Extremely high prevalence of neural tube defects in a 4-county area in Shanxi Province, China

2006 ◽  
Vol 76 (4) ◽  
pp. 237-240 ◽  
Author(s):  
Zhiwen Li ◽  
Aiguo Ren ◽  
Le Zhang ◽  
Rongwei Ye ◽  
Song Li ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Shanxi Province ◽  
High Prevalence

scholarly journals Assessing local determinants of neural tube defects in the Heshun Region, Shanxi Province, China

2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Jin-Feng Wang ◽  
Xin Liu ◽  
George Christakos ◽  
Yi-Lan Liao ◽  
Xue Gu ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Shanxi Province

scholarly journals Folic acid awareness and intake among women in areas with high prevalence of neural tube defects in China: a cross-sectional study

2011 ◽  
Vol 14 (7) ◽  
pp. 1142-1147 ◽  
Author(s):  
Ziqian Zeng ◽  
Ping Yuan ◽  
Yanping Wang ◽  
Xi Ma ◽  
Jun Zhu
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Low Income ◽  
Reproductive Age ◽  
Intake Rate ◽  
Childbearing Age ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
High Prevalence

AbstractObjectiveTo measure folic acid awareness and intake rates among women of childbearing age in certain areas of China with a high prevalence of neural tube defects (NTD).DesignA cross-sectional survey was carried out utilising a nineteen-item questionnaire enquiring into individual women's knowledge of, attitude towards and practice of folic acid supplementation.SettingA total of 293 low-income counties in six provinces of China.SubjectsWomen aged 19–44 years from six provinces with a high prevalence of NTD recruited from June to August 2008.ResultsAmong 33 025 participants, 57 % had heard of folic acid but only 15 % knew all of the core information. The intake rate was 12 %; only 8 % took the recommended dose and only 4 % of non-pregnant women took folic acid. Some women did not take folic acid because they did not know that they should take it (49 %) or they had misconceptions about it (24 %). According to logistic regression analysis, rural residence was a risk factor for folic acid awareness. Ethnicity, educational level, average annual income per person and pregnancy were the influencing factors of folic acid awareness and folic acid intake.ConclusionsAlthough more than half of the respondents had heard of folic acid, the intake rate was still very low in areas with a high prevalence of NTD. Thus, more efforts are needed to increase folic acid awareness and intake among women of reproductive age in these areas.

Bayesian mapping of neural tube defects prevalence in Heshun County, Shanxi Province, China during 1998∼2001

2007 ◽  
Vol 8 (6) ◽  
pp. 921-925 ◽  
Author(s):  
Wen-xue Chi ◽  
Jin-feng Wang ◽  
Xin-hu Li ◽  
Xiao-ying Zheng ◽  
Yi-lan Liao
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Shanxi Province ◽  
Bayesian Mapping

scholarly journals The recurrence risk of neural tube defects (NTDs) in a population with high prevalence of NTDs in northern China

Oncotarget ◽  
2017 ◽  
Vol 8 (42) ◽  
pp. 72577-72583 ◽  
Author(s):  
Jufen Liu ◽  
Zhiwen Li ◽  
Nicholas D.E. Greene ◽  
Hongtian Li ◽  
Aiguo Ren
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Northern China ◽  
Recurrence Risk ◽  
High Prevalence

scholarly journals Evaluating an intervention for neural tube defects in coal mining cites in China: a temporal and spatial analysis

2020 ◽  
Author(s):  
Ningxu Zhang ◽  
Yilan Liao ◽  
Zhoupeng Ren
Keyword(s):  
Coal Mining ◽  
Birth Defects ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Coal Mines ◽  
Intervention Strategy ◽  
Folic Acid Supplementation ◽  
Incidence Rates ◽  
Shanxi Province ◽  
The Government

Abstract Background Neural tube defects (NTDs) are congenital birth defects of the central nervous system that affect 0.5–2 per 1000 pregnancies worldwide. Therefore effective interventions for birth defects, especially NTDs, are very important. Methods Yuanping City is a coal mining city in Shanxi Province, China, with a high incidence of NTDs. This study evaluates the effects of NTD interventions in this city after adjusting for covariates that characterize the native environment. The number of NTD cases and births for the 18 towns in Yuanping City from 2007 to 2014 were included in the study. A shared-component zero-inflated Poisson regression was applied to analyse the temporal–spatial variance among the incidence rates of NTDs in Yuanping City before and after the interventions. Results The results showed that existing interventions to mitigate birth defects, such as folic acid supplementation, reduced the incidence of NTDs by 53.5% in coal mining areas in Yuanping City. However, the NTD risk in areas near coal mines, especially unrestored coal mines, was still high, even after the intervention. Conclusions The government should focus on health hazards related to mining and agricultural production and should provide education and resources to reduce environmental exposure. Reducing environmental risks should be regarded as an early intervention strategy to mitigate birth defects.

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