The lactase persistence genotype is a protective factor for the metabolic syndrome

The aim of the current study was to analyse the food choices and physical activity of obese adult Estonian persons, and associations with the prevalence of metabolic syndrome. The study was carried out on 76 patients aged over 35 years whose body mass index was ≥30 kg/m2. The subjects were recruited through family physicians. The subjects’ consumption of three food groups (fruit, vegetables, whole-grain products) and physical activity based on the IPAQ questionnaire was compared with the prevalence of metabolic syndrome based on five indicators (waist circumference, triglycerides, HDL- cholesterol and fasting plasma glucose, blood pressure). The prevalence of metabolic syndrome was found to be 50%. The results of the study did not show statistically significant correlations between prevalence of metabolic syndrome and age or gender. Neither were there any significant age or gender differences in the subjects’ nutritional and activity behaviour. Comparison of the nutritional behaviour of persons with and without the metabolic syndrome showed that daily consumers of fruit had a 4.48 times lower risk of metabolic syndrome than those who ate fruit more seldom. No statistically significant correlation was found between physical activity and prevalence of metabolic syndrome. Based on the current study, the daily consumption of fruit can be an essential protective factor against metabolic syndrome in obese patients and provides a simple recommendation physicians can give their patients to follow.

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Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang

10.21203/rs.2.24086/v1 ◽

2020 ◽

Author(s):

Hao Hao ◽

Heng Guo ◽

Ru-lin Ma ◽

Yi-zhong Yan ◽

Yun-hua Hu ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Protective Factor ◽

Total Bilirubin ◽

Incidence Density ◽

Cox Regression Analysis ◽

Indirect Bilirubin ◽

The Metabolic Syndrome ◽

High Level

Abstract Background: Some studies have shown that a high level of bilirubin is a protective factor against the metabolic syndrome (MS), while a high level of transaminase is a risk factor for the MS. However, the results are inconsistent, and there are few cohort studies.Methods: Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The serum bilirubin and transaminase levels of the subjects were divided into quartiles, and their relationships with MS and its components were analyzed. The definition of metabolic syndrome was based on the Joint Interim Statement (JIS) diagnostic criteria.Results: The average follow-up time for the subjects was 5.72 years. 204 subjects had MS, the cumulative incidence was 36.11%, and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS. Compared to the lowest quartile level (Q1), the hazard ratios of MS for levels of TBIL at the Q2-Q4 quartile were: 0.408 (0.266-0.626), 0.374 (0.244-0.572), and 0.328 (0.216-0.500) while IBIL at Q2-Q4 level showed an MS hazard ratio of 0.572 (0.374-0.875), 0.432 (0.283-0.659), 0.434 (0.289-0.653), all at a 95% confidence level. In addition, TBIL and IBIL levels were negatively correlated with increased blood pressure, waist circumference, and triglyceride levels, and their highest TBIL quartile risk (Q4) was 0.479, 0.484, and 0.498 times higher than the lowest quartile (Q1).Conclusion: Serum TBIL and IBIL levels were negatively correlated with MS and its components (blood pressure, waist circumference and triglycerides).

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Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang

10.21203/rs.3.rs-19870/v1 ◽

2020 ◽

Author(s):

Hao Hao ◽

Heng Guo ◽

Ru-lin Ma ◽

Yi-zhong Yan ◽

Yun-hua Hu ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Protective Factor ◽

Total Bilirubin ◽

Incidence Density ◽

Cox Regression Analysis ◽

Indirect Bilirubin ◽

The Metabolic Syndrome ◽

High Level

Abstract Background Some studies have shown that a high level of bilirubin is a protective factor against the metabolic syndrome (MS), while a high level of transaminase is a risk factor for the MS. However, the results are inconsistent, and there are few cohort studies.Methods Using an ambispective cohort study, 565 Kazakhs from Xinjiang, China were selected as the study subjects. The serum bilirubin and transaminase levels of the subjects were divided into quartiles, and their relationships with MS and its components were analyzed. The definition of metabolic syndrome was based on the Joint Interim Statement (JIS) diagnostic criteria.Results The average follow-up time for the subjects was 5.72 years. 204 subjects had MS, the cumulative incidence was 36.11%, and the incidence density was 63.10/1000 person-years. Multivariate Cox regression analysis showed that the levels of total bilirubin (TBIL) and indirect bilirubin (IBIL) were negatively correlated with the occurrence of MS. Compared to the lowest quartile level (Q1), the hazard ratios of MS for levels of TBIL at the Q2-Q4 quartile were: 0.408 (0.266-0.626), 0.374 (0.244-0.572), and 0.328 (0.216-0.500) while IBIL at Q2-Q4 level showed an MS hazard ratio of 0.572 (0.374-0.875), 0.432 (0.283-0.659), 0.434 (0.289-0.653), all at a 95% confidence level. In addition, TBIL and IBIL levels were negatively correlated with increased blood pressure, waist circumference, and triglyceride levels, and their highest TBIL quartile risk (Q4) was 0.479, 0.484, and 0.498 times higher than the lowest quartile (Q1).Conclusion Serum TBIL and IBIL levels were negatively correlated with MS and its components (blood pressure, waist circumference and triglycerides).

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Adipokines and Sexual Hormones Associated with the Components of the Metabolic Syndrome in Pharmacologically Untreated Subjects: Data from the Brisighella Heart Study

International Journal of Endocrinology ◽

10.1155/2011/724816 ◽

2011 ◽

Vol 2011 ◽

pp. 1-6 ◽

Cited By ~ 7

Author(s):

Arrigo F. G. Cicero ◽

Paolo Magni ◽

Massimo Moré ◽

Massimiliano Ruscica ◽

Elena Dozio ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Body Mass Index ◽

Protective Factor ◽

Plasma Lipids ◽

Sexual Hormones ◽

Men And Women ◽

The Metabolic Syndrome ◽

Heart Study ◽

Main Factor

We evaluated the association of the sex hormone pattern and the serum level of the main adipokines to metabolic syndrome (MS) and its components in 199 pharmacologically untreated subjects. Men and women included in the age-class subgroups were matched for body mass index, waist circumference, blood pressure, heart rate, fasting plasma glucose, and plasma lipids. Men without MS had significantly lower leptin/adiponectin ratio than men with MS. Women without MS had lower leptin and leptin/adiponectin ratio than women with MS but had significantly higher adiponectin, estrone, and dehydroepiandrosterone levels. In men, the leptin/adiponectin ratio is the main factor associated to MS diagnosis (OR: 3.36, 95% CI 1.40–8.08), while in women adiponectin alone appears to be a protective factor (OR: 0.87, 95% CI 0.79–0.95). In conclusion, in a sample of pharmacologically untreated subjects, leptin/adiponectin ratio seems to be the factor more strongly associated to MS and its components.

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Aptidão cardiorrespiratória e os componentes da síndrome metabólica em homens adultos com idade entre 45 e 55 anos

Revista de Educação Física / Journal of Physical Education ◽

10.37310/ref.v85i4.24 ◽

2016 ◽

Vol 85 (4) ◽

Author(s):

Eduardo Camilo Martinez ◽

Fabiane de Sousa Borges Rudolph

Keyword(s):

Metabolic Syndrome ◽

Waist Circumference ◽

Cardiorespiratory Fitness ◽

Protective Factor ◽

Serum Triglyceride ◽

Inverse Correlation ◽

Adult Males ◽

The Metabolic Syndrome ◽

Sindrome Metabolica ◽

Increased Risk

Introdução: A Síndrome Metabólica (SM), que atinge cerca de 30% dos adultos brasileiros, vem sendo associada ao risco aumentado de doenças cardiovasculares e diabetes. O treinamento de condicionamento cardiorrespiratório tem mostrado relação protetora sobre a dislipidemia, resistência à insulina e hipertensão arterial, além de contribuir para elevar o colesterol HDL e para diminuir a gordura corporal.Objetivo: Avaliar o efeito do treinamento de condicionamento cardiorrespiratório sobre a aptidão cardiorrespiratória e a associação desta com os componentes da SM em militares homens com idade entre 45 e 55 anos.Métodos: Estudo observacional longitudinal, com amostra composta por 35 militares da ativa do Exército Brasileiro (EB), do sexo masculino. Procedeu-se a duas avaliações, com intervalo de quatro meses entre elas. Foram realizados exames bioquímicos, antropométricos, físicos e clínicos. Após a primeira avaliação, os participantes receberam um relatório sobre a situação geral de cada um e um plano de treinamento físico individual. Os participantes foram estimulados a realizar o treinamento, sem controle da execução.RESULTADOS: A amostra apresentou idade de 48,99 ± 2,27 (média ± desvio-padrão) anos, massa corporal de 80,09 ± 10,51 kg, estatura de 174,89 ± 7,31 cm, perímetro de cintura de 93,55 ± 8,11 cm e IMC de 26,19 ± 2,91 kg.m-2. O treinamento de condicionamento cardiorrespiratório desenvolvido de forma livre durante o período de quatro meses não foi suficiente para aumentar a aptidão cardiorrespiratória (média do VO2máx) nem alterar os níveis de triglicerídeos, glicemia, HDL ou perímetro da cintura. No entanto, os dados apresentam correlação inversa entre a variação do VO2máx e dos níveis séricos de triglicerídeos e direta com a alteração dos níveis de HDL circulantes (HDL-c).Conclusão: A correlação positiva da aptidão cardiorrespiratória com os níveis de HDL-c e negativa com os níveis séricos de triglicerídeos, evidenciam a importância do estímulo à pratica de atividade física para a prevenção e controle dos componentes da síndrome metabólica.Cardiorespiratory fitness and components of the metabolic syndrome in adult males aged 45 to 55 yearsIntroduction:Metabolic Syndrome (MS) affects about 30% of Brazilian adults. It is associated with an increased risk of cardiovascular diseases and diabetes. Cardiorespiratory conditioning training has shown to be a protective factor to Objective: To evaluate the effect of cardiorespiratory conditioning training and the correlation between cardiorespiratory fitness and Metabolic Syndrome components in military personnel aged between 45 and 55 years.Methods: A longitudinal observational study was carried out with a sample comprised of 35 military men from the Brazilian Army (EB). They were submitted to two evaluations, with an interval of four months. Biochemical, anthropometric, physical and clinical examinations were used. After the first evaluation, the participants received a report on the overall situation of each and an individual physical training plan. Participants and were encouraged to perform the training, even without control of the execution.Results: The sample presented age of 48.99 ± 2.27 (mean ± standard deviation) years, body mass of 80.09 ± 10.51 kg, height of 174.89 ± 7.31 cm, waist circumference of 93.55 ± 8.11 cm and BMI of 26.19 ± 2.91 kg.m-2. Cardiorespiratory fitness training developed over a four-month period was not sufficient to increase cardiorespiratory fitness (mean VO2máx) or to alter triglyceride levels, blood glucose, HDL or waist circumference. However, the data present an inverse correlation between VO2máx and serum triglyceride levels and direct changes in circulating HDL-C (HDL-C) levels.Conclusion: The positive correlation of the cardiorespiratory fitness with the levels of HDL-c and negative with the serum levels of triglycerides evidence the importance of the stimulus to the practice of physical activity for the prevention and control of the components of the metabolic syndrome.

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