scholarly journals The immediate results of combined operations in patients with advanced ovarian cancer: the experience of N. N. Blokhin National Medical research Center of Oncology, Ministry of health of russia

2019 ◽  
Vol 9 (4) ◽  
pp. 32-36
Author(s):  
O. V. Kozhevnikova ◽  
S. A. Nikogosyan ◽  
V. S. Ananyev ◽  
V. V. Kyznetsov ◽  
A. S. Shevchuk
Keyword(s):  
Ovarian Cancer ◽  
Postoperative Complications ◽  
Medical Research ◽  
Intraoperative Complications ◽  
Advanced Ovarian Cancer ◽  
Research Center ◽  
Ministry Of Health ◽  
National Medical ◽  
Long Term Treatment ◽  
Grade Iii

Objective: to analyze intraoperative and postoperative complications in patients who underwent combination surgeries for advanced ovarian cancer.Materials and methods. This retrospective study included patients that underwent primary or interval cytoreductive combination surgeries for advanced (grade III–IV) ovarian cancer at N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of Russia between 2000 and 2017.Results. We analyzed medical records of 144 patients with grade III–IV ovarian cancer who underwent combination surgery at some stage of their treatment. Almost two-thirds of patients (64.8 %) had complete or optimal volume of surgery. Intraoperative complications were registered in 7 % of patients (n = 10), while postoperative complications were observed in 38.2 % of cases (n = 55). The postoperative death rate was 0.7 % (n = 1).Conclusions. Higher frequency of complete and optimal cytoreduction, as well as acceptable level of intra- and postoperative complications confirm the need for combination surgeries in patients with advanced ovarian cancer. Aggressive surgical tactics should be used only in specialized cancer hospitals with the involvement of a multidisciplinary team that includes cancer surgeons and anesthesiologists in order to improve both short-term and long-term treatment outcomes in patients with advanced ovarian cancer.

scholarly journals A new indolocarbazole derivative in melanoma and carcinoma lung in vivo treatment

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anna Lantsova ◽  
Irina Golubeva ◽  
Larisa Borisova ◽  
Lyudmila Nikolaeva ◽  
Lydia Ektova ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Medical Research ◽  
Russian Federation ◽  
Research Center ◽  
Maximum Effect ◽  
Drug Form ◽  
Ministry Of Health ◽  
F1 Hybrid ◽  
National Medical ◽  
Experimental Drug

Abstract Objective The current scientific research direction is development of drugs with a targeted effect on malignant tumors. One of the promising groups is indolocarbazoles and their derivatives, which can initiate various tumor cell death pathways. Russian scientists from N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russian Federation has developed a new experimental drug form of the original compound LCS 1269 with cytotoxic and antiangiogenic properties, blocking vasculogenic mimicry in tumor. The study aim is the experimental drug form LCS 1269 antitumor activity on models of transplantable mouse tumors B-16 melanoma and Lewis epidermoid lung carcinoma (LLC) with different routes and modes of administration. Material and methods Female F1 hybrid mice (C57Bl/6 x DBA/2) and male and female linear mice C57BL/6 were used for management of tumor strains. Mice were obtained from N. N. Blokhin National Medical Research Center of Oncology of the Ministry of Health of Russian Federation vivarium. The antitumor effect was assessed by tumor growth inhibition (TGI) and increase of treated animal’s life span (ILS) compared to the control. Results The experimental drug form showed high antitumor activity when administered intravenously once at doses of 100 and 120 mg/kg (TGI = 98–82% and TGI = 95–77%, respectively, ILS = 24%, p < 0.05) on melanoma B-16 mice. On LLC mice, the experimental drug form showed that the intravenous administration route was effective in the range of doses from 60 to 80 mg/kg with a 5 day administration regimen with an interval of 24 h. A dose of 70 mg/kg had maximum effect at the level of TGI = 96–77% (p < 0.05) with its retention for 20 days after the end of treatment. Conclusion The studies have shown that the new compound LCS 1269 in the original drug form, has a pronounced antitumor activity and significantly reduces the volume of tumor mass both on melanoma B-16 and on LLC. It allows us to recommend continue the search for sensitivity of animal transplantable tumors to LCS 1269.

scholarly journals Optimization of the Research and Advisory Department of the Oncological Center

2019 ◽  
pp. 35-39
Author(s):  
Igor Anatolevich Doroshev ◽  
Ivan Sokratovich Stilidi ◽  
Zhanna Aleksandrovna Zavolskaia ◽  
Denis Anatolevich Riabchikov ◽  
Vadim Maratovich Kulushev ◽  
...  
Keyword(s):  
Medical Research ◽  
Medical Care ◽  
Health Facilities ◽  
Research Center ◽  
Medical Institution ◽  
Ministry Of Health ◽  
National Medical ◽  
Quality Of Medical Care ◽  
Oncological Center

The article provides an example of a successful optimization of the work in a research and advisory department of N.N. Blokhin National Medical Research Center of Oncology Ministry of Health of Russia. All stages of this process are described in detail – from creating a project office and identifying problems to implementing methods for solving them and evaluating results. This work resulted in improving of the quality of medical care provided to the population, which is the most important task of any medical institution. In addition, this optimization experience may be useful for the implementation of similar activities in other health facilities in Russia.

scholarly journals The experience of managing children and adolescents with Ewing’s sarcoma in the Pediatric Oncology Department of the Federal State Budgetary Institution “National Medical Research Center of Oncology”, Ministry of Health of Russia

2021 ◽  
Vol 8 (2) ◽  
pp. 26-34
Author(s):  
D. Yu. Yurchenko ◽  
S. A. Kuznetsov ◽  
Yu. Yu. Kozel ◽  
E. M. Frantsiyants ◽  
G. A. Mkrtchyan ◽  
...  
Keyword(s):  
Medical Research ◽  
Children And Adolescents ◽  
Pediatric Oncology ◽  
Ewing’S Sarcoma ◽  
Ewing's Sarcoma ◽  
Research Center ◽  
Ministry Of Health ◽  
General Group ◽  
National Medical ◽  
Adolescent Patients

Relevance. One of the leading positions among malignant tumors of the musculoskeletal system in children and adolescents has recently begun to be occupied by Ewing’s sarcoma (ES). The prognosis of patients suffering from this onconosology remains extremely unfavorable even in the absence of distant metastases and timely initiation of antitumor treatment. The authors present 10 years of experience in the management of pediatric and adolescent patients with ES in the pediatric oncology department of the National Medical Research Center of Oncology, Ministry of Health of Russia.Materials and methods. The study included pediatric and adolescent patients diagnosed with ES of I—IV stages of various localizations, who were treated in the Pediatric Oncology Department of the National Medical Research Center of Oncology, Ministry of Health of Russia in the period from 2009 to 2019. We analyzed 2- and 5-year overall (OS) and event-free (EFS) survival in patients who received combined and complex antitumor treatment for various forms of tumor dissemination according to the EURO-EWING 2008protocol, which included neo-and adjuvant polychemotherapy, including high-dose, radical surgical treatment, and also radiation therapy.Results. The median 5-year OS and EFS in the general group of the studied formulations was 60 and 17 months, respectively. The indicators of 2- and 5-year OS and EFS in patients of the general group were 80.6 % and 56.7 %, 38.6 % and 10.6 %, respectively. The volume of the performed antitumor treatment, as well as the form of the advanced tumor process, did not have a significant effect on OS and EFS indicators (p > 0.05). At the same time, the chances of developing ES in boys were statistically significantly higher by 2.2 times in comparison with girls (95 % confidence interval 1.1—4.3).Conclusion. The obtained OS and EFS indices indicate unsatisfactory results of anticancer therapy and extremely high aggressiveness of the biological behavior of the tumor, regardless of the form of spread of the tumor process.

scholarly journals Anniversary of Leonid Aleksandrovich Blatun (March 29, 1941)

2021 ◽  
Vol 8 (1) ◽  
pp. 6-11
Author(s):  
Yu. S. Paskhalova
Keyword(s):  
Medical Research ◽  
Research Center ◽  
Federal State ◽  
Wound Infections ◽  
Ministry Of Health ◽  
80Th Anniversary ◽  
National Medical ◽  
Clinical Microbiologist ◽  
Senior Researcher

The article presents a brief biography of the senior researcher in wounds and wound infections department and clinical microbiologist of the Federal State Budgetary Institution “A. V. Vishnevsky National Medical Research Center of Surgery” Ministry of Health of Russia Leonid Aleksandrovich Blatun (03/29/1941) in honor of his 80th anniversary, of which 55 years passed within the walls of the A. V. Vishnevsky institute of surgery!

scholarly journals Experience in Using Simulation Equipment in Teaching Transthoracic Echocardiography Skills

2021 ◽  
Vol 1 (3) ◽  
pp. 132-133
Author(s):  
Kh. A. Tengizov ◽  
S. V. Shahidzhanova ◽  
M. A. Saidova
Keyword(s):  
Medical Research ◽  
Russian Federation ◽  
Transthoracic Echocardiography ◽  
Research Center ◽  
Federal State ◽  
Ministry Of Health ◽  
National Medical ◽  
The Russian Federation

This paper describes the experience of teaching transthoracic echocardiography (TTE) skills on simulation equipment, accumulated over 2 years of training of residents in the direction of "Cardiology" at the Federal State Budgetary Institution "National Medical Research Center of Cardiology" of the Ministry of Health of the Russian Federation (Cardiocenter).

The use of combined transcranial approaches in the surgical treatment of giant pituitary adenomas

2021 ◽  
pp. 303-310
Author(s):  
A. D. Donskoy ◽  
A. A. Abdilatipov ◽  
Ashraf Abdali ◽  
Ilya V. Chernov ◽  
Egor G. Chmutin
Keyword(s):  
Surgical Treatment ◽  
Postoperative Complications ◽  
Medical Research ◽  
Pituitary Adenomas ◽  
Scientific Literature ◽  
Research Center ◽  
Total Removal ◽  
National Medical ◽  
The World ◽  
Giant Pituitary Adenomas

The issue of total removal of giant pituitary adenomas remains relevant, despite all existing methods of surgical treatment. The use of a combination of transcranial approaches can increase the radicality and reduce the number of postoperative complications in the surgery of these tumors. In the practice of the N. N. Burdenko National Medical Research Center for Neurosurgery, a unique, previously not described experience of using this technique in 33 patients has been accumulated. There are no publications in the world scientific literature devoted to the analysis of the results of surgical treatment of patients with GPA operated on with combined transcranial approaches. In the presented work, the most relevant classifications related to giant pituitary adenomas are collected; the technique of performing combined transcranial approaches and the prospects for its study are indicated.

scholarly journals Anniversary of Professor Alfred Arkadievich Zvyagin (May 22, 1940)

2021 ◽  
Vol 7 (2) ◽  
pp. 6-9
Author(s):  
Yu. S. Paskhalova
Keyword(s):  
Medical Research ◽  
Research Center ◽  
Federal State ◽  
Wound Infections ◽  
Ministry Of Health ◽  
80Th Anniversary ◽  
National Medical

The article presents a brief biography of the permanent head of the anesthesiology and resuscitation group in wounds and wound infections department of the Federal State Budgetary Institution “A. V. Vishnevsky National Medical Research Center of Surgery” Ministry of Health of Russia Alfred A. Zvyagin (05/22/1940) in honor of his 80th anniversary, of which 52 years passed within the walls of the A. V. Vishnevsky institute of surgery!

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