scholarly journals Dexmedetomidine as a part of multimodal analgesia in postoperative period in trauma patients

2018 ◽  
Vol 9 (3) ◽  
pp. 50-53
Author(s):  
N. V. Kutsevolova ◽  
Yu. E. Makhno ◽  
A. E. Kuklenko ◽  
E. V. Vasiliauskiene ◽  
I. V. Andronova ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Postoperative Period ◽  
Severe Pain ◽  
Pain Treatment ◽  
Pain Syndrome ◽  
Multimodal Analgesia ◽  
Trauma Patients ◽  
Endoprosthetic Replacement ◽  
Postoperative Pain Treatment

Despite the large arsenal of analgetics acting through different pharmacological mechanisms and the development of various anesthesia methods, the problem of postoperative pain treatment still remains urgent. Providing a complete pain relief after a surgery remains a desired, but not always a reachable goal. According to the literature, 30 to 75% of patients undergoing surgery suffer from the severe pain syndrome in the postoperative period. This article presents the experience with the use of a prolonged intravenous infusion of Dexmedetomidine as a part of multimodal analgesia in patients who underwent endoprosthetic replacement of large joints.

scholarly journals Multicenter study of the effectiveness of postoperative pain relief in Ukraine using paracetаmol in surgical hospitals – “ROZUM”

Pain medicine ◽  
2021 ◽  
Vol 6 (3) ◽  
pp. 4-14
Author(s):  
Dmytro Dmitriev ◽  
Ya Feleshtynskyi ◽  
S Vasyliuk ◽  
V Shaprynskyi ◽  
Yu Derkach ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Multicenter Study ◽  
Postoperative Period ◽  
Pain Syndrome ◽  
Multimodal Analgesia ◽  
Surgical Patients ◽  
Postoperative Pain Relief

This article is devoted to the effectiveness of postoperative pain relief in surgical hospitals in Ukraine. Multicenter study of the effectiveness of postoperative pain relief in Ukraine using paracetаmol in surgical hospitals – ROZUM is descibed. The effectiveness of multimodal analgesia and other analgesia in the postoperative period has been determined. Predictors of inadequate pain relief in surgical patients were identified, and the risks of pain syndrome development in a surgical hospital were assessed. The use of paracetamol in the schemes of multim

scholarly journals Efficiency and safety of pharmacotherapy for postoperative pain in cardiac surgery

2021 ◽  
Vol 20 (3) ◽  
pp. 2683
Author(s):  
D. A. Sychev ◽  
T. E. Morozova ◽  
D. A. Shatskiy ◽  
E. V. Shikh
Keyword(s):  
Cardiac Surgery ◽  
Postoperative Pain ◽  
Pain Relief ◽  
Postoperative Period ◽  
Multimodal Analgesia ◽  
Early Postoperative Period ◽  
Current Review ◽  
Negative Effect ◽  
Safe Technique

Intraoperative injury with the formation of a sternotomy wound is inevitably accompanied by postoperative pain, which has a negative effect on the postoperative period and prognosis of patients. Today, moderate and severe pain affects at least half of patients in the early postoperative period after cardiac surgery. Inadequate pain relief in the early postoperative period can lead to chronic pain, which significantly reduces the quality of life of patients. The concept of multimodal analgesia with different painkillers is a priority, effective and safe technique both after cardiac surgery and in other areas of surgery. The current review article is devoted to the analysis of efficacy and safety of various drug groups for postoperative pain relief in cardiac surgery.

scholarly journals THE STRUCTURE OF ODONTOGENIC INFLAMMATORY DISEASES AT THE OUTPATIENT SURGICAL DENTISTRY

2018 ◽  
Vol 14 (2) ◽  
pp. 78-85 ◽  
Author(s):  
Ирина Костина ◽  
Irina Kostina ◽  
Александр Чернавский ◽  
Aleksandr Chernavskiy ◽  
Михаил Огнев ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Postoperative Period ◽  
Analgesic Effect ◽  
Inflammatory Diseases ◽  
Surgical Techniques ◽  
Pain Syndrome ◽  
Symptomatic Treatment ◽  
Postoperative Pain Relief ◽  
Dental Procedures

Importance. NSAIDs take one of the leading places in drug therapy for postoperative pain relief. They are among the most common medicines used in clinical practice of a dentist. The article presents a comparative clinical evaluation of NSAID analgesic effect in postoperative period of dental surgical techniques. Objective. is to compare the etoricoxib analgesic effect of oral administration in a dosage of 90 mg and nimesulide in dosage of 100 mg in the postoperative period of dental surgical techniques. Methods. Randomized prospective study included 46 patients aged from 20 to 59 years. Two groups of 23 patients (10 men, 13 women in each group) were formed. They were prescribed medications for the pain relief after surgery. Etoricoxib in tablets of 90 mg 1 time a day was prescribed to the patients of the first group. In the second group nimesulide tablets of 100 mg were taken 2 times a day. The patients had taken the pills for three days. Results. Reduction of pain syndrome took place in the first and third day after tooth extraction. The comparison is performed by using visual analogue scale (VAS). Conclusions. Using of etoricoxib as symptomatic treatment of pain syndrome relief after application of surgical dental procedures provides fast, pronounced and long lasting analgesic effect. The drug is effective for preemptive analgesia and also for prevention of inflammatory complications in ambulatory surgical dentistry. It has a favorable safety profile that allows using it extensively in postoperative pain relief.

scholarly journals Participants with mild, moderate, or severe pain following total hip arthroplasty. A sub-study of the PANSAID trial on paracetamol and ibuprofen for postoperative pain treatment

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Luma Mahmoud Issa ◽  
Kasper Højgaard Thybo ◽  
Daniel Hägi-Pedersen ◽  
Jørn Wetterslev ◽  
Janus Christian Jakobsen ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Total Hip Arthroplasty ◽  
Hip Arthroplasty ◽  
Severe Pain ◽  
Pain Treatment ◽  
Opioid Analgesic ◽  
Opioid Use ◽  
Mild Pain ◽  
Total Hip ◽  
Pain Scores

AbstractObjectivesIn this sub-study of the ‘Paracetamol and Ibuprofen in Combination’ (PANSAID) trial, in which participants were randomised to one of four different non-opioids analgesic regimen consisting of paracetamol, ibuprofen, or a combination of the two after planned primary total hip arthroplasty, our aims were to investigate the distribution of participants’ pain (mild, moderate or severe), integrate opioid use and pain to a single score (Silverman Integrated Approach (SIA)-score), and identify preoperative risk factors for severe pain.MethodsWe calculated the proportions of participants with mild (VAS 0–30 mm), moderate (VAS 31–60 mm) or severe (VAS 61–100 mm) pain and the SIA-scores (a sum of rank-based percentage differences from the mean rank in pain scores and opioid use, ranging from −200 to 200%). Using logistic regression with backwards elimination, we investigated the association between severe pain and easily obtainable preoperative patient characteristics.ResultsAmong 556 participants from the modified intention-to-treat population, 33% (95% CI: 26–42) (Group Paracetamol + Ibuprofen (PCM + IBU)), 28% (95% CI: 21–37) (Group Paracetamol (PCM)), 23% (95% CI: 17–31) (Group Ibuprofen (IBU)), and 19% (95% CI: 13–27) (Group Half Strength-Paracetamol + Ibuprofen (HS-PCM + IBU)) experienced mild pain 6 h postoperatively during mobilisation. Median SIA-scores during mobilisation were: Group PCM + IBU: −48% (IQR: −112 to 31), Group PCM: 40% (IQR: −31 to 97), Group IBU: −5% (IQR: −57 to 67), and Group HS-PCM + IBU: 6% (IQR: −70 to 74) (overall difference: p=0.0001). Use of analgesics before surgery was the only covariate associated with severe pain (non-opioid: OR 0.50, 95% CI: 0.29–0.82, weak opioid 0.56, 95% CI: 0.28–1.16, reference no analgesics before surgery, p=0.02).ConclusionsOnly one third of participants using paracetamol and ibuprofen experienced mild pain after total hip arthroplasty and even fewer experienced mild pain using each drug alone as basic non-opioid analgesic treatment. We were not able, in any clinically relevant way, to predict severe postoperative pain. A more extensive postoperative pain regimen than paracetamol, ibuprofen and opioids may be needed for a large proportion of patients having total hip arthroplasty. SIA-scores integrate pain scores and opioid use for the individual patient and may add valuable information in acute pain research.

scholarly journals TAP-block as a component of multimodal analgesia for postoperative anesthesia in obstetrics and gynecology

Pain medicine ◽  
2018 ◽  
Vol 3 (2) ◽  
pp. 67-74 ◽  
Author(s):  
Ye. V. Grigimalsky ◽  
A. Y. Garga
Keyword(s):  
Postoperative Pain ◽  
Pain Relief ◽  
Multimodal Analgesia ◽  
Postoperative Pain Relief ◽  
Obstetrics And Gynecology ◽  
Tap Block ◽  
Actual Problem ◽  
Advantages And Disadvantages ◽  
Obstetrics And Gynaecology

Postoperative pain relief is still quite actual problem in medicine, particularly in obstetrics and gynaecology. The most appropriate method of adequate post-operative anesthesia is multimodal analgesia. This article describes the features of multimodal analgesia using TAP-block combined with NSAIDs in obstetric and gynaecological patients, advantages and disadvantages of this combination and our own experience of applying this method in our clinic.

Changes in management of patients with diseases of musculoskeletal system and joints

2021 ◽  
pp. 36-40
Author(s):  
A. L. Vertkin ◽  
A. N. Barinov ◽  
G. Yu. Knorring
Keyword(s):  
Side Effects ◽  
Pain Relief ◽  
Severe Pain ◽  
Pain Syndrome ◽  
Cooperative Action ◽  
Pain Syndromes ◽  
Adequate Pain Relief ◽  
Inflammatory Drugs ◽  
Group B ◽  
Group B Vitamins

Pain syndrome accompanies the vast majority of diseases; therefore, the issues of adequate pain relief remain topical not only for urgent conditions, but also for everyday medical practice. Modern and changed in recent years approaches to the appointment of anesthetic therapy should take into account not only the pathogenetic mechanisms of the development of pain syndrome in a particular patient, but also the need to use drug combinations. This allows for the potentiation of the analgesic effect, reduction of effective dosages of individual drugs and minimization of side effects. In case of severe pain syndrome in the presence of signs of impaired nociception, neuropathic and muscle-fascial pain syndromes, the use of non-steroidal anti-inflammatory drugs in conjunction with group B vitamins is justified. The article considers the pathogenetic details of such a combination therapy, reveals the mechanisms of the cooperative action of the proposed combination of drugs.

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