scholarly journals Morphology of autogenous bone graft and castor oil polyurethane in the infraorbital rim of rabbits: a comparative study

2006 ◽  
Vol 21 (5) ◽  
pp. 341-347 ◽  
Author(s):  
José Carlos Garcia de Mendonça ◽  
Rafael De Rossi ◽  
Celso Massaschi Inouye ◽  
Diego Rodrigo Paulillo Bazan ◽  
João Carlos Castro Monteiro ◽  
...  
Keyword(s):  
Bone Graft ◽  
Castor Oil ◽  
Bone Repair ◽  
Bone Defects ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Control Group ◽  
Cell Nuclei ◽  
Zygomatic Bone ◽  
Chi Squared

PURPOSE: Morphological study comparing castor oil polyurethane and autogenous bone graft to repair bone defect in zygomatic bone of rabbits. METHODS: Twenty-four adult, male New Zealand rabbits were randomly distributed between two groups of twelve. Bone defects of 5mm in diameter were cut through the zygomatic bone and filled with polyurethane discs in the experimental group or autogenous bone harvested from the tibia in the control group. Animals were sacrificed after 30, 60 or 90 days, and the zygomatic bones were macro- and microscopically analyzed. Student's, Fisher's, chi-squared and McNemar's tests were used for statistical analysis. RESULTS: Both the castor oil polyurethane and the autograft adapted well to the defect, with no need for fixation. Fibrous connective tissue encapsulated the polyurethane, but no inflammation or giant cell reaction was observed. Acidophilic and basophilic areas were observed inside the micropores of the polyurethane, suggesting cell nuclei. After 90 days, bone repair with a lamellar pattern of organization was observed in the control group. CONCLUSION: The castor oil polyurethane was biocompatible and did not cause inflammation. It may be considered an alternative to fill bone defects.

scholarly journals Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft

2010 ◽  
Vol 6 (1) ◽  
Author(s):  
Edela Puricelli ◽  
Adriana Corsetti ◽  
Deise Ponzoni ◽  
Gustavo L. Martins ◽  
Mauro G. Leite ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Calcium Phosphate Cement ◽  
Bone Repair ◽  
Rat Femur ◽  
Autogenous Bone Graft ◽  
Autogenous Bone

Repair of Cranial Bone Defects With Calcium Phosphate Ceramic Implant or Autogenous Bone Graft

2007 ◽  
Vol 18 (2) ◽  
pp. 281-286 ◽  
Author(s):  
Rosane Vieira da Silva ◽  
Celso Aparecido Bertran ◽  
Elizabete Yoshie Kawachi ◽  
Jos?? Angelo Camilli
Keyword(s):  
Calcium Phosphate ◽  
Bone Graft ◽  
Bone Defects ◽  
Cranial Bone ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Implant

Autogenous Bone Graft Associated With Enamel Matrix Proteins in Bone Repair

2007 ◽  
Vol 16 (4) ◽  
pp. 413-420 ◽  
Author(s):  
Celina A. Prata ◽  
Suzie A. Lacerda ◽  
Luiz Guilherme Brentegani
Keyword(s):  
Bone Graft ◽  
Bone Repair ◽  
Matrix Proteins ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Enamel Matrix ◽  
Enamel Matrix Proteins

scholarly journals Microcomputed Tomography and Histological Study of Bone Regeneration Using Tooth Biomaterial with BMP-2 in Rabbit Calvarial Defects

Scanning ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Puneet Wadhwa ◽  
Jeong Hun Lee ◽  
Bing Cheng Zhao ◽  
HongXin Cai ◽  
Jae-Suk Rim ◽  
...  
Keyword(s):  
Bone Graft ◽  
Bone Regeneration ◽  
Histological Study ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Control Group ◽  
Block Type ◽  
Graft Material ◽  
Synthetic Bone ◽  
Ct Analysis

Our study was aimed to analyze the osteoinductive effect of powdered and block type autogenous bone graft along with bone morphogenetic protein (BMP-2) as compared to synthetic bone graft. Three circular bicortical defects were made in the calvaria of each rabbit and randomly divided into three groups as follows: powdered tooth biomaterial+BMP-2, block tooth biomaterial+BMP-2, and control group: synthetic bone+BMP-2. The samples taken from these defects after 4 and 8 weeks were analyzed histologically along with micro CT analysis. In our study, both powered and block type tooth autogenous bone graft successfully stimulated mesenchymal cells leading to endochondral ossification and bone regeneration. We observed that the powered bone graft material which is acid insoluble especially is preferable as a carrier for BMP-2.

Utilization of Ethyl Cyanoacrylate and 2-Octyl Cyanoacrylate Adhesives for Autogenous Bone Graft Fixation: Histomorphometric Study in Rats

2014 ◽  
Vol 40 (4) ◽  
pp. 411-417 ◽  
Author(s):  
Jônatas Caldeira Esteves ◽  
Jônatas Mattos Monteiro ◽  
Alessandra Marcondes Aranega ◽  
Walter Betoni Junior ◽  
Celso Koogi Sonoda
Keyword(s):  
Bone Graft ◽  
Inflammatory Infiltrate ◽  
Parietal Bone ◽  
Graft Fixation ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
Control Group ◽  
Bone Fragment ◽  
Recipient Site ◽  
Ethyl Cyanoacrylate

The present study analyzes the repair process of autogenous bone graft in a block fixed with ethyl cyanoacrylate and 2-octyl cyanoacrylate adhesives in rat calvaria. Forty-eight rats, divided into 3 groups, received round osteotomies at the right parietal bone for the attainment of autogenous bone graft fragment, which was fixed at the opposite side to the donor site with ethyl cyanoacrylate (ethyl group) and 2-octyl cyanoacrylate (octyl group) adhesives. In the control group, bone fragment was only juxtaposed at the parietal bone surface without any fixation material. The animals were euthanized after 10 and 60 postoperative days. The calvariae were processed in a laboratory for the attainment of slides stained through the hematoxylin and eosin technique for histological and histometric analysis. The qualitative analysis showed a discrete inflammatory infiltrate in the control group and moderate inflammatory infiltrate in the ethyl and octyl groups at the 10-day period, which remained at the 60-day period, mainly in the octyl group. The bone fragment remained bonded to the recipient site through the adhesive, but graft incorporation was not observed in any of the specimens. Resorption was higher in the octyl group followed by the ethyl and control groups, both at the 10- and 60-day periods, but with no statistical significance (P < .05). Although promoting graft fixation and its maintenance at the recipient site, both studied adhesives did not allow the graft incorporation, producing a localized and discrete inflammatory reaction, which persisted at 60 days, being more intense in the octyl cyanoacrylate group.

scholarly journals Evaluation of Amniotic-Derived Membrane Biomaterial as an Adjunct for Repair of Critical Sized Bone Defects

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Mikael Starecki ◽  
John A. Schwartz ◽  
Daniel A. Grande
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Critical Size ◽  
Bone Defects ◽  
Autogenous Bone Graft ◽  
Autogenous Bone ◽  
New Bone Formation ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Introduction. Autogenous bone graft is the gold standard in reconstruction of bone defects. The use of autogenous bone graft is problematic because of limited bone as well as donor site morbidity. This study evaluates a novel biomaterial as an alternative to autogenous bone graft. The biomaterial is amniotic membrane, rich in growth factors. Methods. Twenty-one adult male Sprague-Dawley rats were implanted with biomaterial using the rat critical size femoral gap model. After creation of the critical size femoral gap animals were randomized to one of the following groups: Group 1 (control): gap left empty and received no treatment; Group 2 (experimental): the gap was filled with commercially available bone graft; Group 3 (experimental): the gap was filled with bone graft plus NuCel amniotic tissue preparation. Results. The experimental groups demonstrated new bone formation compared to controls. The results were evident on radiographs and histology. Histology showed Group 1 controls to have 11.1% new bone formation, 37.8% for Group 2, and 49.2% for Group 3. These results were statistically significant. Conclusions. The study demonstrates that amniotic membrane products have potential to provide bridging of bone defects. Filling bone defects without harvesting autogenous bone would provide a significant improvement in patient care.

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