COMPARATIVE EFFICACY OF TEMOBEL AND TEMODAL DRUGS IN MULTIMODALITY TREATMENT OF HIGH-GRADE (III-IV)

2015 ◽  
Vol 14 (2) ◽  
pp. 59-64
Author(s):  
V. V. Sinaiko ◽  
N. A. Artemova ◽  
T. L. Yurkshtovich ◽  
P. M. Bychkovsky ◽  
K. A. Frolenkov

An open-label, retrospective comparative clinical trial evaluated the efficacy of Temobel (RUP Belmedpreparaty) and Temodal (Schering-Plough, the Office of the Joint-Stock Company «Schering-Plough Central East AG») in 90 patients with high-grade (III-IV) glial brain tumors within a postoperative chemoradiotherapy course (a total target dose of 50-60 Gy). The compared groups, 45 patients in each, were fully matchable in prognostic factors affecting treatment outcomes. Median survival, 1- and 3-year overall survivals with Temobel in the combination treatment scheme were 20 months, 72.7±6.7% and 23.7±9.5%, whereas with Temodal they were 17 months, 77.8±6.2% and 30.3±7.0% respectively (P=0.935). Meanwhile, progressive-free median survival and progressive-free 1- and 3-year survival with Temobel and Temodal were 12 months, 51.0±7.5%, 21.3±6.4% and 11 months, 49.3±7.6%, 15.5±5,7% respectively (P=0.814). No statistically significant differences were found in the survival of patients in the compared groups.

2015 ◽  
Vol 18 (3) ◽  
pp. 121-134 ◽  
Author(s):  
Tu Thanh Huynh ◽  
Nghiem Van Truong

This article aims to identify factors that affect job satisfaction of employees of An Giang Power and Water Supply Joint Stock Company and suggest solutions to enhance their satisfaction. Six factors affecting the job satisfaction are as follows (ranked in the order of importance): (1) Training and promotion; (2) company policies; (3) co - workers; (4) working conditions; (5) leadership; and (6) the nature of work, in which all factors are found to have a positive correlation with the job satisfaction, except for the nature of work having a negative impact.


2013 ◽  
Vol 215 ◽  
pp. 104-120
Author(s):  
LAN PHẠM XUÂN ◽  
HỒNG THÁI DOÃN

The paper determines motivational factors affecting employees? organizational commitment in HCMC Trade Union Tourism Joint Stock Company. The research model and scales are constructed on findings of Kovach (1987) and qualitative research results. The paper figures out four important motivational factors, that is: (1) company trade mark and image, (2) good wages, (3) leadership, and (4) interesting work.


2021 ◽  
Vol 2 (11(75)) ◽  
pp. 10-15
Author(s):  
N. Turtygina ◽  
A. Okhrimenko

The work is devoted to a very topical issue - predicting quality indicators in underground mining of ore deposits. In this work, the conditions and ways of improving the quality of ores during mining were studied on the example of deposits of rich ores in the northern flanks of the Talnakh and Oktyabrsky deposits of Talnakh. The studies were carried out in specific conditions at the mining enterprises of the Polar Division of the Public Joint Stock Company Mining and Metallurgical Company Norilsk Nickel. The northern deposits of the Talnakhskoye deposit represent the main prospect for replenishing the retired production capacities for the extraction of high-grade ores. The significant heterogeneity of the distribution of the metal content in industrial reserves of rich copper-nickel ores is the primary cause of high fluctuations in the quality of ore flow, which requires the use of the most advanced mining technologies to control the quality of ores during extraction. The process of forming the required quality level of mined ores at the mines of the Polar Division of PJSC MMC Norilsk Nickel is of paramount importance. However, during the development of deposits of «rich» ores in the ore stream «mine - processing plant», significant fluctuations in the quality of the ore mass are formed, which lead to losses of metals in the process of concentration and during metallurgical redistribution, thereby reducing the economic efficiency of the entire mining and metallurgical complex, as determines the relevance of the work.


2021 ◽  
Vol 05 (03) ◽  
pp. 75-85
Author(s):  
Ngoc Danh Le ◽  
◽  
Ngoc Cam Nhung Tran ◽  
Phuong Uyen Le ◽  
Dinh Luyen Pham ◽  
...  

Objectives: This study is aimed to analyze phamacies’ satisfaction and factors affecting pharmacies’ satisfaction to the medicine supply service of Pymepharco Joint Stock Company in Ho Chi Minh city, in 2020. Methods: Using a mix of qualitative and quantitative methods. The study was employed at 200 pharmacies in 2020. This study proposes a conceptual framework of pharmacies’ satisfaction. The scale’s reliability is assessed using Cronbach’s Alpha and Exploratory Factor Analysis (EFA) model. Therefore, pharmacies’ satisfaction is evaluated by the multiple linear regression model. Main findings: The scale is built with 6 factors, including Product (5 items), Employee service capacity (6 items), Price and Payment (4 items), Response (9 items), Confidence (4 items) and Satisfaction (2 items). When calculating the Crobach’s Alpha with 30 items, Cronbach’s Alpha was from 0.769 to 0.904 for reliability. After applying EFA, all factors are required, of which Eigenvalue of independent element was 1,034 > 1 and Eigenvalue of dependent element was 1,825 > 1. After the linear regression analysis variability, there are 4 crucial factors affecting pharmacies’ satisfaction to the medicine supply service of Pymepharco, In particular, Response is the most powerful factor (standardized Beta coefficient equal to 0.363), the second is Pharmaceutical products (standardized Beta coefficient equal to 0.230), the third is Price and Payment (standardized Beta coefficient equal to 0.149) and finally, Employee Serviceability (standardized Beta coefficient equal to 0.145). Conclusion: The study has proposed a conceptual framework of pharmacies’ satisfaction to the medicine supply service of Pymepharco joint stock company and determined that the response factor is the most influential factor on pharmacy satisfaction. Key words: pharmacies’ satisfaction, medical supply service, Pymepharco Joint Stock Company.


2003 ◽  
pp. 50-61 ◽  
Author(s):  
T. Medvedeva ◽  
A. Timofeev

The article analyzes legal aspects of institutes of corporate governance. Different draft laws "On Joint-Stock Companies" are considered which reflected interests of separate groups of participants of market relations. Stages of property redistribution are outlined. The advantages of the model of the open joint-stock company are formulated. Special attention is paid to the demand for legal institutes of corporate governance as well as to the process of accepting the Federal Law "On Entering Amendments to the Federal Law "On Joint-Stock Companies"" which was enacted in 2002. The article contains proposals directed at improvement of corporate legislation.


Author(s):  
O. Klepikov ◽  
A. Boreyko ◽  
G. Kurenkova

The aim of the study was to assess the professional risk of developing diseases in workers of the railway car repair enterprise. The Voronezh Car Repair Plant, a branch of Vagonremmash Joint-Stock Company, was chosen as the object of study. Methods: «The methodology for calculating individual occupational risk depending on the working conditions and the health status of the employee», developed by the Klin Institute for Protection and Working Conditions in conjunction with the Research Institute of Occupational Medicine (2013), the main professions; cohort study with the calculation of the relative risk of morbidity with temporary disability, the odds ratio, the etiological share of factors in the formation of morbidity (group size: 250 people, experimental group — workers of the main specialties, 95 people — comparison group). Results. According to the research results, the priority factors of occupational health risk include: chemical, noise, heating microclimate, low light level. For certain professions, the share of the contribution of priority factors to the risk profile (PV) reaches 40 %. The indicator of individual occupational risk is 0.12 to 0.26 units. The high level of professional risk (0.22 ÷ 0.26) is characterized by the working conditions of the mechanics for the repair of rolling stock, machine tools (woodworking), casters (metal), thermists, plastic casters. In professional groups with medium and high risk, the indicator of the relative risk of morbidity with temporary disability is higher than 1 (RR = 1.75 and 1.39, respectively), and the etiological share of production factors in the formation of diseases is from 27.95 (subgroup with secondary professional risk) up to 42.88 % (a subgroup with high professional risk), which indicates the professional condition of the disease. Discussion. In general, our data are consistent with the results of similar studies conducted earlier at the car building and car repair enterprises. In order to ensure hygienically safe working conditions and preserve the health of workers, it is necessary to reduce the level of exposure to production factors, including through the introduction of modern equipment and improvement of technological processes.


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