scholarly journals Relationship of Neutrophil Lymphocyte Ratio (NLR) with Parathyroid Hormone (PTH) in Maintenance Hemodialysis Patients

2021 ◽  
Vol 7 (1) ◽  
pp. 17-25
Author(s):  
Dr. Asmita Hazra ◽  
◽  
Dr. Saptarshi Mandal ◽  
Dr. Jayati Chakraborty ◽  
◽  
...  
Keyword(s):  
Complete Blood Count ◽  
Pearson Correlation ◽  
Hemodialysis Patients ◽  
Adverse Outcomes ◽  
Maintenance Hemodialysis ◽  
Care Hospital ◽  
Cross Sectional ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Maintenance Hemodialysis Patients

Background: Neutrophil-Lymphocyte-Ratio (NLR), a simple derived parameter of routine CompleteBlood Counts (CBC), has been shown to be better than WBC count as a marker for inflammation inmany contexts. Inflammation is associated with adverse outcomes in hemodialysis patients.Methods: A cross sectional study was designed on 100 maintenance hemodialysis Patients in atertiary care hospital in Eastern India after IRB permission and informed consent. 88 completeresults became available. Complete blood count (CBC), routine PTH and biochemistry analysis wereperformed. KDIGO 2009 cut offs were used to classify patients by PTH levels (PTH<2ULN, PTH 2-9ULN & PTH>9 ULN). NLR was calculated and NLR of 3.5 was used as high inflammation cut off.Results: In Analysis of 88 samples, significant Pearson Correlation with NLR was shown by Albumin,Hemoglobin, PTH, Gender, Age, and Sugar, but involved collinearities. Multiple Linear Regressionwith Robust estimation of Standard Errors retained only PTH as a significant predictor (Beta=-0.273, P=0.033) of NLR and Albumin as a borderline significant predictor (Beta= -0.501, P=0.061). The population was partitioned into 3 sets based on PTH as per KDIGO guideline.Conclusion: Our study suggests that PTH is a significant predictor of inflammation as measured byNLR, independent of the other parameters, and it has an overall weak negative association withinflammation especially in the mid-range (PTH 2-9 ULN) subgroup, which largely corroborates withavailable but scant literature.

Blood Pressure of Maintenance Hemodialysis Patients in the Dalmatian Region of Croatia: Differences between Hospital and Out-of-Hospital Dialysis Centers

2017 ◽  
Vol 44 (2) ◽  
pp. 110-121
Author(s):  
Marijana Gulin ◽  
Dragan Klarić ◽  
Mario Ilić ◽  
Josipa Radić ◽  
Vedran Kovačić ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Weight Gain ◽  
Beta Blockers ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Interdialytic Weight Gain ◽  
Maintenance Hemodialysis Patients

Aims: This study was aimed at comparing the incidence of arterial hypertension and blood pressure (BP) variance in hospital and out-of-hospital hemodialysis (HD) patients during HD sessions. Methods: A cross-sectional study was conducted for 1 week at all the HD centers in Dalmatia, Croatia. The pre-, intra-, and post-dialysis BP values were collected for 3 consecutive HD sessions per patient. Results: Of the 399 subjects, 73.9% were hypertensives, who showed higher interdialytic weight gain compared to the normotensives (2.58 vs. 2.40). Hospital and out-of-hospital HD patients received identical antihypertensive therapies, except that beta blockers were more frequently administered to out-of-hospital HD patients. Higher pre-, intra-, and post-dialysis BP values were recorded in patients at out-of-hospital HD centers. Conclusion: The differences in BP variability and antihypertensive therapies administered to hospital HD patients as compared to out-of-hospital HD patients may reflect differing approaches by the nephrologists at these centers.

scholarly journals Cross-sectional small intestinal surveillance of maintenance hemodialysis patients using video capsule endoscopy: SCHEMA study

2016 ◽  
Vol 04 (05) ◽  
pp. E589-E596 ◽  
Author(s):  
Naoki Hosoe ◽  
Shigeaki Matsukawa ◽  
Yoshihiko Kanno ◽  
Makoto Naganuma ◽  
Hiroyuki Imaeda ◽  
...  
Keyword(s):  
Capsule Endoscopy ◽  
Hemodialysis Patients ◽  
Video Capsule Endoscopy ◽  
Maintenance Hemodialysis ◽  
Cross Sectional ◽  
Small Intestinal ◽  
Maintenance Hemodialysis Patients

scholarly journals Association of Anabolic Effect of Calcitriol with Osteoclast-Derived Wnt 10b Secretion

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1164 ◽  
Author(s):  
Chien-Lin Lu ◽  
Jia-Fwu Shyu ◽  
Chia-Chao Wu ◽  
Chi-Feng Hung ◽  
Min-Tser Liao ◽  
...  
Keyword(s):  
Bone Development ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Tartrate Resistant Acid Phosphatase ◽  
Dependent Manner ◽  
Mesenchymal Progenitor Cells ◽  
Micro Computed Tomography ◽  
Cross Sectional ◽  
Maintenance Hemodialysis Patients

Canonical Wnt (Wingless/Integrated) signaling is crucial in bone development and the Wnt ligand can promote osteoblast differentiation from mesenchymal progenitor cells. Calcitriol, an active vitamin D3, is used clinically for treatment of secondary hyperparathyroidism (SHPT) in chronic kidney disease (CKD) patients. The bone effects of calcitriol in SHPT remains uncertain. We hypothesized that calcitriol improves bone mass by suppressing osteoclast activity, and simultaneously promoting Wnt ligand secretion. We designed a cross-sectional study in maintenance hemodialysis patients to explore the effects of calcitriol on different bone turnover markers and specifically emphasized the Wnt 10b levels. Then, we explored the source of Wnt 10b secretion by using osteoclasts and osteoblasts treated with calcitriol in cell culture studies. Finally, we explored the effects of calcitriol on bone microarchitectures in CKD mice, using the 5/6 nephrectomy CKD animal model with analysis using micro-computed tomography. Calcitriol promoted the growth of both trabecular and cortical bones in the CKD mice. Wnt 10b and Procollagen 1 N-terminal Propeptide (P1NP) significantly increased, but Tartrate-resistant acid phosphatase 5b (Trap 5b) significantly decreased in the calcitriol-treated maintenance hemodialysis patients. Calcitriol enhanced Wnt 10b secretion from osteoclasts in a dose-dependent manner. Treatment of SHPT with calcitriol improved the bone anabolism by inhibiting osteoclasts and promoting osteoblasts that might be achieved by increasing the Wnt 10b level.

Underreporting of Energy Intake in Maintenance Hemodialysis Patients: A Cross-sectional Study

2012 ◽  
Vol 22 (6) ◽  
pp. 578-583 ◽  
Author(s):  
Denise Mafra ◽  
Cristiane Moraes ◽  
Viviane O. Leal ◽  
Najla E. Farage ◽  
Milena B. Stockler-Pinto ◽  
...  
Keyword(s):  
Energy Intake ◽  
Cross Sectional Study ◽  
Hemodialysis Patients ◽  
Maintenance Hemodialysis ◽  
Sectional Study ◽  
Cross Sectional ◽  
Maintenance Hemodialysis Patients
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