scholarly journals Bovine bilateral mesenchymal hamartomas on the upper eyelid: A case report

2021 ◽  
Author(s):  
Y Eroksuz ◽  
E Polat ◽  
CA Incili ◽  
B Karabulut ◽  
H Eroksuz
Keyword(s):  
Adipose Tissue ◽  
Striated Muscle ◽  
Meibomian Gland ◽  
Squamous Cell Carcinomas ◽  
Surgical Removal ◽  
Medial Canthus ◽  
Upper Eyelid ◽  
Nerve Bundles ◽  
Morphological Diagnosis ◽  
The Masses

A 2-day-old calf was presented with a bilateral mass in the medial canthus of the upper eyelid. The masses were removed surgically. The morphological diagnosis was a bilateral hamartoma characterised by an abnormal mixture of tissue indigenous to that area including blood vessels, striated muscle bundles, adipose tissue, isolated cartilage and nerve bundles. No recurrence developed in the 6 months following the surgical removal. Overall, although this congenital defect is relatively rare, it should be differentiated from eyelid tumours such as haemangiomas, squamous cell carcinomas, Meibomian gland tumours, dermoid cysts and teratomas in cattle.

scholarly journals Bilateral primary eyelid meibomian gland epithelioma in a dog: a case report

2019 ◽  
Vol 70 (1) ◽  
pp. 1435
Author(s):  
A. KOMNENOU ◽  
G. CHARALAMBIDOU ◽  
S. MAKROGKIKAS ◽  
N. PAPAIOANNOU
Keyword(s):  
Lower Eyelid ◽  
Meibomian Gland ◽  
Surgical Removal ◽  
Upper Eyelid ◽  
Palpebral Conjunctiva ◽  
Lateral Canthus ◽  
Tarsal Glands ◽  
The Right ◽  
Left Eyelid ◽  
Periorbital Swelling

In this paper an extremely rare case of primary bilateral eyelid meibomian gland epithelioma in a dog is presented. Meibomian tumors arise from the meibomian (tarsal) glands on the inner aspect of the eyelid, and meibomian gland adenomas and adenocarcinomas are the most frequent neoplasia arising from those glands. A 10-year-old male dog was admitted, with ophthalmic signs of periorbital swelling of the right eye. During the last two years, the dog had a progressive engorgement of the upper eyelid of the right eye, and during the past few months, strabismus and exophthalmos were also noticed, as well as a slighter enlargement on the lower eyelid of the left eye. Upon ophthalmic examination strabismus and periorbital swelling at the lateral canthus of the right eye, accompanied by mild exophthalmos and lagophthalmos, were recorded. Also, deep ulcerative keratitis with corneal oedema and neovascularization were noticed. Intense chemosis, epiphora and a small pinkish mass arising from the palpebral conjunctiva of the left lower eyelid were also seen. Neoplasia of both eyelids was suspected, and a series of diagnostic examinations were carried out. Orbital exenteration of the right eye was performed in the first place, followed by surgical removal of the mass of the left eyelid one month later. Based on clinical and histopathological findings, meibomian gland epithelioma was diagnosed. No relapse or metastases (local or distant) were observed in re-examinations within 18 months after the surgery. This study shows that although meibomian gland epithelioma is rare, it should be considered in the differential diagnosis of cases of orbital and eyelid tumors. Even though this tumor shows low malignancy, prompt surgical intervention and extended excision is the treatment of choice, in order to preserve vision in some cases. To the authors’ knowledge, the present case is the first report of bilateral meibomian gland epithelioma in the veterinary literature.

Histotopography of haemorrhagic infiltration in the hanging cutaneous furrow: Where to look for haemorrhagic infiltration in hanging

2021 ◽  
pp. 002580242110232
Author(s):  
Guendalina Gentile ◽  
Stefano Tambuzzi ◽  
Salvatore Andreola ◽  
Riccardo Zoja
Keyword(s):  
Adipose Tissue ◽  
Microscopic Examination ◽  
Subcutaneous Adipose Tissue ◽  
Transition Point ◽  
Striated Muscle ◽  
Forensic Evidence ◽  
Hematoxylin And Eosin ◽  
Compression Area ◽  
Subcutaneous Adipose ◽  
Masson Trichrome Staining

The forensic evidence of hanging is based on the autopsy demonstration of the traces left by the noose or the ligature on the neck, as well as on the histological assessment of the hanging mark vitality. However, the specific topography of haemorrhagic infiltration in the context of the cervical damaged tissues involved in hanging is not known. We carried out an extensive microscopic examination to identify if haemorrhagic infiltration in hanging appeared in specific topographic locations that could have been considered as elective. From 102 victims of suicidal hanging, a skin fragment was sampled from the maximum compression area of the sulcus, including the skin portions immediately above and below it. The sampling was also extended to collect the subcutaneous adipose tissue and part of the striated muscle. A standard histological examination was performed on all the samples, and hematoxylin and Eosin, Weigert’s resorcin-fuchsin and Goldner’s Masson trichrome staining were performed. In all the cases assessed, the microscopic examination allowed the detection of haemorrhagic infiltration mainly in the deepest areas under the sulcus and especially in the deep dermis and at the transition point between the dermis and the subcutaneous adipose tissue, as well as in the context of its supporting connective tissue. Such areas could therefore be considered as regions in which the presence of haemorrhagic infiltration is more likely to be demonstrated. Accordingly, we recommend performing sampling similar to ours and focusing the search for haemorrhagic infiltration as suggested.

Abstract 15228: Role of Sympathetic Innervation in the Pathogenesis of Abdominal Aortic Aneurysm

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Bin JIANG ◽  
Yugang Liu ◽  
Guillermo A Ameer
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Sympathetic Innervation ◽  
Nerve Fibers ◽  
Elastic Fibers ◽  
Surgical Removal ◽  
Infrarenal Aorta ◽  
Abdominal Aortic ◽  
Nerve Bundles

Introduction: The objective of this study is to understand the role of neurological factors, specifically those from the perivascular sympathetic nervous system (SNS), on the initiation and development of Abdominal Aortic Aneurysm (AAA). Hypothesis: We hypothesize that the formation of AAA is associated with the loss of perivascular SNS-induced vasoconstriction specific to the aneurysm region. Methods: We developed a rat Abdominal Aortic Denervation (AAD) model, where the infrarenal aorta of Spauge Dawley rats was denervated with surgical removal of nerve fibers and chemical denervation with 10% phenol ( Figure. A ). A sham control group was included where the infrarenal aorta was treated with PBS. The arteries were harvested at 1 month after the surgeries for histological assessment. Results: The denervated aortas exhibited significant thinning of the aortic wall including the media and the adventitia, compared to the sham controls ( Figure. B ). Moreover, degradation of elastin, demonstrated by the fragmentation of elastic fibers and the decreased number of lamellar units, was also observed in the dennervated aortas in comparison to the sham controls. While the control aortas were well innervated with perivascular nerve bundles adjacent to the adventitia, no nerves were found surrounding the denervated aortas, suggesting successful denervation. Conclusions: We generated an AAD model that could be used for mechanistic understanding and therapeutic development of AAA. The preliminary data suggest a direct link between the lack of aortic sympathetic innervation and AAA formation. Long-term studies are currently underway to further characterize changes in the aortic walls after sympathetic denervation. Figure. (A) Illustration of the denervated region on the rat infrarenal aorta. ( B ) Histological staining of control and denervated rat abdominal aortas at 1 month after surgery. Yellow stars: para-aortic nerve bundles. Scale bar = 200 μm.

scholarly journals Effects of Chronic Intracerebroventricular Infusion of RFamide-Related Peptide-3 on Energy Metabolism in Male Mice

2020 ◽  
Vol 21 (22) ◽  
pp. 8606
Author(s):  
Shogo Moriwaki ◽  
Yuki Narimatsu ◽  
Keisuke Fukumura ◽  
Eiko Iwakoshi-Ukena ◽  
Megumi Furumitsu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Energy Metabolism ◽  
Food Intake ◽  
Energy Expenditure ◽  
Body Mass ◽  
The Other ◽  
Related Peptide ◽  
Intracerebroventricular Infusion ◽  
Brown Adipose ◽  
The Masses

RFamide-related peptide-3 (RFRP-3), the mammalian ortholog of avian gonadotropin-inhibitory hormone (GnIH), plays a crucial role in reproduction. In the present study, we explored the other functions of RFRP-3 by investigating the effects of chronic intracerebroventricular infusion of RFRP-3 (6 nmol/day) for 13 days on energy homeostasis in lean male C57BL/6J mice. The infusion of RFRP-3 increased cumulative food intake and body mass. In addition, the masses of brown adipose tissue (BAT) and the liver were increased by the administration of RFRP-3, although the mass of white adipose tissue was unchanged. On the other hand, RFRP-3 decreased O2 consumption, CO2 production, energy expenditure, and core body temperature during a short time period in the dark phase. These results suggest that the increase in food intake and the decrease in energy expenditure contributed to the gain of body mass, including the masses of BAT and the liver. The present study shows that RFRP-3 regulates not only reproductive function, but also energy metabolism, in mice.

scholarly journals Management of Adnexal Mass During Cesarean Section

2018 ◽  
Vol 12 (2) ◽  
pp. 48-51
Author(s):  
Monica Gurung ◽  
Gehanath Baral
Keyword(s):  
Retrospective Study ◽  
Cesarean Section ◽  
Adnexal Mass ◽  
Cystic Teratoma ◽  
Mature Cystic Teratoma ◽  
Surgical Removal ◽  
Cesarean Sections ◽  
Operation Theatre ◽  
Adnexal Masses ◽  
The Masses

Aims: To find out the prevalence of adnexal mass during Cesarean Section, its management and histological profile.Methods: This is a retrospective study conducted for 4 years from 2013 to 2017 at Paropakar Maternity and Women’s Hospital, Kathmandu, Nepal. There were 18993 Cesarean Sections out of 72263 total births screened for adnexal masses from operation theatre register and record section.Results: The incidence of adnexal mass during cesarean section was 0.31% (58 out of 18993). Among them 15.52 % diagnosed antenatally and 84.48 % were incidentally diagnosed during cesarean section. Among 58 cases, 6 (10%) were bilateral amounting to 64 adnexal masses among which 35 (54.69%) masses had cystectomy, 20 (31.25%) masses had oophorectomy, 6 (9.37%) had aspiration/ drilling done and 3(4.69 %) masses were left without intervention. Among those cases only 48 histopathological reports were available. All the masses were benign and the most common was benign mature cystic teratoma (34; 69.38 %) and the least common was fibroma (1; 2.04%).Conclusions:  Adnexal masses during cesarean section should undergo surgical removal.

scholarly journals Upper eyelid and medial canthus reconstructive surgery after histiocytoma resection in a dog: a case report

2010 ◽  
Vol 55 (No. 3) ◽  
pp. 137-143 ◽  
Author(s):  
M. Lew ◽  
S. Lew ◽  
A. Rozicka
Keyword(s):  
Histopathological Examination ◽  
Donor Site ◽  
Medial Canthus ◽  
Pedicle Flap ◽  
Upper Eyelid ◽  
Complete Excision ◽  
Pale Pink ◽  
Skin Loss ◽  
Graft Donor ◽  
Treatment Surgery

A six year old crossbred male dog presented with non-pigmented, pale pink, unhaired, ulcerative tumor of the medial canthus and upper eyelid region. As treatment, surgery was proposed. During the surgery complete excision of the tumor was performed. The extent of skin loss, especially in the upper eyelid required plastic reconstruction by pedicle flap transposition. The soft skin of the cheek was chosen as a graft donor site. The postoperative period proceeded without any complications and ended with successful engraftment. The soft cheek skin did not impede movement of the upper eyelid. Histopathological examination indicated histiocytoma and tumor-free excisional margins were confirmed. There has been no recurrence during the subsequent 12 month period.

scholarly journals Epididymal Fat Is Necessary for Spermatogenesis, but not Testosterone Production or Copulatory Behavior

Endocrinology ◽  
2010 ◽  
Vol 151 (12) ◽  
pp. 5669-5679 ◽  
Author(s):  
Ye Chu ◽  
Gloria G. Huddleston ◽  
Andrew N. Clancy ◽  
Ruth B. S. Harris ◽  
Timothy J. Bartness
Keyword(s):  
Adipose Tissue ◽  
Sertoli Cells ◽  
Marked Decrease ◽  
Copulatory Behavior ◽  
Surgical Removal ◽  
Laboratory Rats ◽  
Sham Surgery ◽  
Serum Lh ◽  
Epididymal White Adipose Tissue ◽  
Testicular Histology

Surgical removal of the epididymal white adipose tissue (EWAT) depot (lipectomy; EWATx) in laboratory rats or mice decreases spermatogenesis, but this phenomenal finding has not been investigated in depth. Specifically, detailed histology, neuroendocrine profiles, copulatory behavior, lipectomy of other WAT depots, rescue by autologous EWAT transplants, or tests whether this EWATx effect is due to disruption of testes innervation occurring during EWATx have not been performed. Therefore, in the first study, we performed EWATx in male Syrian hamsters and attempted to rescue spermatogenesis by transplanting the removed EWAT to the animal’s subcutaneous dorsum, removed comparable or larger amounts of non-gonadal WAT [inguinal WAT (IWAT)] and conducted mating behavior tests. In a second study we conducted detailed testicular histology and assayed serum LH, FSH, and testosterone (T). In a third study, we surgically denervated the testes without removing EWAT and compared testicular histology with that of EWATx or sham surgery. We found that EWATx, but not IWATx, virtually eliminated spermatogenesis producing a marked decrease in size of the seminiferous tubule cellular lining including the Sertoli cells and spermatogonia that could not be rescued by autologous EWAT transplant to the subcutaneous dorsum. EWATx did not change serum LH or T concentrations but approximately doubled serum FSH concentrations. EWATx did not alter copulatory behavior but resulted in aspermatic ejaculate. Selective surgical testicular denervation did not affect spermatogenesis. Collectively, these results suggest the presence of a local, but currently unidentified, growth and/or nutritive factor from EWAT that promotes spermatogenesis.

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