scholarly journals Effects of acute and chronic physical exercise and stress on different types of memory in rats

2008 ◽  
Vol 80 (2) ◽  
pp. 301-309 ◽  
Author(s):  
Pâmela Billig Mello ◽  
Fernando Benetti ◽  
Martín Cammarota ◽  
Iván Izquierdo
Keyword(s):  
Physical Exercise ◽  
Open Field ◽  
Spatial Learning ◽  
Recognition Task ◽  
Long Term Memory ◽  
Training Procedure ◽  
Chronic Exercise ◽  
Different Types ◽  
Male Wistar Rats

Here we study the effect of acute and chronic physical exercise in a treadmill and of daily stress (because forced exercise involves a degree of stress) during 2 or 8 weeks on different types of memory in male Wistar rats. The memory tests employed were: habituation in an open field, object recognition and spatial learning in the Morris water maze. Daily foot-shock stress enhanced habituation learning after 2 but not after 8 weeks; it hindered both short- (STM) and long-term memory (LTM) of the recognition task at 2 weeks but only STM after 8 weeks and had no effect on spatial learning after either 2 or 8 weeks. Acute but not chronic exercise also enhanced habituation in the open field and hindered STM and LTM in the recognition task. Chronic exercise enhanced one important measure of spatial learning (latency to escape) but not others. Our findings indicate that some care must be taken when interpreting effects of forced exercise on brain parameters since at least part of them may be due to the stress inherent to the training procedure.

Effect of sleep on memory for binding different types of visual information

2020 ◽  
Author(s):  
John J Shaw ◽  
Zhisen Urgolites ◽  
Padraic Monaghan
Keyword(s):  
Visual Information ◽  
Storage Capacity ◽  
Declarative Memory ◽  
Recognition Task ◽  
Forced Choice ◽  
Long Term Memory ◽  
Term Memory ◽  
Different Types ◽  
Types Of Information

Visual long-term memory has a large and detailed storage capacity for individual scenes, objects, and actions. However, memory for combinations of actions and scenes is poorer, suggesting difficulty in binding this information together. Sleep can enhance declarative memory of information, but whether sleep can also boost memory for binding information and whether the effect is general across different types of information is not yet known. Experiments 1 to 3 tested effects of sleep on binding actions and scenes, and Experiments 4 and 5 tested binding of objects and scenes. Participants viewed composites and were tested 12-hours later after a delay consisting of sleep (9pm-9am) or wake (9am-9pm), on an alternative forced choice recognition task. For action-scene composites, memory was relatively poor with no significant effect of sleep. For object-scene composites sleep did improve memory. Sleep can promote binding in memory, depending on the type of information to be combined.

The Acute Effect of Alcohol on Various Memory Processes

2010 ◽  
Vol 24 (4) ◽  
pp. 249-252 ◽  
Author(s):  
Márk Molnár ◽  
Roland Boha ◽  
Balázs Czigler ◽  
Zsófia Anna Gaál
Keyword(s):  
Low Dose ◽  
Short Term Memory ◽  
Acute Effect ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Processes ◽  
Different Types ◽  
The Brain ◽  
Legal Consequences

This review surveys relevant and recent data of the pertinent literature regarding the acute effect of alcohol on various kinds of memory processes with special emphasis on working memory. The characteristics of different types of long-term memory (LTM) and short-term memory (STM) processes are summarized with an attempt to relate these to various structures in the brain. LTM is typically impaired by chronic alcohol intake but according to some data a single dose of ethanol may have long lasting effects if administered at a critically important age. The most commonly seen deleterious acute effect of alcohol to STM appears following large doses of ethanol in conditions of “binge drinking” causing the “blackout” phenomenon. However, with the application of various techniques and well-structured behavioral paradigms it is possible to detect, albeit occasionally, subtle changes of cognitive processes even as a result of a low dose of alcohol. These data may be important for the consideration of legal consequences of low-dose ethanol intake in conditions such as driving, etc.

scholarly journals Spatial learning and long-term memory impairments in RasGrf1 KO, Pttg1 KO, and double KO mice

2018 ◽  
Vol 8 (11) ◽  
pp. e01089 ◽  
Author(s):  
Lara Manyes ◽  
Sarah Holst ◽  
Manuel Lozano ◽  
Eugenio Santos ◽  
Alberto Fernandez-Medarde
Keyword(s):  
Spatial Learning ◽  
Long Term Memory ◽  
Term Memory ◽  
Memory Impairments

scholarly journals The language of mental images: Characterizing hippocampal contributions to imageable word use during event construction

2020 ◽  
Author(s):  
Elizabeth Race ◽  
Camille Carlisle ◽  
Ruchi Tejwani ◽  
Mieke Verfaellie
Keyword(s):  
Language Production ◽  
Long Term Memory ◽  
Hippocampal Damage ◽  
Healthy Controls ◽  
Term Memory ◽  
Word Use ◽  
The Past ◽  
Different Types ◽  
Imageable Word

AbstractAccumulating evidence suggests that the hippocampus plays a critical role in the creative and flexible use of language. For example, amnesic patients with hippocampal damage produce less coherent and cohesive verbal discourse when constructing narratives about the past, present, and future. A recent study by Hilverman and colleagues (2017) found that amnesic patients with hippocampal damage also use less imageable words during narrative construction compared to healthy controls. These results suggest that in addition to supporting language use at the discourse level, the hippocampus also influences the quality of language at the single word level. However, the generalizability of these results to different types of language production tasks and the relationship to patients’ broader impairments in episodic memory have yet to be examined. In the current study, we investigated whether amnesic patients with hippocampal damage produce less imageable words compared to healthy controls in two different types of language production tasks. In Experiment 1, participants constructed narratives about events depicted in visually presented pictures (picture narratives). In Experiment 2, participants constructed verbal narratives about remembered events from the past or simulated events in the future (past/future narratives). Across all types of narratives, patients produced words that were rated as having similar levels of imageability compared to controls. Importantly, this was the case both in patients’ picture narratives, which did not require generating details from long-term memory and were matched to controls’ with respect to narrative content, and in patients’ narratives about past/future events, which required generating details from long-term memory and which were reduced in narrative content compared to those of controls. These results reveal that the hippocampus is not necessary for the use of imageable representations at the linguistic level, and that hippocampal contributions to imageable word use are independent of hippocampal contributions to episodic memory.

Separate chemical inhibitors of long-term and short-term memory: contrasting effects of cycloheximide, ouabain and ethacrynic acid on various learning tasks in chickens

1977 ◽  
Vol 196 (1123) ◽  
pp. 171-195 ◽  
Keyword(s):  
Visual Discrimination ◽  
Short Term Memory ◽  
Ethacrynic Acid ◽  
Fixed Number ◽  
Long Term Memory ◽  
Training Procedure ◽  
Memory Retention ◽  
Short Term ◽  
Term Memory

Cycloheximide injected into the brains of chickens 10 min before training does not effect their learning of a visual discrimination task, or memory of that task for at least 1 h after training. When tested 24 h later no memory of the training procedure is detectable. In contrast, ouabain injected 10 min before training prevents the expression of learning during training. The block lasts for up to 1 h, but from that time on memory begins to appear. Ouabain does not affect performance when injected just before testing for memory retention 24 h after training. It therefore affects neither the readout of long-term memory nor motivation nor perceptual abilities necessary for performance of the learning task. In birds treated with ouabain, after training on an operant task for heat reward by a procedure requiring a fixed number of reinforcements, memory is absent 20 min later but is well established at 24 h. Cycloheximide blocks long-term memory of this task. Like ouabain, ethacrynic acid, injected into the brain of chickens 10 min before training prevents the expression of learning of visual discrimination. Ethacrynic acid hastens the decline of memory after one-trial passive avoidance learning. It also blocks observational learning. We conclude that ouabain and ethacrynic acid block access to short-term memory, whereas cycloheximide interferes with the registration of long-term memory. Comparing the pharmacology of ethacrynic acid and ouabain their common known actions are on the Na/K fluxes across cell membranes. We suggest that long lasting changes in distribution of these ions in recently active nerve cells may be at the basis of access to memory during and shortly after learning.

scholarly journals Neonatal Desflurane Exposure Induces More Robust Neuroapoptosis than Do Isoflurane and Sevoflurane and Impairs Working Memory

2011 ◽  
Vol 115 (5) ◽  
pp. 979-991 ◽  
Author(s):  
Mitsuyoshi Kodama ◽  
Yasushi Satoh ◽  
Yukiko Otsubo ◽  
Yoshiyuki Araki ◽  
Ryuji Yonamine ◽  
...  
Keyword(s):  
Working Memory ◽  
Open Field ◽  
Elevated Plus Maze ◽  
Memory Task ◽  
Adenosine Diphosphate ◽  
Long Term Memory ◽  
Neonatal Exposure ◽  
Term Memory ◽  
Plus Maze

Background In animal models, neonatal exposure to volatile anesthetics induces neuroapoptosis, leading to memory deficits in adulthood. However, effects of neonatal exposure to desflurane are largely unknown. Methods Six-day-old C57BL/6 mice were exposed to equivalent doses of desflurane, sevoflurane, or isoflurane for 3 or 6 h. Minimum alveolar concentration was determined by the tail-clamp method as a function of anesthesia duration. Apoptosis was evaluated by immunohistochemical staining for activated caspase-3, and by TUNEL. Western blot analysis for cleaved poly-(adenosine diphosphate-ribose) polymerase was performed to examine apoptosis comparatively. The open-field, elevated plus-maze, Y-maze, and fear conditioning tests were performed to evaluate general activity, anxiety-related behavior, working memory, and long-term memory, respectively. Results Minimum alveolar concentrations at 1 h were determined to be 11.5% for desflurane, 3.8% for sevoflurane, and 2.7% for isoflurane in 6-day-old mice. Neonatal exposure to desflurane (8%) induced neuroapoptosis with an anatomic pattern similar to that of sevoflurane or isoflurane; however, desflurane induced significantly greater levels of neuroapoptosis than almost equivalent doses of sevoflurane (3%) or isoflurane (2%). In adulthood, mice treated with these anesthetics had impaired long-term memory, whereas no significant anomalies were detected in the open-field and the elevated plus-maze tests. Although performance in a working memory task was normal in mice exposed neonatally to sevoflurane or isoflurane, mice exposed to desflurane had significantly impaired working memory. Conclusions In an animal model, neonatal desflurane exposure induced more neuroapoptosis than did sevoflurane or isoflurane and impaired working memory, suggesting that desflurane is more neurotoxic than sevoflurane or isoflurane.

scholarly journals Effects of Pramipexole on Learning and Memory Processes in Naïve and Haloperidol-challenged Rats in Active Avoidance Test

Folia Medica ◽  
2019 ◽  
Vol 61 (2) ◽  
pp. 258-265 ◽  
Author(s):  
Anita S. Mihaylova ◽  
Ilia D. Kostadinov ◽  
Nina D. Doncheva ◽  
Hristina I. Zlatanova ◽  
Delian P. Delev
Keyword(s):  
Learning And Memory ◽  
Active Avoidance ◽  
Memory Test ◽  
Long Term Memory ◽  
Motor Symptoms ◽  
Term Memory ◽  
Avoidance Test ◽  
Male Wistar Rats ◽  
Active Avoidance Test

Abstract Background: Parkinson’s disease (PD) is the second most common neurode-generative disease, usually detected by its motor symptoms. The non-motor symptoms, including cognitive deficits, have been of great interest to researchers in the last few decades. Aim: To assess the effect of pramipexole on learning and memory in naïve and haloperidol-challenged rats. Materials and methods: Male Wistar rats divided into 9 groups (n=8): naïve - saline, pramipexole 0.5; 1 and 3 mg/kg bw; Haloperidol groups - saline, haloperidol, haloperidol + pramipexole 0.5; 1 and 3 mg/kg bw. Two-way active avoidance test (TWAA) and activity cage were performed. The studied parameters were: number of conditioned and unconditioned responses, vertical and horizontal movements. Statistical analysis was done using SPSS 19. Results: The naïve experimental groups significantly increased the number of conditioned responses during the tests for short- and long-term memory, compared with the saline groups (p<0.05). During the short-memory test only the animals with the lowest dose of PMX significantly increased the number of unconditioned responses whereas during the long-term memory test all experimental groups increased the number of escapes in comparison with the saline groups (p<0.05). Challenge dose of haloperidol attenuates learning and memory in pramipexol treated rats. Only the highest dose of pramipexol showed significant increase in conditioned and unconditioned responses compared with the haloperidol group (p<0.05). Conclusion: Pramipexole improves learning and memory in naïve rats by enhancing dopaminergic neurotransmission. This is probably not the only mechanism involved. This is confirmed by the decrease in learning and memory ability in rats with haloperidol-challenge.

scholarly journals Acute physical exercise improves memory consolidation in humans via BDNF and endocannabinoid signaling

2017 ◽  
Author(s):  
Blanca Marin Bosch ◽  
Aurélien Bringard ◽  
Maria Grazia Logrieco ◽  
Estelle Lauer ◽  
Nathalie Imobersteg ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Acute Exercise ◽  
Memory Performance ◽  
Long Term Memory ◽  
Hippocampal Activity ◽  
High Exercise Intensity ◽  
Acute Physical Exercise ◽  
Term Performance ◽  
The Impact

AbstractRegular physical exercise enhances memory functions and neurogenesis in the hippocampus, an effect partially mediated by BDNF (Brain Derived Neurotrophic Factor). Acute exercise promotes the release of endocannabinoids (especially anandamide, AEA), which enhance BDNF release and improve hippocampal plasticity in rodents. How acute exercise affects BDNF and AEA levels and influences memory performance in humans remains to date unknown. Here we combined blood biomarkers, behavioral and fMRI measurements to assess the impact of acute physical exercise on associative memory and underlying neurophysiological mechanisms. For each participant, memory was tested after three conditions: rest, moderate or high exercise intensity. A long-term memory retest took place 3 months later. At both test and retest, memory performance increased after moderate but not high intensity exercise or rest. We also show that memory benefited from exercise-related increases in both AEA and BNDF levels: AEA boosted hippocampal activity during memory recall, while BDNF enhanced hippocampal memory representations and long-term performance.

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