DEVELOPMENTAL EFFECTS ON LIVER d-GLUCURONOLACTONE DEHYDROGENASE LEVELS AND ON d-GLUCARIC ACID EXCRETION IN URINE; HORMONAL EFFECTS ON d-GLUCARIC ACID EXCRETION IN URINE

1968 ◽  
Vol 42 (4) ◽  
pp. 585-590 ◽  
Author(s):  
A. P. MOWAT
Keyword(s):  
Body Weight ◽  
Premature Infants ◽  
Direct Relationship ◽  
Serum Bilirubin ◽  
Serum Bilirubin Level ◽  
Acid Excretion ◽  
Glucaric Acid ◽  
Contraceptive Agents ◽  
Developmental Effects ◽  
Unit Body Weight

SUMMARY Total urinary d-glucaric acid excretion increased with age and weight gain in males and was found to be low in terms of unit body weight in the newborn. In premature infants, there was a direct relationship between the serum bilirubin level and urinary d-glucaric acid excretion. In women excretion was not found to vary with the menstrual cycle, but was increased during prolonged therapy with contraceptive agents.

Non-Hemolytic Hyperbilirubinemia

PEDIATRICS ◽  
1965 ◽  
Vol 36 (5) ◽  
pp. 807-808 ◽  
Author(s):  
HAROLD M. MAURER
Keyword(s):  
Premature Infants ◽  
Exchange Transfusion ◽  
Serum Bilirubin ◽  
Study Groups ◽  
Serum Bilirubin Level ◽  
Study Group ◽  
Neurological Sequelae ◽  
Indirect Bilirubin ◽  
Significant Difference ◽  
Symptoms And Signs

On what basis do Drs. Wishingrad, Cornblath, Takakuwa, Rozenfeld, Elegant, Kaufman, Lassers, and Klein (Studies of Non-Hemolytic Hyperbilirubinemia in Premature Infants, Pediatrics, 36:162, 1965) recommend exchange transfusion for non-hemolytic hyperbilirubinemia of the premature at a serum bilirubin level equal to or greater than 24 mg/100 ml when no significant difference is apparent in mortality and neurological sequelae in the study groups at greater than 24 mg/100 ml serum indirect bilirubin? The only patient who developed kernicterus in the study already demonstrated symptoms and signs at 10.8 mg/100 ml indirect serum bilirubin which tends to exclude him from the study group called "greater than 24 mg/100 ml."

Idiopathic Hyperbilirubinemia and Phototherapy—Evidence Suggesting a Decreased Incidence of Kernicterus

PEDIATRICS ◽  
1974 ◽  
Vol 54 (5) ◽  
pp. 654-655
Author(s):  
C. Petrich ◽  
U. Göbel
Keyword(s):  
Premature Infants ◽  
Bilirubin Level ◽  
Recent Article ◽  
Serum Bilirubin ◽  
Serum Bilirubin Level ◽  
Full Term ◽  
Healthy Infants

The recent article by Lewak1 dealing with hyperbilirubinemia and phototheraphy prompted us to try to answer the following three questions: 1. Does phototherapy reduce the incidence of kernicterus? Although Lewak's article concerns full-term healthy infants, we believe our experience with premature infants is important. From 1965 to 1967 only those premature infants whose serum bilirubin level rose higher than 18 mg/100 ml received exchange transfusions. As Table I indicates, pathologists found kernicterus in two to four children every year.

A Novel Approach to Phototherapy Initiation in Preterm Infants

2020 ◽  
Vol 1 (1) ◽  
pp. 1-3
Author(s):  
Shabih Manzar
Keyword(s):  
Body Weight ◽  
Birth Weight ◽  
Preterm Infants ◽  
Bilirubin Level ◽  
Serum Bilirubin ◽  
Serum Bilirubin Level ◽  
Therapeutic Interventions ◽  
Novel Approach

Therapeutic interventions in preterm infants are determined based on birth weight. Phototherapy (PTx) is the treatment for hyperbilirubinemia, started based on serum bilirubin level. However, weight-based guidelines for PTx in preterm infants are lacking. We present a simple way of calculating the bilirubin to initiate PTx. A percentage body weight, ranging from 0.5%-1%, is used to calculate bilirubin.

STUDIES ON THE EFFECT OF ORALLY ADMINISTERED AGAR ON THE SERUM BILIRUBIN LEVEL OF PREMATURE INFANTS and MATURE NEWBORNS

1975 ◽  
Vol 64 (5) ◽  
pp. 699-702 ◽  
Author(s):  
A. WINDORFER Jr ◽  
W. KÜNZER ◽  
H. BOLZE ◽  
K. ASCHER ◽  
F. WILCKEN ◽  
...  
Keyword(s):  
Premature Infants ◽  
Bilirubin Level ◽  
Serum Bilirubin ◽  
Serum Bilirubin Level

Cerebrospinal Fluid Isoniazid Concentrations in Children With Tuberculous Meningitis: The Influence of Dosage and Acetylation Status

PEDIATRICS ◽  
1992 ◽  
Vol 89 (2) ◽  
pp. 247-250
Author(s):  
Peter R. Donald ◽  
William L. Gent ◽  
Heiner I. Seifart ◽  
Johan H. Lamprecht ◽  
Donald P. Parkin
Keyword(s):  
Cerebrospinal Fluid ◽  
Body Weight ◽  
Mycobacterium Tuberculosis ◽  
Tuberculous Meningitis ◽  
Inhibitory Concentration ◽  
Serum Bilirubin ◽  
Clinical Signs ◽  
Serum Bilirubin Level ◽  
Acetylation Status ◽  
Period 2

Cerebrospinal fluid (CSF) and plasma isoniazid (INFO concentrations were determined on 96 occasions in 38 children (median age 1.5 years) with tuberculous meningitis, and the effects of INH elimination status and test dosages of 10 mg/kg body weight and 20 mg/kg body weight was studied. Maximum cerebrospinal fluid INH concentrations were reached during the period 2 to 4 hours after dosing and cerebrospinal fluid and plasma INH concentrations did not differ significantly during this period. Cerebrospinal fluid INH concentrations following a dosage of 10 mg/kg (4.6 ± 2.4 µg/mL) were, however, significantly lower than those following a dosage of 20 mg/kg (11.6 ± 2.7 µg/mL). Cerebrospinal fluid INH concentrations in faster acetylators at a dosage of 10 mg/kg (3.2 ± 1.1 µg/mL) were significantly lower than in slower acetylators (7.7 ± 1.3 µg/mL), as was the case with a dosage of 20 mg/kg, where faster acetylators had cerebrospinal fluid INH concentrations of 10.5 ± 2.5 µg/mL compared with 14.1 ± 1.4 µg/mL in slower acetylators. Following dosages of both 10 mg/kg and 20 mg/kg, INH concentrations in excess of the minimal inhibitory concentration for Mycobacterium tuberculosis persisted in the CSF 12 to 14 hours later. Despite the patients' being young and frequently malnourished, suffering from advanced forms of tuberculous meningitis, and receiving high dosages of INH, rifampicin, and pyrazinamide, none developed any clinical signs of hepatotoxicity and in only one child did the serum bilirubin level rise to 19 µg/mL.

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