Bayesian mapping of neural tube defects prevalence in Heshun County, Shanxi Province, China during 1998∼2001

Abstract Background Neural tube defects (NTDs) are congenital birth defects of the central nervous system that affect 0.5–2 per 1000 pregnancies worldwide. Therefore effective interventions for birth defects, especially NTDs, are very important. Methods Yuanping City is a coal mining city in Shanxi Province, China, with a high incidence of NTDs. This study evaluates the effects of NTD interventions in this city after adjusting for covariates that characterize the native environment. The number of NTD cases and births for the 18 towns in Yuanping City from 2007 to 2014 were included in the study. A shared-component zero-inflated Poisson regression was applied to analyse the temporal–spatial variance among the incidence rates of NTDs in Yuanping City before and after the interventions. Results The results showed that existing interventions to mitigate birth defects, such as folic acid supplementation, reduced the incidence of NTDs by 53.5% in coal mining areas in Yuanping City. However, the NTD risk in areas near coal mines, especially unrestored coal mines, was still high, even after the intervention. Conclusions The government should focus on health hazards related to mining and agricultural production and should provide education and resources to reduce environmental exposure. Reducing environmental risks should be regarded as an early intervention strategy to mitigate birth defects.

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Erratum to maternal prepregnancy body mass index and risk of neural tube defects: A population-based case-control study in shanxi province, China

Birth Defects Research Part A Clinical and Molecular Teratology ◽

10.1002/bdra.23410 ◽

2015 ◽

Vol 103 (7) ◽

pp. 648-648

Author(s):

Zhiwen Li ◽

Jianmeng Liu ◽

Rongwei Ye ◽

Le Zhang ◽

Lijun Pei ◽

...

Keyword(s):

Body Mass Index ◽

Body Mass ◽

Neural Tube ◽

Neural Tube Defects ◽

Case Control Study ◽

Population Based ◽

Case Control ◽

Shanxi Province ◽

Prepregnancy Body Mass Index ◽

Control Study

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Prevalence and trend of neural tube defects in five counties in Shanxi province of Northern China, 2000 to 2014

Birth Defects Research Part A Clinical and Molecular Teratology ◽

10.1002/bdra.23486 ◽

2016 ◽

Vol 106 (4) ◽

pp. 267-274 ◽

Cited By ~ 49

Author(s):

Jufen Liu ◽

Le Zhang ◽

Zhiwen Li ◽

Lei Jin ◽

Yali Zhang ◽

...

Keyword(s):

Neural Tube ◽

Neural Tube Defects ◽

Northern China ◽

Shanxi Province

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High Ratios of C20:4n-6/C20:5n-3 and Thromboxane B2/6-Keto-Prostaglandin F1αin Placenta Are Potential Risk Contributors for Neural Tube Defects: A Case-Control Study in Shanxi Province, China

Birth Defects Research ◽

10.1002/bdr2.1003 ◽

2017 ◽

Vol 109 (8) ◽

pp. 550-563 ◽

Cited By ~ 4

Author(s):

Kelei Li ◽

Xiaotian Zhang ◽

Lijun Pei ◽

Gong Chen ◽

Jianmeng Liu ◽

...

Keyword(s):

Neural Tube ◽

Neural Tube Defects ◽

Potential Risk ◽

Case Control Study ◽

Case Control ◽

Thromboxane B2 ◽

Shanxi Province ◽

Control Study

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MiR-324–5p Regulation in Disturbed Embryogenesis Induced by Folate Deficiency

Current Developments in Nutrition ◽

10.1093/cdn/nzaa058_037 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 1279-1279

Author(s):

Li Wang ◽

Shao-Yan Chang ◽

Ting Zhang

Keyword(s):

Dna Methylation ◽

Spina Bifida ◽

Neural Tube ◽

Neural Tube Defects ◽

Target Genes ◽

Folate Deficiency ◽

Neural Tube Closure ◽

Shanxi Province ◽

Mice Model ◽

Deficiency Group

Abstract Objectives Folate plays key role during embryogenesis. It is proved that folate deficiency is a risk factor for birth defects mainly exerting its effects through DNA methylation. Here, we want to discover the epigenetic process of DNA methylation in the regulation of miRNAs and thereby regulates neural tube closure through actions on target genes. Methods 40 fetuses with spina bifida and 46 control fetuses from Shanxi Province in China were enrolled to study miR-324–5p alternations with folate deficiency. Meanwhile, mice model with folate deficiency diet were built to study the effects and possible mechanisms of pregnancy folate deficiency. Overexpressed miR-324–5p zebras model were used to detected the role of miR-324–5p during embryogenesis. And disturbed folic acid metabolism cell and mice model were used to confirm the mechanisms of miR-324–5p in neural tube defects induced by folate deficiency. Results We observed decreased miR-324–5p methylation in the brains of individuals with spina bifida. Hypomethylation of miR-324–5 increased the risk of spina bifida, with an odds ratio of 7.0 (95% CI: 2.10–23.36; P < 0.0001). A positive correlation between miR-324–5p methylation and folate levels were verified, and higher folate concentration reversed miR-324–5p alternations. We also observed increased miR-324–5p expression in the folate deficiency group, with concomitant decreased expression of its putative target genes, GLI1 and SMO. Furthermore, overexpression of miR-324–5p induced neural tube defects with inhibition of cell proliferation and migration. Similarly, we confirmed suppression of GLI1 and SMO expression in the brain of individuals with spina bifida. Conclusions The effect of folate deficiency on neural tube development may be mediated by miR-324–5p and its target genes. Funding Sources The National Natural Science Fund of China (81,670,802/H0724), National Key Research and Developmwnt Program (2016YFC1000502).

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