Risk predictive tools of perioperative drug hypersensitivity reaction: a case-control v1 (protocols.io.bqukmwuw)

protocols.io ◽  
2020 ◽  
Author(s):  
Dr. Ujal
Keyword(s):  
Hypersensitivity Reaction ◽  
Drug Hypersensitivity ◽  
Case Control ◽  
Predictive Tools ◽  
Drug Hypersensitivity Reaction

scholarly journals Risk predictive tools of perioperative drug hypersensitivity reaction: A case-control study

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0262362
Author(s):  
Ujal Pradhan ◽  
Maliwan Oofuvong ◽  
Orarat Karnjanawanichkul ◽  
Jatuporn Pakpirom
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Hypersensitivity Reaction ◽  
Case Control Study ◽  
Drug Hypersensitivity ◽  
Case Control ◽  
Drug Hypersensitivity Reaction ◽  
History Of ◽  
Control Study ◽  
Type Of Surgery

Objective We aimed to determine the risk factors of perioperative drug hypersensitivity reaction (DHR) and develop a predictive score for use in clinical practice. Methods A case-control study was conducted in patients who underwent anesthesia at a tertiary hospital in Thailand, between 2015–2018. DHR cases were graded clinically from 1 to 4 according to the World Federation of Societies of Anesthesiologists by two anesthesiologists. Controls were randomly matched with cases (ratio 2:1) by age group and month and type of surgery. Patient and anesthesia-related factors and agents given intraoperatively were recorded. A risk score was derived from the coefficients of the significant predictors of the final multivariate logistic regression model. Risk scores, adjusted odds ratios (OR) for perioperative DHR and 95% confidence intervals (CI) were determined. Results Overall, 325 cases and 650 controls were recruited. The severity of DHR was grade 1 (72.9%), grade 2 (24%), and grade 3 (3.1%). Our risk predictive tools for perioperative DHR provided a sensitivity of 62% and specificity of 65%. Predictive scores of subgroups of moderate to severe DHR showed high specificity (80%) but low sensitivity (47%). Common predictors of overall DHR and moderate to severe DHR were history of drug allergy to 2 or more drug categories (score 2.5–3.5), being allergic to analgesics (score 2.5–4.0), and intraoperative morphine use (score of 1). The sole predictor of high-risk perioperative DHR (score ≥3.5) was airway management with an endotracheal tube intubation (OR 5.6, 95% CI 2.2–14.4) whereas history of allergic rhinitis (OR 11.7, 95% CI 1.3–105.1) was a predictor of high-risk moderate to severe DHR (score ≥2.5). Conclusions Our predictive tool for perioperative DHR provided a modest predictive ability. History of drug allergies, rhinitis, morphine use and endotracheal intubation were significant risk factors of DHR after adjusting for age and type of surgery.

Bleomycin-induced urticarial flagellate drug hypersensitivity reaction

1999 ◽  
Vol 38 (2) ◽  
pp. 140-141 ◽  
Author(s):  
Nelly G.. Rubeiz ◽  
Ziad Salem ◽  
Rania Dibbs ◽  
Abdul-Ghani Kibbi
Keyword(s):  
Hypersensitivity Reaction ◽  
Drug Hypersensitivity ◽  
Drug Hypersensitivity Reaction

Life-Threatening Non-Allergic Drug Hypersensitivity Reaction as a Very Rare Side Effect of Rivaroxaban Administration in the Netherlands

2021 ◽  
pp. 153857442110047
Author(s):  
Nadia A. G. Hakkenbrak ◽  
Maarten Truijers
Keyword(s):  
The Netherlands ◽  
Hypersensitivity Reaction ◽  
Anaphylactic Reaction ◽  
Side Effect ◽  
Drug Hypersensitivity ◽  
Oral Anticoagulants ◽  
Clinical Signs ◽  
Hemorrhagic Complications ◽  
Drug Hypersensitivity Reaction ◽  
Life Threatening

Background: Anticoagulant therapy is indicated for the prevention and treatment of thromboembolic disease. Direct oral anticoagulants (DOACs) are frequently prescribed and Rivaroxaban is the most frequently administered DOAC in the Netherlands. Most side effects relate to hemorrhagic complications, however, also non-hemorrhagic side effect may be potentially life threatening. Case presentation: A 74-year-old man presented at the emergency department with a ruptured infrarenal abdominal aortic aneurysm for which open aneurysm repair was performed. Postoperatively, the patient developed neurological deficit, respiratory and circulatory failure following rivaroxaban administration, initiated for atrial fibrillation. Even though, the clinical signs resembled an anaphylactic reaction, the skin-prick test was negative and complications most likely resulted from a non-allergic drug hypersensitivity reaction. Conclusion: This case report shows that non-allergic drug hypersensitivity reactions may mimic an anaphylactic reaction and can be potentially life threatening. In addition, severe non-hemorrhagic complications after rivaroxaban administration do occur and should be considered in case of acute clinical deterioration.

scholarly journals Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation

2021 ◽  
Vol 55 (1) ◽  
pp. 54
Author(s):  
Nur Moya Isyroqiyyah ◽  
Gatot Soegiarto ◽  
Yuani Setiawati
Keyword(s):  
Hypersensitivity Reaction ◽  
Drug Hypersensitivity ◽  
Demographic Data ◽  
Stevens Johnson Syndrome ◽  
Type I ◽  
Type Iv ◽  
Drug Eruptions ◽  
Johnson Syndrome ◽  
Drug Hypersensitivity Reaction ◽  
Type I Hypersensitivity

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient’s demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.

Severe Drug Hypersensitivity Reaction in a Young Woman Treated with Doxycycline

Dermatology ◽  
2008 ◽  
Vol 217 (1) ◽  
pp. 23-26 ◽  
Author(s):  
David T. Robles ◽  
Jennifer L. Leonard ◽  
Nicholas Compton ◽  
Alpana Waghmare ◽  
Karen A. McDonough ◽  
...  
Keyword(s):  
Hypersensitivity Reaction ◽  
Young Woman ◽  
Drug Hypersensitivity ◽  
Drug Hypersensitivity Reaction

scholarly journals Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation

2019 ◽  
Vol 55 (1) ◽  
pp. 54
Author(s):  
Nur Moya Isyroqiyyah ◽  
Gatot Soegiarto ◽  
Yuani Setiawati
Keyword(s):  
Hypersensitivity Reaction ◽  
Drug Hypersensitivity ◽  
Demographic Data ◽  
Stevens Johnson Syndrome ◽  
Type I ◽  
Type Iv ◽  
Drug Eruptions ◽  
Johnson Syndrome ◽  
Drug Hypersensitivity Reaction ◽  
Type I Hypersensitivity

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient’s demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.

scholarly journals Congenital ichthyosis associated with Trichophyton rubrum tinea, imitating drug hypersensitivity reaction

2020 ◽  
Vol 29 ◽  
pp. 15-17
Author(s):  
Eszter Szlávicz ◽  
Csongor Németh ◽  
Éva Szepes ◽  
Csaba Gyömörei ◽  
Rolland Gyulai ◽  
...  
Keyword(s):  
Hypersensitivity Reaction ◽  
Trichophyton Rubrum ◽  
Drug Hypersensitivity ◽  
Congenital Ichthyosis ◽  
Drug Hypersensitivity Reaction
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