Risk factors and characterization of post-COVID-19 syndrome in patients from Colombia v1

2021 ◽  
Author(s):  
Jorge Machado Alba
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Acute Phase ◽  
Older Patients ◽  
Multivariate Analyses ◽  
Inhaled Corticosteroids ◽  
Clinical Manifestations ◽  
Acute Illness ◽  
Prior Informed Consent

Introduction: A high percentage of people who have suffered from COVID-19 present clinical manifestations that persist long after recovery from the acute phase. Objective: To determine the proportion of patients who presented post-COVID-19 syndrome, its clinical picture, and its risk factors in a group of patients from Colombia. Methods: This was an observational, longitudinal study of patients with SARS-CoV-2 treated in a network of clinics in Colombia. Over the telephone, after they gave prior informed consent, we evaluated whether the patients had post-COVID-19 syndrome and other clinical variables. Descriptive, bivariate, and multivariate analyses were performed. Results: A total of 311 patients (50.2% women) from 19 different cities were identified, with a median age of 47.0 years. In 63.0% of cases, symptoms persisted more than 3 months after recovery from the acute phase of the disease. Most common were dyspnea (54.1%), fatigue (42.9%), and muscle pain (36.2%). Greater age (30-59 vs. <30 years: OR: 2.67; 95% CI: 1.33-5.34; and ≥60 years vs. <30 years: OR: 3.23; 95% CI: 1.28-8.15), use of bronchodilators or inhaled corticosteroids (OR: 1.78; 95% CI: 1.02-3.10), and presenting cough at the time of diagnosis of COVID-19 (OR: 2, 39; 95% CI 1.23-4.65) increased the probability of prolonged clinical manifestations. Conclusions:Post-COVID-19 syndrome is a frequent condition characterized by heterogeneous symptoms. Older patients, those who present cough during the acute illness, and those who are managed with bronchodilators or inhaled corticosteroids have a higher risk of presenting it.

Characterization of and Risk Factors for the Acute-Phase Response After Zoledronic Acid

2011 ◽  
Vol 66 (2) ◽  
pp. 97-99 ◽  
Author(s):  
I. R. Reid ◽  
G. D. Gamble ◽  
P. Mesenbrink ◽  
P. Lakatos ◽  
D. M. Black
Keyword(s):  
Risk Factors ◽  
Zoledronic Acid ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response

scholarly journals Observation of risk factors, clinical manifestations and genetic characterization of recent Newcastle Disease Virus outbreak in West Malaysia

2015 ◽  
Vol 11 (1) ◽  
Author(s):  
Seetha Jaganathan ◽  
Peck Toung Ooi ◽  
Lai Yee Phang ◽  
Zeenathul Nazariah Binti Allaudin ◽  
Lai Siong Yip ◽  
...  
Keyword(s):  
Risk Factors ◽  
Newcastle Disease Virus ◽  
Disease Virus ◽  
Newcastle Disease ◽  
Genetic Characterization ◽  
Clinical Manifestations

Risk factors for orofacial and limbtruncal tardive dyskinesia in older patients: a prospective longitudinal study

1996 ◽  
Vol 123 (4) ◽  
pp. 307-314 ◽  
Author(s):  
J. S. Paulsen ◽  
M. P. Caligiuri ◽  
B. Palmer ◽  
L. A. McAdams ◽  
D. V. Jeste
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Tardive Dyskinesia ◽  
Older Patients ◽  
Prospective Longitudinal Study ◽  
Prospective Longitudinal

Effects of Mixed Dietary Supplements on Total Plasma Homocysteine Concentrations (tHcy): A Randomized, Double-Blind, Placebo-Controlled Trial

2012 ◽  
Vol 82 (4) ◽  
pp. 260-266 ◽  
Author(s):  
Salah E. Gariballa ◽  
Sarah J. Forster ◽  
Hilary J. Powers
Keyword(s):  
Older Patients ◽  
Controlled Trial ◽  
Plasma Homocysteine ◽  
Acute Illness ◽  
Vitamin B ◽  
Total Plasma ◽  
Double Blind ◽  
Double Blind Placebo ◽  
Nutrient Supplement ◽  
Plasma Thcy

Background: Although a number of studies have reported raised total plasma homocysteine (tHcy) concentrations in free-living older people, there are no data on homocysteine response to a mixed nutrient supplement in older patients. A raised plasma homocysteine concentration in older patients is partly a reflection of their co-morbidity, including impaired renal function, and there is uncertainty about the extent to which dietary interventions can improve plasma tHcy. Aim: To determine the plasma tHcy response to dietary supplements during acute illness. Methods: Two-hundred and thirty-six hospitalized, acutely ill older patients, who were part of a randomized double-blind placebo-controlled trial, were assigned to receive a daily oral nutritional supplement drink containing 1.3 mg of vitamin B2, 1.4 mg of vitamin B6, 1.5 μg of B12, 200 μg of folic acid, or a placebo, for 6 weeks. Outcome measures were plasma tHcy concentration at baseline, 6 weeks, and 6 months. Results: The mean plasma tHcy concentration fell among patients given the supplements (mean difference 4.1 µmol/L [95 % C.I, 0.14 to 8.03), p = 0.043], but tHcy concentration increased between 6 weeks and 6 months, after patients stopped taking the supplements [mean difference -2.0 µmol/L (95 % C.I, -03.9 to -0.18), p = 0.033]. About 46 % of patients in the placebo group and 55 % of patients in the supplement group had hyperhomocysteinemia (>14 µmol/L) at baseline compared with 45 % and 29 % at the end of the treatment period. Conclusions: A mixed nutrient supplement containing physiological amounts of B vitamins significantly reduced plasma tHcy concentrations in older patients recovering from acute illness.

Understanding Terminal Decline in Cognition and Risk of Death

2006 ◽  
Vol 11 (3) ◽  
pp. 164-171 ◽  
Author(s):  
Patrick Rabbitt ◽  
Mary Lunn ◽  
Danny Wong
Keyword(s):  
Risk Factors ◽  
Longitudinal Study ◽  
Test Scores ◽  
Intelligence Test ◽  
Practice Effects ◽  
Risk Of Death ◽  
Risk Of Mortality ◽  
Impending Death ◽  
Intelligence Test Scores ◽  
Reduced Risk

There is new empirical evidence that the effects of impending death on cognition have been miscalculated because of neglect of the incidence of dropout and of practice gains during longitudinal studies. When these are taken into consideration, amounts and rates of cognitive declines preceding death and dropout are seen to be almost identical, and participants aged 49 to 93 years who neither dropout nor die show little or no decline during a 20-year longitudinal study. Practice effects are theoretically informative. Positive gains are greater for young and more intelligent participants and at all levels of intelligence and durations of practice; declines in scores of 10% or more between successive quadrennial test sessions are risk factors for mortality. Higher baseline intelligence test scores are also associated with reduced risk of mortality, even when demographics and socioeconomic advantage have been taken into consideration.

Clinical and molecular cytogenetic characterization of two cases of inverted duplication deletion 8p

2020 ◽  
pp. 41-42
Author(s):  
Д.А. Юрченко ◽  
М.Е. Миньженкова ◽  
Е.Л. Дадали ◽  
Н.В. Шилова
Keyword(s):  
Mental Retardation ◽  
Congenital Heart ◽  
Heart Defects ◽  
Clinical Manifestations ◽  
Formation Mechanisms ◽  
Agenesis Of Corpus Callosum ◽  
Molecular Cytogenetic ◽  
Inverted Duplication ◽  
Cytogenetic Characterization

Синдром инвертированной дупликации короткого плеча хромосомы 8 со смежной терминальной делециенй (inv dup del(8p), ORPHA 96092) - редкая хромосомная аномалия (ХА) с частотой 1/10000-1/30000 живорожденных. В статье представлены клинические и молекулярно-цитогенетические характеристики двух неродственных пациентов с синдромом inv dup del(8p) и уточнены механизмы формирования хромосомного дисбаланса. Inverted duplication deletion 8p syndrome (inv dup del(8p), ORPHA 96092) is a rare chromosomal abnormality with a frequency of 1:10,000 - 30,000 newborns. Clinical manifestations of this syndrome include mental retardation, facial anomalies, hypoplasia/agenesis of corpus callosum, scoliosis and/or kyphosis, hypotonia, congenital heart defects. The article presents the clinical and molecular cytogenetic characteristics of two patients with inv dup del (8p) syndrome and clarifies the formation mechanisms.

Colon cancer: risk factors and screening

2020 ◽  
pp. 13-22
Author(s):  
Mark Natanson
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Cancer Risk ◽  
Clinical Manifestations ◽  
Dysplastic Lesion ◽  
Test Analysis ◽  
Cancer Risk Factors ◽  
Colon Cancer Risk ◽  
Neoplastic Process ◽  
Rectal Cancers

Colon and rectal cancers are usually combined under the same term "colorectal cancer". It should be noted that the lesion of the colon is much more common. Colorectal cancer ranks fourth in the overall structure of oncological pathology in terms of prevalence, and in some countries even comes third after lung and stomach cancer. Risk factors that contribute to the development of colorectal cancer include bowel polyps, ulcerative colitis and Crohn's disease, and a genetic predisposition. Most often, neoplastic transformation occurs at the site of an adenoma or dysplastic lesion of the intestinal mucosa. Due to the high risk of neoplastic process in a sufficiently large number of elderly people, it is recommended that every person over the age of 50 should undergo compulsory screening to detect latent cancer. The simplest, but at the same time insufficiently informative method is a blood culture test - analysis for the presence of blood in the feces. Method of total colonoscopy and double-contrast radiography is distinguished by a higher information content, but at the same time a higher cost. It is recommended to have these examinations every three to five years after the age of 50 years without clinical manifestations, and after the age of 40 for those at risk for colorectal cancer.

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