Serological survey for Chagas' disease in school children in the Rio de Janeiro State, Brazil

A serological survey for Chagas' disease was carried out in school children in the Rio de Janeiro State, a zone considered as non-endemic for the infection. A total of 168 schools in 20 municipalities have been visited and 13,254 blood samples were obtained. The blood eluates were screened by the indirect fluorescence test (IFT), and all positive samples were checked and confirmed in sera by the complement fixation test (CFT). AH serologically positive children were subject to a clinical scrutiny, and the houses where the children lived have been searched for triatomine bugs. Only in two municipalities, Magé and Araruama, there was a significant number of children found positive. The total number of reactive samples by IFT and CFT from 13,004 blood samples screened was 143 (1.00 per cent). No serious clinicai symptoms suggestive of Chagas' disease have been found in any of the positive children, and no triatomine bugs were discovered in the dwellings where the children lived. The overall small percentage of children with positive serology postulates that the infection is not a serious health problem in the area investigated. It is recommended, however, to carry out a more detailed study in Magé and Araruama to find the reason for the relatively high percentage of serologically positive children encountered in these two municipalities.

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Additional data on the epidemiology of chagas disease in the municipality of Caxias, Rio de Janeiro state, Brazil

Revista da Sociedade Brasileira de Medicina Tropical ◽

10.1590/s0037-86821975000200005 ◽

1975 ◽

Vol 9 (2) ◽

pp. 83-89 ◽

Cited By ~ 1

Author(s):

J. Rodrigues Coura ◽

Walter B. Petana

Keyword(s):

Chagas Disease ◽

Rio De Janeiro ◽

Additional Data ◽

Serological Test ◽

Triatoma Infestans ◽

Dense Population ◽

Triatomine Bugs ◽

Sanitary Conditions ◽

Janeiro State ◽

Epidemiological Information

An area believed to be an autochthonous focus for Chagas' disease was investigated in the municipality of Caxias, Rio de Janeiro State. The study included search for domestic triatomine bugs, serological test (IFT and CFT) in persons in whose house infested bugs were discovered, detailed clinicai examination and xenodiagnosis test of ali serologicall/ yy positive persons, and xenodiagnosis test on dogs from households in which infected triatomine bugs have been found. Only in one of the locatities (Piranema) domestic Triatoma infestans have been discovered. some of which were infected with T. cruzi. A small number of persons (mostly children) had a positive serologicál test for Chagas’ disease, but in all of them the infection was clinically asymptomatic. From two dogs, belonging to a household in which serologically positive children and infected T. infestans were discovered, T. cruzi was isolated by xenodiagnosis. The importunt epidemiological information obtained from this investigation was the discovery of domestic adaptation of T. infestans in an area with dense population .and with very low social and sanitary conditions, in a locality considered as non-endemic for the infection.

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FIRST REPORT OF ACUTE CHAGAS DISEASE BY VECTOR TRANSMISSION IN RIO DE JANEIRO STATE, BRAZIL

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652015000400017 ◽

2015 ◽

Vol 57 (4) ◽

pp. 361-364 ◽

Cited By ~ 2

Author(s):

Luiz Henrique Conde SANGENIS ◽

Andréa Silvestre DE SOUSA ◽

Gilberto Marcelo SPERANDIO DA SILVA ◽

Sérgio Salles XAVIER ◽

Carolina Romero Cardoso MACHADO ◽

...

Keyword(s):

Case Report ◽

Chagas Disease ◽

Rio De Janeiro ◽

Skin Lesions ◽

Vector Transmission ◽

Left Wrist ◽

Triatomine Bugs ◽

Means Of Transmission ◽

Acute Chagas Disease ◽

Janeiro State

SUMMARY Chagas disease (CD) is an endemic anthropozoonosis from Latin America of which the main means of transmission is the contact of skin lesions or mucosa with the feces of triatomine bugs infected by Trypanosoma cruzi. In this article, we describe the first acute CD case acquired by vector transmission in the Rio de Janeiro State and confirmed by parasitological, serological and PCR tests. The patient presented acute cardiomyopathy and pericardial effusion without cardiac tamponade. Together with fever and malaise, a 3 cm wide erythematous, non-pruritic, papule compatible with a "chagoma" was found on his left wrist. This case report draws attention to the possible transmission of CD by non-domiciled native vectors in non-endemic areas. Therefore, acute CD should be included in the diagnostic workout of febrile diseases and acute myopericarditis in Rio de Janeiro.

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Autochthonous transmission of Chagas disease in Rio de Janeiro State, Brazil: a clinical and eco-epidemiological study

BMC Infectious Diseases ◽

10.1186/s12879-014-0732-8 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 11

Author(s):

Luiz Henrique Conde Sangenis ◽

Roberto Magalhães Saraiva ◽

Ingebourg Georg ◽

Liane de Castro ◽

Valdirene dos Santos Lima ◽

...

Keyword(s):

Epidemiological Study ◽

Chagas Disease ◽

Rio De Janeiro ◽

Autochthonous Transmission ◽

Janeiro State

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Serological survey of cases of canine visceral leishmaniasis and evaluation of phlebotomine fauna on Marambaia Island, municipality of Mangaratiba, Rio de Janeiro state, Brazil

Revista Brasileira de Ciência Veterinária ◽

10.4322/rbcv.2015.304 ◽

2014 ◽

Vol 21 (4) ◽

pp. 247-251

Author(s):

Livia Aparecida Lopes do Carmo ◽

Marcos Barbosa de Souza ◽

Valmir Laurentino da Silva ◽

Fernanda Nunes Santos ◽

Adilson Benedito de Almeida ◽

...

Keyword(s):

Visceral Leishmaniasis ◽

Rio De Janeiro ◽

Canine Visceral Leishmaniasis ◽

Serological Survey ◽

Marambaia Island ◽

Janeiro State

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Chagas' disease in the Brazilian Amazon: III. a cross-sectional sutdy

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46651995000500006 ◽

1995 ◽

Vol 37 (5) ◽

pp. 415-420 ◽

Cited By ~ 19

Author(s):

José Rodrigues Coura ◽

Henry Percy Faraco Willcox ◽

Margarita Arboleda Naranjo ◽

Octavio Fernandes ◽

Daurita Darci de Paiva

Keyword(s):

Chagas Disease ◽

Rural Areas ◽

Brazilian Amazon ◽

Positive Serology ◽

Cross Sectional ◽

Blood Samples ◽

Rio Negro ◽

The Right ◽

The Town ◽

Indirect Immunofluorescent

Two serological surveys for Chagas' infection were carried out, in 1991 and 1993, respectively, using a conglomerate family samples from the residents in the town of Barcelos (in the northern part of the State of Amazonas, on the right bank of the Rio Negro, 490 Km up-river from Manaus), using indirect immunofluorescent tests for anti-T. cruzi antibodies. In the first survey (1991), 628 blood samples from the residents of 142 dwellings were tested, showing positive in 12.7% for anti-T. cruzi antibodies and in 1993 an other 658 samples from residents of 171 dwellings showed positive in 13.7% of the tests, thus confirming the previous results. From 170 individuals with positive serology for T. cruzi antibodies, 112 (66%) were interviewed and submitted to electrocardiographic and clinical examinations; 82 (73.2%) of them gave consent for xenodiagnosis. From the 112 interviewed 52 (46.4%) recognized the triatomines as "piaçavas' lice", 48 (42.8%) knew the bugs from their work places being gatherers of piaçava fibers in rural areas and 19 (16.9%) said that have been bitten by bugs in their huts. Only 2 (2.4%) of 82 xenodiagnosis applied were positive for T. cruzi and 9 (8%) of the ECG had alterations compatible with Chagas' disease.

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Elevated Pediatric Chagas Disease Burden Complicated by Concomitant Intestinal Parasites and Malnutrition in El Salvador

Tropical Medicine and Infectious Disease ◽

10.3390/tropicalmed6020072 ◽

2021 ◽

Vol 6 (2) ◽

pp. 72

Author(s):

Melissa S. Nolan ◽

Kristy O. Murray ◽

Rojelio Mejia ◽

Peter J. Hotez ◽

Maria Jose Villar Mondragon ◽

...

Keyword(s):

El Salvador ◽

Chagas Disease ◽

Intestinal Parasites ◽

Case Reports ◽

Clinical Care ◽

Parasitic Infection ◽

Positive Serology ◽

Cross Sectional ◽

Number Of Children ◽

Disease Case

The eradication of the vector Rhodnius prolixus from Central America was heralded as a victory for controlling transmission of Trypanosoma cruzi, the parasite that causes Chagas disease. While public health officials believed this milestone achievement would effectively eliminate Chagas disease, case reports of acute vector transmission began amassing within a few years. This investigation employed a cross-sectional serosurvey of children either presenting with fever for clinical care or children living in homes with known triatomine presence in the state of Sonsonate, El Salvador. Over the 2018 calendar year, a 2.3% Chagas disease seroprevalence among children with hotspot clustering in Nahuizalco was identified. Positive serology was significantly associated with dogs in the home, older participant age, and a higher number of children in the home by multivariate regression. Concomitant intestinal parasitic infection was noted in a subset of studied children; 60% having at least one intestinal parasite and 15% having two or more concomitant infections. Concomitant parasitic infection was statistically associated with an overall higher parasitic load detected in stool by qPCR. Lastly, a four-fold higher burden of stunting was identified in the cohort compared to the national average, with four-fifths of mothers reporting severe food insecurity. This study highlights that polyparasitism is common, and a systems-based approach is warranted when treating Chagas disease seropositive children.

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Congenital Chagas disease of second generation in Santiago, Chile. Report of two cases

Revista do Instituto de Medicina Tropical de São Paulo ◽

10.1590/s0036-46652001000400011 ◽

2001 ◽

Vol 43 (4) ◽

pp. 231-232 ◽

Cited By ~ 19

Author(s):

Hugo SCHENONE ◽

María GAGGERO ◽

Jorge SAPUNAR ◽

María del C. CONTRERAS ◽

Antonio ROJAS

Keyword(s):

Latin America ◽

Chagas Disease ◽

Second Generation ◽

Fatal Case ◽

Urban Residents ◽

Blood Transfusions ◽

Positive Serology ◽

Triatomine Bugs ◽

The City ◽

Spleen Enlargement

Congenital Chagas disease (CChD) has been reported in different countries, mostly in Latin America. In 1987 a fatal case of CChD of second generation (CChDSG) was published. Within a period of six months - 1989-1990 - two cases of CChDSG were diagnosed and studied in the city of Santiago. Two premature newborns, sons of two sisters, with moderate liver and spleen enlargement, were found to have positive serology for Chagas disease and xenodiagnoses. The mothers, urban residents all their lives, without antecedents of triatomine bugs contact or blood transfusions, showed positive serology and xenodiagnoses. Their mother (grandmother of the infants), lived 20 years in a Northern rural Chagas disease endemic locality, in a triatomine infested house. Afterwards, she moved to Santiago, where she married and has resided up to now. Serology and xenodiagnoses were also positive. All the Trypanosoma cruzi infected individuals were successfully treated with nifurtimox.

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