scholarly journals Confocal laser endomicroscopy in the diagnosis of extrahepatic bile duct diseases

2019 ◽  
Vol 24 (1) ◽  
pp. 11-16
Author(s):  
E. N. Solodinina ◽  
N. V. Fomicheva ◽  
D. N. Ulyanov
Keyword(s):  
Bile Duct ◽  
Extrahepatic Bile Duct ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Targeted Biopsy ◽  
Bile Duct Diseases ◽  
Edematous Pancreatitis ◽  
Sensitivity Specificity

Aim. To evaluate information content of confocal laser endomicroscopy with targeted biopsy in verifying etiology of extrahepatic bile duct strictures.Material and methods. There were 28 patients with extrahepatic bile duct strictures who underwent retrograde intervention with confocal laser endomicroscopy and targeted biopsy. Data of confocal laser endomicroscopy and biopsy were compared with final postoperative and histological diagnosis. Follow-up within 1–4 years after endoscopic treatment was also considered.Results. Diagnostic sensitivity, specificity and overall accuracy of the method in differential diagnosis of common bile duct strictures were 91.7%, 93.7% and 92.8%, respectively. Complication (acute edematous pancreatitis) occurred in 1 (3.6%) case.Conclusion. Confocal laser endomicroscopy is new effective method for in vivo microscopic assessment of mucous membrane. Despite technical complexity, the method is not associated with advanced morbidity and, accordingly, has no additional contraindications in comparison with ERCP.

S1426: High-Definition In-Vivo Probe-Based Confocal Laser Endomicroscopy of the Common Bile Duct

2010 ◽  
Vol 71 (5) ◽  
pp. AB158-AB159 ◽  
Author(s):  
Frederick K. Shieh ◽  
Michael H. Nathanson ◽  
Hillary Drumm ◽  
Priya A. Jamidar
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
High Definition ◽  
The Common

scholarly journals Development and Validation of a Confocal Laser Endomicroscopy-Based Score for In Vivo Assessment of Mucosal Healing in Ulcerative Colitis Patients

2017 ◽  
Vol 24 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Gheorghe Hundorfean ◽  
Mircea T Chiriac ◽  
Sidonia Mihai ◽  
Arndt Hartmann ◽  
Jonas Mudter ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
High Sensitivity ◽  
Mucosal Healing ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Mayo Score ◽  
Before And After ◽  
Sensitivity Specificity ◽  
Development And Validation

Abstract Background Endoscopic monitoring is fundamental for evaluating the therapeutic response in IBD, but a validated endomicroscopic mucosal healing (MH) score is not available to date. However, confocal laser endomicroscopy (CLE) might define MH more precisely than conventional endoscopy. The major aim was to establish and validate an MH score for ulcerative colitis (UC), based on CLE. Methods In an initial pilot study (n = 10), various CLE changes were analyzed for identification of reproducible criteria for establishing a CLE score. Four reproducible CLE criteria were implemented in a following validation study. Subsequently, active UC patients (n = 23, Mayo score ≥6) were prospectively included and underwent colonoscopy with CLE before and after 3 anti-TNF applications. Patients were clinically followed over a period of 3 years. The endomicroscopic MH score (eMHs; range, 0–4) was compared with histopathology and endoscopy scores from the same colonic location. Results The eMHs showed high sensitivity, specificity, and accuracy values (100% with 95% confidence interval [CI] of 15.81%–100%; 93.75% with 95% CI of 69.77%–99.84%, and 94.44%, respectively). The eMHs showed a good correlation with the histological Gupta score (rs = 0.82, P < 0.0001) and the endoscopic Mayo subscore (rs = 0.81%, P < 0.0001). Sixty percent of therapy responders presented an eMHs <1, which translated into long-lasting clinical remission and reduced hospitalization, steroid, and surgery need. Conclusions CLE can accurately assess MH based on the newly developed and statistically validated eMHs in UC, and it is superior in predicting the long-lasting clinical outcome based on both descriptive and functional barrier imaging (NCT01417728).

scholarly journals A Review on the Use of Confocal Laser Endomicroscopy in the Bile Duct

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Ioana Smith ◽  
Pamela E. Kline ◽  
Monica Gaidhane ◽  
Michel Kahaleh
Keyword(s):  
Bile Duct ◽  
Tertiary Care ◽  
Biliary Tree ◽  
Multicenter Trial ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Biliary Strictures ◽  
Confocal Endomicroscopy ◽  
Pubmed Search

Background. Current methods to diagnose malignant biliary strictures are of low sensitivity. Probe-based confocal laser endomicroscopy (pCLE) is a new approach that can be used to evaluate in vivo histopathology of the GI tract. This paper is of studies evidencing pCLE’s application in the diagnosis of indeterminate biliary strictures.Methods. This paper examined peer-reviewed studies conducted between January 2000 and November 2011. A PubMed search for relevant articles was performed using the following keywords:“pCLE”, “confocal”, “endomicroscopy”, “probe-based confocal laser endomicroscopy”, “and “bile duct”. Further individual review was done to assess the screened articles’ relevance to the topic.Results. After individual review, 6 studies were included; with a cumulative sample size of 165, with 75 subjects identified as having a malignancy. These studies included tertiary care centers in Germany, France, and USA, including one multicenter trial. 3 studies assessed pCLE’s specificity (range 67%–88%) ,sensitivity (range 83%–98), and accuracy (range 81%–86%).Conclusion. Confocal endomicroscopy is a novel and promising modality for the biliary tree. Further studies need to be conducted both to establish its usefulness for the diagnosis of indeterminate biliary strictures and to understand the histological meaning of the imaging patterns that are observed.

Visualization of brain microvasculature and blood flow in vivo: Feasibility study using confocal laser endomicroscopy

2021 ◽  
Author(s):  
Evgenii Belykh ◽  
Xiaochun Zhao ◽  
Brandon Ngo ◽  
Dara S. Farhadi ◽  
Adam Kindelin ◽  
...  
Keyword(s):  
Blood Flow ◽  
Feasibility Study ◽  
Confocal Laser Endomicroscopy ◽  
Confocal Laser ◽  
Brain Microvasculature

scholarly journals Endomicroscopy and Cancer: A New Approach to the Visualization of Neoangiogenesis

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Renato Cannizzaro ◽  
Maurizio Mongiat ◽  
Vincenzo Canzonieri ◽  
Mara Fornasarig ◽  
Stefania Maiero ◽  
...  
Keyword(s):  
Cancer Progression ◽  
Confocal Laser Endomicroscopy ◽  
Molecular Profile ◽  
Confocal Laser ◽  
Antiangiogenic Treatment ◽  
New Approach ◽  
Angiogenic Therapy ◽  
Imaging Tool ◽  
Subcellular Resolution

Probe-based Confocal Laser Endomicroscopy (pCLE) is a novel imaging technique for gastrointestinal endoscopy providingin vivomicroscopy at subcellular resolution. It offers the possibility to analyze neoangiogenesis and vessel densityin vivo. Angiogenetic switch is essential in cancer progression. Aim of the paper was to review the use of this imaging tool to analyze colorectal and gastric cancers vascularizationin vivo. The aim is to provide the possibility of combining diagnostic evidences with vascularization and molecular profile to evaluate the efficacy of an antiangiogenic treatment in association with conventional therapy. pCLE can be considered a revolutionary method for real-time assessment of changes in vascularization pattern in this tumors and it may open the possibility to address the use of anti-angiogenic therapy in order to improve the outcome of the treatment.

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