scholarly journals FEATURES OF APPLICATION OF EXTERNAL OSTEOSYNTHESIS IN CORRECTION OF VARUS DEFORMATION OF LOWER EXTREMITIES IN PATIENTS WITH GONARTHROSIS

2021 ◽  
Author(s):  
Aleksander Aleksandrovich Artemiev ◽  
Alexander A. Akhpashev ◽  
Medetbek Djumabekovich Abakirov ◽  
Andrej Nikolaevich Reshetnikov ◽  
Gevorg Georgievich Gululyan ◽  
...  
Keyword(s):  
Knee Joint ◽  
Elderly Patients ◽  
Corrective Osteotomy ◽  
Young Patients ◽  
Varus Deformity ◽  
Ilizarov Method ◽  
Osteoarthritis Of The Knee ◽  
Keywords Knee ◽  
Postoperative Control ◽  
Ilizarov Apparatus

Background: Arthrosis of the knee joint is one of the most common diseases in elderly patients with varus deformity. One of the treatment methods is corrective osteotomy. Aims: optimization of the diagnosis of deformities in patients with gonarthrosis, improvement of the technique of operation and postoperative control of the main reference lines and angles, assessment of correction results, analysis of complications. . Materials and methods: Under observation were 39 patients, who performed 78 operations on both legs simultaneously. In all cases, tibia bone osteotomies and osteosynthesis with Ilizarov apparatus were used. All patients underwent x-ray of the legs along the entire length with the definition of the main reference lines and angles. . Results: In all cases, it was possible to normalize the position of the mechanical axis and the angle of orientation of the knee joint. After surgery, the wounds were not sutured for the prevention of compartment syndrome. Correction was performed simultaneously in elderly patients, gradually in young patients. The fixation period by Ilizarov apparatus was 16.6 + 3.1 weeks. . Conclusions: The Ilizarov method has significant advantages: low invasiveness, stable fixation, absence of foreign bodies at the end of treatment. This allows us to recommend it for wider use in patients with gonarthrosis and varus deformity. Keywords: Knee Osteoarthritis, ilizarov method, Genu Varus, Osteoarthritis of the Knee .

scholarly journals Impact of cardiovascular disease and risk factors on fatal outcomes in patients with COVID-19 according to age: a systematic review and meta-analysis

Heart ◽  
2020 ◽  
pp. heartjnl-2020-317901
Author(s):  
SungA Bae ◽  
So Ree Kim ◽  
Mi-Na Kim ◽  
Wan Joo Shim ◽  
Seong-Mi Park
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Relative Risk ◽  
Elderly Patients ◽  
Meta Analysis ◽  
Fatal Outcome ◽  
Young Patients ◽  
Lower Prevalence ◽  
Prevalence Rates ◽  
The Impact

ObjectivePrevious studies that evaluated cardiovascular risk factors considered age as a potential confounder. We aimed to investigate the impact of cardiovascular disease (CVD) and its risk factors on fatal outcomes according to age in patients with COVID-19.MethodsA systematic literature review and meta-analysis was performed on data collected from PubMed and Embase databases up to 11 June 2020. All observational studies (case series or cohort studies) that assessed in-hospital patients were included, except those involving the paediatric population. Prevalence rates of comorbid diseases and clinical outcomes were stratified by mean patient age in each study (ranges: <50 years, 50–60 years and ≥60 years). The primary outcome measure was a composite fatal outcome of severe COVID-19 or death.ResultsWe included 51 studies with a total of 48 317 patients with confirmed COVID-19 infection. Overall, the relative risk of developing severe COVID-19 or death was significantly higher in patients with risk factors for CVD (hypertension: OR 2.50, 95% CI 2.15 to 2.90; diabetes: 2.25, 95% CI 1.89 to 2.69) and CVD (3.11, 95% 2.55 to 3.79). Younger patients had a lower prevalence of hypertension, diabetes and CVD compared with older patients; however, the relative risk of fatal outcomes was higher among the former.ConclusionsThe results of the meta-analysis suggest that CVD and its risk factors (hypertension and diabetes) were closely related to fatal outcomes in COVID-19 for patients across all ages. Although young patients had lower prevalence rates of cardiovascular comorbidities than elderly patients, relative risk of fatal outcome in young patients with hypertension, diabetes and CVD was higher than in elderly patients.Prospero registration numberCRD42020198152.

Neurospect Findings in Patients Exposed to Neurotoxic Chemicals

1994 ◽  
Vol 10 (4-5) ◽  
pp. 561-571
Author(s):  
Gunnar Heuser ◽  
Ismael Mena ◽  
Francisca Alamos
Keyword(s):  
Elderly Patients ◽  
Qualitative Analysis ◽  
Right Hemisphere ◽  
Young Patients ◽  
Chronic Fatigue ◽  
Psychiatric Symptomatology ◽  
Elderly Individuals ◽  
Parietal Lobes ◽  
The Right ◽  
The Brain

Exposures to neurotoxic chemicals such as pesticides, glues, solvents, etc. are known to induce neurologic and psychiatric symptomatology. We report on 41 patients 16 young patients (6 males, 10 females, age 34 8 yrs.) and 25 elderly patients (9 males, 16 females, age 55 7 yrs). Fifteen of them were exposed to pesticides, and 29 to solvents. They were studied with quantitative and qualitative analysis of regional cerebral bood flow (rCBF), performed with 30 mCi of Xe-133 by inhalation, followed by 30 mCi of Tc-HMPAO given intravenously. Imaging was performed with a brain dedicated system, distribution of rCBF was assessed with automatic ROI definition, and HMPAO was normalized to maximal pixel activity in the brain. Results of Xe rCBF are expressed as mean and S.D. in ml/min/100g, and HMPAO as mean and S.D. uptake per ROI, and compared with age-matched controls 10 young and 20 elderly individuals. Neurotoxics HMPAO Uptake Young Elderly R. Orbital frontal R. Dorsal frontal .70 .66 p < 0.05 R. Temporal .64 p < 0.001 R. Parietal .66 .66 We conclude that patients exposed to chemicals present with diminished CBF, worse in the right hemisphere, with random presentation of areas of hypoperfusion, more prevalent in the dorsal frontal and parietal lobes. These findings are significantly different from observations in patients with chronic fatigue and depression, suggesting primary cortical effect, possibly due to a vasculitis process.

scholarly journals Evaluation and Validation of a Joint Stress Test to Induce Activity-Related Knee Joint Discomfort — a Prospective Case-Control Study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Christiane Schön ◽  
Claudia Reule ◽  
Katharina Knaub ◽  
Antje Micka ◽  
Manfred Wilhelm ◽  
...  
Keyword(s):  
Knee Joint ◽  
Healthy Subjects ◽  
Stress Test ◽  
Osteoarthritis Of The Knee ◽  
Time Interval ◽  
Short Time Interval ◽  
Joint Stress ◽  
Joint Health ◽  
The Impact ◽  
Health Function

Abstract Background The assessment of improvement or maintenance of joint health in healthy subjects is a great challenge. The aim of the study was the evaluation of a joint stress test to assess joint discomfort in subjects with activity-related knee joint discomfort (ArJD). Results Forty-five subjects were recruited to perform the single-leg-step-down (SLSD) test (15 subjects per group). Subjects with ArJD of the knee (age 22–62 years) were compared to healthy subjects (age 24–59 years) with no knee joint discomfort during daily life sporting activity and to subjects with mild-to-moderate osteoarthritis of the knee joint (OA, Kellgren score 2–3, age 42–64 years). The subjects performed the SLSD test with two different protocols: (I) standardization for knee joint discomfort; (II) standardization for load on the knee joint. In addition, range of motion (ROM), reach test, acute pain at rest and after a single-leg squat and knee injury, and osteoarthritis outcome score (KOOS) were assessed. In OA and ArJD subjects, knee joint discomfort could be reproducibly induced in a short time interval of less than 10 min (200 steps). In healthy subjects, no pain was recorded. A clear differentiation between study groups was observed with the SLSD test (maximal step number) as well as KOOS questionnaire, ROM, and reach test. In addition, a moderate to good intra-class correlation was shown for the investigated outcomes. Conclusions These results suggest the SLSD test is a reliable tool for the assessment of knee joint health function in ArJD and OA subjects to study the improvements in their activities. Further, this model can be used as a stress model in intervention studies to study the impact of stress on knee joint health function.

scholarly journals Growth rate after limb deformity correction by the Ilizarov method with or without knee joint distraction

2009 ◽  
Vol 80 (3) ◽  
pp. 338-343 ◽  
Author(s):  
Hubert J Oostenbroek ◽  
Ronald Brand ◽  
Peter M van Roermund
Keyword(s):  
Growth Rate ◽  
Knee Joint ◽  
Deformity Correction ◽  
Ilizarov Method ◽  
Limb Deformity ◽  
Joint Distraction

Predictors of response to intra-articular steroid injections in patients with osteoarthritis of the knee joint

2016 ◽  
Vol 35 (10) ◽  
pp. 2541-2547 ◽  
Author(s):  
Nibah Fatimah ◽  
Babur Salim ◽  
Ejaz-ul-Haq Raja ◽  
Amjad Nasim
Keyword(s):  
Knee Joint ◽  
Osteoarthritis Of The Knee ◽  
Steroid Injections ◽  
Predictors Of Response

scholarly journals Experience of Domed High Tibial Osteotomy in Osteoarthritis of the Knee joint

1983 ◽  
Vol 31 (4) ◽  
pp. 768-773
Author(s):  
M. Oryoji ◽  
Y. Takeda ◽  
M. Kijima ◽  
K. Yoshinaga ◽  
K. Tomari
Keyword(s):  
Knee Joint ◽  
High Tibial Osteotomy ◽  
Osteoarthritis Of The Knee ◽  
Tibial Osteotomy

scholarly journals Elderly Asian Patients Have Lower Revascularisation Rates and Poorer Outcomes for ST-Elevation Myocardial Infarction Compared to Younger Patients

2020 ◽  
Vol 49 (1) ◽  
pp. 3-14
Author(s):  
James X Cai ◽  
Jonathan Yap ◽  
Fei Gao ◽  
Tian Hai Koh ◽  
Khim Leng Tong ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Percutaneous Coronary Intervention ◽  
Elderly Patients ◽  
Young Patients ◽  
Coronary Intervention ◽  
St Elevation Myocardial Infarction ◽  
Younger Patients ◽  
Asian Patients ◽  
Percutaneous Coronary ◽  
St Elevation

Introduction: There is limited information on elderly patients presenting with ST elevation myocardial infarction (STEMI). This study aimed to study the outcomes of elderly Asian patients with STEMI compared to younger patients. Materials and Methods: The study utilised data from 2007 to 2012 from the Singapore Myocardial Infarction Registry, a mandatory national population-based registry. Elderly patients were defined as ≥80 years of age, middle-aged to old (MAO) patients were defined as 45–80 years of age and young patients were defined as ≤45 years of age. The primary outcome of the study was 1-year mortality and secondary outcomes included in-hospital complications and mortality. Results: There were 12,409 STEMI patients with 1207 (9.7%) elderly patients, 10,093 (81.3%) MAO patients and 1109 (8.9%) young patients. Elderly patients had more cardiovascular risk factors and lower rates of total percutaneous coronary intervention (26.0% vs 72.4% vs 85.5%, respectively; P <0.0001) compared to MAO and young patients. They had higher 1-year mortality (60.6% vs 18.3% vs 4.1%, respectively; P <0.0001) when compared to MAO and young patients. Conclusion: Elderly patients with STEMI have poorer outcomes than MAO and young patients. This is potentially attributable to a myriad of factors including age, higher burden of comorbidities and a lesser likelihood of receiving revascularisation and guideline-recommended medical therapy. Keywords: Coronary artery bypass graft, Percutaneous coronary intervention

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