scholarly journals Poisonings in Singapore: A Poison Center Perspective

2019 ◽  
Vol 4 (1) ◽  
pp. 8-12
Author(s):  
Ponampalam R ◽  
Keyword(s):  
Author(s):  
Laila Abd El-Megid ◽  
Mohamed El-Gendy ◽  
Fayez Hafez ◽  
Mohamed Abd El-Aziz

2021 ◽  
Vol 128 (5) ◽  
pp. 699-708
Author(s):  
Britni Overall ◽  
Stephanie L. Hon ◽  
Alison Jones ◽  
Tim P. Moran ◽  
Kevin Hunt
Keyword(s):  

2013 ◽  
Vol 52 (1) ◽  
pp. 54-62 ◽  
Author(s):  
N. R. Kelly ◽  
J. T. Harding ◽  
J. E. Fulton ◽  
C. A. Kozinetz

PEDIATRICS ◽  
1994 ◽  
Vol 94 (2) ◽  
pp. 220-224 ◽  
Author(s):  
Frederick H. Lovejoy ◽  
William O. Robertson ◽  
Alan D. Woolf

The first poison centers were established in the United States in the early 1950s, stimulated by an American Academy of Pediatrics' survey of office-based pediatric practices which ascertained that its members had no place to turn for ingredient information on medications and household products.1 With the help of the Academy, pediatrician Dr. Edward Press, the Illinois Department of Health, and several community hospitals, the first poison center emerged. Over the subsequent 40 years, remarkable progress has occurred in the fields of clinical toxicology, poison control, and poison prevention. Yet despite these accomplishments, challenging clouds are appearing on the horizon which threaten these gains. This commentary, by the authors who have viewed and participated in a large part of the history of this progress, will focus on these major accomplishments with an emphasis on (a) poison prevention utilizing the pre-event (primary prevention), (b) the event (secondary prevention), and (c) the postevent (tertiary prevention) model.2


PEDIATRICS ◽  
1991 ◽  
Vol 88 (5) ◽  
pp. 907-912
Author(s):  
W. Lynn Augenstein ◽  
David G. Spoerke ◽  
Ken W. Kulig ◽  
Alan H. Hall ◽  
Priscilla K. Hall ◽  
...  

All cases of fluoride ingestion in children younger than 12 years old reported to the Rocky Mountain Poison Center between January 1 and December 31, 1986, were retrospectively reviewed. Eighty-seven cases were identified. Eighty-four cases involved accidental ingestion of dental fluoride products in the home (tablets, drops, rinses) in children 8 months to 6 years old. Two older children (8 and 9 years old) became symptomatic after fluoride treatment by a dentist. A 13-month-old child died after ingesting an unknown amount of sodium fluoride insecticide, the only insecticide exposure in our series. Postmortem total serum calcium value was 4.8 mg/dL (normal 8.8 to 10.3). No other patients had serious symptoms or sequelae. Twenty-six (30%) of 87 became symptomatic, with gastrointestinal symptoms (nausea, vomiting, diarrhea, abdominal pain) in 25 patients and drowsiness in 1. Only 3 patients became symptomatic later than 1 hour after ingestion. Analysis of data from 70 cases with sufficient information revealed that as the amount of fluoride ingested increased, the percentage of patients with symptoms increased. Not including the fatal case, 6 patients had serum calcium levels measured, and all were normal. Children who ingested up to 8.4 mg/kg of elemental fluoride in dental products had mild and self-limited symptoms, mostly gastrointestinal.


PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262215
Author(s):  
Anna Tupetz ◽  
Loren K. Barcenas ◽  
Ashley J. Phillips ◽  
Joao Ricardo Nickenig Vissoci ◽  
Charles J. Gerardo

Introduction Antivenom is currently considered standard treatment across the full spectrum of severity for snake envenomation in the United States. Although safe and effective antivenoms exist, their use in clinical practice is not universal. Objective This study explored physicians’ perceptions of antivenom use and experience with snake envenomation treatment in order to identify factors that influence treatment decisions and willingness to administer. Methods We conducted a qualitative study including in-depth interviews via online video conferencing with physicians practicing in emergency departments across the United States. Participants were selected based on purposive sampling methods. Data analysis followed inductive strategies, conducted by two researchers. The codebook and findings were discussed within the research team. Findings Sixteen in-depth interviews with physicians from nine states across the US were conducted. The participants’ specialties include emergency medicine (EM), pediatric EM, and toxicology. The experience of treating snakebites ranged from only didactic education to having treated over 100 cases. Emergent themes for this manuscript from the interview data included perceptions of antivenom, willingness to administer antivenom and influencing factors to antivenom usage. Overall, cost-related concerns were a major barrier to antivenom administration, especially in cases where the indications and effectiveness did not clearly outweigh the potential financial burden on the patient in non-life- or limb-threatening cases. The potential to decrease recovery time and long-term functional impairments was not commonly reported by participants as an indication for antivenom. In addition, level of exposure and perceived competence, based on prior education and clinical experience, further impacted the decision to treat. Resources such as Poison Center Call lines were well received and commonly used to guide the treatment plan. The need for better clinical guidelines and updated treatment algorithms with clinical and measurable indicators was stated to help the decision-making process, especially among those with low exposure to snake envenomation patients. Conclusions A major barrier to physician use of antivenom is a concern about cost, cost transparency and cost–benefit for the patients. Those concerns, in addition to the varying degrees of awareness of potential long-term benefits, further influence inconsistent clinical treatment practices.


Author(s):  
Nurul Akilah Mohd Yusoff ◽  
Tuan Nadrah Naim Ismail Ismail ◽  
Wan Nazatul Shima Shahidan

Introduction: Alocasia denudata is a herbal plant used by traditional healers as a wound healing agent and its potential as a healer has been proven scientifically. Normally, wounded tissue offers the opportunity for microflora to adhere, colonize, invade, and infect the surrounding healthy tissue. Therefore, the aim of this study is to assess the antimicrobial effect of A. denudata on selective oral pathogen as well as to analyze its phytochemical compound. Methods: The stem of A. denudata was extracted with 80% ethanol solution, freeze-dried, and sent to poison center to analyze its phytochemical constituents. The bioassay applied for determining the antimicrobial effect employs the well agar diffusion method to the selected Gram-positive oral bacteria; Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, and non-oral pathogen Streptococcus pyogenes. These bacteria were incubated and the inhibition zone was recorded. Results: Our results showed that the mean yield of extraction was 12.8% and that the different concentrations of A. denudata show no antimicrobial effects toward the selected Gram-positive oral pathogen including non-oral pathogen bacteria. However, the gas chromatography–mass spectrometry result showed that antimicrobial compound is present along with anti-inflammatory and antioxidant compounds but showed no effect on the oral pathogen. Conclusion: A. denudata extract has antimicrobial compound but did not show antimicrobial activity toward the selected Gram-positive oral pathogen.


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