scholarly journals Association of lipoprotein levels with sleep apnea: role of autonomic dysfunction

2021 ◽  
Vol 55 (1) ◽  
pp. 22-29
Author(s):  
Pavel Siarnik ◽  
Adela Penesova ◽  
Zofia Radikova ◽  
Alzbeta Hluchanova ◽  
Oto Hanus ◽  
...  
Keyword(s):  
Oxygen Saturation ◽  
Autonomic Dysfunction ◽  
Linear Regression Analysis ◽  
Area Under The Curve ◽  
Density Lipoprotein ◽  
Receiver Operating Curve ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Significant Difference

Abstract Objectives. Although multiple mechanisms, including autonomic dysfunction, seem to link sleep-disordered breathing (SDB) with dyslipidemia in animal studies, the data in clinical studies are limited. The aim of this study was to explore the association of lipoprotein levels with SDB measures in healthy habitual snorers. We supposed that autonomic dysfunction is the linking mechanism. Methods. We enrolled 110 previously healthy subjects with complaints of habitual snoring. To assess SDB, polysomnography was performed. Blood samples for the analysis of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides (TG) were obtained in a fasting condition after the polysomnography. Baroreflex sensitivity (BRS) was used to assess the autonomic dysfunction. Results. In stepwise multiple linear regression analysis, minimal nocturnal blood oxygen saturation (beta=–0.240, p=0.020) and neck circumference (beta=0.224, p=0.03) were the only significant contributors in model predicting TG. SDB measures were not identified as significant contributors in models predicting TC, LDL, and HDL. We failed to find any significant difference in BRS in SDB subjects when compared according to the presence or absence of hypercholesterolemia/ hypertriglyceridemia. In SDB subjects, the area under the curve in a receiver operating curve to predict hypercholesterolemia and hypertriglyceridemia by BRS was 0.468 (95% CI: 0.328–0.608) and 0.425 (95% CI: 0.304–0.546), respectively. Conclusions. Our results suggest that minimal nocturnal blood oxygen saturation is significant contributor in model predicting TG. No significant decrease in BRS was found in SDB subjects with hypercholesterolemia and hypertriglyceridemia. In SDB subjects, the role of autonomic dys-function in the development of dyslipidemia remains controversial.

scholarly journals Respiratory Consequences of N95 Mask during Covid-19 Pandemic- An Observational Study

2021 ◽  
Vol 11 (4) ◽  
pp. 55-61
Author(s):  
Rajesh Prabhakar Gaikwad ◽  
Akshaya Bhupesh Banodkar ◽  
Vaibhavi Pandurang Nandgaonkar
Keyword(s):  
Oxygen Saturation ◽  
Saturation Level ◽  
World Health ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Oxygen Saturation Level ◽  
Significant Difference ◽  
Before And After ◽  
Precautionary Measures ◽  
Health Organization

Background: Outbreak of novel corona virus has led World Health Organization (WHO) to come up with healthcare guidelines which includes wearing of N95 mask. The aim of this study was to evaluate whether blood oxygen saturation level is affected by wearing of N95 mask for the duration of 4 hours. Materials and Methods: A total of 90 exam going students were included in this study, who were instructed to wear N95 mask. Blood oxygen saturation level (SpO2) was checked both before and after wearing of N95 mask for a period of 4 hours. Results: It was observed that, before wearing N95 mask at 9 am, SpO2 values were 96.64±0.196 while at 1 pm after removing N95 mask, the saturation values were 95.68±0.235 (p=0.000) among all the students. There was a statistically highly significant difference seen for the values between the time intervals (p<0.01) with higher values at 9 am and lesser at 1pm. On comparing the SpO2 levels among males and females, a statistically nonsignificant difference was seen. Thus, reduction in blood oxygen saturation level can be a major parameter to evaluate the respiratory consequences of N95 mask. Conclusion: Various adverse effects of N95 mask were quoted in literature but respiratory consequences due to reduction in blood oxygen saturation level can be harmful. Thus, to avoid such consequences, precautionary measures are advised to be taken. Key words: N95 mask, SpO2, Blood oxygen saturation, COVID-19.

Oxidative stress and inflammation in COVID-19 pathogenesis

2020 ◽  
Vol 26 (4) ◽  
Author(s):  
Vladimir G. Kukes ◽  
Olga K. Parfenova ◽  
Nikita G. Sidorov ◽  
Yuri V. Olefir ◽  
Albina А. Gazdanova
Keyword(s):  
Oxidative Stress ◽  
Severe Acute Respiratory Syndrome ◽  
Oxygen Saturation ◽  
Viral Infections ◽  
Blood Oxygen ◽  
The Novel ◽  
Blood Oxygen Saturation ◽  
Metabolic Products ◽  
Respiratory Viral Infections

This study discusses the role of oxidative stress and inflammation in the development of severe acute respiratory syndrome (SARS) associated with COVID-19 caused by the novel SARS-CoV-2 coronavirus. An analysis of the literature revealed that the development of respiratory viral infections, including COVID-19, is usually accompanied by the accumulation of acidic metabolic products in the blood and tissues and, accordingly, oxidative stress and increased levels of cytokines. In this regard, it seems appropriate to use the second-generation low-toxic antioxidant Ethoxidol, manufactured in Russia, which reduces the intensity of inflammation, and also improves blood oxygen saturation.

scholarly journals PENGARUH AIR MINERAL DAN AIR MINUM BEROKSIGEN TERHADAP SATURASI OKSIGEN DARAH PESENAM ZUMBA

2015 ◽  
Vol 3 (1) ◽  
Author(s):  
Brenda N. E. Pelealu ◽  
Maya E.W. Moningka ◽  
Jimmy F. Rumampuk
Keyword(s):  
Physical Activity ◽  
Oxygen Saturation ◽  
Mineral Water ◽  
Wilcoxon Test ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Significant Difference ◽  
Before And After ◽  
Post Test ◽  
Oxygenated Water

Abstract: During physical activity, blood flow and oxygen usage will increase in order to transport oxygen which is required by muscles during exercise. One of the parameters to check the amount of oxygen that is bound to hemoglobin is oxygen saturation. This study aimed to determine the level of blood oxygen saturation of those who consumed mineral water and high oxygenated water during zumba gymnastics. This was an analytical experiments method with pre and post test approach. Total samples were 31 people who met the criteria and were willing to become the respondents. Data were analyzed using Wilcoxon Test. The results showed that the oxygen saturation before and after consuming mineral water (97.5±0.9) and (97.7±1.03) meanwhile before and after consuming high oxygenated water (97.6±0.75) and (98.7±0.44). The Wilcoxon test showed that there was a significant difference of blood oxygen saturation between before and after consuming high-oxygenated water (p=0.000) whereas for other respondents who consumed mineral water, there was no significant difference in their condition before and after consuming mineral water (p=0.198). Conclusion: There was a higher increase in blood oxygen saturation value before and after consuming oxygenated water compared to before and after consuming mineral water.Keywords: oxygen saturation, mineral water, and oxygenated water.Abstrak: Ketika beraktivitas fisik, aliran darah dan penggunaan oksigen akan meningkat untuk mengangkut oksigen yang diperlukan pada otot selama latihan. Salah satu parameter untuk melihat kadar oksigen yang berikatan dengan hemoglobin adalah Saturasi Oksigen. Penelitian ini bertujuan untuk mengetahui nilai saturasi oksigen darah pada orang yang mengkonsumsi air mineral dan air beroksigen tinggi pada senam zumba. Penelitian ini menggunakan metode analitik eksperimental dengan pendekatan pre and post test. Sampel penelitian berjumlah 31 orang yang memenuhi kriteria dan bersedia menjadi responden. Analisis data dilakukan dengan menggunakan uji Wilcoxon test. Hasil penelitian menunjukkan bahwa saturasi oksigen sebelum dan sesudah mengonsumsi air mineral (97,5±0,9) dan (97,7±1,03) sedangkan sebelum dan sesudah mengonsumsi air beroksigen tinggi (97,6±0,75) dan (98,7±0,44). Hasil uji Wilcoxon test menunjukkan perbedaan yang signifikan pada responden sebelum dan sesudah mengonsumsi air beroksigen (p=0,000) sedangkan ketika responden mengonsumsi air mineral terdapat perbedaan yang tidak signifikan pada kondisi sebelum dan sesudah mengkonsumsi air mineral (p=0,198). Simpulan: Terjadi peningkatan yang lebih tinggi dalam nilai saturasi oksigen darah sebelum dan sesudah mengkonsumsi air beroksigen dibandingkan dengan air mineral.Kata kunci: saturasi oksigen, air mineral, air beroksigen.

scholarly journals Role of Blood Oxygen Saturation During Post-Natal Human Cardiomyocyte Cell Cycle Activities

2020 ◽  
Vol 5 (5) ◽  
pp. 447-460 ◽  
Author(s):  
Lincai Ye ◽  
Lisheng Qiu ◽  
Bei Feng ◽  
Chuan Jiang ◽  
Yanhui Huang ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Oxygen Saturation ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation

EVALUATION OF BLOOD OXYGEN SATURATION OF HIGH JUMPERS BASED ON ISOKINETIC TEST

2021 ◽  
Vol 27 (7) ◽  
pp. 722-724
Author(s):  
Qiang Yao
Keyword(s):  
Oxygen Saturation ◽  
Test System ◽  
Muscle Group ◽  
Extensor Muscle ◽  
Blood Oxygen ◽  
Flexor Muscle ◽  
Blood Oxygen Saturation ◽  
Test Speed ◽  
Isokinetic Test ◽  
Significant Difference

ABSTRACT Introduction: An isokinetic test refers to the test of the force of a muscle or muscle group during centripetal and centrifugal movements at a constant speed in the whole range of joint motion by means of a isokinetic force tester. Objective: To explore the application of the knee centripetal flexor and extensor muscle groups in the blood oxygen saturation of high jumpers. Methods: Eighteen teenage female high jumper athletes above level 2 in a city sports school were selected. Their ages was 16.89±1.02 years old; height, 168.31±6.32cm; weight, 55.36±6.75kg. Results: At 60° S and 120° S test speed, the peak moment of the extensor muscle group on the same side of the knee was significantly greater than that of the flexor muscle group (P<0.05), while at 240° S test speed, it was the opposite. There was a significant difference in the peak moment of the flexor muscle group on the left and right side of the knee (P<0.01). Conclusions: The function of the dynamic muscle strength test system is one of the methods of studying the human muscle function. and can be used to test and evaluate the general strength of athletes. Level of evidence II; Therapeutic studies - investigation of treatment results.

scholarly journals PSIX-9 Impacts of bunk management on feedlot performance, carcass characteristics, hydrogen sulfide concentration and blood oxygen saturation in steers fed 25 or 50% modified distillers grains plus solubles

2020 ◽  
Vol 98 (Supplement_4) ◽  
pp. 422-422
Author(s):  
Rebecca L Moore ◽  
Cierrah J Kassetas ◽  
Leslie A LeKatz ◽  
Bryan W Neville
Keyword(s):  
Hydrogen Sulfide ◽  
Oxygen Saturation ◽  
Management Strategy ◽  
Distillers Grains ◽  
Feed Ratio ◽  
Sulfide Concentration ◽  
Blood Oxygen ◽  
Blood Oxygen Saturation ◽  
Feedlot Performance ◽  
Arterial Blood

Abstract One hundred and twenty-six yearling angus steers (initial body weight 445.87 ± 7.13 kg) were utilized in a 2 x 2 factorial design to evaluate the impacts of bunk management and modified distillers grains plus solubles (mDGS) inclusion on feedlot performance, hydrogen sulfide concentrations and blood oxygen saturation. Treatments included bunk management strategy either control bunk management (CON; clean bunks at the time of next day’s feeding) or long bunk management (LONG; feed remaining at time of next day’s feeding), and two inclusion rates of mDGS either 25% or 50% (DM Basis). On d 0, 7, 14, 21, 28 and 35 rumen gas samples were collected via rumenocentesis, and arterial blood samples were collected on two steers from each pen. No differences (P ≥ 0.09) were observed for dry matter intake, average daily gain and gain-to-feed ratio for bunk management or mDGS inclusion. Hot carcass weight, ribeye area, marbling score and quality grade were not affected (P ≥ 0.48) by either bunk management or mDGS inclusion. Back fat was greater (P = 0.04) for CON steers compared to LONG (1.30 vs 1.12 ± 0.05cm, respectively), but was not affected (P = 0.59) by mDGS inclusion. Steers on CON had greater (P = 0.03) yield grades compared to LONG (3.21 vs 2.96 ± 0.11, respectively). Bunk management strategy did not impact hydrogen sulfide concentrations or blood oxygen saturation (P = 0.82). Hydrogen sulfide concentrations increased (P &lt; 0.001) with increasing mDGS inclusion. Blood oxygen saturation was influenced by day of sampling (P = 0.01). Blood oxygen saturation was not affected (P = 0.07) by mDGS inclusion. The fact that ruminal hydrogen sulfide concentrations increased while blood oxygen saturation remained similar raises questions about the quantity of hydrogen sulfide and metabolic fate of excess hydrogen sulfide in the blood of ruminant animals.

scholarly journals THU0433 TREATMENT WITH PEGLOTICASE IMPROVES HEPATIC FIBROSIS ESTIMATED BY FIBROSIS-4 INDEX IN SUBJECTS WITH CHRONIC REFRACTORY GOUT

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 454.1-454
Author(s):  
N. Schlesinger ◽  
A. Yeo ◽  
P. Lipsky
Keyword(s):  
Liver Disease ◽  
Linear Regression ◽  
Rank Order ◽  
Linear Regression Analysis ◽  
Area Under The Curve ◽  
Serum Urate ◽  
Complete Analysis ◽  
Alcoholic Fatty Liver ◽  
Significant Difference ◽  
The Impact

Background:Hyperuricemia is associated with non-alcoholic fatty liver disease (NAFLD)1,2, but the relationship to fibrosis remains uncertain3. Moreover, it is not known whether lowering serum urate will affect the course of NAFLD. The availability of data from two randomized trials of pegloticase, a pegylated recombinant mammalian uricase, that profoundly decreases serum urate afforded the opportunity to test the hypothesis that lowering urate might improve NAFLD.Objectives:To determine whether treatment of chronic refractory gout patients with pegloticase was associated with improvement in NAFLD determined by Fibrosis 4 index (Fib4).Methods:Databases from patients with chronic refractory gout who participated in two randomized 6 month clinical trials (RCTs) of pegloticase were analyzed4. Sub-sets who had persistent urate lowering to levels <1 mg/dL in response to biweekly pegloticase (Responders, n=36) were compared to those who received placebo (n=43). Since liver biopsy information was not available on these subjects, we relied on Fib4, a validated non-invasive estimate of liver fibrosis in a variety of liver diseases5,6calculated from measurements of AST, ALT, platelet count and age (Age x AST/platelets x √ALT). A Fib4 value of 1.3 is an indication that further evaluation of liver disease is warranted.Results:At baseline, the mean Fib4 values were 1.40 ± 0.86 in pegloticase responders and 1.04 ± 0.53 in subjects receiving placebo. As shown in figure 1, subjects receiving placebo exhibited a change of 0.26 ± 0.41 in the Fib4 score over the six months of the RCTs compared with 0.13 ± 0.62 in the pegloticase responders (p=0.048; by linear regression). When only the subjects with a Fib4 value > 1.3 were considered, a significant difference in the change in the Fib4 values over the 6 months of the trial between pegloticase responders and those receiving placebo was also observed (-0.15 ± 0.67 vs 0.37 ± 0.42, p=0.004, by linear regression). The correlations between serum urate area under the curve (AUC) over the 6 months of the trial and the change in Fib4 value was rs=0.33, p=0.0.0004 (Spearman rank-order correlation coefficient). Finally, multiple linear regression analysis indicated serum urate AUC (as a surrogate measure for group) is the main contributor to the change in Fib4 (p=0.018 by linear regression).Conclusion:The data are consistent with the conclusion that persistent lowering of serum urate had a significant impact on Fib4 levels, implying a possible effect on the course of NAFLD. The results support a more complete analysis involving biopsy examination of the impact of urate on liver inflammation and fibrosis.References:[1]Yang C et al. PlosOne2017; 12:e0177249[2]Jaruvongvanich V et al. Eur J Gastroenterol Hepatol 2017; 29:1031[3]Jaruvongvanich V et al. Eur J Gastroenterol Hepatol 2017; 29:694[4]Sundy JS, et al. JAMA. 2011; 306 (7):711-20[5]Sterling RK et al. Hepatol 2006; 43:1317[6]Shah AG et al. Clin Gastroenterol Hepatol 2009;7:1104Disclosure of Interests: :Naomi Schlesinger Grant/research support from: Pfizer, Amgen, Consultant of: Novartis, Horizon Therapeutics, Selecta Biosciences, Olatec, IFM Therapeutics, Mallinckrodt Pharmaceuticals, Anthony Yeo Employee of: Horizon Therapeutics, Peter Lipsky Consultant of: Horizon Therapeutics

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