scholarly journals Isolation of Carbazole Alkaloids and Coumarins from Aegle marmelos and Murraya koenigii and Their Antioxidant Properties

2018 ◽  
Vol 47 (8) ◽  
pp. 1749-1756 ◽  
Author(s):  
Rou Chian Ng ◽  
Nur Kartinee Kassim ◽  
Yu Yeap Yunie Soon ◽  
Lian Ee Gwendoline Cheng ◽  
Saiful Latifah Yazan ◽  
...  
1997 ◽  
Vol 46 (4) ◽  
pp. 751-755 ◽  
Author(s):  
Manas Chakrabarty ◽  
Amar C. Nath ◽  
Shampa Khasnobis ◽  
Manju Chakrabarty ◽  
Yaeko Konda ◽  
...  

2019 ◽  
Vol 13 (3) ◽  
pp. 2288-2297
Author(s):  
Vandana Sablania ◽  
Sowriappan John Don Bosco ◽  
Tanveer Ahmed ◽  
V. Venkateswara Sarma

2020 ◽  
Vol 12 (4) ◽  
pp. 665-672
Author(s):  
M. Chakraborty

The plant Murraya koenigii, commonly known as curry leaf tree is a rich source of carbazole alkaloids. A number of monomeric as well as dimeric carbazoles with C13, C18 and C23 skeleton have been isolated from the plant. In my present work, a new carbazole alkaloid, designated as mumunine, was isolated from the bark of Murraya koenigii (Linn) Spreng, along with a known carbazole alkaloid, viz. mahanimbine. The structure of the new alkaloid 1 was elucidated on the basis of 1D and 2D NMR spectral data analysis. In this paper, the isolation and structure elucidation of the new compound will be discussed in detail.


Author(s):  
BRIJYOG ◽  
LALITESHWAR PRATAP SINGH ◽  
SUSHIL KUMAR ◽  
SHWETA VERMA

Objective: Anacardium occidentale, Achyranthes aspera, and Aegle marmelos are the common plants found in North and South India. The present study identifies the active phytochemicals and antioxidant properties in various extracts derived from dried bark, whole aerial parts, and leaves of the above plants. Materials and Methods: Phytochemical screening included extracts of pet ether, hydroalcoholic, and aqueous. The antioxidant activity was determined by measuring total phenolic contents (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (RSA), and total flavonoid content (TFC). Results: The phytochemical screening of A. occidentale, A. aspera, and A. marmelos of dried bark, whole aerial parts, and leaves revealed the presence of flavonoids, phenols, tannins, and proteins. It also contains alkaloids and glycosides. Hydroalcoholic extract of A. occidentale, A. aspera, and A. marmelos showed highest TPC 0.125 mg/g, 0.256 mg/g, and 0.254 mg/g, respectively. TFCs 0.094 mg/g, 0.145 mg/g, and 0.121 mg/g and highest DPPH RSA with the half maximal inhibitory concentration of 125 μg/mL, 105.58 μg/mL, and 98.89 μg/mL compare to the standard ascorbic acid of 21.65 μg/mL. Conclusion: This study showed that the hydroalcoholic extract of A. occidentale, A. aspera, and A. marmelos is potential source of natural antioxidants.


Phytomedicine ◽  
2006 ◽  
Vol 13 (5) ◽  
pp. 359-365 ◽  
Author(s):  
C. Ito ◽  
M. Itoigawa ◽  
K. Nakao ◽  
T. Murata ◽  
M. Tsuboi ◽  
...  

1992 ◽  
Vol 31 (8) ◽  
pp. 2877-2879 ◽  
Author(s):  
Johannes Reisch ◽  
Olav Goj ◽  
Anura Wickramasinghe ◽  
H.M.T. Bandara Herath ◽  
Gerald Henkel

2007 ◽  
Vol 100 (2) ◽  
pp. 742-747 ◽  
Author(s):  
L. Jagan Mohan Rao ◽  
K. Ramalakshmi ◽  
B.B. Borse ◽  
B. Raghavan

2008 ◽  
Vol 3 (10) ◽  
pp. 1934578X0800301 ◽  
Author(s):  
Suvra Mandal ◽  
Anupam Nayak ◽  
Samir K. Banerjee ◽  
Julie Banerji ◽  
Avijit Banerji

A new carbazole alkaloid (kurryam) oxygenated at the 4-position, hitherto unknown among carbazole alkaloids, has been isolated from the seeds of an Indian medicinal plant, Murraya koenigii (Rutaceae). The structure has been established as 4-hydroxy-(2′,2′,3)-trimethyl-(6,7)-dimethoxy pyranocarbazole from extensive 2D NMR spectral studies. In addition, two known carbazole alkaloids, (2′,2′,3)-trimethyl 6-methoxy pyranocarbazole and (2′,2′,3)-trimethyl 6-hydroxy pyranocarbazole were isolated from the seeds of the same plant, of which (2′,2′,3)-trimethyl 6-methoxy pyranocarbazole exhibited significant antidiarrhoeal activity, as also did the new compound.


2016 ◽  
Vol 14 (12) ◽  
pp. 3322-3332 ◽  
Author(s):  
Yedukondalu Nalli ◽  
Vidushi Khajuria ◽  
Shilpa Gupta ◽  
Palak Arora ◽  
Syed Riyaz-Ul-Hassan ◽  
...  

Four new and 18 known carbazole alkaloids were isolated from CHCl3 : MeOH crude extracts of the stem and leaves ofMurraya koenigii(Linn.) Spreng, and evaluated for their anti-inflammatory and antimicrobial activity.


Drug Research ◽  
2018 ◽  
Vol 68 (11) ◽  
pp. 631-636 ◽  
Author(s):  
Fauzul Husna ◽  
Franciscus Suyatna ◽  
Wawaimuli Arozal ◽  
Erni Poerwaningsih

Abstract Aim and Objective The present study aims to investigate whether the antihyperglycemic effect of Murraya koenigii is mediated by antioxidant properties and insulin mimetic effect. Methods Thirty Spraque-Dawley rats were induced hyperglycemia by streptozotocin and nicotinamide (STZ-NA). The STZ-NA diabetic rats were treated with an ethanolic extract of Murraya koenigii 200 mg/kg b.w and 400 mg/kg b.w. One group was treated with glibenclamide (1 mg/kg b.w). After the administration of Murraya koenigii extract and glibenclamide for four weeks, the rats were sacrificed. Blood and organ samples were collected under a fasting condition. The body weight and blood glucose levels were measured. Hepatic enzymes were determined using a commercial kit, protein levels were estimated by Bradford’s method, and plasma insulin was assayed by an ELISA kit. Malondialdehyde (MDA) and reduced glutathione (GSH) levels were estimated by the TBA-Wills method and Ellman’s method, respectively. Results Ethanolic extract of Murraya koenigii showed a significant reduction in blood glucose level at both doses, 200 and 400 mg/kg b.w. In addition, Murraya koenigii exhibited a profound antioxidant effect with decreased MDA level and increased GSH level, particularly at the 200 mg/kg b.w. and significantly decreased the HOMA-IR index. Conclusions The present study reveals that Murraya koenigii possesses antidiabetic activity and antioxidant effects on STZ-NA induced diabetes mellitus.


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