scholarly journals Free serum testosterone level in male rats treated with tribulus alatus extracts

2007 ◽  
Vol 33 (4) ◽  
pp. 554-559 ◽  
Author(s):  
Walid H. El-Tantawy ◽  
Abeer Temraz ◽  
Omayma D. El-Gindi
Keyword(s):  
Testosterone Level ◽  
Serum Testosterone ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Free Serum

scholarly journals The immune system cell populations were increased in salt-induced hypertensive rats without an increase in the serum testosterone level (Short communication)

2018 ◽  
Vol 105 (2) ◽  
pp. 110-115
Author(s):  
FO Awobajo ◽  
AE Okafor ◽  
HO Adebayo
Keyword(s):  
Blood Cell ◽  
White Blood Cell ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Male Rats ◽  
Feed Consumption ◽  
Serum Testosterone Level ◽  
Dietary Salt ◽  
Blood Samples ◽  
Cell Counts

The consumption of dietary salt has significantly increased globally, especially in the developed countries. High dietary salt intake has been linked to onset and complications in hypertension with a dimorphism tendency. There is scanty information about the influence of high salt diet on the immune cell population and androgen level in circulation. Male Sprague–Dawley rats of 8 weeks old were used for this study. They were divided into control (fed 0.1% salted feed) and salt-loaded groups (fed 8% salted feed) for 8 weeks. All experimental rats were allowed access to clean drinking water; daily feed consumption was measured in addition to weekly weight. On confirmation of hypertension using PowerLab® data acquisitions system, the rats were sacrificed and blood samples were collected into EDTA and sterile sample bottles. EDTA-blood samples were used for white blood cell and CD4 counts while the serum was used for hormonal assays. All salt-loaded rats became hypertensive, with a significant increase in total white blood cell, lymphocyte, neutrophil, monocyte, and CD4 cell counts. However, the eosinophil count was significantly decreased in salt-loaded rats. This study showed no change in the serum testosterone in salt-loaded male rats compared with control. In summary, dietary salt loading while precipitating hypertension also activated increased production of white blood cells and CD4 cells without any change in the serum testosterone level.

Transient Rise of Serum Testosterone Level after Single Sildenafil Treatment of Adult Male Rats

2012 ◽  
Vol 9 (10) ◽  
pp. 2534-2543 ◽  
Author(s):  
Marija M. Janjic ◽  
Natasa J. Stojkov ◽  
Maja M. Bjelic ◽  
Aleksandar I. Mihajlovic ◽  
Silvana A. Andric ◽  
...  
Keyword(s):  
Adult Male ◽  
Testosterone Level ◽  
Serum Testosterone ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Transient Rise

scholarly journals Examination of Apoptotic and Autophagic Effects of Chronic Roflumilast Use on Rat Testicular Tissue by Immunohistochemical and Immunofluorescence Methods

2021 ◽  
Author(s):  
arzu gezer ◽  
Ebru KARADAĞ SARI
Keyword(s):  
Testosterone Level ◽  
Caspase 3 ◽  
Serum Testosterone ◽  
Testicular Tissue ◽  
Male Rats ◽  
Pde4 Inhibitor ◽  
Serum Testosterone Level ◽  
Sprague Dawley ◽  
Negative Effects ◽  
Testosterone Levels

Abstract Roflumilast (ROF) (3-cyclo-propylmethoxy-4-difuorome-thoxy-N-[3,5-di-chloropyrid-4-yl] benzamide) is a second generation and forcible phosphodiesterase-4 (PDE4) inhibitor. This study aims to investigate the effects of chronic Roflumilast in different doses on testicular tissue and testosterone levels in healthy Sprague-Dawley rats. During the research, the 6 weeks old (180–200 gr), 36 male rats were divided into 4 groups. Roflumilast (ROF) was administered as 0.5 mg/kg and 1 mg/kg by oral gavage for four weeks, once each day. Hematoxylin-Eosin (H&E) staining for histopathological examinations in testicular tissue, immunohistochemical and immunofluorescence examinations for Caspase-3, Apoptosis Inducing Factor (AIF) and Light Chain 3β (LC3B) expression levels, and ELISA method used to determine serum testosterone levels. Data were analyzed using SPSS v.22 with Kruskal-Wallis, Mann Whitney-U, and Wilcoxon tests. Roflumilast group lost weight compared to the control and sham. Shedding in the seminiferous epithelium, degenerations in the interstitial area, separation between cells, desquamation, interstitial edema and degenerative changes in the testicular tissue was observed. While apoptosis and autophagy determined by Caspase-3, AIF and LC3B were close and statistically insignificant in control and sham, there was significantly increased apoptotic and autophagic changes and immunopositivity in the ROF groups. The 1 mg/kg Roflumilast group’s serum testosterone level was lower than control, sham and 0.5 mg/kg Roflumilast groups. When the research data was evaluated, it was determined that the chronic use of the active ingredient Roflumilast, which has a broad-spectrum area such as COPD, arthritis, neurodegenerative diseases, liver and dermatology, had negative effects on the testicular tissue and testosterone level of rats.

scholarly journals Study the biological activities of Tribulus terrestris extracts

2010 ◽  
Vol 4 (1) ◽  
pp. 55-60
Author(s):  
Abbas A. Mohammed ◽  
Ahmed AbdulAmier Hussain Al-Amiery ◽  
Heba. H. I. Al-Mosowy I. Al-Mosowy ◽  
Amir H. Abbas
Keyword(s):  
Testosterone Level ◽  
Biological Activities ◽  
Serum Testosterone ◽  
Serum Testosterone Level ◽  
Klebsiella Pneumonia ◽  
Tribulus Terrestris ◽  
Polar Solvents ◽  
E Coli ◽  
Gram Positive Bacteria ◽  
Free Serum

In this study the extracts of the Iraqi herb Tribulus terrestris (Al-Hassage or Al-Kutub) was done by using of polar and non polar solvents, then the biological activity of these extractants was studied in two field. First, the antibacterial activity invitro on gram positive bacteria (Staphylococcus aureus), and gram negative bacteria (E. coli, Proteus vulgaris, Pseudomonas aerugiuosa, and Klebsiella pneumonia), all extracts showed considerable activity against all bacteria. Second, the effect of extracts on free serum testosterone level in male mice invivo, the alcoholic, and acetonitrilic extracts showed significant (P < 0.05) increase in free serum testosterone level, and we found that the extracts contained compounds with less genotoxic effects in mice germ cells.

scholarly journals EFFECTS OF AQUEOUS STEM BARK EXTRACT OF XYLOPIA AETHIOPICA ON THE REPRODUCTIVE FUNCTIONS OF MALE RATS

2018 ◽  
Vol 10 (1) ◽  
pp. 113
Author(s):  
Cyprien Magloire Hambe ◽  
Marie Ngaha Njila ◽  
Hubert Kenmogne ◽  
Brice Landry Koloko ◽  
Dieudonne Massoma Lembe
Keyword(s):  
Testosterone Level ◽  
Vas Deferens ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Stem Bark ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Bark Extract ◽  
Stem Bark Extract ◽  
Xylopia Aethiopica

Objective: The sexual stimulatory effect of aqueous stem bark extract of Xylopia aethiopica which is commonly used traditionally for the treatment of fertility-related problems in males is reported in this work.Methods: The present study investigated the effect of 14 d oral administration of 1 ml/kg distilled water (control), 100, 200 and 300 mg/kg of body weight of the stem bark extract on some fertility parameters of the Swiss male rats. So, all the target organs (testis, epididymis, vas deferens, seminal vesicle and prostate) were weighed. The sperm motility and sperm count in testis, epididymis and vas deferens were determined. Serum and tissue protein, as well as cholesterol, were evaluated. The serum testosterone level was also assessed.Results: The extract did not produced significant change in the mobility of sperm, the sperm count in vas deferens, the relative weight of body and accessory organs at all doses. The daily sperm production (DSP) and the weight of prostate significantly increased at a dose of 100 mg/kg (p<0.01) while the sperm count in cauda epididymis increased at a dose of 200 mg/kg. The testicular and serum cholesterol significantly increased (p<0.001) at the dose of 100 mg/kg whereas the testicular and serum proteins increased (p<0.001) at the dose of 200 mg/kg. The serum testosterone level increased following 14 d of treatment (p<0.01) at the dose of 100 mg/kg.Conclusion: The results suggest that Xylopia aethiopica may have the potentials of being developed into a male fertility enhancing drug.

scholarly journals Effects of curcumin on sperm parameters abnormalities induced by morphine in rat

2017 ◽  
Vol 6 (2) ◽  
pp. 1-10
Author(s):  
S.H. Roshankhah ◽  
M.R. Salahshoor ◽  
S. Aryanfar ◽  
F. Jalili ◽  
M. Sohrabil ◽  
...  
Keyword(s):  
Sperm Motility ◽  
Testosterone Level ◽  
Sperm Count ◽  
Serum Testosterone ◽  
Treated Group ◽  
Sperm Parameters ◽  
Male Rats ◽  
Serum Testosterone Level ◽  
Seminiferous Tubules ◽  
Control Group

Opioids are the most potent and effective analgesics available and have become accepted as appropriate treatment for acute, cancer and non-cancer. Morphine, which is commonly used for the treatment of severe pain, gastrointestinal tract and kidneys. Curcumin petals consist of, glycosides, flavonoids, and anthocyanin. The study aims at evaluating curcumin effect and morphine on sperm parameters, testis tissue and serum testosterone level in rat. In this experimental study, 48 male rats with 28 weeks of age and limited weight of 270 to 300g were selected. They were divided into eight groups of 6, untreated control group; morphine – treated group (20 mg/kg/day); curcumin -treated groups (10, 30, 60 mg/kg/day); and morphine and curcumin treated group intraperitoneal administration for successive 28 days. After 24hours animals were killed. Sperm motility was measured using WHO protocols. The sperm parameter such as motility, sperm count, morphology, seminiferous tubules diameter, weight testis, and serum testosterone level were analyzed (oneway ANOVA). Curcumin (10, 30 and 60 mg/kg) significantly increased mean percentage of sperm motility, count, testis weight, and serum testosterone level compared to control group (p<0.05). Testosterone level decreased significantly in rats treated with morphine. Co-administration of curcumin to morphine-treated rats improved the histopathological alterations induced by morphine in testis and increased the sperm count. Curcumin has a very strong antioxidant effects at applied doses and it can probably be used as an antioxidant and food supplement in reproductive disorders.Journal of Medical and Biomedical Sciences (2017) 6(2), 1-10

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