scholarly journals A linear oscillator model predicts dynamic temporal attention and pupillary entrainment to rhythmic patterns

2018 ◽  
Vol 11 (2) ◽  
Author(s):  
Lauren K. Fink ◽  
Brian K. Hurley ◽  
Joy J. Geng ◽  
Petr Janata
Keyword(s):  
Time Course ◽  
Phase Relationship ◽  
Pupillary Response ◽  
Linear Oscillator ◽  
Oscillator Model ◽  
Modes Of Processing ◽  
Dynamic Attention ◽  
Resonator Model ◽  
Thresholding Algorithm ◽  
Auditory Scenes

Rhythm is a ubiquitous feature of music that induces specific neural modes of processing. In this paper, we assess the potential of a stimulus-driven linear oscillator model (Tomic & Janata, 2008) to predict dynamic attention to complex musical rhythms on an instant-by-instant basis. We use perceptual thresholds and pupillometry as attentional indices against which to test our model pre- dictions. During a deviance detection task, participants listened to continuously looping, multi- instrument, rhythmic patterns, while being eye-tracked. Their task was to respond anytime they heard an increase in intensity (dB SPL). An adaptive thresholding algorithm adjusted deviant in- tensity at multiple probed temporal locations throughout each rhythmic stimulus. The oscillator model predicted participants’ perceptual thresholds for detecting deviants at probed locations, with a low temporal salience prediction corresponding to a high perceptual threshold and vice versa. A pupil dilation response was observed for all deviants. Notably, the pupil dilated even when partic- ipants did not report hearing a deviant. Maximum pupil size and resonator model output were sig- nificant predictors of whether a deviant was detected or missed on any given trial. Besides the evoked pupillary response to deviants, we also assessed the continuous pupillary signal to the rhythmic patterns. The pupil exhibited entrainment at prominent periodicities present in the stimuli and followed each of the different rhythmic patterns in a unique way. Overall, these results repli- cate previous studies using the linear oscillator model to predict dynamic attention to complex auditory scenes and extend the utility of the model to the prediction of neurophysiological signals, in this case the pupillary time course; however, we note that the amplitude envelope of the acoustic patterns may serve as a similarly useful predictor. To our knowledge, this is the first paper to show entrainment of pupil dynamics by demonstrating a phase relationship between musical stimuli and the pupillary signal.

scholarly journals Time-course of adaptations for electroretinography and pupillography

2021 ◽  
Vol 9 (4) ◽  
Author(s):  
Ken Asakawa
Keyword(s):  
Dark Adaptation ◽  
Time Course ◽  
Light Adaptation ◽  
Light Condition ◽  
Pupillary Response ◽  
Implicit Time ◽  
Scotopic Vision ◽  
Adaptation Time ◽  
Practical Applications ◽  
Rod Response

Cones are primarily involved in photopic vision and light adaptation. Rods are responsible for scotopic vision and dark adaptation. The typical time-courses of light and dark adaptations have been known for century. However, information regarding the minimal adaptation time for electroretinography (ERG) and pupillography would be helpful for practical applications and clinical efficiency. Therefore, we investigated the relationship between adaptation time and the parameters of ERG and pupillography. Forty-six eyes of 23 healthy women (mean age, 21.7 years) were enrolled. ERG and pupillography were tested for right and left eyes, respectively. ERG with a skin electrode was used to determine amplitude (µV) and implicit time (msec) by the records of rod-, flash-, cone-, and flicker-responses with white light (0.01–30 cd·s/m2). Infrared pupillography was used to record the pupillary response to 1-sec stimulation of red light (100 cd/m2). Cone- and flicker- (rod-, flash-, and pupil) responses were recorded after light (dark) adaptation at 1, 5, 10, 15, and 20 min. Amplitude was significantly different between 1 min and ≥5 or ≥10 min after adaptation in b-wave of cone- or rod-response, respectively. Implicit time differed significantly between 1 min and ≥5 min after adaptation with b-wave of cone- and rod-response. There were significant differences between 1 min and ≥10 or ≥5 min after dark adaptation in parameter of minimum pupil diameter or constriction rate, respectively. Consequently, light-adapted ERGs can be recorded, even in 5 min of light adaptation time without special light condition, whereas dark-adapted ERGs and pupillary response results can be obtained in 10 min or longer of dark adaptation time in complete darkness.

Activity rhythm in High Arctic Svalbard ptarmigan (Lagopus mutus hyperboreus)

1998 ◽  
Vol 76 (11) ◽  
pp. 2031-2039 ◽  
Author(s):  
Eirik Reierth ◽  
Karl-Arne Stokkan
Keyword(s):  
Activity Rhythm ◽  
Feeding Activity ◽  
Phase Relationship ◽  
High Arctic ◽  
Oscillator Model ◽  
The Sun ◽  
Activity Time ◽  
Intermittent Feeding ◽  
Lagopus Mutus ◽  
Activity Onset

Feeding activity was recorded in captive Svalbard ptarmigan (Lagopus mutus hyperboreus) under natural photoperiodic conditions at 70°N and 79°N. At 79°N, activity was intermittent and non-circadian in summer, when the sun was permanently above the horizon, and in midwinter, when the sun was permanently lower than 6° below the horizon. The intermittent feeding pattern was evident in summer at 70°N, whereas feeding activity in winter appeared to be entrained. In spring and autumn all birds were diurnal, with morning and evening bouts of feeding activity. The phase relationship between the onset or end of activity and the photoperiod showed marked changes, especially at 79°N, but in general, activity onset was more precise relative to twilight than activity end. At 79°N there was a sigmoidal relationship between activity time and photoperiod and activity time was longer in autumn than in spring at equal photoperiods. Based on our results, the activity pattern of Svalbard ptarmigan may be described in terms of a two-oscillator model, although a one-oscillator model cannot be excluded. The possibility is discussed that rhythmic feeding or food availability may act as a zeitgeber in addition to the light-dark cycle.

scholarly journals Children's gradient sensitivity to phonological mismatch: considering the dynamics of looking behavior and pupil dilation

2018 ◽  
Vol 46 (1) ◽  
pp. 1-23 ◽  
Author(s):  
Katalin TAMÁSI ◽  
Cristina MCKEAN ◽  
Adamantios GAFOS ◽  
Barbara HÖHLE
Keyword(s):  
Time Course ◽  
Pupillary Response ◽  
Pupil Dilation ◽  
The Other ◽  
Preferential Looking ◽  
Differential Responses ◽  
First Time ◽  
Phonological Mismatch ◽  
Over Time

AbstractIn a preferential looking paradigm, we studied how children's looking behavior and pupillary response were modulated by the degree of phonological mismatch between the correct label of a target referent and its manipulated form. We manipulated degree of mismatch by introducing one or more featural changes to the target label. Both looking behavior and pupillary response were sensitive to degree of mismatch, corroborating previous studies that found differential responses in one or the other measure. Using time-course analyses, we present for the first time results demonstrating full separability among conditions (detecting difference not only between one vs. more, but also between two and three featural changes). Furthermore, the correct labels and small featural changes were associated with stable target preference, while large featural changes were associated with oscillating looking behavior, suggesting significant shifts in looking preference over time. These findings further support and extend the notion that early words are represented in great detail, containing subphonemic information.

Effect of asymmetrical reductions of photoperiod on pineal melatonin, locomotor activity and gonadal condition of male Syrian hamsters

1987 ◽  
Vol 114 (2) ◽  
pp. 221-229 ◽  
Author(s):  
M. H. Hastings ◽  
A. P. Walker ◽  
J. Herbert
Keyword(s):  
Locomotor Activity ◽  
Time Course ◽  
Activity Rhythm ◽  
Phase Relationship ◽  
Serum Testosterone ◽  
Stable Phase ◽  
Common Mechanism ◽  
Neural Basis ◽  
Syrian Hamsters ◽  
Melatonin Synthesis

ABSTRACT This study investigated the relationship of two overt circadian rhythms, locomotor activity and melatonin synthesis in the pineal gland, by comparing their responses to asymmetrical reductions in photoperiod. Transfer of male Syrian hamsters from long to short daylengths led to an increase in the duration of both locomotor activity and the period of melatonin synthesis. Over the course of re-entrainment, the two rhythms were held in a stable phase relationship, and the direction of the switch did not influence the rate of decompression or the final phase relationships established after 8 weeks in short daylengths. Decompression of the activity rhythm was not influenced by pinealectomy. Exposure to short photoperiods caused gonadal regression and a consequent decline in serum testosterone levels from 10 to <1 nmol/l. The direction of the photoperiodic switch did not affect the time-course of gonadal regression. These data demonstrate the important influence of photoperiod upon the duration of the nocturnal peak of melatonin production by the pineal and also demonstrate that this effect is one example of a more widespread response of the circadian system. A qualitatively similar signal controls both locomotor activity and melatonin synthesis, although the neural basis of this common mechanism is unclear. J. Endocr. (1987) 114, 221–229

scholarly journals Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2

2016 ◽  
Vol 113 (47) ◽  
pp. 13516-13521 ◽  
Author(s):  
Tetsuya Gotoh ◽  
Jae Kyoung Kim ◽  
Jingjing Liu ◽  
Marian Vila-Caballer ◽  
Philip E. Stauffer ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Time Course ◽  
Experimental Approach ◽  
Ectopic Expression ◽  
Phase Relationship ◽  
Genotoxic Stress ◽  
Period 2 ◽  
Nuclear Shuttling ◽  
The Stability

The circadian clock and cell cycle networks are interlocked on the molecular level, with the core clock loop exerting a multilevel regulatory role over cell cycle components. This is particularly relevant to the circadian factor Period 2 (Per2), which modulates the stability of the tumor suppressor p53 in unstressed cells and transcriptional activity in response to genotoxic stress. Per2 binding prevents Mdm2-mediated ubiquitination of p53 and, therefore, its degradation, and oscillations in the peaks of Per2 and p53 were expected to correspond. However, our findings showed that Per2 and p53 rhythms were significantly out-of-phase relative to each other in cell lysates and in purified cytoplasmic fractions. These seemingly conflicting experimental data motivated the use of a combined theoretical and experimental approach focusing on the role played by Per2 in dictating the phase of p53 oscillations. Systematic modeling of all possible regulatory scenarios predicted that the observed phase relationship between Per2 and p53 could be simulated if (i) p53 was more stable in the nucleus than in the cytoplasm, (ii) Per2 associates to various ubiquitinated forms of p53, and (iii) Per2 mediated p53 nuclear import. These predictions were supported by a sevenfold increase in p53’s half-life in the nucleus and by in vitro binding of Per2 to the various ubiquitinated forms of p53. Last, p53’s nuclear shuttling was significantly favored by ectopic expression of Per2 and reduced because of Per2 down-regulation. Our combined theoretical/mathematical approach reveals how clock regulatory nodes can be inferred from oscillating time course data.

Transcutaneous electrical stimulation applied to the infratrochlear nerve induces a homatropine-resistant miosis in humans

1990 ◽  
Vol 78 (5) ◽  
pp. 457-462 ◽  
Author(s):  
B. M. Fusco ◽  
M. Alessandri ◽  
V. Campagnolo ◽  
M. Fanciullacci
Keyword(s):  
Electrical Stimulation ◽  
High Intensity ◽  
Healthy Subjects ◽  
Time Course ◽  
Contralateral Side ◽  
Pupillary Response ◽  
Transcutaneous Electrical Stimulation ◽  
Antidromic Activation ◽  
Light Reflex ◽  
Low Intensity

1. Both high- and low-intensity transcutaneous electrical stimuli were applied to the emergence of the infratrochlear nerve in 18 healthy subjects. The effect on the size of the homolateral pupil was investigated. The width of the pupil was also measured when high-intensity transcutaneous electrical stimulation was applied to the contralateral side. 2. The high-intensity pulse resulted in constriction of the pupil when the stimulation was homolateral. The miosis was slow in onset (120 s latency) and long-lasting (80 s). No pupillary changes were detected after either ipsilateral low-intensity or contralateral high-intensity stimuli. 3. In 11 healthy subjects, the pupillary response to transcutaneous electrical stimulation was evaluated during iris parasympathetic blockade induced by homatropine eyedrops. The disappearance of the light reflex due to homatropine was considered an index of the parasympathetic blockade. Afterwards, a high-intensity pulse was transcutaneously delivered to the emergence of the infratrochlear nerve and the ipsilateral pupil size was measured. 4. A reduction in the pupillary size followed the electrical stimulation, still under the effect of homatropine which abolished the light reflex. The time course of this pupillary constriction was similar to that seen without the influence of homatropine. 5. The findings suggest that homolateral miosis, observed after unilateral high-intensity stimulation of the infratrochlear nerve, does not stem from cholinergic activation. It has been suggested that miosis induced by transcutaneous electrical stimulation may be due to an antidromic activation of the iris sensory fibres.

Ultrastructural Changes of the Symbiotic Chlorella-Like Alga Isolated from Hydra Viridis

1982 ◽  
Vol 40 ◽  
pp. 320-321
Author(s):  
K.W. Lee ◽  
R.H. Meints ◽  
D. Kuczmarski ◽  
J.L. Van Etten
Keyword(s):  
Time Course ◽  
Reciprocal Cross ◽  
Ultrastructural Level ◽  
Ultrastructural Changes ◽  
Symbiotic Relationship ◽  
Cell Recognition ◽  
Green Hydra ◽  
Different Strains ◽  
Hydra Viridis

The physiological, biochemical, and ultrastructural aspects of the symbiotic relationship between the Chlorella-like algae and the hydra have been intensively investigated. Reciprocal cross-transfer of the Chlorellalike algae between different strains of green hydra provide a system for the study of cell recognition. However, our attempts to culture the algae free of the host hydra of the Florida strain, Hydra viridis, have been consistently unsuccessful. We were, therefore, prompted to examine the isolated algae at the ultrastructural level on a time course.

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