scholarly journals Gene-environment interactions as the basis of health formation

2017 ◽  
Vol 15 (4) ◽  
pp. 19-32 ◽  
Author(s):  
Aksana N. Kucher
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Health Data ◽  
Genetic Program ◽  
Biologically Active ◽  
Gene Environment ◽  
Polymorphic Variants ◽  
Genetic And Environmental Factors ◽  
Active Substances

The review discusses issues related to the importance of interaction between genetic and environmental factors for the implementation of the genetic program of individuals and determining the level of health. Data on the importance of some nutrients (vitamins, bio-elements) for formation of health, about a role of genetic factors in maintenance of a homeostasis of biologically active substances, about associations of the genes involved in a metabolism of nutrients with various pathologies, and examples of modification of effects of genetic polymorphic variants on risk of development of common diseases by various factors (bio-elements and other components of a diet, adverse factors of environment, drugs, etc.) are presented.

The molecular basis of non-syndromic orofacial clefts and tooth agenesis

2018 ◽  
Vol 86 (4) ◽  
pp. 321
Author(s):  
Agnieszka Danuta Gaczkowska ◽  
Paweł Piotr Jagodziński ◽  
Adrianna Mostowska
Keyword(s):  
Genetic Factors ◽  
Tooth Agenesis ◽  
Chromosomal Locus ◽  
Orofacial Clefts ◽  
Factors Influencing ◽  
Polymorphic Variants ◽  
Methodological Approaches ◽  
Genetic And Environmental Factors ◽  
European Populations

Non-syndromic orofacial clefts and tooth agenesis are two of the most common craniofacial birth defects. Both of them have a complex etiology, with genetic and environmental factors involved. Additionally, the epigenetic modifications have been implicated in the pathogenesis of these structural malformations. Despite an increasing number of research studies, using a variety of methodological approaches, the role of genetic factors in the etiology of orofacial clefts and tooth agenesis is still not well elucidated. The most consistent findings across studies concerning the genetic factors influencing the risk to orofacial clefts include the association of polymorphic variants of the IRF6 gene and the chromosomal locus 8q24.21. The major candidate gene for tooth agenesis in the European populations is WNT10A; its pathogenic mutations are present in more than 50% of patients with this dental anomaly. It has been found that both orofacial clefts and tooth agenesis, which co-occurrence is often reported, may share common candidate genes.

Sources of Stability in Social and Economic Ideological Orientations: Cohort, Context, and Construct Effects

2020 ◽  
Vol 32 (4) ◽  
pp. 711-730
Author(s):  
Aleksander Ksiazkiewicz ◽  
Robert Klemmensen ◽  
Christopher T Dawes ◽  
Kaare Christensen ◽  
Matt McGue ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Life Experiences ◽  
National Context ◽  
Social Ideology ◽  
Age Cohort ◽  
Economic Ideology ◽  
Genetic And Environmental Factors ◽  
The Stability

Abstract Existing research shows that ideological orientations are stable after young adulthood. Extending research on the sources of ideological stability, we examine social and economic ideology over a 3- to 4-year period in two twin panels (one Danish and one American). We find evidence for the importance of genetic influences and individual life experiences on the stability of social ideology in both contexts; shared environmental factors play an important role in the younger, Danish sample only. For economic ideology, genetic factors contribute to stability in the American sample only. Our findings show that the role of genetic and environmental factors in the stability of ideological orientations varies by type of ideology, national context, and, possibly, age cohort.

Concordance for Stuttering in Monozygotic and Dizygotic Twin Pairs

1981 ◽  
Vol 24 (3) ◽  
pp. 317-321 ◽  
Author(s):  
Pauline M. Howie
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Identical Twins ◽  
Dizygotic Twin ◽  
Same Sex ◽  
Maximum Accuracy ◽  
Estimated Risk ◽  
Genetic And Environmental Factors

The role of genetic factors in the etiology of stuttering was investigated in 30 pairs of same-sex twins, each pair containing at least one stutterer. Care was taken to ensure maximum accuracy in zygosity classification and objectivity in stuttering diagnosis. Zygosity classification was made independently of stuttering diagnosis. Pair-wise concordance for stuttering was significantly higher in identical twins (63%) than in fraternal same-sex twins (19%). The estimated risk of stuttering in the monozygotic (MZ) co-twin of a stutterer was .77, and .32 in the dizygotic (DZ) co-twin of a stutterer, The findings strongly suggest the operation of genetic factors in stuttering, However, the presence of as many as six pairs of identical twins who were discordant for stuttering underlines the importance of the interaction of genetic and environmental factors in the etiology of this disorder.

scholarly journals Genetic origin of the relationship between parental negativity and behavior problems from early childhood to adolescence: A longitudinal genetically sensitive study

2013 ◽  
Vol 25 (2) ◽  
pp. 487-500 ◽  
Author(s):  
Silvia Alemany ◽  
Frühling V. Rijsdijk ◽  
Claire Margaret Alison Haworth ◽  
Lourdes Fañanás ◽  
Robert Plomin
Keyword(s):  
Early Childhood ◽  
Environmental Factors ◽  
Behavior Problems ◽  
Genetic Factors ◽  
Causal Pathways ◽  
Longitudinal Association ◽  
Genetic And Environmental Factors ◽  
And Behavior ◽  
The Relationship

AbstractLittle is known about how genetic and environmental factors contribute to the association between parental negativity and behavior problems from early childhood to adolescence. The current study fitted a cross-lagged model in a sample consisting of 4,075 twin pairs to explore (a) the role of genetic and environmental factors in the relationship between parental negativity and behavior problems from age 4 to age 12, (b) whether parent-driven and child-driven processes independently explain the association, and (c) whether there are sex differences in this relationship. Both phenotypes showed substantial genetic influence at both ages. The concurrent overlap between them was mainly accounted for by genetic factors. Causal pathways representing stability of the phenotypes and parent-driven and child-driven effects significantly and independently account for the association. Significant but slight differences were found between males and females for parent-driven effects. These results were highly similar when general cognitive ability was added as a covariate. In summary, the longitudinal association between parental negativity and behavior problems seems to be bidirectional and mainly accounted for by genetic factors. Furthermore, child-driven effects were mainly genetically mediated, and parent-driven effects were a function of both genetic and shared-environmental factors.

scholarly journals Heritability of Cortisol Production and Metabolism Throughout Adolescence

2019 ◽  
Vol 105 (2) ◽  
pp. 443-452 ◽  
Author(s):  
Britt J van Keulen ◽  
Conor V Dolan ◽  
Ruth Andrew ◽  
Brian R Walker ◽  
Hilleke E Hulshoff Pol ◽  
...  
Keyword(s):  
Individual Differences ◽  
Environmental Factors ◽  
Genetic Factors ◽  
Environmental Influences ◽  
Broad Sense ◽  
Broad Sense Heritability ◽  
Total Contribution ◽  
Cortisol Metabolism ◽  
Genetic And Environmental Factors

Abstract Context Inter-individual differences in cortisol production and metabolism emerge with age and may be explained by genetic factors. Objective To estimate the relative contributions of genetic and environmental factors to inter-individual differences in cortisol production and metabolism throughout adolescence. Design Prospective follow-up study of twins. Setting Nationwide register. Participants 218 mono- and dizygotic twins (N = 109 pairs) born between 1995 amd 1996, recruited from the Netherlands Twin Register. Cortisol metabolites were determined in 213, 169, and 160 urine samples at the ages of 9, 12, and 17, respectively. Main outcome measures The total contribution of genetic factors (broad-sense heritability) and shared and unshared environmental influences to inter-individual differences in cortisol production and activities of 5α-reductase, 5β-reductase, and 11β-hydroxysteroid dehydrogenases and cytochrome P450 3A4. Results For cortisol production rate at the ages of 9, 12, and 17, broad-sense heritability was estimated as 42%, 30%, and 0%, respectively, and the remainder of the variance was explained by unshared environmental factors. For cortisol metabolism indices, the following heritability was observed: for the A-ring reductases (5α-and 5β-reductases), broad-sense heritability increased with age (to >50%), while for the other indices (renal 11β-HSD2, global 11β-HSD, and CYP3A4), the contribution of genetic factors was highest (68%, 18%, and 67%, respectively) at age 12. Conclusions The contribution of genetic factors to inter-individual differences in cortisol production decreased between 12 and 17y, indicative of a predominant role of individual circumstances. For cortisol metabolism, distinct patterns of genetic and environmental influences were observed, with heritability that either increased with age or peaked at age 12y.

scholarly journals Heritability of Caries Scores, Trajectories, and Disease Subtypes

2020 ◽  
Vol 99 (3) ◽  
pp. 264-270 ◽  
Author(s):  
S. Haworth ◽  
A. Esberg ◽  
P. Lif Holgerson ◽  
R. Kuja-Halkola ◽  
N.J. Timpson ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Genetic Factors ◽  
Caries Experience ◽  
Tooth Surfaces ◽  
Molar Teeth ◽  
Caries Progression ◽  
Disease Subtypes ◽  
Dental Records ◽  
Genetic And Environmental Factors

Previous studies report that dental caries is partially heritable, but there is uncertainty in the magnitude of genetic effects and little understanding of how genetic factors might influence caries progression or caries subtypes. This study aimed to estimate the relative importance of genetic and environmental factors in the etiology of different caries outcomes using a twin-based design. Analysis included up to 41,678 twins in the Swedish Twin Register aged 7 to 97 y, and dental data were obtained from preexisting dental records. The outcome measures were 1) summary indices of caries experience, 2) parameters representing trajectory in caries progression derived from longitudinal modeling, and 3) caries scores in groups of biologically similar tooth surfaces derived from hierarchical clustering of tooth surfaces (termed caries clusters). Additive genetic factors explained between 49.1% and 62.7% of variation in caries scores and between 50.0% and 60.5% of variation in caries trajectories. Seven caries clusters were identified, which had estimates of heritability lying between 41.9% and 54.3%. Shared environmental factors were important for only some of these clusters and explained 16% of variation in fissure caries in molar teeth but little variation in other clusters of caries presentation. The genetic factors influencing these clusters were only partially overlapping, suggesting that different biological processes are important in different groups of tooth surfaces and that innate liability to some patterns of caries presentation may partially explain why groups of tooth surfaces form clusters within the mouth. These results provide 1) improved quantification of genetic factors in the etiology of caries and 2) new data about the role of genetics in terms of longitudinal changes in caries status and specific patterns of disease presentation, and they may help lay the foundations for personalized interventions in the future.

Some aspects of management of patients with occupational chronic obstructive pulmonary disease: the value of bronchoscopy

2020 ◽  
pp. 817-817
Author(s):  
M. L. Shteiner ◽  
A. V. Zhestkov ◽  
N. E. Lavrentieva
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Pulmonary Disease ◽  
Biologically Active ◽  
Chronic Obstructive ◽  
Common Disease ◽  
Obstructive Pulmonary Disease ◽  
Production Factors ◽  
Causes Of Disease ◽  
Genetic And Environmental Factors ◽  
Active Substances

Chronic obstructive pulmonary disease is a common disease that could lead to death. Pathogenesis of COPD involves both genetic and environmental factors. Such unfavorable production factors as dust, smoke, toxic and biologically active substances are the causes of disease in 15% of cases.

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