scholarly journals Inhibitory Effect of lncRNA GHRLOS on Colon Cancer Metastasis and its Molecular Mechanism

2021 ◽  
Vol 7 (4) ◽  
Author(s):  
Mao X ◽  
Liu J ◽  
Wu S
Keyword(s):  
Colon Cancer ◽  
Molecular Mechanism ◽  
Expression Profile ◽  
Cancer Metastasis ◽  
Inhibitory Effect ◽  
Colon Cancer Metastasis ◽  
Non Coding Rnas ◽  
Cancer Tissues ◽  
Microarray Detection

Background: LncRNA GHRLOS is a long non-coding RNAs (lncRNAs). Microarray detection for expression profile revealed that lncRNA GHRLOS was significantly under-expressed in colon cancer tissues, while its role in a tumor remained unclear.

scholarly journals Colon cancer metastasis to the lateral skull base masquerading as mastoiditis

2019 ◽  
Vol 13 ◽  
pp. 100126
Author(s):  
Nathan R. Lindquist ◽  
David C. Wilde ◽  
Eric N. Appelbaum ◽  
Edward A. Duckworth ◽  
Alex D. Sweeney
Keyword(s):  
Colon Cancer ◽  
Skull Base ◽  
Cancer Metastasis ◽  
Colon Cancer Metastasis ◽  
Lateral Skull Base

Su1772 - The RNA Binding Protein Imp1 Enhances Colon Cancer Metastasis via Promotion of a Pro-Metastatic Gene Expression Program

2018 ◽  
Vol 154 (6) ◽  
pp. S-585
Author(s):  
Sarah F. Andres ◽  
Kathy N. Williams ◽  
Kathryn E. Hamilton ◽  
Rei Mizuno ◽  
Jeff Headd ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cancer Metastasis ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Gene Expression Program ◽  
Colon Cancer Metastasis ◽  
Expression Program

scholarly journals Exosomal lncRNA PVT1/VEGFA Axis Promotes Colon Cancer Metastasis and Stemness by Downregulation of Tumor Suppressor miR-152-3p

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Shiue-Wei Lai ◽  
Ming-Yao Chen ◽  
Oluwaseun Adebayo Bamodu ◽  
Ming-Shou Hsieh ◽  
Ting-Yi Huang ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Growth Factor ◽  
Cell Lines ◽  
Distant Metastasis ◽  
Cancer Metastasis ◽  
Lovo Cell ◽  
Promoting Effect ◽  
Colon Cancer Metastasis

Background. Treating advanced colon cancer remains challenging in clinical settings because of the development of drug resistance and distant metastasis. Mechanisms underlying the metastasis of colon cancer are complex and unclear. Methods. Computational analysis was performed to determine genes associated with the exosomal long noncoding (lncRNA) plasmacytoma variant translocation 1 (PVT1)/vascular endothelial growth factor A (VEGFA) axis in patients with colon cancer. The biological importance of the exosomal lncRNA PVT1/VEGFA axis was examined in vitro by using HCT116 and LoVo cell lines and in vivo by using a patient-derived xenograft (PDX) mouse model through knockdown (by silencing of PVT1) and overexpression (by adding serum exosomes isolated from patients with distant metastasis (M-exo)). Results. The in silico analysis demonstrated that PVT1 overexpression was associated with poor prognosis and increased expression of metastatic markers such as VEGFA and epidermal growth factor receptor (EGFR). This finding was further validated in a small cohort of patients with colon cancer in whom increased PVT1 expression was correlated with colon cancer incidence, disease recurrence, and distant metastasis. M-exo were enriched with PVT1 and VEGFA, and both migratory and invasive abilities of colon cancer cell lines increased when they were cocultured with M-exo. The metastasis-promoting effect was accompanied by increased expression of Twist1, vimentin, and MMP2. M-exo promoted metastasis in PDX mice. In vitro silencing of PVT1 reduced colon tumorigenic properties including migratory, invasive, colony forming, and tumorsphere generation abilities. Further analysis revealed that PVT1, VEGFA, and EGFR interact with and are regulated by miR-152-3p. Increased miR-152-3p expression reduced tumorigenesis, where increased tumorigenesis was observed when miR-152-3p expression was downregulated. Conclusion. Exosomal PVT1 promotes colon cancer metastasis through its association with EGFR and VEGFA expression. miR-152-3p targets both PVT1 and VEGFA, and this regulatory pathway can be explored for drug development and as a prognostic biomarker.

scholarly journals Effects of propofol on colon cancer metastasis through STAT3/HOTAIR axis by activating WIF‐1 and suppressing Wnt pathway

2020 ◽  
Vol 9 (5) ◽  
pp. 1842-1854 ◽  
Author(s):  
Yun‐Fei Zhang ◽  
Chang‐Sheng Li ◽  
Yi Zhou ◽  
Xi‐Hua Lu
Keyword(s):  
Colon Cancer ◽  
Wnt Pathway ◽  
Cancer Metastasis ◽  
Colon Cancer Metastasis
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