Correlation between hamstring tightness and time duration of disease in knee osteoarthritis: an observational cross-sectional study.

Background: Osteoarthritis (OA) is gradually developing articular diseases that originate in the cartilage and affects the underlying bone, soft tissues as well as synovial fluid. OA usually occurs late in life and mainly it affects the hand and large weight-bearing joints such as the knee and hip. The knee joint is largely affected due to its weight-bearing nature. In many studies, this functional loss is related to muscular weakness caused by OA in particular the quadriceps and hamstring muscles. Flexibility is the ability of a muscle to lengthen and allow one joint [or more than one joint in a series] to move through a range of motion. The hamstring muscle group have tendency to shorten and the tightening results in increased patello-femoral compressive force, which may eventually lead to patello-femoral syndrome often associated with osteoarthritis. Method: Seventeen patients with knee osteoarthritis matched with the inclusion criteria were included in the study. Sit and Reach test was used to evaluate the hamstring tightness. Goniometer was used to evaluate knee active range of motion Spearman’s correlation was used to determine the relationship between hamstring tightness and duration of disease in knee osteoarthritis. Result: The present study found significant inverse correlation (r = -0.07) between hamstring tightness and duration of disease such that the hamstring flexibility decreases with increase in the duration of knee osteoarthritis. However, the correlation between duration of disease and knee active range of motion was negligible (r = 0.25). Conclusion: The results states that hamstring tightness and duration of the disease in knee osteoarthritis are correlated. Further research is indicated with a larger sample size. Keywords: Knee osteoarthritis, hamstring tightness, osteoarthritis.

Gambaran Nyeri Pada Osteoartritis Lutut Setelah Pemberian Intervensi Dengan Modalitas Ultrasound: Literature Review

Knee Osteoarthritis is characterized by pain, deformity, and limitation of movement. To reduce pain in patients with knee osteoarthritis, interventions can be given, one of which is ultrasound with continuous current. Determine the description of pain in knee osteoarthritis after intervention with ultrasound modality. PICO writing method is used as the selection of articles in this literature review research. This article was obtained from PubMed and NCBI with predetermined inclusion and exclusion criteria. The measuring instrument used in the literature review is the visual analogue scale (VAS). The results of the literature review analysis in these five articles showed that pain reduction before the procedure were 6.79 and after the procedure were 3.43 with a difference of 3.36. From the results of the literature review of these five articles, it shows that there is a change in the depiction of pain in knee osteoarthritis patients after being given ultrasound intervention. Keywords: Knee Osteoarthritis; Visual Analogue Scale (VAS), Ultrasound Abstrak Osteortritis lutut ditandai dengan nyeri, deformitas, dan hambatan gerak. Untuk menurunkan nyeri pada pasien osteoartritis lutut dapat diberikan intervensi salah satunya adalah ultrasound dengan arus continuous. Mengetahui gambaran nyeri pada osteoartritis lutut setelah pemberian intervensi dengan modalitas ultrasound. Pemilihan artikel pada penelitian literature review ini menggunakan PICO. Artikel ini didapatkan dari PubMed dan NCBI dengan kriteria inklusi dan kriteria ekslusi yang telah ditentukan. Alat ukur yang digunakan dalam literature review adalah visual analogue scale (VAS). Hasil analisis literature review pada kelima artikel ini menunjukkan bahwa penurunan nyeri sebelum tindakan 6,79 dan sesudah tindakan 3,43 dengan selisih 3,36. Dari hasil literature review kelima artikel ini menunjukkan bahwa ada perubahan gambaran nyeri pada pasien osteoartritis lutut sesudah diberikan intervensi ultrasound. Kata Kunci : Osteoartritis Lutut, Visual Analgogue Scale (VAS), Ultrasound

Gambaran Nyeri Pada Osteoartritis Lutut Setelah Pemberian Intervensi Dengan Modalitas Ultrasound : Literature Review

Knee Osteoarthritis is characterized by pain, deformity, and limitation of movement. To reduce pain in patients with knee osteoarthritis, interventions can be given, one of which is ultrasound with continuous current.. Determine the description of pain in knee osteoarthritis after intervention with ultrasound modality. PICO writing method is used as the selection of articles in this literature review research. This article was obtained from PubMed and NCBI with predetermined inclusion and exclusion criteria. The measuring instrument used in the literature review is the visual analogue scale (VAS). The results of the literature review analysis in these five articles showed that pain reduction before the procedure were 6.79 and after the procedure were 3.43 with a difference of 3.36. From the results of the literature review of these five articles, it shows that there is a change in the depiction of pain in knee osteoarthritis patients after being given ultrasound intervention. Keywords: Knee Osteoarthritis; Visual Analogue Scale (VAS), Ultrasound Abstrak Osteortritis lutut ditandai dengan nyeri, deformitas, dan hambatan gerak. Untuk menurunkan nyeri pada pasien osteoartritis lutut dapat diberikan intervensi salah satunya adalah ultrasound dengan arus continuous. Mengetahui gambaran nyeri pada osteoartritis lutut setelah pemberian intervensi dengan modalitas ultrasound. Pemilihan artikel pada penelitian literature review ini menggunakan PICO. Artikel ini didapatkan dari PubMed dan NCBI dengan kriteria inklusi dan kriteria ekslusi yang telah ditentukan. Alat ukur yang digunakan dalam literature review adalah visual analogue scale (VAS). Hasil analisis literature review pada kelima artikel ini menunjukkan bahwa penurunan nyeri sebelum tindakan 6,79 dan sesudah tindakan 3,43 dengan selisih 3,36. Dari hasil literature review kelima artikel ini menunjukkan bahwa ada perubahan gambaran nyeri pada pasien osteoartritis lutut sesudah diberikan intervensi ultrasound. Kata Kunci : Osteoartritis Lutut, Visual Analgogue Scale (VAS), Ultrasound

Genome-wide studies of knee osteoarthritis (review)

Introduction. Knee Osteoarthritis (OA) is a multifactorial disease resulting from the interaction of many environmental, epigenetic and genetic risk factors, and the latter account for 40% to 65%. Genetic bases of the knee OA based on genome-wide association search (GWAS) are being actively studied by many scientific teams around the world. At the same time, the results obtained are often contradictory and ambiguous, as for the conducted replicative studies of knee OA. This dictates the need for additional replicative studies in various populations, including populations of Russia, which are characterized by significant ethno-territorial variability, in order to identify specific GWAS-significant polymorphic markers of candidate genes associated with OA in these individual populations. The aim of the study was to analyze genome-wide studies of knee OA and to establish GWAS-significant polymorphic loci associated with OA. Materials and methods. The search for publications was carried out in the electronic databases PubMed, PubMedCentral, eLIBRARY, in the GWAS catalog for the period from 2008 to the present by the keywords: knee osteoarthritis, GWAS studies, candidate genes. Results. First, to date, 14 genome-wide studies of knee OA have been performed, as a result of which about 80 GWAS-significant polymorphic loci associated with the risk of knee OA have been identified. Secondly, all GWAS of the knee OA were carried out abroad on samples from various foreign populations, and the samples from the Russian Federation were not included in these studies. Third, only two GWAS-significant polymorphic loci for OA (rs143384 of the GDF5 gene and rs3771501 of the TGFA gene) were replicated at the genome-wide significance level (p5x10-08) in two different studies. Fourth, the data obtained indicate the presence of two regions of chromosomes (6p21.32 and 7q22.3), in which the largest number of GWAS-significant polymorphic loci for OA is located - 3SNPs in each (6p21.32 - rs10947262, rs7775228, rs9277552; 7q22.3 - rs4730250, rs10953541, rs3815148). Fifth, with an increase in the volume of the studied samples of patients and control in genome-wide studies of knee OA, the number of identified GWAS-significant polymorphisms also increases. Conclusion. The main genome-wide studies of knee OA were reviewed and GWAS-significant polymorphisms associated with OA were identified. The obtained materials on GWAS-significant loci can be used both in the selection of polymorphisms in replicative studies of OA in various populations of Russia, and for expanding the understanding of the molecular genetic mechanisms of the disease development.

HUBUNGAN ANTARA DIABETES MELLITUS TIPE II DENGAN DERAJAT OSTEOARTHRITIS LUTUT

Osteoarthritis is a degenerative disease that cause damage to joint cartilage damage. Osteoarthritis affects 151,4 million people in the world, including 27,4 million in Southeast Asia. Osteoarthritis is a disease that is a burden on public health and the country. The prevalence of osteoarthritis is one in four people aged 50 years and individuals aged 65 years are more at risk of developing calcification of the knee joint. Risk factors such as type II Diabetes Mellitus are observed in one of osteoarthritis research. A hispanic study explained the prevalence of osteoarthritis patient are twice as much in diabetic patient than non-diabetic patient. A score of 6.5% of HbA1c test is required to diagnose diabetes. The goal of this study is to find out the connection of type 2 diabetes mellitus and knee osteoarthritis. This research uses observational analytic with cross sectional research design with a total of 45 patient from Orthopedic clinic of Al – Fauzan General Hospital in 2016 – 2019 and analyzed with chi square test. According to the result, the most group of age is elderly about 34 people (75,6%), the most group of gender is women about 34 people (75,6%), the most group of HbA1c is non-diabetes mellitus group about 30 people (66,7%), the most group of osteoarthritis stage is severe de (4) about 28 people (62,2%), and there is no connection between type II diabetes mellitus with the stage of knee osteoarthritis with p value of 0,828 (p > 0.05). this research shows no significant correlation between type II diabetes mellitus and the stage of knee osteoarthritis. Keywords : Knee Osteoarthritis; HbA1c; Type II Diabetes Mellitus AbstrakOsteoarthritis adalah penyakit degeneratif yang disebabkan kerusakan tulang rawan sendi. Osteoarthritis dialami 151,4 juta orang di dunia dan 27,4 juta orang di Asia Tenggara. Osteoarthritis merupakan penyakit yang menjadi beban kesehatan masyarakat dan negara. Prevalensi terjadinya osteoarthritis yaitu satu dari empat orang berusia 50 tahun dan individu berusia lebih dari 65 tahun beresiko mengalami pengapuran sendi lutut. Penelitian osteoarthritis mengamati faktor risiko terjadinya osteoarthritis seperti diabetes mellitus tipe 2. Studi Hispanik menjelaskan prevalensi penderita osteoarthritis dua kali lebih banyak terjadi pada penderita dengan diabetes dibandingkan penderita tanpa diabetes. Pemeriksaan HbA1c direkomendasikan untuk mendiagnosis diabetes, dengan batas nilai 6,5 %. Tujuan penelitian ini adalah untuk mengetahui hubungan antara diabetes mellitus tipe II dengan derajat osteoarthritis lutut. Penelitian ini menggunakan analitik observasional dengan desain penelitian potong lintang dengan jumlah sampel 45 pasien di Poli Orthopedi Rumah Sakit Umum Al – Fauzan tahun 2016 – 2019 dan dianalisa menggunakan uji kai kuadrat. Berdasarkan hasil penelitian, usia terbanyak adalah lansia yaitu 34 orang (75,6 %), jenis kelamin terbanyak adalah perempuan yaitu 34 orang (75,6 %), HbA1c terbanyak adalah non diabetes mellitus yaitu 30 orang (66,7 %), derajat osteoarthritis lutut terbanyak adalah derajat berat (4) yaitu 28 orang (62,2 %), dan tidak terdapat hubungan yang bermakna antara diabetes mellitus tipe II dengan derajat osteoarthritis lutut dengan nilai p sebesar 0,828 (p > 0,05). Penelitian ini menunjukan tidak terdapat hubungan yang bermakna antara diabetes mellitus tipe II dengan derajat osteoarthritis lutut

Osteoarthritis

Osteoarthritis is a common form of arthritis characterized by degeneration of articular cartilage and pathologic changes in surrounding bone and periarticular tissue. The disease process results in pain and dysfunction of affected joints and is a major cause of disability in the general population. Prognosis is variable; greater muscle strength, mental health, self-efficacy, social support, and aerobic exercise are associated with better outcomes. This review outlines the classification of osteoarthritis (primary and secondary) and its epidemiology and etiologic factors, including risk factors, normal articular cartilage, and pathologic changes. Diagnosis is reviewed in terms of general considerations and specific joint involvement and related complications. The differential diagnosis is discussed. Management of osteoarthritis includes nonpharmacologic measures, pharmacologic therapy, surgery, and disease-modifying or chondroprotective therapy. This review contains 6 figures, 8 tables, and 84 references. Keywords: Knee, hand, hip, osteoarthritis, joint pain, synovial fluid, inflammation, weight-bearing

Osteoarthritis

Osteoarthritis is a common form of arthritis characterized by degeneration of articular cartilage and pathologic changes in surrounding bone and periarticular tissue. The disease process results in pain and dysfunction of affected joints and is a major cause of disability in the general population. Prognosis is variable; greater muscle strength, mental health, self-efficacy, social support, and aerobic exercise are associated with better outcomes. This review outlines the classification of osteoarthritis (primary and secondary) and its epidemiology and etiologic factors, including risk factors, normal articular cartilage, and pathologic changes. Diagnosis is reviewed in terms of general considerations and specific joint involvement and related complications. The differential diagnosis is discussed. Management of osteoarthritis includes nonpharmacologic measures, pharmacologic therapy, surgery, and disease-modifying or chondroprotective therapy. This review contains 6 figures, 8 tables, and 84 references. Keywords: Knee, hand, hip, osteoarthritis, joint pain, synovial fluid, inflammation, weight-bearing

Osteoarthritis

Osteoarthritis is a common form of arthritis characterized by degeneration of articular cartilage and pathologic changes in surrounding bone and periarticular tissue. The disease process results in pain and dysfunction of affected joints and is a major cause of disability in the general population. Prognosis is variable; greater muscle strength, mental health, self-efficacy, social support, and aerobic exercise are associated with better outcomes. This review outlines the classification of osteoarthritis (primary and secondary) and its epidemiology and etiologic factors, including risk factors, normal articular cartilage, and pathologic changes. Diagnosis is reviewed in terms of general considerations and specific joint involvement and related complications. The differential diagnosis is discussed. Management of osteoarthritis includes nonpharmacologic measures, pharmacologic therapy, surgery, and disease-modifying or chondroprotective therapy. This review contains 6 figures, 8 tables, and 84 references. Keywords: Knee, hand, hip, osteoarthritis, joint pain, synovial fluid, inflammation, weight-bearing

FEATURES OF APPLICATION OF EXTERNAL OSTEOSYNTHESIS IN CORRECTION OF VARUS DEFORMATION OF LOWER EXTREMITIES IN PATIENTS WITH GONARTHROSIS

Background: Arthrosis of the knee joint is one of the most common diseases in elderly patients with varus deformity. One of the treatment methods is corrective osteotomy. Aims: optimization of the diagnosis of deformities in patients with gonarthrosis, improvement of the technique of operation and postoperative control of the main reference lines and angles, assessment of correction results, analysis of complications. . Materials and methods: Under observation were 39 patients, who performed 78 operations on both legs simultaneously. In all cases, tibia bone osteotomies and osteosynthesis with Ilizarov apparatus were used. All patients underwent x-ray of the legs along the entire length with the definition of the main reference lines and angles. . Results: In all cases, it was possible to normalize the position of the mechanical axis and the angle of orientation of the knee joint. After surgery, the wounds were not sutured for the prevention of compartment syndrome. Correction was performed simultaneously in elderly patients, gradually in young patients. The fixation period by Ilizarov apparatus was 16.6 + 3.1 weeks. . Conclusions: The Ilizarov method has significant advantages: low invasiveness, stable fixation, absence of foreign bodies at the end of treatment. This allows us to recommend it for wider use in patients with gonarthrosis and varus deformity. Keywords: Knee Osteoarthritis, ilizarov method, Genu Varus, Osteoarthritis of the Knee .

Clinically Relevant Molecular Biomarkers for Use in Human Knee Osteoarthritis: A Systematic Review

Objective Biomarkers in osteoarthritis (OA) could serve as objective clinical indicators for various disease parameters, and act as surrogate endpoints in clinical trials for disease-modifying drugs. The aim of this systematic review was to produce a comprehensive list of candidate molecular biomarkers for knee OA after the 2013 ESCEO review and discern whether any have been studied in sufficient detail for use in clinical settings. Design MEDLINE and Embase databases were searched between August 2013 and May 2018 using the keywords “knee osteoarthritis,” “osteoarthritis,” and “biomarker.” Studies were screened by title, abstract, and full text. Human studies on knee OA that were published in the English language were included. Excluded were studies on genetic/imaging/cellular markers, studies on participants with secondary OA, and publications that were review/abstract-only. Study quality and bias were assessed. Statistically significant data regarding the relationship between a biomarker and a disease parameter were extracted. Results A total of 80 studies were included in the final review and 89 statistically significant individual molecular biomarkers were identified. C-telopeptide of type II collagen (CTXII) was shown to predict progression of knee OA in urine and serum in multiple studies. Synovial fluid vascular endothelial growth factor concentration was reported by 2 studies to be predictive of knee OA progression. Conclusion Despite the clear need for biomarkers of OA, the lack of coordination in current research has led to incompatible results. As such, there is yet to be a suitable biomarker to be used in a clinical setting.