Prevalência de sarcopenia na Doença Pulmonar Obstrutiva Crônica: revisão sistemática

2018 ◽  
Vol 8 (4) ◽  
pp. 564-578
Author(s):  
Kelly Roberta Souza Andrade Caria ◽  
Fernanda Warken Rosa Camelier ◽  
Natasha Cordeiro ◽  
Airton Moreira ◽  
Bárbara Silva dos Santos ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
X Ray ◽  
Para Determinar

INTRODUÇÃO: DPOC está associada a um processo inflamatório sistêmico que pode causar sarcopenia, redução da função e massa muscular, embora sua frequência e intensidade não seja completamente conhecida em portadores dessa enfermidade. OBJETIVO: descrever a prevalência e métodos de identificação da sarcopenia na DPOC através de uma revisão sistemática. MATERIAIS E MÉTODOS: Revisão sistemática utilizando a metodologia PICO e palavras-chave (Chronic Obstructive Pulmonary Disease, Sarcopenia). Foram incluídos estudos publicados que estimaram a prevalência de sarcopenia na DPOC. Excluídos aqueles cujo método não detalhou o diagnóstico da sarcopenia. RESULTADOS: A pesquisa resultou inicialmente em 897 artigos. Desses, 877 foram excluídos, sendo 20 selecionados (15 transversais, cinco longitudinais, um caso/controle). As amostras variaram de 57 a 2.582 participantes, a maioria (70%) conduzida em ambulatório. Um estudo foi de base populacional. A idade média foi de 66 anos. A prevalência de sarcopenia na DPOC variou (4,4% a 86,5%). Os métodos diagnósticos utilizados para determinar massa muscular foram o Dual X-ray Absorptiometry, a bioimpedância e as equações de referência. A força muscular foi estimada utilizando-se a preensão manual em dinamômetros portáteis ou a flexão/extensão do joelho através do dinamômetro isocinético. A capacidade funcional foi avaliada pelo teste de caminhada dos seis minutos ou através do teste de velocidade da marcha. CONCLUSÃO: A prevalência de sarcopenia na DPOC encontrada nos estudos (4,4 a 86,5%) é muito variável. Influenciada não somente pela característica do paciente, mas também pelo local, delineamento e método diagnóstico utilizado. Uma padronização de métodos parece ser necessária para se uniformizar condutas na literatura.

scholarly journals The influence of body composition assessed by dual-energy x-ray absorptiometry on functional capacity of patients with chronic obstructive pulmonary disease

2013 ◽  
Vol 26 (1) ◽  
pp. 71-78
Author(s):  
Gualberto Ruas ◽  
Gabriel Gomes Ribeiro ◽  
Juliane Moreira Naves ◽  
Mauricio Jamami
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Body Composition ◽  
Pulmonary Disease ◽  
Functional Capacity ◽  
Lower Limb ◽  
Dual Energy ◽  
Step Test ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
X Ray

INTRODUCTION: The individual with chronic obstructive pulmonary disease (COPD) can experience a significant reduction of body composition, peripheral muscle dysfunction, resulting in a negative influence on functional capacity. OBJECTIVES: To analyze the influence of body composition assessed by dual-energy x-ray absorptiometry on functional capacity of patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS: Eleven male patients with COPD (COPDG), seven presenting moderate obstruction and four severe, and 11 sedentary male subjects (CG) were evaluated by dual-energy x-ray absorptiometry to assess their body composition. All subjects also performed the 6-minute walk test (6MWT) and Step Test (6MST) to assess their functional capacity. RESULTS: No significant differences were found between groups for anthropometric data such as age, weight, height and body mass index (BMI). However, the COPDG presented Forced Vital Capacity (FVC), Forced Expiratory Volume in one second (FEV1), FEV1/FVC ratio, Maximal Voluntary Ventilation (MVV), Walked Distance (WD) and Number of Steps (NS) significantly lower than the CG (p < 0.05, Student's t-test). The Body Bone Mass (BBM), BBM%, Lean Mass (LM), LM%, and Right Lower Limb (RLL) and Left Lower Limb (LLL) were significantly lower in the COPDG when compared with the CG, presenting statistically significant positive correlations with 6MWT's WD and 6MST's NS (p < 0.05, Pearson's test). CONCLUSION: We conclude that body composition is an important prognostic factor for patients with COPD, which reinforces the importance of assessing body composition by dual-energy absorptiometry since it has demonstrated with satisfactory accuracy in clinical practice. Moreover, it is a useful parameter for evaluation and reassessment in pulmonary rehabilitation programs.

scholarly journals Osteoporosis in Chronic obstructive Pulmonary Disease (COPD) Patients

2018 ◽  
Vol 19 (2) ◽  
pp. 114-118
Author(s):  
Md Khairul Islam ◽  
Fahima Sharmin Hossain ◽  
Mostofa Kamal Chowdhury ◽  
Prodip Kumar Biswas
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Complete Blood Count ◽  
Demographic Data ◽  
Smoking History ◽  
Chronic Obstructive ◽  
Mineral Density ◽  
Obstructive Pulmonary Disease ◽  
X Ray ◽  
Copd Patients

Background: Osteoporosis is one of the most common systemic features of Chronic obstructive pulmonary disease (COPD). But there had been no data regarding osteoporosis in COPD patients in Bangladesh. Objectives: To determine the frequency of osteoporosis in COPD patients.Materials & Methods: This was a cross sectional observational study. COPD patients were recruited from Sarkari kormachari hospital. Patients were excluded if they had asthma, any disease affecting bones and calcium homeostasis or were receiving drugs related to bone metabolism. Demographic data were collected including age, smoking history, inhaled corticosteroid use, body mass index, treatment history hospital admission. Chest x-ray was done to exclude any infection or malignancy. Blood was obtained for complete blood count, renal function test, CRP. Bone mineral density (BMD; g/cm2) was conducted by using dual energy x-ray absorptiometry scan (DXA scan) at second to fourth lumbar spines (L2-4) and femoral neck.Results: The overall prevalence of osteoporosis according to the lowest T-score at either L2-4 or femoral neck were 56.7%. This is very high than other country. BMI and CRP were significantly associated with osteoporosis.Conclusion: The frequency of osteoporosis in Bangladeshi COPD patients was higher than others. Osteoporosis was associated with low BMI and high level of CRP.J MEDICINE JUL 2018; 19 (2) : 114-118

scholarly journals Papel da relação neutrófilo-linfócito no valor prognóstico para exacerbação e mortalidade entre indivíduos com Doença Pulmonar Obstrutiva Crônica: revisão integrativa da literatura

2021 ◽  
Vol 10 (12) ◽  
pp. e86101220080
Author(s):  
Barbara Rocha Alves Araújo ◽  
Clara Alvina Davi Coelho ◽  
Júlia Oliveira Santos ◽  
Marcella Luciano de Oliveira ◽  
Rita de Cássia Medeiros Queiroz ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Acute Exacerbation ◽  
Neutrophil To Lymphocyte Ratio ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Lymphocyte Ratio ◽  
Para Determinar

A DPOC é uma doença caracterizada por restrição do fluxo aéreo, inflamação sistêmica e a períodos de exacerbação aguda. Recentemente, demonstrou-se que a relação neutrófilo-linfócito (RNL) é preditor sensível de exacerbação aguda e do prognóstico do paciente com DPOC. Objetivou-se discutir a conformidade entre a RNL na exacerbação da DPOC, apresentando informações que correlacionam a alteração leucocitária com o agravamento dos sintomas e do desfecho do paciente com DPOC. Assim, foi realizada revisão Integrativa da literatura na base de dados PubMed das produções dos últimos 10 anos. Os descritores utilizados foram: “Neutrophil to Lymphocyte Ratio”, “Chronic Obstructive Pulmonary Disease” e “Acute Exacerbation”, os quais foram conjugados para delimitação da busca. Foram selecionados 10 artigos ao final das buscas, sendo os anos de 2015, 2018 e 2020 os mais prevalentes com 20% das publicações cada um. Os estudos tiveram origem na Turquia, responsável por 40% deles, 30% das publicações foram realizadas na China, e Irã, Israel e Japão, cada país com 10%. Encontrou-se níveis mais altos de RNL em pacientes que tiveram morte intra-hospitalar (≥ 4) e admissão hospitalar (≥ 2,7). Todavia, alguns estudos demonstraram que a RNL não é útil para determinar o fenótipo eosinofílico da DPOC exacerbada, e que marcadores inflamatórios se elevam distintamente de acordo com o endotipo de exacerbação. Portanto, a RNL é parâmetro simples e custo efetivo para predição, acompanhamento e prognóstico da exacerbação aguda de DPOC, inclusive nos pacientes estáveis, evidenciando associação positiva entre exacerbação aguda e relações celulares nos pacientes portadores de DPOC.

scholarly journals OPPORTUNITIES OF LOW-DOSE DIGITAL FLUOROGRAPHY IN DIAGNOSIS OF PHENOTYPIC VARIANTS OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

2018 ◽  
Vol 99 (4) ◽  
pp. 191-196
Author(s):  
N. A. Gorbunov ◽  
A. P. Dergilev ◽  
V. I. Kochura ◽  
Ya. L. Manakova ◽  
S. N. Volchenko ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Differential Diagnosis ◽  
Pulmonary Disease ◽  
Optical Density ◽  
Low Dose ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
X Ray ◽  
Average Value ◽  
Lung Emphysema

Objective. To determine the opportunities of low-dose digital fluorography (LDDF) in differential diagnosis of phenotypic variants of chronic obstructive pulmonary disease (COPD).Material and methods. There were 107 patients with clinically diagnosed COPD of varying severity examined. The average age of the patients was 51.8±1.5 years (46–59 years). All patients for LDDF of the chest in the frontal projection in the inspiratory and expiratory phase of respiration were undergone.Results. The electron optical density of the lungs was determined in the upper, middle and lower zones of both lungs. As a result in patients with a predominance of emphysematous variant of COPD (n=15) the most characteristic radiological symptom was lung hyperventilation (14% of 107 patients) and inspiratory electron optical density value was 748.18±4.72 optical density units (ODU). In patients with a predominance of bronchitic variant of COPD (n=43) the most common radiological symptom was the presence of symptom amplification and deformation of lung pattern (40% of 107 patients) and inspiratory electron optical density value was 668.04±12.26 ODU. For patients with mixed phenotypic variant of COPD (n=49) it was characterized by a combination of X-ray symptom amplification and deformation of lung pattern with lung emphysema (46% of 107 patients); the average value of inspiratory electron optical density value was 815.24±17.25 ODU.Conclusion. The technique of LDDF can detect X-ray symptoms and determine inspiratory and expiratory electron optical density of the lungs in patients with COPD that allows optimizing the differential diagnosis of phenotypic variants of chronic obstructive pulmonary disease.

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