scholarly journals High-Quality Donor: Criteria for the Selection of Gamete Donors in the Russian Field of Assisted Reproductive Technologies

2021 ◽  
Vol 22 (5) ◽  
Author(s):  
Anastasia Grishanina ◽  
Alexandra Narskaya ◽  
Polina Smirnova
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
High Quality ◽  
Donor Criteria ◽  
Selection Of

scholarly journals From egg to embryo: a peripatetic journey

Reproduction ◽  
2005 ◽  
Vol 130 (6) ◽  
pp. 825-828 ◽  
Author(s):  
Richard M Schultz
Keyword(s):  
Gene Expression ◽  
Assisted Reproductive Technologies ◽  
Egg Quality ◽  
Reproductive Technologies ◽  
Molecular Signature ◽  
High Quality ◽  
Long Term Consequences ◽  
The Uk ◽  
Effect Gene

The recent surge of interest in oocyte development has been spurred in large part by the increasing implementation of assisted reproductive technologies (ART) to treat human infertility. What is becoming apparent is that ‘egg quality’ is a primary factor in the success of ART (Sauer 1998), and yet we know virtually nothing about the molecular signature of a ‘high quality’ oocyte, i.e., an oocyte that is capable of maturing, being fertilized and supporting development to term. We are gaining marked insights, however, into how sperm activate eggs and the changes in gene expression that accompany preimplantation development. Nevertheless, embryo culture is known to effect gene expression (Rinaudo & Schultz 2004), the long-term consequences of which are only recently being unmasked. This review will briefly highlight these topics that were presented during the Biennial Joint Meeting of the UK Fertility Societies at Warwick University in April 2005.

scholarly journals ДИСТАНЦІЙНЕ НАВЧАННЯ СУЧАСНИМ МЕДИЧНИМ ТЕХНОЛОГІЯМ ЗА ДОПОМОГОЮ СТРУКТУРОВАНИХ І ФОРМАЛІЗОВАНИХ ДЕКЛАРАТИВНИХ

2013 ◽  
Author(s):  
S. V. Denysenko
Keyword(s):  
Educational Technology ◽  
Data Clustering ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Reproductive Technology ◽  
Educational Systems ◽  
Basic Information ◽  
The Third ◽  
Internet Networks ◽  
Selection Of

<p class="41">There is not enough іп most cases to provide syntactic interoperabi1i1y for interaction between the different educational systems іп the Intranet / Internet networks. Today there is virtually no educational systems that solve this problem by using a single dictionary (taxonomy) with descriptions of the data used (ontology). So, that is the problem of lack of clear semantic definitions prevents the unification of educational systems from different manufacturers.</p><p class="41">The article first considered the possibility of using ontological representations for selection of assisted reproductive technologies for infertility. Specific criteria for assessing the effectiveness of ontological structures are proposed. In the development of ontology to summarize knowledge of assisted reproductive technology used five-level scheme. The first level is reserved for basic information, where we use all theoretically possible terms and concepts, and the second - is designed to solve diagnostic problems, the third - to address the medical, therapeutic management of fourth-and fifth process - educational technology. A scheme for data clustering survey of patients requiring the use of assisted reproductive technologies, containing 11 clusters of attributes.</p><p class="41">The possibilities of practical use of medical ontology’s are discussed.</p>

scholarly journals International Legal Regulation of Preimplantation Genetic Diagnostics (PGD) and Trends in the Development of Russian Legislation in the Field of Assisted Reproductive Technologies

Lex Russica ◽  
2019 ◽  
pp. 9-17
Author(s):  
N. A. Altynnik ◽  
V. V. Komarova ◽  
M. A. Borodina ◽  
E. I. Suvorova ◽  
S. S. Zenin ◽  
...  
Keyword(s):  
Assisted Reproductive Technologies ◽  
Genetic Research ◽  
Reproductive Technologies ◽  
Legal Framework ◽  
Legal Regulation ◽  
Genetic Diagnostics ◽  
Chromosomal Disorder ◽  
Right Not To Know ◽  
The Right ◽  
Selection Of

The article analyzes key instruments of international legal regulation of preimplantation genetic diagnostics (PGD) procedure. The authors substantiate the conclusion that the requirements and principles formulated in these instruments can be successfully used for the development and improvement of the national legal framework aimed at regulating the PGA. The main directions of such use are defined. First, it is necessary to consider the existence of genetic predisposition to a particular disease or chromosomal disorder (the medical purpose) and provide a qualified consultation of a genetic scientist concerning the mechanism and consequences of diagnostics. Secondly, the legal regulation of genetic information obtained through the PGA requires an independent normative framework: determining the framework the law-maker must be guided by the fact that any intervention in the human genome aimed at modifying it may be carried out only for preventive, diagnostic or therapeutic purposes. In this regard, it is important to prohibit the PGA for social purposes (selection of embryo according to specific characteristics, establishment of compatibility between a donor and a recipient, looking beyond the prohibition to choose the embryo gender that is currently imposed under Russian legislation). Third, a separate regulatory framework is needed to resolve the problem of informing the patient about the results of examination: in addition to the right to be informed of the results of examination, it is also necessary to recognize the individual’s «right not to know,» particularly relevant to predictive genetic research.

scholarly journals In Vitro Microvibration Increases Implantation Rate after Embryonic Cell Transplantation

2017 ◽  
Vol 26 (5) ◽  
pp. 789-794 ◽  
Author(s):  
Vladimir Isachenko ◽  
Karl Sterzik ◽  
Robert Maettner ◽  
Evgenia Isachenko ◽  
Plamen Todorov ◽  
...  
Keyword(s):  
In Vitro Culture ◽  
Assisted Reproductive Technologies ◽  
Implantation Rate ◽  
Reproductive Technologies ◽  
Embryonic Cell ◽  
Embryonic Cells ◽  
Natural Conditions ◽  
High Quality ◽  
Oviductal Fluid

In natural conditions the oocyte and embryo are subjected to ever-changing dynamic processes. However, the routine assisted reproductive technologies today involve the use of static in vitro culture systems. The objective was to determine whether there is any difference in the viability of embryos after in vitro culture under static and mechanical microvibration conditions. The viability of embryonic cells (9,624 embryos) generated from 4,436 couples after in vitro culture was evaluated. For groups ≤29, 30-34, 35-39, and ≥40 years, the following rates of high-quality embryos without fragmentation (two to four blastomeres on day 2; six to eight blastomeres and compacting morula on day 3; blastocyst, expanded and hatching blastocyst on day 5) were detected (static vs. vibration, respectively): 65% versus 71%, 44% versus 69%, 67% versus 76% (for statistically significant differences between respective rates in these three groups, p <0.05), and 67% versus 66% (p > 0.1). The following baby-take-home rates were determined for groups ≤29, 30-34, 35-39, and ≥40 years (static vs. vibration, respectively): 30% versus 31% (p > 0.1, increasing only on the level of tendency), 28% versus 37%, 23% versus 29%, and 9% versus 15% (differences between respective rates in these three groups with p < 0.05). It was concluded that in vitro culture of embryos under microvibration (with a mimic of conditions in nature whereby oviductal fluid is mechanically agitated by the epithelial cilia) significantly increases the baby-take-home rate for patients 30 years and older.

scholarly journals An Update on Semen Physiology, Technologies, and Selection Techniques for the Advancement of In Vitro Equine Embryo Production: Section II

Animals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3319
Author(s):  
Morgan F. Orsolini ◽  
Stuart A. Meyers ◽  
Pouya Dini
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Future Application ◽  
Embryo Production ◽  
Future Developments ◽  
Production Section ◽  
In Vitro Embryo Production ◽  
Equine Industry ◽  
Selection Of

As the use of assisted reproductive technologies (ART) and in vitro embryo production (IVP) expand in the equine industry, it has become necessary to further our understanding of available semen selection techniques. This segment of our two-section review will focus on the selection of spermatozoa based on quality and sex for equine intracytoplasmic sperm injection (ICSI), as well as current and future developments in sperm sorting technologies. Ultimately, novel methods of semen selection will be assessed based on their efficacy in other species and their relevance and future application towards ARTs in the horse.

scholarly journals The Presence of D-Penicillamine during the In Vitro Capacitation of Stallion Spermatozoa Prolongs Hyperactive-Like Motility and Allows for Sperm Selection by Thermotaxis

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1467
Author(s):  
Sara Ruiz-Díaz ◽  
Ivan Oseguera-López ◽  
David De La Cuesta-Díaz ◽  
Belén García-López ◽  
Consuelo Serres ◽  
...  
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Protein Tyrosine Phosphorylation ◽  
Sperm Selection ◽  
Optimal Conditions ◽  
High Quality ◽  
Vitro Fertilization ◽  
Sperm Preparation ◽  
Preparation Strategy

Assisted reproductive technologies (ARTs) in the horse still yield suboptimal results in terms of pregnancy rates. One of the reasons for this is the lack of optimal conditions for the sperm capacitation in vitro. This study assesses the use of synthetic human tubal fluid (HTF) supplemented with D-penicillamine (HTF + PEN) for the in vitro capacitation of frozen/thawed stallion spermatozoa by examining capacitation-related events over 180 min of incubation. Besides these events, we explored the in vitro capacity of the spermatozoa to migrate by thermotaxis and give rise to a population of high-quality spermatozoa. We found that HTF induced higher levels of hyperactive-like motility and protein tyrosine phosphorylation (PTP) compared to the use of a medium commonly used in this species (Whitten’s). Also, HTF + PEN was able to maintain this hyperactive-like motility, otherwise lost in the absence of PEN, for 180 min, and also allowed for sperm selection by thermotaxis in vitro. Remarkably, the selected fraction was enriched in spermatozoa showing PTP along the whole flagellum and lower levels of DNA fragmentation when compared to the unselected fraction (38% ± 11% vs 4.4% ± 1.1% and 4.2% ± 0.4% vs 11% ± 2% respectively, t-test p < 0.003, n = 6). This procedure of in vitro capacitation of frozen/thawed stallion spermatozoa in HTF + PEN followed by in vitro sperm selection by thermotaxis represents a promising sperm preparation strategy for in vitro fertilization and intracytoplasmic sperm injection in this species.

Reducing time to pregnancy and facilitating the birth of healthy children through functional analysis of embryo physiology†

2019 ◽  
Vol 101 (6) ◽  
pp. 1124-1139 ◽  
Author(s):  
Laura Ferrick ◽  
Yee Shan Lisa Lee ◽  
David K Gardner
Keyword(s):  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Healthy Children ◽  
Success Rates ◽  
Embryo Viability ◽  
Time To Pregnancy ◽  
Indirect Measure ◽  
Offspring Health ◽  
Viable Embryo ◽  
Selection Of

Abstract An ever-increasing number of couples rely on assisted reproductive technologies (ART) in order to conceive a child. Although advances in embryo culture have led to increases in the success rates of clinical ART, it often takes more than one treatment cycle to conceive a child. Ensuring patients conceive as soon as possible with a healthy embryo is a priority for reproductive medicine. Currently, selection of embryos for transfer relies predominantly on the morphological assessment of the preimplantation embryo; however, morphology is not an absolute link to embryo physiology, nor the health of the resulting child. Non-invasive quantitation of individual embryo physiology, a key regulator of both embryo viability and health, could provide valuable information to assist in the selection of the most viable embryo for transfer, hence reducing the time to pregnancy. Further, according to the Barker Hypothesis, the environment to which a fetus is exposed to during gestation affects subsequent offspring health. If the environment of the preimplantation period is capable of affecting metabolism, which in turn will affect gene expression through the metaboloepigenetic link, then assessment of embryo metabolism should represent an indirect measure of future offspring health. Previously, the term viable embryo has been used in association with the potential of an embryo to establish a pregnancy. Here, we propose the term healthy embryo to reflect the capacity of that embryo to lead to a healthy child and adult.

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