scholarly journals Malformations in the offspring of women with thyroid cancer treated with radioiodine for the ablation of thyroid remnants

2006 ◽  
Vol 50 (5) ◽  
pp. 930-933 ◽  
Author(s):  
Pedro Weslley S. do Rosário ◽  
Álvaro Luís Barroso ◽  
Leonardo Lamego Rezende ◽  
Eduardo Lanza Padrão ◽  
Michelle A. Ribeiro Borges ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Ovarian Function ◽  
Radioiodine Therapy ◽  
Unfavorable Outcome ◽  
Favorable Outcome ◽  
Spontaneous Abortions ◽  
Radioiodine Treatment ◽  
Ablative Therapy ◽  
One Year

RATIONALE: Since ovarian function is only temporarily compromised by radioiodine therapy, many women with thyroid cancer treated with radioiodine can become pregnant. The present study evaluated the evolution of these pregnancies and the consequences for the offspring. PATIENTS AND METHODS: We retrospectively analyzed 78 pregnancies of 66 women submitted to total thyroidectomy, followed by radioiodine therapy (3.75.5 GBq 131I, mean 4.64 GBq). In all patients, conception occurred one year after ablative therapy (mean of 30 months). Age ranged form 19 to 36 years (mean of 30.6 years) at the time of radioiodine treatment and from 23 to 39 years (mean of 32.8 years) at the time of conception. RESULTS: Four (5.1%) of the 78 pregnancies resulted in spontaneous abortions. Three (4%) of the 74 deliveries were preterm and there was no case of stillbirth. The birthweight was > 2500 g in 94.6% of the children (mean ± SD: 3350 ± 450 g) and only one infant (1.3%) presented an apparent malformation at birth (intraventricular communication). No difference in the age at the time of radioiodine therapy or conception or in radioiodine dose was observed between pregnancies with an unfavorable outcome and those with a favorable outcome. CONCLUSION: We conclude that pregnancies that occur 12 months after ablative therapy are safe.

scholarly journals Time course of Graves’ orbitopathy after total thyroidectomy and radioiodine therapy for thyroid cancer

Medicine ◽  
2016 ◽  
Vol 95 (48) ◽  
pp. e5474 ◽  
Author(s):  
Camille Louvet ◽  
Annamaria De Bellis ◽  
Bruno Pereira ◽  
Claire Bournaud ◽  
Antony Kelly ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Time Course ◽  
Radioiodine Therapy ◽  
Graves Orbitopathy

scholarly journals Oxidative stress and radioiodine treatment of differentiated thyroid cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Angelika Buczyńska ◽  
Iwona Sidorkiewicz ◽  
Mariusz Rogucki ◽  
Katarzyna Siewko ◽  
Agnieszka Adamska ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Thyroid Cancer ◽  
Stress Level ◽  
Differentiated Thyroid Cancer ◽  
Radioactive Iodine ◽  
Serum Levels ◽  
Radioiodine Treatment ◽  
Future Health ◽  
Oxidative Stress Level ◽  
One Year

AbstractIt is hypothesized that the oxidative stress level in thyroid cancer patients is additionally upregulated by radioactive iodine (RAI) treatment, that may exert an important impact on future health concerns. In our study, we evaluated the oxidative stress level changes using the measurement of malondialdehyde (MDA) concentration in patients with differentiated thyroid cancer (DTC) undergoing RAI treatment. Considering the results obtained in the study group, the serum levels of MDA in DTC patients were significantly higher compared to the healthy subjects (p < 0.05). The MDA concentration was significantly higher on the third day after RAI (p < 0.001) and significantly lower one year after RAI (p < 0.05) in DTC patients compared to the baseline concentration. Moreover, the redox stabilization after RAI treatment in patients with DTC during a year-long observation was demonstrated. Accordingly, an increased oxidative stress impact on the related biochemical parameters reflecting the health conditions of the DTC patients was determined. Our study showed that increased oxidative stress reflected by MDA measurements in DTC patients is further enhanced by RAI, but this effect is no longer observed one year after the therapy.

scholarly journals Management of papillary and follicular (differentiated) thyroid carcinoma - an update

1970 ◽  
Vol 16 (2) ◽  
pp. 126-130
Author(s):  
Md Abdul Mobin Choudhury ◽  
Md Abdul Alim Shaikh
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Differentiated Thyroid Cancer ◽  
Radioiodine Therapy ◽  
Endemic Goiter ◽  
Follicular Carcinoma ◽  
Differentiated Thyroid Carcinoma ◽  
Thyroid Cancers ◽  
Surgical Options ◽  
Definitive Management

Thyroid cancers are quite rare, accounting for only 1.5% of all cancers in adults and 3% of all cancers in children. Differentiated thyroid cancer comprises 95% of all thyroid cancers. Of all thyroid cancers 74-80% of cases are papillary cancers. Incidences of follicular carcinoma are higher in regions where incidence of endemic goiter is high. Surgery is the definitive management of thyroid cancer. There is agreement that patients with large, locally aggressive or metastatic differentiated thyroid cancer require total thyroidectomy but there is continuing disagreement on the most appropriate operation for 'low risk' differentiated thyroid cancer. Adjuvant treatments are thyroid hormone suppression and radioiodine therapy rather than chemotherapy and radiotherapy. Prognosis is generally excellent and is influenced by factors related to the patient, the disease and the therapy. This article reviews the basis of surgical treatment of differentiated thyroid cancer and assesses the evidences supporting the surgical options. Key words: Papillary Carcinoma; Follicular Carcinoma; Hemithyroidectomy; Total Thyroidectomy DOI: 10.3329/bjo.v16i2.6848Bangladesh J Otorhinolaryngol 2010; 16(2): 126-130

scholarly journals Surgical management of recurrent thyroid cancer

2003 ◽  
Vol 50 (3) ◽  
pp. 147-153
Author(s):  
Aleksandar Diklic ◽  
Vladan Zivaljevic ◽  
Ivan Paunovic ◽  
Ksenija Krgovic ◽  
Rastko Zivic ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Nodes ◽  
Total Thyroidectomy ◽  
Nerve Palsy ◽  
Radioiodine Therapy ◽  
Surgical Excision ◽  
Thyroid Tumors ◽  
Primary Tumors ◽  
Postoperative Hypoparathyroidism ◽  
Second Procedure

Recurrent thyroid tumors are much less frequent but more aggressive than primary tumors. The aim is to find out their characteristics, aggressiveness and the possibility of radical surgical excision as well as the frequency of complications. Method and material: retrospective study on 69 patients operated for recurrent thyroid tumors. Results: Recurrent tumors were found in 42 patients with papillary, 11 with follicular (8 with Hurthle), 9 with medullary and 7 with anaplastic thyroid tumors. Relapse in thyroid bed on dominant side had 41 patients (59.4%), relapse on the opposite side we found in 19 patients (27.5%) and relapse in lymph nodes outside of thyroid bed in 37 patients (53.6%). In 33/69 patients, the first procedure was incomplete (reduction in 5, partial resection in 19, hemithyroidectomy in 9). The second procedure was incomplete in 14, near total thyroidectomy in 2, total thyroidectomy in 33 and dissection of lymph nodes in 33, among them in 20 with the operation in thyroid bed. Preoperative recurent nerve palsy had 2 patients and transitional recurent nerve palsy occured after second procedure in 2 patients. Among 33 patients after thyroidectomy for recurent tumor, postoperative hypoparathyroidism occured in 8 (24.2%), of whome in 2 permanent (6%). In the group of 54 patients with recurent differentiated thyroid cancer, radioiodine therapy after first operation had received only 7 patients (13%). Conclusion: the main causes of thyroid cancer relapse are incomplete first procedure and agressiveness of cancer. It is not always possible to excise the complete recurrent tumor. After surgery for papillary cancer, radioiodine therapy is seldom used.

Favorable Long Term Results in Patients with Small Differentiated Thyroid Cancer not Treated with Radioiodine

1989 ◽  
Vol 75 (1) ◽  
pp. 57-59 ◽  
Author(s):  
Benedetto Busnardo ◽  
Maria Elisa Girelli ◽  
Domenico Rubello ◽  
Maria Rosa Pelizzo ◽  
Natalino Simioni ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Differentiated Thyroid Cancer ◽  
Radioiodine Therapy ◽  
Stage I ◽  
Long Term Results ◽  
Old Patients ◽  
Very Old Patients

Data on a group of 110 patients with differentiated thyroid cancer not treated by radioiodine are reported. Most of them had intrathyroid (stage I) papillary or capsuled follicular cancer of less than 3 cm diameters. They all received thyroxine at TSH suppressive doses. The follow-up ranged between 4 and 25 years, mean 8.7. No patient died of tumor. Two very old patients died free of disease. Four recurrences occurred, within 8 years, all in patients over 45 years, all local or nodal, all papillary, 3 out of 4 after total thyroidectomy. This study shows that radioiodine therapy may be avoided and that lobectomy may be sufficient in patients under 45 years with small papillary or capsuled follicular cancer.

Ovarian Function after Radioiodine Therapy in Patients with Thyroid Cancer

2005 ◽  
Vol 113 (06) ◽  
pp. 331-333 ◽  
Author(s):  
P. Souza Rosário ◽  
T. Alvarenga Fagundes ◽  
A. Villas-Boas Fagundes ◽  
Á. Barroso ◽  
L. Lamego Rezende ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Ovarian Function ◽  
Radioiodine Therapy

Abstract #1086: Patient Experience with Severe Low Energy Following Total Thyroidectomy for Papillary Thyroid Cancer

2017 ◽  
Vol 23 ◽  
pp. 258
Author(s):  
Elizabeth Wendt ◽  
Maria Bates ◽  
Reese Randle ◽  
Jason Orne ◽  
Cameron Macdonald ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Total Thyroidectomy ◽  
Papillary Thyroid Cancer ◽  
Patient Experience ◽  
Low Energy ◽  
Papillary Thyroid
Sign in / Sign up

Export Citation Format

Share Document