scholarly journals Hydrastinine with uterine bleeding.

2020 ◽  
Vol 6 (5) ◽  
pp. 517-518
Author(s):  
А. Czempin.
Keyword(s):  
Effective Means ◽  
Uterine Bleeding ◽  
Pharmaceutical Treatment ◽  
Hydrastis Canadensis ◽  
Chronic Endometritis ◽  
Liquid Extract ◽  
Secondary Bleeding ◽  
Postpartum Involution

Analyzing the pharmaceutical treatment of uterine bleeding, the author quite rightly stops at ergot preparations and hydrastis canadensis, as the most effective means. Ergot acts mainly on the very muscle of the uterus and, therefore, is shown in atonic bleeding, depending for example. from insufficient postpartum involution of the uterus, while hydrastis is most useful for so-called secondary bleeding that occurs under the influence of diseases of the uterine appendages, with chronic endometritis, in the menopausal period, in girls, etc. The disadvantage of this remedy, in the form of a liquid extract, is that it does not work well when used when bleeding has already occurred, and that to get the proper effect, it must be taken long (two weeks) before the expected Meno-or metrorrhagia.

Etiological structure and diagnosis of abnormal uterine bleeding

GYNECOLOGY ◽  
2018 ◽  
Vol 20 (2) ◽  
pp. 14-17
Author(s):  
G E Chernukha ◽  
I A Ivanov ◽  
Z N Efendieva ◽  
M R Dumanovskaya ◽  
A V Asaturova
Keyword(s):  
Diagnostic Accuracy ◽  
Endometrial Hyperplasia ◽  
Ultrasound Examination ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Histological Diagnosis ◽  
Reproductive Age ◽  
Endometrial Polyps ◽  
Chronic Endometritis ◽  
Endometrial Pathology

Abnormal uterine bleeding (AUB) is one of the most common indications for hysteroscopy. Most of the AUB cases occur due to endometrial or myometrium pathology. Among it, endometrial polyps (EP) and chronic endometritis (CE) prevalent in reproductive age, while endometrial hyperplasia (EH) and EP dominate in perimenopause. It was determined that EP and CE are characterized with menorrhagia and metrorrhagia approximately equally, whereas EH reveals AUB with oligomenorrhoea. Verification of exact endometrial pathology by ultrasound examination is hindered, that results in deviations of ultrasound and histological diagnosis. The usage of ultrasound data and AUB’s characteristics may improve the diagnostic accuracy on preadmission period.

Routine Syndecan-1 Immunohistochemistry Aids in the Diagnosis of Chronic Endometritis

2004 ◽  
Vol 128 (9) ◽  
pp. 1000-1003 ◽  
Author(s):  
Ilene B. Bayer-Garner ◽  
Jennifer A. Nickell ◽  
Soheila Korourian
Keyword(s):  
Plasma Cells ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Endometrial Polyp ◽  
Chronic Endometritis ◽  
Underlying Malignancy ◽  
Proliferative Endometrium ◽  
Exogenous Progesterone ◽  
Secretory Endometrium

Abstract Context.—Chronic endometritis is reportedly observed in 3% to 10% of women undergoing endometrial biopsy for abnormal uterine bleeding. The diagnosis of chronic endometritis rests on the identification of the plasma cells. Their identification may be obscured by a mononuclear cell infiltrate, plasmacytoid stromal cells, abundant stromal mitoses, a pronounced predecidual reaction in late secretory endometrium, menstrual features, or secondary changes due to exogenous progesterone treatment prior to the biopsy. Syndecan-1 is a proteoglycan that is found on the cell surface of plasma cells and keratinocytes. Immunohistochemistry stains for this antibody may facilitate diagnosis of chronic endometritis. Objective.—To determine whether or not routine syndecan-1 immunohistochemistry will aid in the diagnosis of chronic endometritis. Design.—Immunohistochemistry stains for syndecan-1 were performed on 3 levels of 47 endometrial biopsies from patients with abnormal uterine bleeding. None of the patients had endometrial hyperplasia or an underlying malignancy. Clinical correlation and follow-up was attempted in 20 cases that showed evidence of plasma cells by syndecan-1 by immunohistochemistry. Results.—Plasma cells were identified in 20 cases, 7 of which were initially diagnosed as chronic endometritis. The remaining 13 positive cases were diagnosed as tubal metaplasia (1), secretory endometrium (4), proliferative endometrium (4), menstrual endometrium (1), endometrial polyp (1), secretory endometrium with endometrial polyp (1), and endometrial polyp with exogenous hormone effect (1) based on the original hematoxylin-eosin section. Conclusions.—Syndecan-1 may be a useful adjunct in the diagnosis of chronic endometritis. Approximately half of the cases of chronic endometritis responded to an antibiotic regime; thus, this diagnosis is important and may potentially obviate the need for surgical intervention.

Subinvolution of the Placental Site as an Anatomic Cause of Postpartum Uterine Bleeding: A Review

2006 ◽  
Vol 130 (10) ◽  
pp. 1538-1542 ◽  
Author(s):  
Jamie A. Weydert ◽  
Jo Ann Benda
Keyword(s):  
Literature Review ◽  
Uterine Bleeding ◽  
Data Sources ◽  
Placental Site ◽  
Postpartum Involution ◽  
Arterial Development ◽  
Histopathologic Findings ◽  
Histopathologic Features

Abstract Context.—Subinvolution of the placental site is an anatomic cause of delayed postpartum uterine bleeding that may be underrecognized by general surgical pathologists. Objective.—To review the physiology of uteroplacental arterial development and normal postpartum involution, and to present the characteristic clinical and histopathologic features of subinvolution. Data Sources.—Literature review (MEDLINE via PubMed and Ovid) regarding the pathology and pathophysiology of placental site subinvolution. Review of the clinical and pathologic characteristics of our own institution's previously diagnosed cases of subinvolution from hysterectomy and endomyometrial curettage specimens. Conclusions.—Surgical pathologists must be aware of the cardinal histopathologic findings of subinvolution, and this diagnosis must be considered in every postpartum curettage or hysterectomy specimen presented to the surgical pathologist. Subinvolution of the placental site is an important diagnosis, as this process implies an idiopathic cause, rather than an iatrogenic cause, of postpartum uterine bleeding. The etiology of placental site subinvolution remains poorly characterized.

scholarly journals G. Narkevich. Gossypii herbacei action. (Zemsky Doctor, 1894., No. 5)

2020 ◽  
Vol 8 (6) ◽  
pp. 584
Author(s):  
N. Rachinskiy
Keyword(s):  
Side Effects ◽  
Uterine Bleeding ◽  
Liquid Extract

The author prefers a fresh infusion of 15.0 to 180.0 to a liquid extract of gossypii herbacei, after 1 / 2-1 hour a tablespoon; indications - uterine bleeding, atonic state of the uterus after childbirth. The author did not have to observe any side effects from this remedy.

scholarly journals Chronic endometritis and endometriosis: is there an interrelationship?

2021 ◽  
Vol 10 (3) ◽  
pp. 83-91
Author(s):  
N.Y. Pedachenko ◽  
R.A. Tukhtarian ◽  
I.L. Avetis'yan ◽  
T.L. Shemelko
Keyword(s):  
Pelvic Pain ◽  
Medical Information ◽  
Clinical Symptoms ◽  
Abnormal Uterine Bleeding ◽  
Uterine Bleeding ◽  
Cochrane Library ◽  
Control Group ◽  
Chronic Endometritis ◽  
Timely Diagnosis ◽  
Inflammatory Processes

Background. Chronic endometritis and endometriosis have a lot in common. Both diseases are long-term inflammatory processes, with definitively unspecified etiological factors and pathogenetic mechanisms that negatively affect fertility and may cause pelvic pain or abnormal uterine bleeding. The issue of effective and timely diagnosis of chronic endometritis remains open due to the lack of specific clinical symptoms and clinical examination data. Assessment of current scientific evidence of the interrelationship between endometriosis and chronic endometritis. Materials and methods. A systematic search of scientific medical information has been conducted in English-language databases: MEDLINE, Scopus, Web of Science, Medline, The Cochrane Library, PubMed. Results. According to the review of various scientific studies that have recently been conducted, it has been found that patients with endometriosis statistically have a significantly higher risk of developing chronic endometritis by 1.3-2.5 times than women without endometriosis. Using a histological endometrial study and detection of CD138, chronic endometritis was found in 52.94 % of women in the endometriosis group and in 27.02 % of patients in the endometriosis-free group; the rate was significantly higher in the endometriosis group than in the control group (p = 0.0311). Moreover, 76% of women with endometriosis showed inflammatory processes of pelvic organs (compared to the control group, where inflammation was found in 38.4 % of women, p < 0.0001). Conclusions. Patients with endometritis demonstrate a positive correlation with development of endometriosis. Given the inability to establish a causal relationship between endometriosis and chronic endometritis, extended diagnosis is necessary to eliminate chronic endometritis, especially if women have abnormal uterine bleeding or chronic pelvic pain. The combination of histological and immunohistochemical endometrial examination methods has shown its effectiveness in timely diagnosis of chronic endometritis. Identifying and adequately treating this condition will help avoid unnecessary surgery.

scholarly journals Evaluation of Endometrium for Chronic Endometritis by Using Syndecan-1 in Abnormal Uterine Bleeding

2012 ◽  
Vol 4 (02) ◽  
pp. 069-073 ◽  
Author(s):  
Vidyavathi Kannar ◽  
Harendra Kumar Malligere Lingaiah ◽  
Venigalla Sunita
Keyword(s):  
Plasma Cells ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Biopsy ◽  
Uterine Bleeding ◽  
Endometrial Polyps ◽  
Chronic Endometritis ◽  
Proliferative Endometrium ◽  
Stromal Edema ◽  
Clinically Significant ◽  
Mononuclear Infiltrate

ABSTRACT Context: Chronic endometritis is a condition observed in 3-10% of women with abnormal uterine bleeding (AUB). Diagnosis depends upon the histological detection of plasma cells within the inflammatory infiltrate in the endometrium. Plasma cells on H and E may be obscured by a mononuclear infiltrate, plasmacytoid stromal cells, abundant stromal mitosis, a pronounced predecidual reaction, menstrual features or secondary changes due to exogenous progesterone treatment prior to biopsy. Aims: The objective of this study was to determine utility of syndecan-1 in diagnosis of chronic endometritis in patients with AUB, and to see if any of the secondary histologic features in endometrial biopsy, correlated with the presence of plasma cells on immunohistochemistry (IHC). Materials and Methods: Fifty endometrial biopsies with a clinical diagnosis of AUB were taken. Endometrium in proliferative phase, secretory phase, endometrial polyps, and disordered proliferative endometrium were studied for the presence of plasma cells. IHC was done using syndecan-1. The secondary histologic features of chronic endometritis like gland architectural irregularity, spindled stroma, stromal edema and hemorrhage with the presence of plasma cells was statistically analysed. Values of P < 0.05 were considered as significant. Results: Plasma cells were seen in 11 (69%) of DPE, 8 (66%) of PEB, and 1 (7%) of normal proliferative endometrium and in 2 (40%) of secretory endometrium. Presence of stromal breakdown showed a significant association with plasma cells (P = 0.02) whereas gland architecture irregularity (P = 0.28), stromal edema (P = 0.71) and spindled stromal (P = 0.72) did not show a significant association. Conclusions: Plasma cells were significantly present in AUB patients. Syndecan-1 maybe helpful in unusual cases, where chronic endometritis is suspected as the cause of clinically significant ongoing abnormal bleeding.

scholarly journals COMPARATIVE EFFICACY OF HORMONAL DRUGS FOR THE PREPARATION OF THE ENDOMETRIUM FOR ABLATION IN PREMENOPAUSAL PATIENTS

2019 ◽  
Vol 6 (3) ◽  
pp. 151-156
Author(s):  
Sergey P. Sinchikhin ◽  
E. V Kostenko ◽  
L. V Stepanyan
Keyword(s):  
Endometrial Hyperplasia ◽  
Effective Means ◽  
Abnormal Uterine Bleeding ◽  
Endometrial Ablation ◽  
Uterine Bleeding ◽  
Comparative Efficacy ◽  
Gonadotropin Releasing Hormone Agonist ◽  
Results Of Treatment ◽  
Uterine Mucosa ◽  
Premenopausal Patients

The aim of the study is to compare the effectiveness of the use of hormonal drugs before hysteroresectoscopic ablation of the endometrium in premenopausal patients with abnormal uterine bleeding. Were examined 145 women aged from 45 to 54 years with recurrent endometrial hyperplasia, which were divided into three groups depending on the preoperative use of one of the hormonal drugs (gestagen preparation, microdose estrogen-gestagen contraceptive, gonadotropin-releasing hormone agonist - GnRHa). When medication-induced endometrial atrophy was achieved, the patients underwent hysteroresectoscopic endometrial ablation using the coagulation vaporization technique. The results of the study showed the feasibility of preoperative thinning of the uterine mucosa to improve the results of treatment of its benign changes. The most effective means for accelerating the attainment of drug regression of the endometrium were GnRHa, whose effectiveness was 95.7%. The estrogen-gestagen-containing contraceptive and gestagen preparation showed an efficacy of 65.3% and 42.8%, respectively. The results of the study should be considered when choosing the optimal tactics for management of premenopausal patients with abnormal uterine bleeding.

scholarly journals Вивчення складу біологічно активних речовин і гемостатичних властивостей рідкого екстракту кукурудзи стовпчиків з приймочками для використання в акушерстві та гінекології

2018 ◽  
Author(s):  
U. V. Кarpiuk ◽  
N. N. Seredynskaya ◽  
V. S. Kyslychenko
Keyword(s):  
Quantitative Methods ◽  
Economic Problem ◽  
Uterine Bleeding ◽  
Biologically Active ◽  
Female Rats ◽  
White Female ◽  
Phytochemical Study ◽  
Hemostatic Effect ◽  
Corn Silk ◽  
Liquid Extract

Introduction. Uterine bleeding is an important social and economic problem. Herba drugs are used both in folk and in evidence medicine for atony of the uterus and uterine bleeding. Therefore, the development and research of herbal preparations with a hemostatic effect for use in uterine bleeding is an important issue.The aim of the study – to conduct a phytochemical study of the liquid extract of corn silk, as well as study its hemostatic effect.Research Methods. Phytochemical study of qualitative composition and quantitative content of biologically active substances of liquid extract of cron silk was carried out by qualitative reactions, spectrophotometric and titrimetric methods. A study of the hemostatic effect of a liquid extract of corn silk was carried out on outbred, mature white female rats on a model of capillary bleeding from a cut wound of the uterus. The preparation of the comparison was an extract of water pepper.Results and Discussion. Sugars, glycosides, tannins, flavonoids, coumarins, saponins were identified in the liquid extract of corn silk. It was determined that the sum of polyphenols in the liquid extract of corn silk is (8.0±0.51) %, tannins – (1.4±0.03) %, flavonoids – (2.35±0.07) %, hydroxycinnamic acids – (3.3±0.23) %, organic acids – (3.23±0.46) % by the quantitative methods of investigation. As a result of prophylactic administration of a liquid extract of corn silk to female rats, the duration of capillary bleeding from the cut cervical wound was significantly reduced. The haemostatic activity of the reference preparation was somewhat lower.Conclusions. The conducted researches give grounds to assert about the prospects and the need for further research of the hemostatic effect of the liquid extract of corn silk.

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