scholarly journals Relationship between vitamin D and lung function, physical performance and balance on patients with stage I-III chronic obstructive pulmonary disease

2015 ◽  
Vol 61 (2) ◽  
pp. 132-138 ◽  
Author(s):  
Tuncay Yumrutepe ◽  
Zeynep Ayfer Aytemur ◽  
Ozlem Baysal ◽  
Hulya Taskapan ◽  
Cagatay M. Taskapan ◽  
...  
Keyword(s):  
Vitamin D ◽  
Muscle Strength ◽  
Vitamin D Deficiency ◽  
Physical Performance ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Lung Functions ◽  
Knee Muscle ◽  
Knee Muscle Strength

Summary Objectives: vitamin D is important for muscle function and it affects different aspects of muscle metabolism. This study aim to determine whether serum 25(OH) D levels are related to lung functions, physical performance and balance in patients with chronic obstructive pulmonary disease (COPD). Methods: in 90 patients with COPD and 57 healthy controls lung function tests, physical performance tests (time up and go, gait velocity test, sit-to-stand test, isometric strength, isokinetic strength), static (functional reach test) and dynamic (time up and go) balance tests and the association of 25(OH)D levels with lung functions, physical performance and balance were evaluated. Results: the COPD patients had significantly more deficit in physical function and balance parameters, and in dynamic balance test (p<0.005). Isokinetic knee muscle strength (flexor and extensor) in COPD patients was significantly lower than in the controls (p<0.05); FEV1 (p=0.008), FVC (p=0.02), FEV1/FVC (p=0.04), TLC (p=0.01) were lower in COPD patients with vitamin D deficiency [25(OH) D less than 15ng/mL] than in COPD patients without vitamin D deficiency. Hand grip test (p=0.000) and isokinetic knee muscle strength (flexor and extensor) (p<0.05) were also lower in COPD patients with vitamin D deficiency. Vitamin D deficiency was more pronounced in patients with stage III COPD (p<0.05). Conclusion: patients with COPD had worst physical functioning, poor balance and less muscle strength. Severe disturbed lung and peripheral muscle functions are more pronounced in COPD patients with vitamin D deficiency.

scholarly journals Prevalence of vitamin D deficiency in chronic obstructive pulmonary disease and it’s correlation with forced expiratory volume in one second: a tertiary care centre study

2018 ◽  
Vol 6 (7) ◽  
pp. 2396
Author(s):  
Laxma Reddy S. ◽  
Ravicharan Avala ◽  
Rajshekar Varma ◽  
Narendrakumar Narahari ◽  
Bhaskar K. ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Tertiary Care ◽  
Serum Vitamin ◽  
Forced Expiratory Volume ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Serum Vitamin D ◽  
Copd Patients ◽  
Vitamin D Levels

Background: Vitamin D deficiency is common all over the Indian subcontinent, with a prevalence of 70-100% in the general population. Vitamin D deficiency has a role in several diseases of the respiratory system including chronic obstructive pulmonary disease (COPD). Studies have shown that vitamin D deficient COPD patients have lower lung function measured by FEV1. We conducted a study to see prevalence of Vitamin D deficiency in COPD patients and it’s correlation with Forced Expiratory Volume in 1 second.Methods: A cross sectional observational study was performed in a tertiary care hospital in Hyderabad, Telangana during the period of one and half year. This included 104 COPD cases attending outpatient department of pulmonary medicine. Serum vitamin D levels were measured, and spirometry was done in all patients and data was analyzed accordingly.Results: Among 104 patients, 87 were males and 17 were females. Most of the study population (44.2%) was aged between 60-70 years. Mean BMI was 26.40 (±5.77) kg/m2. Majority of study populations (66.34%) were in GOLD stage 1 and 2. The mean Vitamin D value of the study population was 20.77±11.74ng/ml. Majority of the COPD patients were vitamin D deficient (69.2%). 25.0 % was severely deficient of vitamin D. The mean FEV1 volume (%) was 83.15±11.53, 60.97±17.47, 30.71±7.96 in sufficient, deficient and severe deficient patients.Conclusions: Vitamin D deficiency is common in COPD patients. Serum vitamin D deficiency increases with increased severity of COPD. There is positive correlation between serum vitamin D levels and post bronchodilator FEV1 (%). 

scholarly journals Is There Relation Between 25(OH) Vitamin D and Chronic Obstructive Pulmonary Disease?

2017 ◽  
Vol 5 (2) ◽  
pp. 87-91
Author(s):  
Farshid Divani ◽  
Alireza zahedi ◽  
Maryam Vasheghani ◽  
Ebrahim Nadi ◽  
Jalal Poorolajal ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Serum Level ◽  
Vitamin D Deficiency ◽  
Pulmonary Disease ◽  
Control Group ◽  
Chronic Obstructive ◽  
Case Group ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients

Background: Vitamin D level can affect pulmonary function in patient who have chronic obstructive pulmonary disease (COPD). Objectives: There are few studies that assess this subject, so we investigate the relation of Vitamin D and COPD. Materials and Methods: A case-control study was conducted among the patients referred to the pulmonology clinic of Shahid Beheshti hospital of Hamadan, in which 68 of patients were assigned into the case group with COPD and 68 patients into the control group. Both groups were evaluated for respiratory differences as clinical or laboratory and the blood level of vitamin D was measured. Results: Of 136 evaluated participants with the mean age of 58.83 years old, 68 patients were studied as case group consisting of 2 females and 66 males. The results suggested that the serum level of vitamin D in COPD patients and control group patients were 22.22 ± 15.83 ng/mL and 27.47 ± 21.43 ng/mL, respectively. It was also found that there was a positive correlation between lung function and serum level of vitamin D in COPD. The greater the severity of COPD (forced expiratory volume in the first second [FEV1] lower level) was, the more the vitamin D deficiency was seen. It was also clarified that there was an indirect correlation between the serum level of vitamin D in COPD patients and body mass index (BMI). Conclusions: Prevalence of vitamin D deficiency in COPD patients was more than that in control group patients. Due to the growing prevalence of vitamin D deficiency in such patients, any use of vitamin D maybe suggested.

scholarly journals Sarcopenia and Sarcopenic Obesity in Chronic Obstructive Pulmonary Disease Patients with Different Levels of Severity

2018 ◽  
Vol 3 (1) ◽  
pp. 17
Author(s):  
Katayoun Samadi ◽  
Shahram Kharabian ◽  
Atefeh Abedini ◽  
Foroogh Mohammadi ◽  
Azam Adeli ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Muscle Strength ◽  
Pulmonary Disease ◽  
Muscle Mass ◽  
Physical Performance ◽  
Sarcopenic Obesity ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
The Relationship

Background: Sarcopenia is defined as loss of muscle mass with attendant loss of muscle strength and physical function and is associated with advancing age. Inflammatory condition of chronic disease leads to more rapid progression of this syndrome, which may adversely affect quality of life. The aim of this study was to determine the relationship between chronic obstructive pulmonary disease (COPD) and sarcopenia.Methods: This study included 108 COPD patients who were treated in the pulmonary clinic at Masih Daneshvari Hospital. Patients were categorized into three groups based on Global Initiative for Obstructive Lung Disease criteria. Sarcopenic parameters including muscle mass, muscle strength, and physical performance were measured by Bioimpedance Analysis, hand grip dynamometer, and the Short Physical Performance Battery test, respectively. According to the European Working Group on Sarcopenia in Older People cutoff points and the definition of sarcopenic obesity, sarcopenic patients were diagnosed and categorized based on different COPD severity scores.Results: The relationship between sarcopenia and COPD grading, which was assessed using multiple regression models with adjustment of confounding factors, including age, chronic diseases, and smoking, was statistically insignificant. However, by using forced expiratory volume in 1 second (FEV1) or ratio of FEV1 to forced vital capacity in this model, the results were significant (P = 0.026). A positive linear correlation was observed between skeletal muscle index (SMI) and spirometric data, which was assessed by Spearman’s correlation test. By exploring the association between sarcopenia and obesity with the one-way analysis of variance test, sarcopenic patients represented to have the minimal spirometric measures. However, this difference was only significant for actual measurements.Conclusion: This study showed that sarcopenic COPD patients had smaller spirometric measurements and that sarcopenia and magnitude of SMI were positively correlated with obstruction severity.

Inspiratory muscle strength in chronic obstructive pulmonary disease depending on disease severity

2007 ◽  
Vol 113 (5) ◽  
pp. 243-249 ◽  
Author(s):  
Hans-Joachim Kabitz ◽  
Stephan Walterspacher ◽  
David Walker ◽  
Wolfram Windisch
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Muscle Strength ◽  
Pulmonary Disease ◽  
Disease Severity ◽  
Inspiratory Muscle ◽  
Walking Distance ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Inspiratory Muscle Strength

Staging criteria for COPD (chronic obstructive pulmonary disease) include symptoms and lung function parameters, but the role of reduced inspiratory muscle strength related to disease severity remains unclear. Therefore the present study tested whether inspiratory muscle strength is reduced in COPD and is related to disease severity according to GOLD (Global Initiative for Chronic Obstructive Lung Disease) criteria and assessed its clinical impact. PImax (maximal inspiratory mouth occlusion pressure), SnPna (sniff nasal pressure) and TwPmo (twitch mouth pressure) following bilateral anterior magnetic phrenic nerve stimulation were assessed in 33 COPD patients (8 GOLD0, 6 GOLDI, 6 GOLDII, 7 GOLDIII and 6 GOLDIV) and in 28 matched controls. Furthermore, all participants performed a standardized 6 min walking test. In comparison with controls, PImax (11.6±2.5 compared with 7.3±3.0 kPa; P<0.001), SnPna (9.7±2.5 compared with 6.9±3.3 kPa; P<0.001) and TwPmo (1.6±0.6 compared with 0.8±0.4 kPa; P<0.001) were markedly lower in COPD patients. TwPmo decreased with increasing COPD stage. TwPmo was correlated with walking distance (r=0.75; P<0.001), dyspnoea (r=−0.61; P<0.001) and blood gas values following exercise (r>0.57; P<0.001). Inspiratory muscle strength, as reliably assessed by TwPmo, decreased with increasing severity of COPD and should be considered as an important factor in rating disease severity and to reflect burden in COPD.

scholarly journals The potential for correction of depressive disorders in patients with chronic obstructive pulmonary disease

2020 ◽  
Vol 48 (5) ◽  
pp. 299-306
Author(s):  
E. V. Bolotova ◽  
A. V. Dudnikova ◽  
V. V. Trembach
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Vitamin D ◽  
Depressive Disorders ◽  
Severe Depression ◽  
Chronic Obstructive ◽  
Control Groups ◽  
Obstructive Pulmonary Disease ◽  
Copd Patients ◽  
Vitamin D Levels ◽  
And Control

Background: The use of vitamin D in the treatment of depressive disorders in patients with chronic obstructive pulmonary disease (COPD) is justified by its pathophysiology, but it is not always feasible in clinical practice. This may be related to the lack of guidelines for implementation for this patient group, as well as to the inadequate sample of patients with baseline high vitamin D levels or mild psychoemotional distress.Objective: To assess the changes of psychoemotional status over time in COPD patients against the maintenance of vitamin D levels at>34.3 ng/ml for one year.Materials and methods: The study included 264 COPD patients randomized into the treatment and control groups (135 and 129 patients, respectively). The patients in both groups were divided into 4 subgroups according to their forced expiratory volume in 1 second (FEV1) values and vitamin D levels. All the patients were administered an inactive vitamin D (colecalciferol): in the main group, according to the scheme ensuring maintenance of the micronutrient value above the goal for 12 months, and in the control group according to the standard scheme of correction of vitamin D deficiency. Depression symptoms were assessed in Geriatric Depression Scale (GDS-15) at the beginning of the study and at its end.Results: After 12 months of vitamin D treatment, the main group showed a statistically significant decrease in the rate of severe depression (14.8% vs 6.7%, χ2=4.67, p=0.04) and an increase in the proportion of patients with normal psychoemotional status (28.2% vs 49.6%, χ2=13.11, p=0.03). In addition, there was a significant difference between the rates of severe depression in the main and control groups after 12 months of treatment: 6.7% vs 14.7% (χ2=4.52, p=0.02).Conclusion: Maintenance of vitamin D levels above 34.3 ng/ml in COPD patients for 12 months reduces the proportion of patients with severe depression.

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