scholarly journals Application of microfluidic chips in anticancer drug screening

2021 ◽  
Author(s):  
Xin-yue Fan ◽  
Zhuo-fen Deng ◽  
Yan-yan Yan ◽  
Valerii E. Orel ◽  
Andrii Shypko ◽  
...  
Keyword(s):  
Drug Screening ◽  
Microfluidic Chip ◽  
Structural Design ◽  
Chemical Properties ◽  
Structure Design ◽  
Remote Detection ◽  
Microfluidic Chips ◽  
Chip Technology ◽  
Detection Technology ◽  
System Cell

With the continuous development of drug screening technology, new screening methodologies and technologies are constantly emerging, driving drug screening into rapid, efficient and high-throughput development. Microfluidics is a rising star in the development of innovative approaches in drug discovery. In this article, we summarize the recent years' progress of microfluidic chip technology in drug screening, including the developmental history, structural design, and applications in different aspects of microfluidic chips on drug screening. Herein, the existing microfluidic chip screening platforms are summarized from four aspects: chip structure design, sample injection and drive system, cell culture technology on a chip, and efficient remote detection technology. Furthermore, this review discusses the application and developmental prospects of using microfluidic chips in drug screening, particularly in screening natural product anticancer drugs based on chemical properties, pharmacological effects,  and drug cytotoxicity.

scholarly journals Applications and Prospects of Microfluidic Chips in Orthopaedic Diseases

2021 ◽  
Vol 7 ◽  
Author(s):  
Xiran Yang ◽  
Qiangqiang Tang ◽  
Chen Lai ◽  
Kai Wu ◽  
Xuetao Shi
Keyword(s):  
Bone Metastasis ◽  
Microfluidic Chip ◽  
Poor Prognosis ◽  
Microfluidic Chips ◽  
Ageing Society ◽  
Osteolytic Lesions ◽  
Experimental Platform ◽  
Chip Technology

With the advent of an ageing society, bone-related diseases such as osteoporosis have become a major human health issue, and osteolytic lesions caused by cancer bone metastasis have always had a poor prognosis. Researchers have studied the pathogenesis of these orthopaedic diseases to obtain efficacious treatments. Microfluidic chip technology is a popular technology developed in recent years. This technology can build an experimental platform for a bionic in vivo microenvironment in vitro, which has been favored by an increasing number of researchers. In this review, we will take osteoporosis and cancer bone metastasis as examples to illustrate the pathogenesis, introduce the latest progress in the research of orthopaedics-related diseases of the microfluidic model, and describe the current approaches and their limitations.

Kinematics and Dynamics Simulation Research for Roller Coaster Multi-Body System

2011 ◽  
Vol 421 ◽  
pp. 276-280 ◽  
Author(s):  
Ge Ning Xu ◽  
Hu Jun Xin ◽  
Feng Yi Lu ◽  
Ming Liang Yang
Keyword(s):  
Structural Design ◽  
3D Model ◽  
Structure Design ◽  
Dynamics Simulation ◽  
Body System ◽  
Load Spectrum ◽  
Roller Coaster ◽  
Simulation Research ◽  
Calculation Results ◽  
Multi Body

To assess the roller coaster multi-body system security, it is need to extract the running process of kinematics, dynamics, load spectrum and other features, as basis dates of the roller coaster structural design. Based on Solidworks/motion software and in the 3D model, the calculation formula of the carrying car velocity and acceleration is derived, and the five risk points of the roller coaster track section are found by simulation in the running, and the simulation results of roller coaster axle mass center velocity are compared with theoretical calculation results, which error is less than 4.1%, indicating that the calculation and simulation have a good fit and providing the evidence for the roller coaster structure design analysis.

Study on the Manufacture of Microfluidic Chip with Coated Glass

2012 ◽  
Vol 548 ◽  
pp. 254-257 ◽  
Author(s):  
Yan He ◽  
Bai Ling Huang ◽  
Yong Lai Zhang ◽  
Li Gang Niu
Keyword(s):  
Microfluidic Chip ◽  
Low Cost ◽  
Microfluidic Channel ◽  
Critical Factor ◽  
Wet Etching ◽  
Microfluidic Chips ◽  
Etching Technique ◽  
Chip Quality ◽  
Wet Chemical ◽  
Wet Chemical Etching

In this paper, a simple and facile technique for manufacturing glass-based microfluidic chips was developed. Instead of using expensive dry etching technology, the standard UV lithography and wet chemical etching technique was used to fabricate microchannels on a K9 glass substrate. The fabrication process of microfluidic chip including vacuum evaporation, annealing, lithography, and BHF (HF-NH4F-H2O) wet etching were investigated. Through series experiments, we found that anneal was the critical factor for chip quality. As a representative example, a microfluidic channel with 20 m of depth, and 80 m of width was successfully prepared, and the channel surfaces are quite smooth. These results present a simple, low cost, flexible and easy way to fabricate glass-based microfluidic chips.

Experimental Study of Urea Depositions in Urea-SCR System

2014 ◽  
Vol 937 ◽  
pp. 74-79 ◽  
Author(s):  
Shu Zhan Bai ◽  
Shuai Guo Lang ◽  
Ke Ping Yuan ◽  
Yang Liu ◽  
Guo Xiang Li
Keyword(s):  
Control Strategy ◽  
Structural Design ◽  
Cyanuric Acid ◽  
Exhaust System ◽  
Structure Design ◽  
Exhaust Pipe ◽  
Front End ◽  
Urea Crystallization ◽  
Exhaust Stream ◽  
Scr System

Avoiding the urea deposition in the exhaust stream is one of the basic requirements for SCR system normal application. Unreasonable structure design, machining and installation position all could lead to urea crystallization on the wall of exhaust pipe and the front end surface of the catalyst, in addition, unreasonable control strategy also could deteriorate this phenomenon. The components of the urea depositions are the urea and cyanuric acid analyzed by thermogravimetry - FTIR technology. The integrated injector mounting is designed to alleviate the urea crystallization based on analysis results. The engine test and the vehicle road test are all shown that the optimal structural design and calibration strategies could avoid crystallization and sedimentation effectively in the exhaust system.

Automation of seismic design of high-rise structure with braced steel frame

2021 ◽  
Author(s):  
Xin Zhao ◽  
Gang Wang ◽  
Jinlun Cai ◽  
Junchen Guo
Keyword(s):  
Seismic Performance ◽  
Seismic Design ◽  
Structural Design ◽  
Structure Design ◽  
Steel Frame ◽  
Design Methods ◽  
Automatic Design ◽  
Component Level ◽  
Design Algorithm ◽  
High Rise

<p>With the continuous development and progress of society, the structure of high-rise buildings has been paid more and more attention by the engineering community. However, the existing high- rise structure design methods often have a lot of redundancy and have a lot of room for optimization. Most of the existing seismic design methods of high-rise structures are based on engineering experience and manual iterative methods, so that the efficiency of design can not meet the needs of the society. if the method of design automation is adopted, the workload of designers can be greatly reduced and the efficiency of structural design can be improved. Based on the digital modeling theory, this paper proposes a MAD automatic design algorithm, in which the designer provides the initial design of the structure, and the algorithm carries out the modeling, analysis, optimization and design of each stage of the structure, and finally obtains the optimal structure. The structural design module of this algorithm starts from the component level, when the component constraint design meets the limit requirements of the specification, it enters and completes the component constraint design and the global constraint design of the structure in turn. In this paper, taking a ten-story braced steel frame high-rise structure as an example, the optimal design is carried out, and its seismic performance is analyzed. the results show that the MAD automatic design algorithm can distribute the materials to each part reasonably, which can significantly improve the seismic performance of the structure and realize the effective seismic design.</p>

Remote detection NMR imaging of gas phase hydrogenation in microfluidic chips

Lab on a Chip ◽  
2013 ◽  
Vol 13 (8) ◽  
pp. 1554 ◽  
Author(s):  
Vladimir V. Zhivonitko ◽  
Ville-Veikko Telkki ◽  
Jarmo Leppäniemi ◽  
Gianmario Scotti ◽  
Sami Franssila ◽  
...  
Keyword(s):  
Gas Phase ◽  
Remote Detection ◽  
Nmr Imaging ◽  
Microfluidic Chips

scholarly journals Structure design and reliability analysis of Al-Ti lugs

2021 ◽  
Vol 39 (1) ◽  
pp. 1-8
Author(s):  
Yunwen Feng ◽  
Jiale Zhang ◽  
Xiaofeng Xue ◽  
Xiaoping Zhong ◽  
Wei Xie
Keyword(s):  
Reliability Analysis ◽  
Structural Design ◽  
Design Principle ◽  
Load Transfer ◽  
Design Method ◽  
Static Strength ◽  
Structure Design ◽  
Safety Design ◽  
Design Requirements ◽  
Metal Materials

Aircraft lug joint is the key part of load transfer. In order to improve the safety of lug joint, on the premise of meeting the design requirements of static strength and fatigue, the composite connection lug structure design technology of different metal materials is proposed in this paper. Firstly, the damage safety design and life reliability analysis of the lug structure are studied theoretically. Secondly, based on the concept of damage safety design and the design principle of deformation coordination, the design method of composite connection lug with deformation coordination is proposed, and the thickness ratio of single ear is 0.8:1:0.8. Finally, the reliability of the composite lug is analyzed. The results show that the structural design scheme of aluminum-titanium composite ear piece can meet the requirements of static strength and damage tolerance, and compared with the conventional ear structure, the failure probability of structure mission life is greatly reduced when the weight of the composite connection lug is only increased by 4.9%. The proposed method can effectively guide the structural design of composite ear piece.

scholarly journals Discussion on Prefabricated Concrete Structure Design Method under BIM Technology

2020 ◽  
Vol 198 ◽  
pp. 03011
Author(s):  
Wang Hongyan ◽  
Zhang Zihong
Keyword(s):  
Life Cycle ◽  
Structural Design ◽  
Concrete Structure ◽  
Production Efficiency ◽  
Design Method ◽  
Collaborative Work ◽  
Structure Design ◽  
Building Information ◽  
Correct Understanding ◽  
Design Construction

BIM is a data tool used in various stages of design, construction and management. It can integrate different models of buildings and realize sharing and transmission during the life cycle of the project, ensuring that engineering technicians can access different building information with a correct understanding and real-time response, it lays a good foundation for different participants including design, construction and management to achieve collaborative work. It is very important whether it is to ensure production efficiency, save costs and shorten construction periods. For the newly emerging prefabricated buildings, their structural design will become more efficient, accurate and reasonable due to the introduction of BIM technology.

Structural Design of the Robot Arm for Massage Based on the Chain Drive

2012 ◽  
Vol 605-607 ◽  
pp. 1547-1551
Author(s):  
Zhan Li Wang ◽  
Qian Liang ◽  
Bang Cheng Zhang
Keyword(s):  
Structural Design ◽  
Elbow Joint ◽  
Structure Design ◽  
Robot Arm ◽  
Chain Drive ◽  
Element Analysis ◽  
Overall Design ◽  
Transfer Mode ◽  
Design Requirements ◽  
Robot Technology

With the development of robot technology, massage robot has attracted fully attention, and the study about robot arm has been a growing interest in the area of massage robot. This article has put forward a new massage robot arm, which uses the chain as the main transfer mode by the requirements of the overall design massage of the robot arm. The design of big arm, shoulder joint, forearm, elbow joint and wrist are introduced. Based on the design requirements, we made some improvements with sprockets, ensuring transmission conditions and meeting the massage requirements. And finite element analysis for the designed arm, results show that the structure design can meet the requirements.

scholarly journals Fracture analysis and countermeasures of the grid switch castings

2020 ◽  
Vol 165 ◽  
pp. 06015
Author(s):  
Chao Feng ◽  
Siyuan Yang ◽  
Qiao Li ◽  
Mengbao Zhou ◽  
Songqi Wu ◽  
...  
Keyword(s):  
Chemical Properties ◽  
Fracture Analysis ◽  
Casting Defects ◽  
Physical And Chemical Properties ◽  
Direct Reading ◽  
X Ray ◽  
Detection Technology ◽  
Two Stages ◽  
Physical And Chemical ◽  
And Chemical Properties

Based on the detection technology of direct reading spectrum, metallographic microscope and X-ray, the defects of the grid switch castings were analyzed. The four main forms of casting fracture were summarized as poor physical and chemical properties, material misuse, casting defects and designing defects. In order to strengthen the quality control of the source of the product, it was proposed to carry out targeted network inspection in the two stages of material arrival and infrastructure acceptance.

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