. Slides that performed poorly were then reviewed to identify the cytologic characteristics that may have contributed to their poor performance. Results.—A total of 6249 participant responses with general interpretations of benign (n = 4642) or malignant (n= 1607) were reviewed. The sensitivity and specificity of the participant responses for correctly interpreting the cases as benign or malignant were 73% and 91%, respectively. Benign cases with the highest false-positive rates were monomorphic adenoma (53% false-positive), intraparotid lymph node (36%), oncocytoma (18%), and granulomatous sialadenitis (10%). Malignant cases with the highest false-negative rates were lymphoma (57%), acinic cell carcinoma (49%), low-grade mucoepidermoid carcinoma (43%), and adenoid cystic carcinoma (33%). Selected review of the most discordant individual cases revealed possible explanations for some of the interpretative errors. Conclusions.—These data confirm the difficulty associated with interpretation of salivary gland FNA specimens. Cytologists should be aware of the potential false-positive and false-negative interpretations that can occur in FNAs from this organ site in order to minimize the possibility of diagnostic errors.

scholarly journals US-guided Fine-Needle Aspiration of Major Salivary Gland Masses and Adjacent Lymph Nodes: Accuracy and Impact on Clinical Decision Making

Radiology ◽  
2011 ◽  
Vol 259 (2) ◽  
pp. 471-478 ◽  
Author(s):  
Gaurav Sharma ◽  
Alexander S. Jung ◽  
Dennis R. Maceri ◽  
Dale H. Rice ◽  
Sue Ellen Martin ◽  
...  
Keyword(s):  
Decision Making ◽  
Salivary Gland ◽  
Lymph Nodes ◽  
Fine Needle Aspiration ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Needle Aspiration ◽  
Major Salivary Gland ◽  
Fine Needle

scholarly journals Endobronchial ultrasound-guided transbronchial needle aspiration for lung cancer staging: early experience in Brazil,

2015 ◽  
Vol 41 (1) ◽  
pp. 23-30 ◽  
Author(s):  
Viviane Rossi Figueiredo ◽  
Paulo Francisco Guerreiro Cardoso ◽  
Márcia Jacomelli ◽  
Sérgio Eduardo Demarzo ◽  
Addy Lidvina Mejia Palomino ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cancer Staging ◽  
Accurate Method ◽  
Needle Aspiration ◽  
Endobronchial Ultrasound ◽  
Lymph Node Staging ◽  
Ultrasound Guided ◽  
Transbronchial Needle Aspiration

Objective: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive, safe and accurate method for collecting samples from mediastinal and hilar lymph nodes. This study focused on the initial results obtained with EBUS-TBNA for lung cancer and lymph node staging at three teaching hospitals in Brazil. Methods: This was a retrospective analysis of patients diagnosed with lung cancer and submitted to EBUS-TBNA for mediastinal lymph node staging. The EBUS-TBNA procedures, which involved the use of an EBUS scope, an ultrasound processor, and a compatible, disposable 22 G needle, were performed while the patients were under general anesthesia. Results: Between January of 2011 and January of 2014, 149 patients underwent EBUS-TBNA for lymph node staging. The mean age was 66 ± 12 years, and 58% were male. A total of 407 lymph nodes were sampled by EBUS-TBNA. The most common types of lung neoplasm were adenocarcinoma (in 67%) and squamous cell carcinoma (in 24%). For lung cancer staging, EBUS-TBNA was found to have a sensitivity of 96%, a specificity of 100%, and a negative predictive value of 85%. Conclusions: We found EBUS-TBNA to be a safe and accurate method for lymph node staging in lung cancer patients.

scholarly journals Distribution of Various Malignant Lesions in Lymph Node Cytology – A 1 Year Population Based Study from a Tertiary Care Centre in North-East India

2021 ◽  
Vol 8 (17) ◽  
pp. 1090-1094
Author(s):  
Badrinath Venkatesh ◽  
Khagokpam Ambala Devi ◽  
Soram Gayatri Gatphoh
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Fine Needle Aspiration ◽  
Tertiary Care ◽  
Needle Aspiration ◽  
Undifferentiated Carcinoma ◽  
Metastatic Tumour ◽  
Fine Needle ◽  
North East ◽  
Malignant Lesions

BACKGROUND Lymph nodes (LN) are an integral component of the immune system. Enlarged lymph nodes are a prime target for fine needle aspiration (FNA). Lymph nodes greater than 1 to 2 cm are an immediate source of concern. Lymphadenopathy is a common presenting symptom in various diseases. Fine needle aspiration cytology (FNAC) confirms the presence of metastatic disease and gives a clue regarding its nature and origin of primary malignancy. In many metastatic malignancies, FNAC may be the only tool for diagnosis and further management of the patients. We intend to assess the cytomorphological patterns of both primary tumour and metastatic tumour in a lymph node. METHODS A retrospective study was conducted in the Department of Pathology, RIMS, Imphal, over a period of one year from January 1, 2018 to December 31, 2018. Five hundred and fifty-five lymph nodes were aspirated, out of which 99 cases turned out to be malignant lesions. Giemsa and PAP stained FNAC slides were collected and reviewed. Data entry and analysis were done by using SPSS version 21. RESULTS Out of 99 cases, 88.9 % were metastatic tumours and 11.1 % were of primary lymphoproliferative disorders. Thirty three percent of malignant lymphadenopathy were found in fifth decade. Undifferentiated carcinoma constituted around 32.3 % of all the cases of malignant lymphadenopathy. Cervical group of lymph nodes were involved in 46.5 % of cases. CONCLUSIONS FNAC has proved to be a useful tool in diagnosing malignancy with good certainty. FNAC of lymph nodes prevents complications associated with lymph node biopsy. KEYWORDS FNAC, Lymph Node, Undifferentiated Carcinoma, Squamous Cell Carcinoma

scholarly journals DIAGNOSIS OF ROSAI-DORFMAN DISEASE BY FINE NEEDLE ASPIRATION CYTOLOGY- A STUDY OF ELEVEN CASES WITH EMPHASIS ON SITE

2020 ◽  
pp. 1-3
Author(s):  
Rinsha Surendranath ◽  
M Rajani
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Cervical Lymph Node ◽  
Age Distribution ◽  
Needle Aspiration ◽  
Cervical Region ◽  
Axillary Lymph ◽  
Diagnostic Significance ◽  
Massive Lymphadenopathy ◽  
Rosai Dorfman Disease

Rosai Dorfman Disease also called as Sinus Histiocytosis with Massive Lymphadenopathy is a benign proliferative disorder of histiocytes which typically affects lymph nodes of cervical region ,however extranodal sites are also being reported by many authors[1].FNAC is the investigation of choice as is it less invasive and more reliable.Aims :To study the various sites of involvement and diagnostic significance of FNAC along with the pattern of site and age distribution .We studied a series of 11 cases for a period of one year.Materials and methods: Eleven cases studied in the department of Pathology Govt. Siddhartha Medical College,Vijayawada.Material collected from Govt. General Hospital,Vijayawada.Results:The present study showed two extranodal,one axillary lymph node,one inguinal lymph node and seven cervical lymph node involment.Conclusion:Rosai- dorfman disease main clinical manifestion is cervical lymph node enlargement ,but other lymph nodes and extranodal site can also be involved.Most common age of presentation was between 20-40years

scholarly journals Mammary analogue secretory carcinoma: a rare salivary gland tumor

2020 ◽  
Vol 6 (5) ◽  
pp. 998
Author(s):  
Shashikant Anil Pol ◽  
Surinder K. Singhal ◽  
Nitin Gupta ◽  
Himanshu Bayad
Keyword(s):  
Salivary Gland ◽  
Salivary Gland Tumor ◽  
Needle Aspiration ◽  
Good Prognosis ◽  
Low Grade ◽  
Secretory Carcinoma ◽  
Mammary Analogue Secretory Carcinoma ◽  
Grade Malignancy ◽  
Enhanced Computed Tomography ◽  
Slow Growing

<p>Mammary analogue secretary carcinoma are salivary gland tumors similar to secretary carcinoma of breast histologically. It usually affects adults with mean age group of 45 years. Clinically it is usually slow growing, low grade malignancy with favorable prognosis. We are reporting a case of 47 years old female presented with complaints of swelling behind left ear for last 7 years. It was slow growing, painless and persistent. On examination, 4 x 3 cm swelling was present just below left ear lobule. It was nontender, firm, irregular in shape with smooth surface with slight mobility and overlying skin pinchable. Fine needle aspiration cytology suggested benign tumor with cystic change. On contrast enhanced computed tomography scan, there was a lobulated hypodense lesion measuring 24×35×32 mm with internal septations and enhancement of wall in expected location of superficial as well as deep lobe of left parotid gland. Patient underwent left total conservative parotidectomy and histopathology came out to be secretory analogue mammary carcinoma. Subsequently she received post-operative radiotherapy. Patient is on regular follow up and disease free till date. Usually mammary analogue secretory carcinoma is a low-grade malignancy with good prognosis. Immunohistochemistry is confirmatory which shows positivity for S-100 protein and mammaglobin.</p>

scholarly journals Fine needle aspiration cytology of head and neck lesions and its correlation with histopathology

2016 ◽  
Vol 6 (12) ◽  
pp. 985-989
Author(s):  
R Pathak ◽  
KBR Prasad ◽  
SK Rauniyar ◽  
S Pudasaini ◽  
K Pande ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Thyroid Gland ◽  
Head And Neck ◽  
Soft Tissues ◽  
Neck Region ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Head And Neck Region ◽  
Needle Aspiration Cytology

Background: Fine needle aspiration cytology is a minimally invasive technique used in the initial diagnosis of different types of lesions located in head and neck region commonly originating from cervical lymph node, thyroid gland, salivary glands and soft tissues. The objective of this study was to evaluate the diagnostic accuracy, sensitivity and speci city of FNAC in various head and neck lesions in correlation with their histopathological examination. Materials and methods: A hospital based prospective study was conducted among 209 patients with palpable head and neck region swellings in the Department of Pathology, Bhaktapur Cancer Hospital and the Department of Pathology, Nepal Medical College from August 2014 to July 2015. FNAC were done from palpable masses of head and neck regions. Data entry and analysis were done using SPSS 17. Result: There were 209 FNAC cases enrolled, out of which lymph node lesions (n=128) were the most common lesions followed by thyroid (n=40), other soft tissues (n=27) and salivary gland (n=14). Reactive lymph nodes, colloid goiter, epidermoid cyst and sialadenosis were the predominant diagnosis of lymph nodes, thyroid gland, soft tissues and salivary gland respectively. Highest accuracy, sensitivity and speci city were observed in thyroid gland, salivary gland and soft tissues. However, four false negative results for malignancy were reported in lymph node lesions. Conclusion: Head and neck region swellings are the commonly encountered conditions. FNAC being highly accurate, sensitive and speci c makes it useful and reliable procedure for screening and diagnosis of palpable masses in head and neck region. 

CYTOPATHOLOGICAL SPECTRUM OF FNAC IN PALPABLE HEAD AND NECK LESIONS

2021 ◽  
pp. 53-54
Author(s):  
Devendu Bose ◽  
Bejoy Chand Banerjee
Keyword(s):  
Salivary Gland ◽  
Lymph Node ◽  
Soft Tissue ◽  
Head And Neck ◽  
Clinical History ◽  
Needle Aspiration ◽  
Minimal Risk ◽  
Neck Swelling ◽  
Neck Masses ◽  
Common Diagnosis

Introduction: Head and neck lesions comprises a large number of congenital, inammatory or neoplastic lesions including different anatomic sites and originating in different tissues and organs. Fine needle aspiration cytology (FNAC) is a simple, quick, feasible, repeatable and outpatient procedure with minimal risk of complication. Aim: To study the role of FNAC and its utility in diagnosis of palpable head neck masses and to determine the spectrum of various lesions. Materials And Methods: A retrospective study was conducted in pathology department of Shaheed Nirmal Mahato Medical College, Dhanbad, Jharkhand from January 2016 to December 2020 on patients with palpable head and neck swelling. Detailed clinical history of patient was noted. Aspirations were done by using 10 ml syringe and 22/23 gauge needles. Smears were stained with PAP, Haematoxylin and Eosin and Leishman stain. Cytomorphological diagnosis was given. Results: Out of 562 patients of head and neck swelling, 61.92% (348 cases) were of lymph node, 20.28% (114 cases) were of thyroid, 3.38% from salivary gland (19 cases), 14.06% (79 cases) from skin and soft tissue swellings. The most common diagnosis was reactive lymphadenitis (32.74%) followed by granulomatous lymphadenitis (18.33%). The mean age of study population was 32 years. There was female preponderance (88.59%) in thyroid lesions whereas lymph node lesions (60.91%), salivary gland lesions (73.68%) and soft tissue swellings (59.49%) were more common in males. Conclusion: From our study we concluded that FNAC is simple, quick, inexpensive, repeatable and minimally invasive rst line investigation for differential diagnosis of head and neck lesions.

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