Comparative efficacy analysis of photodynamic therapy for involution skin changes in monotherapy and in combination with photosensitizing agents based on chlorine E6

2021 ◽  
Vol 20 (6) ◽  
pp. 126
Author(s):  
M.A. Beimanova ◽  
V.V. Petunina ◽  
B.V. Shilov ◽  
R.Kh. Belkharoeva
Keyword(s):  
Photodynamic Therapy ◽  
Comparative Efficacy ◽  
Skin Changes ◽  
Efficacy Analysis ◽  
Photosensitizing Agents ◽  
Chlorine E6

Use of photodynamic therapy for photodamage skin (review of literature)

2019 ◽  
Vol 1 (7) ◽  
pp. 19-23
Author(s):  
S. I. Surkichin ◽  
N. V. Gryazeva ◽  
L. S. Kholupova ◽  
N. V. Bochkova
Keyword(s):  
Photodynamic Therapy ◽  
Comparative Evaluation ◽  
Clinical Manifestations ◽  
Light Sources ◽  
Review Of Literature ◽  
Photosensitizing Agents ◽  
Selection Of

The article provides an overview of the use of photodynamic therapy for photodamage of the skin. The causes, pathogenesis and clinical manifestations of skin photodamage are considered. The definition, principle of action of photodynamic therapy, including the sources of light used, the classification of photosensitizers and their main characteristics are given. Analyzed studies that show the effectiveness and comparative evaluation in the selection of various light sources and photosensitizing agents for photodynamic therapy in patients with clinical manifestations of photodamage.

scholarly journals Photosensitizer Chlorin e6 Internalization into Tumor Cells in Phospholipid Nanoparticles Conjugated with Peptide Containing the NGR Sequence

2018 ◽  
Vol 1 (4) ◽  
pp. e00063 ◽  
Author(s):  
V.N. Prozorovskiy ◽  
L.V. Kostryukova ◽  
E.I. Korotkevich ◽  
T.I. Torkhovskaya ◽  
G.E. Morozevich ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Amino Acid ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Aminopeptidase N ◽  
Chlorin E6 ◽  
Phospholipid Nanoparticles ◽  
Chlorine E6 ◽  
Targeting Peptide ◽  
Mcf 7

The possibility of increased internalization of the photosensitizer chlorin e6 in tumor cells was investigatedusing soy phosphatidylcholine nanoparticles 20-30 nm with or without attached peptide containing Asn-Gly-Arg (NGR) motif was studied. This amino acid sequence exhibits affinity to aminopeptidase N (CD13), wich is overexpressed in a number of tumor cells and vessels. Nanoparticles with chlorin e6 were prepared with added of distearoylphosphatidylcholine (DSPE) conjugated through PEG with a hexapeptide containing the NGR sequence, and then were incubated with tumor cells НерG2 and MCF-7. Chlorin e6 accumulation in СD13-negative cells (MCF-7) did not depend on the presence of peptide NGR in nanoparticles. However, for НерG2 cells a twofold increase of chlorine e6 internalization was observed as compared with the same particles without NGR. Differences in the response of these two cell lines, differed in expression of aminopeptidase N (APN), suggest the possibility of this protein using for targeted delivery. The prospectivity of usage of phospholipids nanoparticles conjugated with targeting peptide for photodynamic therapy is discussed, taking into account possible variation of APN expression, inherent for many solid tumors.

scholarly journals P1.01-83 Comparative Efficacy Analysis Between Entrectinib Trial and Crizotinib Real-World ROS1 Fusion-Positive (ROS1+) NSCLC Patients

2019 ◽  
Vol 14 (10) ◽  
pp. S392
Author(s):  
R. Doebele ◽  
L. Perez ◽  
H. Trinh ◽  
M. Martinec ◽  
R. Martina ◽  
...  
Keyword(s):  
Real World ◽  
Comparative Efficacy ◽  
Efficacy Analysis ◽  
Nsclc Patients

Quantum Dot anti-CD Conjugates:  Are They Potential Photosensitizers or Potentiators of Classical Photosensitizing Agents in Photodynamic Therapy of Cancer?

Nano Letters ◽  
2004 ◽  
Vol 4 (9) ◽  
pp. 1567-1573 ◽  
Author(s):  
Rumiana Bakalova ◽  
Hideki Ohba ◽  
Zhivko Zhelev ◽  
Toshimi Nagase ◽  
Rajan Jose ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Dot ◽  
Photodynamic Therapy Of Cancer ◽  
Photosensitizing Agents

scholarly journals Photodynamic therapy for correction of involutive facial skin changes

2021 ◽  
Vol 19 (3) ◽  
pp. 140-144
Author(s):  
S. I. Surkichin ◽  
N. V. Bochkova ◽  
L. S. Kholupova
Keyword(s):  
Photodynamic Therapy ◽  
Light Exposure ◽  
Transepidermal Water Loss ◽  
Coherent Radiation ◽  
Chlorin E6 ◽  
Skin Changes ◽  
Self Confidence ◽  
Photodamaged Skin ◽  
The Face ◽  
Group 2

Background.The appearance of the skin is of high social importance, largely determining the behavior and self-confidence of a person. The relevance of methods for the correction of involutive skin changes is growing every year. One modern treatment for photodamaged skin is photodynamic therapy. Objective:the study evaluated the effectiveness of photodynamic therapy using chlorin E6 as a photosensitizer for the correction of involutive changes in the skin of the face compared to using only light exposure. Methods.The study involved patients aged 4060 years with signs of involutive changes in the skin of the face. In group 1 (n=36), patients underwent therapy using only light coherent radiation. In group 2 (n=35), patients underwent PDT using light coherent radiation. Results.According to the results of elastometry, corneometry, assessment of transepidermal water loss, ultrasound examination of the skin in group2, more positive indicators were obtained than in group1. When assessing safety, the results in groups 1 and2 are comparable. Conclusions.The method of photodynamic therapy using chlorin E6 can be recommended for course use in wide clinical practice.

scholarly journals Current state of methods of correction of involutional changes of skin and the place of photodynamic therapy among them

2020 ◽  
Vol 8 (4) ◽  
pp. 28-35
Author(s):  
M. A. Beimanova ◽  
N. N. Potekaev ◽  
V. V. Petunina
Keyword(s):  
Photodynamic Therapy ◽  
Life Expectancy ◽  
De Novo ◽  
Skin Neoplasms ◽  
The Elderly ◽  
Scientific Data ◽  
Skin Changes ◽  
Age Cohorts ◽  
Current State ◽  
Age Cohort

This work is a review of modern scientific data on the process of aging, as well as the prospect of using photodynamic therapy for correction of involutional skin changes in the age cohorts, cohorts with a burdened medical history, including cancerous and precancerous skin neoplasms. The data on the predicted increase in life expectancy and, as a consequence, the potential risk of pathologies, including those with skin localization, progression of malignancy processes, as well as the formation of de novo elements, is presented. The increase in life expectancy also demonstrates the socialization of the elderly population, along with the increasing need for correction of involutional skin changes. However, considering the risks associated with the chronic diseases and increased malignancy in this cohort, methods have to be carefully selected. One such technique is photodynamic therapy (PDT). PDT is actively used in oncology, and recently has been increasingly showing its aesthetic effectiveness. It can be predictably used not only on cancer patients, but also in an age cohort.

scholarly journals History and Basic Principles of Photodynamic Therapy Use in Ophthalmology

2021 ◽  
Vol 5 (1) ◽  
pp. 168-176
Author(s):  
Abdul Karim Ansyori
Keyword(s):  
Photodynamic Therapy ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Pathological Myopia ◽  
Basic Principles ◽  
Age Related ◽  
Photosensitizing Agents ◽  
History Of ◽  
First Time ◽  
Photodynamic Reaction

Photodynamic therapy (PDT) is a therapy that uses drugs, called photosensitizers or photosensitizing agents, and a specific type of light. When photosensitizers are exposed to certain wavelengths of light, they produce oxygen that kills nearby cells. PDT is achieved by a photodynamic reaction induced by the excitation of a photosensitizer exposed to light. In the field of ophthalmology, PDT was approved for the first time about ten years ago for cases of age-related macular degeneration (AMD). Neovascular age-related macular degeneration (AMD) is a vision-threatening disease characterized by pathological macular neovascularization. After that, PDT was approved for use in choroidal neovascularization (CNV) cases in pathological myopia.3 This literature review aims to describe the history of PDT use and the basic principles of photodynamic therapy in ophthalmology.

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