Control of thyroglobulin secretion from the rat thyroid gland
Keyword(s):
ABSTRACT Serum thyroglobulin (Tg), measured by radioimmunoassay, was high in 6-propylthiouracil (PTU)-treated rats but low in thyroxine (T4)-treated animals compared with euthyroid controls. Thyroid-stimulating hormone (TSH) stimulated Tg release in vitro from enzymatically dispersed normal rat thyroid cells in a dose-dependent manner. Thyroid cells prepared from T4-treated animals behaved similarly to cells from control rats, whereas in vitro basal release of Tg from thyroid cells prepared from PTU-treated animals was high and the response to TSH was lost. Our data confirm the TSH dependency of Tg release in vivo and in vitro and our system provides a means of studying the control of Tg secretion in vitro. J. Endocr. (1984) 101, 107–111
Keyword(s):
Keyword(s):
2007 ◽
Vol 53
(3)
◽
pp. 380-390
◽
Keyword(s):
2014 ◽
Vol 26
(8)
◽
pp. 1084
◽
2011 ◽
Vol 2011
◽
pp. 1-9
◽
Keyword(s):
1996 ◽
Vol 63
(2)
◽
pp. 257-267
◽
Keyword(s):
Keyword(s):