Oxidative stress and inflammation in COVID-19 pathogenesis

2020 ◽  
Vol 26 (4) ◽  
Author(s):  
Vladimir G. Kukes ◽  
Olga K. Parfenova ◽  
Nikita G. Sidorov ◽  
Yuri V. Olefir ◽  
Albina А. Gazdanova
Keyword(s):  
Oxidative Stress ◽  
Severe Acute Respiratory Syndrome ◽  
Oxygen Saturation ◽  
Viral Infections ◽  
Blood Oxygen ◽  
The Novel ◽  
Blood Oxygen Saturation ◽  
Metabolic Products ◽  
Respiratory Viral Infections

This study discusses the role of oxidative stress and inflammation in the development of severe acute respiratory syndrome (SARS) associated with COVID-19 caused by the novel SARS-CoV-2 coronavirus. An analysis of the literature revealed that the development of respiratory viral infections, including COVID-19, is usually accompanied by the accumulation of acidic metabolic products in the blood and tissues and, accordingly, oxidative stress and increased levels of cytokines. In this regard, it seems appropriate to use the second-generation low-toxic antioxidant Ethoxidol, manufactured in Russia, which reduces the intensity of inflammation, and also improves blood oxygen saturation.

scholarly journals Association of lipoprotein levels with sleep apnea: role of autonomic dysfunction

2021 ◽  
Vol 55 (1) ◽  
pp. 22-29
Author(s):  
Pavel Siarnik ◽  
Adela Penesova ◽  
Zofia Radikova ◽  
Alzbeta Hluchanova ◽  
Oto Hanus ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Autonomic Dysfunction ◽  
Linear Regression Analysis ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Receiver Operating Curve ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Significant Difference

Abstract Objectives. Although multiple mechanisms, including autonomic dysfunction, seem to link sleep-disordered breathing (SDB) with dyslipidemia in animal studies, the data in clinical studies are limited. The aim of this study was to explore the association of lipoprotein levels with SDB measures in healthy habitual snorers. We supposed that autonomic dysfunction is the linking mechanism. Methods. We enrolled 110 previously healthy subjects with complaints of habitual snoring. To assess SDB, polysomnography was performed. Blood samples for the analysis of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides (TG) were obtained in a fasting condition after the polysomnography. Baroreflex sensitivity (BRS) was used to assess the autonomic dysfunction. Results. In stepwise multiple linear regression analysis, minimal nocturnal blood oxygen saturation (beta=–0.240, p=0.020) and neck circumference (beta=0.224, p=0.03) were the only significant contributors in model predicting TG. SDB measures were not identified as significant contributors in models predicting TC, LDL, and HDL. We failed to find any significant difference in BRS in SDB subjects when compared according to the presence or absence of hypercholesterolemia/ hypertriglyceridemia. In SDB subjects, the area under the curve in a receiver operating curve to predict hypercholesterolemia and hypertriglyceridemia by BRS was 0.468 (95% CI: 0.328–0.608) and 0.425 (95% CI: 0.304–0.546), respectively. Conclusions. Our results suggest that minimal nocturnal blood oxygen saturation is significant contributor in model predicting TG. No significant decrease in BRS was found in SDB subjects with hypercholesterolemia and hypertriglyceridemia. In SDB subjects, the role of autonomic dys-function in the development of dyslipidemia remains controversial.

scholarly journals A Novel Severity Scoring Derived from Chest Radiographic Findings in COVID 19 Patients Admitted to a COVID Care University Hospital in India

2021 ◽  
pp. 17-25
Author(s):  
Abhijit Mahavir Patil ◽  
Meenakshi Bhakare ◽  
Sundeep Salvi
Keyword(s):  
Oxygen Saturation ◽  
Clinical Severity ◽  
Host Cells ◽  
University Hospital ◽  
Disease Spread ◽  
Blood Oxygen ◽  
The Novel ◽  
Blood Oxygen Saturation ◽  
Radiographic Findings ◽  
Radiographic Score

Coronavirus (COVID 19) disease predominantly affects the Respiratory system and cause by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV2). It enters into the host cells via angiotensin-converting enzyme-2 (ACE-2), a part of the renin-angiotensin system (RAS) found in the epithelium of the nasal, lungs. Aim: Chest Radiographic findings in COVID-19 patients detected for COVID care. Applying the novel chest radiographic scoring in disease-spread patients is admitted to the COVID care center and its correlation with blood oxygen saturation (SpO2) and clinical severity. Objective: 1) To apply the novel chest radiographic scoring in patients of COVID 19 infection are admitted to our Covid Care Centre and 2) To apply its correlation with blood oxygen saturation (SpO2) and clinical severity. Results: 1) We found a moderate negative correlation between the chest radiographic score and SpO2. 2) Weak positive correlation between Clinical grading and CxR score. Conclusion: Chest radiographic score taking into account the nature of opacities and extent is useful in classifying the patients into mild-moderate, severe, and critical grades. Take-home Message: A chest radiograph can be used as a baseline radiological investigation in COVID 19 patients as it can help to triage them according to the severity and treat them accordingly.

scholarly journals Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities

2020 ◽  
Vol 5 (5) ◽  
pp. 447-460 ◽  
Author(s):  
Lincai Ye ◽  
Lisheng Qiu ◽  
Bei Feng ◽  
Chuan Jiang ◽  
Yanhui Huang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Oxygen Saturation ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation

scholarly journals PSIX-9 Impacts of bunk management on feedlot performance, carcass characteristics, hydrogen sulfide concentration and blood oxygen saturation in steers fed 25 or 50% modified distillers grains plus solubles

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 422-422
Author(s):  
Rebecca L Moore ◽  
Cierrah J Kassetas ◽  
Leslie A LeKatz ◽  
Bryan W Neville
Keyword(s):  
Hydrogen Sulfide ◽  
Oxygen Saturation ◽  
Management Strategy ◽  
Distillers Grains ◽  
Feed Ratio ◽  
Sulfide Concentration ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Feedlot Performance ◽  
Arterial Blood

Abstract One hundred and twenty-six yearling angus steers (initial body weight 445.87 ± 7.13 kg) were utilized in a 2 x 2 factorial design to evaluate the impacts of bunk management and modified distillers grains plus solubles (mDGS) inclusion on feedlot performance, hydrogen sulfide concentrations and blood oxygen saturation. Treatments included bunk management strategy either control bunk management (CON; clean bunks at the time of next day’s feeding) or long bunk management (LONG; feed remaining at time of next day’s feeding), and two inclusion rates of mDGS either 25% or 50% (DM Basis). On d 0, 7, 14, 21, 28 and 35 rumen gas samples were collected via rumenocentesis, and arterial blood samples were collected on two steers from each pen. No differences (P ≥ 0.09) were observed for dry matter intake, average daily gain and gain-to-feed ratio for bunk management or mDGS inclusion. Hot carcass weight, ribeye area, marbling score and quality grade were not affected (P ≥ 0.48) by either bunk management or mDGS inclusion. Back fat was greater (P = 0.04) for CON steers compared to LONG (1.30 vs 1.12 ± 0.05cm, respectively), but was not affected (P = 0.59) by mDGS inclusion. Steers on CON had greater (P = 0.03) yield grades compared to LONG (3.21 vs 2.96 ± 0.11, respectively). Bunk management strategy did not impact hydrogen sulfide concentrations or blood oxygen saturation (P = 0.82). Hydrogen sulfide concentrations increased (P < 0.001) with increasing mDGS inclusion. Blood oxygen saturation was influenced by day of sampling (P = 0.01). Blood oxygen saturation was not affected (P = 0.07) by mDGS inclusion. The fact that ruminal hydrogen sulfide concentrations increased while blood oxygen saturation remained similar raises questions about the quantity of hydrogen sulfide and metabolic fate of excess hydrogen sulfide in the blood of ruminant animals.

Pulse Oximetry and Breathing Training1

Biofeedback ◽  
2012 ◽  
Vol 40 (4) ◽  
pp. 137-141 ◽  
Author(s):  
Christopher Gilbert
Keyword(s):  
Oxygen Saturation ◽  
Pulse Oximetry ◽  
Medical Condition ◽  
Noninvasive Monitoring ◽  
Control Of Breathing ◽  
Oxygen Absorption ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Training Control ◽  
Pulse Oximeters

Small pulse oximeters have become widely available and can be useful for noninvasive monitoring of blood oxygen saturation by nonmedical personnel. When training control of breathing, an oximeter helps to reassure clients who hyperventilate that their oxygenation is adequate, offsetting their perception that they are not getting enough air. Low saturation may indicate a medical condition that impairs oxygen absorption. In that case, hyperventilation is a biological compensation that should not be tampered with.

Blood Oxygen Saturation Measurement Using Polarization-Dependent Optical Sectioning

2017 ◽  
Vol 17 (12) ◽  
pp. 3900-3908 ◽  
Author(s):  
Deepak Mishra ◽  
Neha Priyadarshini ◽  
Supriya Chakraborty ◽  
Mukul Sarkar
Keyword(s):  
Oxygen Saturation ◽  
Blood Oxygen ◽  
Optical Sectioning ◽  
Blood Oxygen Saturation ◽  
Saturation Measurement
Sign in / Sign up

Export Citation Format

Share Document