scholarly journals Donation of oocytes as treatment for infertility in patients with premature ovarian failure: awarded the "Nicolau de Moraes Barros" prize for gynecology

1994 ◽  
Vol 112 (1) ◽  
pp. 510-516 ◽  
Author(s):  
José Gonçalves Franco Júnior ◽  
Ricardo Luiz Razera Baruffi ◽  
Ana Lúcia Mauri ◽  
Cláudia Guilhermino Pertersen ◽  
Márcia Siste Campos ◽  
...  
Keyword(s):  
Premature Ovarian Failure ◽  
Clomiphene Citrate ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Oocyte Donation ◽  
Ovarian Failure ◽  
Cleavage Rate ◽  
Brazilian Literature ◽  
Human Menopausal Gonadotrophin ◽  
Embryo Implantation Rate

A total of 7 cycles of embryo transfer by oocyte donation were performed on 5 patients with premature ovary failure (POF). All donors were under 35 of age and the recipients average age was 38.6 years. For synchronization between donor and recipient a semi programmed menstrual cycle was used by means of oral contraceptive followed by ovarian stimulation of donor with clomiphene citrate and human menopausal gonadotrophin. The recipients were easily adjusted to the donors by a flexible model of gradually increasing doses of estradiol valerianate. The average number of oocytes donated was 3.14 and average embryo cleavage rate was 80.2%. The average number of embryos transferred was 2.57. Embryo implantation rate was 22.2%. Clinical gestations occurred in 57.1% of the cycles. This series is probably the first one in Brazilian literature on oocyte donation as treatment for infertility in patients with premature ovarian failure.

P–329 Müllerian anomalies and embryo implantation in oocyte donation

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
E Muño. Muñoz ◽  
I Fernandez ◽  
M Cerrillo ◽  
J Aguilar ◽  
A Pellicer ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Oocyte Donation ◽  
Miscarriage Rate ◽  
Ongoing Pregnancy Rate ◽  
Septate Uterus ◽  
Unicornuate Uterus ◽  
Biochemical Pregnancy ◽  
Embryo Implantation Rate

Abstract Study question Do patients with Mullerian anomalies (MA) who receive donated oocytes have different embryo implantation rate than patients with normal uterus? Summary answer In oocyte donation, patients with MA had lower implantation rate than patients with normal uterus. What is known already MA are associated with infertility and miscarriage but the mechanisms to explain this relation are not known. Some studies describe both oocyte and/or uterine factor. All studies describing the outcome in patients with MA, so far, are with own oocytes but none in oocyte donation. Study design, size, duration A multicentre restrospective cohort study from January 2000 to December 2019. Patients receiving donated oocytes were divided between those with MA (n = 473) according ESHRE classification and other group with normal uterus (n = 57 869). The primary outcome was implantation rate at fresh embryo transfer. Secondary aims were biochemical pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, miscarriage rate and live pregnancy rate. Participants/materials, setting, methods We considered the first oocyte donation cycle, without severe male factor, myomas, hydrosalpinx, Asherman syndrome, polyps or indication for preimplantational genetic diagnosis divided in two groups; patients with MA and no malformed uterus. MA group includes cycles of complete bicorporeal uterus (162), partial bicorporeal (30), bicorporeal septate (15), T shaped uterus (26), infantilis uterus (8), complete septate uterus (110), partial septate uterus (94) and hemi-uterus without rudimentary cavity (29). Main results and the role of chance We registered 58 342 patients from our oocyte donation program. Results are shown as mean and 95%CI and differences in pregnancy rates were expressed as relative risks (RR) with 95% CI being reference patients with normal uterus. In patients with MA, the implantation rate was different according the categories being significantly lower in patients with unicornuate uterus (0.29 95%CI: 0.14–0.43. p = 0.03). Biochemical pregnancy rate was significantly higher in patients with septate uterus (RR 1.51 (95%CI 1.02–2.22, p = 0.03) and significantly lower in unicornuate uterus (RR 0.49 (95%CI 0.27–0.90). No differences were found in clinical pregnancy rate among groups, but ongoing pregnancy rate and live birth rate were lower in unicornuate uterus ( RR 0.28 (95%CI 0.13–0.63, p = 0.002), (RR 0.32 (95%CI 0.14–0.73, p = 0.007) respectively. Miscarriage rate was significantly higher in patients with septate uterus (RR 1.78 (95%CI 1.18–2.68, p = 0.006) Limitations, reasons for caution As this was a retrospective cohort study, we were unable to study differences due to modifications in medical or laboratory protocols during this long period time. Different size of sample in some groups of MA makes impossible to translate conclusions to general population. Wider implications of the findings: Our results indicate that there might be a defect in the embryo implantation rate in patients with MA depending on uterine factor. Different sample size among groups and some groups with scarce number of cases make less precise results. More studies controlling biases are needed to confirm our results. Trial registration number NCT04571671

Implantation: Oocyte donation in humans: a model to study the effect of age on embryo implantation rate

1994 ◽  
Vol 9 (11) ◽  
pp. 2160-2163 ◽  
Author(s):  
Jose P. Balmaceda ◽  
Luca Bernardini ◽  
Italo Ciuffardi ◽  
Carlos Felix ◽  
Teri Ord ◽  
...  
Keyword(s):  
Embryo Implantation ◽  
Implantation Rate ◽  
Oocyte Donation ◽  
Effect Of Age ◽  
Embryo Implantation Rate

P–315 Ultrasound diagnosis of adenomyosis: impact on pregnancy rate in ivf cycles with donated oocytes

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
C Exacoustos ◽  
L Loiudice ◽  
M Cosentino ◽  
D Galliano ◽  
F G Martire ◽  
...  
Keyword(s):  
Pregnancy Rate ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
First Trimester ◽  
Oocyte Donation ◽  
Control Group ◽  
Miscarriage Rate ◽  
Increased Risk ◽  
The Impact ◽  
Embryo Implantation Rate

Abstract Study question The aim was to evaluate in patients who underwent embryo transfer (ET) in an oocyte donation cycle, the impact of adenomyosis, diagnosed by transvaginal sonographic (TVS), on the implantation rate. Summary answer We observed a slightly higher miscarriage rate in the first trimester in patients with adenomyosis in particular in the diffuse type. What is known already What we know from literature is that there are pro studies such as Costello and Vercellini’s which show a reduced pregnancy rate and birth rate, and cons studies which find no effects at all of adenomyosis on IVF treatments. However, both show an increased risk of miscarriage and obstetric complications Study design, size, duration This prospective observational study involved a total of 72 patients: 33 with adenomyosis and 39 without adenomyosis from June 2019 to December 2020. All had a workup which included history, pelvic exam and 2/3D TVS scan which was saved as images, videoclips and volumes and stored. The off line evaluation was performed blind to IVF indication and outcomes by expert sonographer, who assessed the presence or absence of TVS signs of adenomyosis. Participants/materials, setting, methods All the patients aged ≤ 45 years old undergoing, for several personal problems, their first oocyte donation at IVI center Rome.Patients were divided into 2 groups according to findings on a baseline pre-treatment TVS: patients with and without adenomyosis. In the patients with adenomyosis, the disease was further classified according to type (diffuse,focal), localization (inner and outer myometrium) and extension inside the uterus (mild, moderate, severe) and correlated to pregnancy rate and outcome Main results and the role of chance A total of 72 patients were included in this study: 33 with adenomyosis and 39 without adenomyosis. The presence, type and degree of adenomyosis doesn’t show a correlation to embryo implantation rate (64.1% in the control group vs 63.6% in adenomyosis group). However we found an increased risk of early miscarriage in the patients with adenomyosis ( 12% in the control group vs 23.8% in adenomyosis group). Women with adenomyosis that infiltrated only the external myometrium showed a lower pregnancy rate (40%) compared to those who had the involvement of only the inner myometrium (77,7%). The presence of ultrasound findings of focal disease was associated with a lower pregnancy rate (53,3%) compared to the diffuse disease (72,2%); We observed a slightly higher miscarriage rate in the first trimester in patients with adenomyosis in particular in the diffuse type .The presence, type and degree of adenomyosis doesn’t show a correlation to embryo implantation rate. Limitations, reasons for caution Most of the patients included in our study has an age > 40. This could determine an increased number of high-risk pregnancies. Wider implications of the findings: Results of this study may be used to evaluate the impact of different medical or surgical treatment in women with adenomyosis undergoing IVF. Trial registration number Not applicable

scholarly journals Tumor necrosis factor-308 polymorphism increases the embryo implantation rate in women undergoing in vitro fertilization

2013 ◽  
Vol 28 (10) ◽  
pp. 2774-2783 ◽  
Author(s):  
F. Vialard ◽  
M. El Sirkasi ◽  
V. Tronchon ◽  
R. Boudjenah ◽  
D. Molina-gomes ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Vitro Fertilization ◽  
Embryo Implantation Rate ◽  
Necrosis Factor

370 BILATERAL DIFFERENTIAL TESTICULAR BIOPSIES IMPROVE TESE AND ICSI OUTCOMES IN NON-OBSTRUCTIVE AND OBSTRUCTIVE AZOOSPERMIC INFERTILE PATIENTS

2007 ◽  
Vol 19 (1) ◽  
pp. 300
Author(s):  
S. M. Al-Ansari ◽  
M. T. Ridha-Albarzanchi ◽  
Z. A. Kanan ◽  
A. A. Al-Badri ◽  
S. K. Al-Atraqchi
Keyword(s):  
Embryo Transfer ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Seminiferous Tubules ◽  
Testicular Sperm Extraction ◽  
Sperm Retrieval ◽  
Cleavage Rate ◽  
Male Patients ◽  
Testicular Size ◽  
Icsi Outcomes

The goal of the present study was to evaluate the clinical significance of bilateral differential testicular biopsies (BDTB) to improve testicular sperm extraction (TESE) and ICSI outcomes in non-obstructive azoospermic (NOA) men. The male patients were divided into an obstructive azoospermic group (OAG, n = 40) and an NOA group (n = 50). The women in both groups had normal ovulatory cycles and reproductive hormone concentrations. BDTB were taken from upper, middle, and lower zones of the testes. At least 50 transverse histologic sections of seminiferous tubules were examined in each biopsy. The FSH, LH, and prolactin concentrations were significantly higher in the NOA group compared to the OAG (18.3 vs. 6.2 mIU mL-1, 8.5 vs. 4.1 mIU mL-1, and 9.6 vs. 6.4 ng mL-1, respectively; P < 0.01), whereas the testosterone level and testicular size were significantly lower in the NOA group vs. the OAG (3.7 vs. 5.3 ng mL-1 and 3.3 vs. 4.4 cm, respectively; P < 0.01). A new method (BDTB) for scoring testicular biopsies was used. This method is different from Johnson's method as SCO or TF or complete MA. Following positive BDTB results, TESE and ICSI were performed. The oocyte recovery rate/patient was 3.8% (154/40) and 3.6% (178/50) in the OAG and the NOA group, respectively (P > 0.05). The TESE-ICSI rates were 75.9% (117/154) in the OAG and 59.5% (106/178) in the NOA group (P < 0.005). The embryo cleavage rate was significantly higher in the OAG compared to the NOA group (98/117 = 83.8% vs. 66/106 = 62.3%, respectively; P < 0.005). The number of embryos transferred/patient in the OAG was significantly higher compared to that in the NOA group (2.5 vs. 1.3, respectively; P < 0.01). The embryo implantation rate per embryo transfer in the OAG was 52% (51/98) vs. 45.5% (30/66); P > 0.05. The clinical pregnancy rate per embryo transfer was 52.5% in the OAG and 40% in the NOA group (P > 0.05). It was concluded from the results of this study that both the BDTB and TESE were useful diagnostic and prognostic predictors of successful sperm retrieval for ICSI treatment in the non-obstructive and obstructive azoospermic male patients. The clinical embryo implantation rates were not significantly different between both groups (NOA group and OAG) which may indicate that the embryos of both groups have similar implantation potentials. Bilateral differential testicular biopsies were found to be positively correlated with the TESE and ICSI outcomes.

scholarly journals Spontaneous pregnancy in a patient with a combination of ovarian and thyroid failure

2011 ◽  
Vol 55 (4) ◽  
pp. 291-293 ◽  
Author(s):  
Bashir Ahmad Laway ◽  
Syed Tufail ◽  
Mir Iftikhar Bashir ◽  
Mohd Ashraf Ganie ◽  
Abdul Hamid Zargar
Keyword(s):  
General Population ◽  
Premature Ovarian Failure ◽  
Hormone Replacement ◽  
Estrogen Therapy ◽  
Oocyte Donation ◽  
Ovarian Failure ◽  
Primary Hypothyroidism ◽  
Spontaneous Pregnancy

Premature ovarian failure has an overall prevalence of 0.3% to 0.9% in general population. If fertility is a concern, treatment usually consists of estrogen therapy as hormone replacement and oocyte donation. Spontaneous pregnancy in affected women is uncommon. We report a case of a 34-year old woman, who had premature ovarian failure and primary hypothyroidism, and conceived spontaneously eleven years after the development of premature ovarian failure and correction of hypothyroidism.

Gamete intra fallopian transfer (GIFT) and oocyte donation—a novel treatment for infertility in premature ovarian failure

1987 ◽  
Vol 1 (1) ◽  
pp. 105-111 ◽  
Author(s):  
R. H. Asch ◽  
J. P. Balmaceda ◽  
T. Ord ◽  
C. Borrero ◽  
L. J. Rodriguez Rigau ◽  
...  
Keyword(s):  
Premature Ovarian Failure ◽  
Oocyte Donation ◽  
Ovarian Failure ◽  
Novel Treatment

scholarly journals Granulocyte Colony-Stimulating Factor Combined With Transcutaneous Electrical Acupoint Stimulation in Treatment of Unresponsive Thin Endometrium in Frozen Embryo Transfer Cycles

2021 ◽  
Vol 3 ◽  
Author(s):  
Linjiang Song ◽  
Qinxiu Zhang ◽  
Shaomi Zhu ◽  
Xudong Shan
Keyword(s):  
Embryo Transfer ◽  
Endometrial Thickness ◽  
Embryo Implantation ◽  
Implantation Rate ◽  
Granulocyte Colony Stimulating Factor ◽  
Thin Endometrium ◽  
Treatment Groups ◽  
Stimulating Factor ◽  
Embryo Implantation Rate ◽  
Acupoint Stimulation

Objective: This trial was designed to assess the treatment effects of granulocyte colony-stimulating factor (G-CSF) and transcutaneous electrical acupoint stimulation (TEAS) on thin endometrium in frozen-thawed embryo transfer (FET) cycles.Methods: Ninety-nine patients with previous cancellations of embryo transfer were included, 56 of whom were prospectively treated with intrauterine perfusion of G-CSF in subsequent FET cycles. The selected patients were randomized into the G-CSF perfusion only group and the G-CSF perfusion combined with TEAS group. The other 43 patients were retrospectively included as controls.Results: Compared to previous cycles, endometrial thickness was statistically significantly increased in the two treatment groups (5.97 ± 0.60, 7.52 ± 0.56, 6.14 ± 0.52, and 7.66 ± 0.44; P = 0.00 and 0.00, respectively). The increases in endometrial thickness suggested that no statistically significant difference was found between the two treatment groups. The G-CSF with TEAS group suggested a higher embryo implantation rate than the G-CSF perfusion only and control groups (33.33 and 29.1% and 33.33 and 17.39%; P = 0.412 and 0.091, respectively). The G-CSF combined with TEAS group demonstrated nominally higher clinical and ongoing pregnancy rates than the G-CSF perfusion-only group and controls, though, the difference was not statistically significant.Conclusion: G-CSF has a potential role in improving endometrium thickness in patients with thin unresponsive endometrium in FET treatment cycles. In addition, when combined with TEAS, G-CSF perfusion treatment also improves the embryo implantation rate; however, randomized controlled trials are highly demanded to provide high-grade evidence regarding clinical pregnancy rate after G-CSF perfusion treatment.

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