Sir William Osler: founder of Anglo-American Scientific Clinical Medicine and its teaching

2005 ◽  
Vol 54 (2) ◽  
Author(s):  
EMM Besterman
2020 ◽  
pp. 096777202096097
Author(s):  
John Pearn

In 1912, the Guy’s Hospital Assistant Physician, Dr Herbert French FRCP, published a magnum opus, An Index of Differential Diagnosis of Main Symptoms by Various Authors. This pioneering work was to formalise the paradigm of a six-chain sequence which underpins best-practice clinical medicine today. That chain comprises: taking a history, examination, compiling a differential diagnosis, tests and investigations, and formulating a diagnosis. Herbert French coined the term “differential diagnosis”; and formalised the earlier developments of Thomas Sydenham (1624 – 1689), Hermann Boerhaave (1668 – 1738) and later(1892), those of Sir William Osler in his The Principles and Practice of Medicine. French placed differential diagnosis formally as the pivot of the sequence of Oslerian medicine which distinguishes modern Western medicine from other healthcare systems. Herbert French was the Goulstonian Lecturer of the Royal College of Physicians (1907), a doctor-soldier in World War I and one of the Royal Physicians to H. M. Household. A prolific writer in the medical press, French updated and personally edited the first six editions of his Differential Diagnosis. The thirteenth edition (1996) was described as a work which “had no parallel” .This work, today in its sixteenth edition, remains “a reference unique in medical literature”.


2018 ◽  
Vol 60 (1) ◽  
pp. 50
Author(s):  
Chris Ellis

In his book Equanimitas, written in 1904, Sir William Osler laments that very few doctors go into public life to help advise and manage the delivery of health care. “As a rule,” he says “doctors make bad citizens taking little or no interest in civic, state or national politics”. Most of us do not like leaving the comfort zone of clinical medicine and entering the more robust arena of medical politics.


Author(s):  
Sarah A. Luse

In the mid-nineteenth century Virchow revolutionized pathology by introduction of the concept of “cellular pathology”. Today, a century later, this term has increasing significance in health and disease. We now are in the beginning of a new era in pathology, one which might well be termed “organelle pathology” or “subcellular pathology”. The impact of lysosomal diseases on clinical medicine exemplifies this role of pathology of organelles in elucidation of disease today.Another aspect of cell organelles of prime importance is their pathologic alteration by drugs, toxins, hormones and malnutrition. The sensitivity of cell organelles to minute alterations in their environment offers an accurate evaluation of the site of action of drugs in the study of both function and toxicity. Examples of mitochondrial lesions include the effect of DDD on the adrenal cortex, riboflavin deficiency on liver cells, elevated blood ammonia on the neuron and some 8-aminoquinolines on myocardium.


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